Optimization Of Care In Patients With Stroke

Introduction: Optimizing care for neurological patients is a process requiring continuous monitoring, assessment and intervention by physicians and nurses.Aim: The aim of this study is to investigate the opinion of nurses in neurology wards about the optimization of care for patients with a stroke and the need to introduce a nursing dossier for neurological patients.Materials and Methods: The opinion of 72 nurses working in neurology clinics and wards in the hospitals in Varna, Sliven, Veliko Tarnovo, Gorna Oryahovitsa, Pavlikeni, Gabrovo, Tryavna has been studied. The survey covers the May - July 2018 period. Documentary, survey and statistical methods were used.Results and Discussion: The highest percentage (36%) is that of nurses with more than 30 years of work experience in neurology wards. About 50% of respondents believe that additional qualifications for nurses are needed to improve care for stroke patients. Eighty-eight percent believe that insufficient nursing staff is one of the causes of inadequate care of stroke patients. Relatively low is the percentage (26%) of those who believe that the introduction of a nursing dossier would have a positive impact on the healthcare provided to patients with a stroke

Diversity and biosynthetic potential of culturable aerobic heterotrophic bacteria isolated from Magura Cave, Bulgaria

Biocapacity of bacteria inhabiting karstic caves to produce valuable biologically active compounds is still slightly investigated. A total of 46 culturable heterotrophic bacteria were isolated under aerobic conditions from the Gallery with pre-historical drawings in Magura Cave, Bulgaria. Phylogenetic analysis revealed that most of bacterial isolates aff iliated with Proteobacteria (63%), followed by Actinobacteria (10.9%), Bacteroidetes (10.9%), and Firmicutes (6.5%). A strong domination of Gram-negative bacteria (total 81%) belonging to nine genera: Serratia, Pseudomonas, Enterobacter, Sphingobacterium, Stenotrophomonas, Commamonas, Acinetobacter, Obesumbacterium, and Myroides, was observed. Gram-positive isolates were represented by the genera Bacillus, Arthrobacter, and Micrococcus. One isolate showed a signif icant phylogenetic distance to the closest neighbor and could represent а novel species. Heterotrophic bacterial isolates from Magura Cave were investigated for hydrolytic enzymes production, antimicrobial and hemolytic activity. Predominance of producers of protease (87%), followed by xanthan lyase (64%), lipase (40%), β-glycosidase (40%), and phytase (21%) was observed. Over 75% of the isolates demonstrated antimicrobial and hemolytic activity. The results suggest that heterotrophic bacteria isolated from Magura Cave could be a valuable source of industrially relevant psychrotolerant enzymes and bioactive metabolites. This study is a f irst report on the taxonomic composition and biological activity of culturable bacteria inhabiting a cave in Bulgaria

An overview of the role of long non-coding RNAs in human choriocarcinoma

Funding: The publication of this manuscript was funded by the European Cooperation in Science & Technology Program (EU COST)–COST Action CA18117: GYNOCARE- “European network for Gynaecological Rare Cancer research: From Concept to Cure”. R.D.F., S.S., A.F., S.A.O., J.J.O., M.P.W., J.B., M.S., P.O., A.Y., M.V.-S., B.E., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1–3, and J.C.-A. is the Chairperson of this Action.Choriocarcinoma (CC), a subtype of trophoblastic disease, is a rare and highly aggressive neoplasm. There are two main CC subtypes: gestational and non-gestational, (so called when it develops as a component of a germ cell tumor or is related to a somatic mutation of a poorly differentiated carcinoma), each with very diverse biological activity. A therapeutic approach is highly effective in patients with early-stage CC. The advanced stage of the disease also has a good prognosis with around 95% of patients cured following chemotherapy. However, advancements in diagnosis and treatment are always needed to improve outcomes for patients with CC. Long non-coding (lnc) RNAs are non-coding transcripts that are longer than 200 nucleotides. LncRNAs can act as oncogenes or tumor suppressor genes. Deregulation of their expression has a key role in tumor development, angiogenesis, differentiation, migration, apoptosis, and proliferation. Furthermore, detection of cancer-associated lncRNAs in body fluids, such as blood, saliva, and urine of cancer patients, is emerging as a novel method for cancer diagnosis. Although there is evidence for the potential role of lncRNAs in a number of cancers of the female genital tract, their role in CC is poorly understood. This review summarizes the current knowledge of lncRNAs in gestational CC and how this may be applied to future therapeutic strategies in the treatment of this rare cancer.publishersversionpublishe

INTELLIGENT METHODS FOR ATTESTATION OF SCIENTIFIC AND TEACHING STAFF. RASCH MODEL

Introduced in many universities quality management systems suggest the development of appropriate technologies for the assessment of learning results. Unfortunately, some of the real tasks remain outside the scope of the systems due to complexity, non-formalization, unawareness or lack of adequate mathematical models, software and more. Such is the task of attestation of the research and teaching staff, which is being periodically solved in universities. The work proposed model for the formalization of the problem of attestation of scientific and pedagogical staff, based on an adapted version of the one-parameter Rasch model for dichotomic data. The model allows software implementation and help to reduce the subjectivism in evaluating the performance of teachers in universities

Акупунктурен третман за мигрена

Вкупниот број на заболени од мигрена е висок, и влијае на висока стапка на возрасните во репродуктивната фаза од нивниот живот, предизвикувајќи значителна попреченост и губење на дневните активности, со релевантни социјални и економски трошоци Истражувањето на ефикасноста на акупунктурата за лекување на мигрената е спроведено во ординација за Традиционална Кинеска Медицина во Скопје, Република Македонија, од страна на доктор специјалист по акупунктура. Вклучени се 25 пациенти, од кои 13 жени и 12 мажи. По изведените третмани е направена целосна евиденција на податоците и постигнатите резултати се целосно обработени, како застапеноста на мигрената, болката, полот и ефикасноста на лекувањето според бројот на спроведени терапии. Според податоците кои се обработени во овој труд можеме да заклучиме дека акупунктурата е доста ефикасен алтернативен метод на лекување на мигрената. Овој метод на лекување е безболен, безбеден и без несакани дејства

Using the Mathematica package in teaching mathematical disciplines

This article analyzes the capabilities of the Wolfram Mathematica computer system, examines the feasibility of using its tools in the study of mathematical disciplines. The authors propose and demonstrate by examples a methodology for building a training course based on the integration of the methods of the discipline being studied and their implementation in the Mathematica environment. The paper explores the practical significance of including the Mathematica toolkit in the training course, which makes it possible to mathematically model various processes in modern society, demonstrate the solution of mathematically complex problems using the built-in functions of the package, as well as provide visualization of analytically obtained solutions

Computer vision syndrome in the nurse`s daily activities

Новите технологии наложиха ежедневна работа с компютър във всички сфери на производството, услугите и образованието. Компютърният зрителен синдром (КЗС) представлява комплекс от негативни усещания и включва намаляване на броя на премигванията и понижена слъзна секреция.Компютърната грамотност е част от квалификационната характеристика на медицинската сестра, a работата пред монитор е ежедневие в сестринската практика. Това довежда до често срещани оплаквания: сълзене на очите, парене, усещане за „пясък в очите`, зрителна умора, главоболие. За появата на тези симптоми в голяма степен допринасят и постоянното префокусиране на погледа от клавиатурата върху екрана или печатни документи.Целта на настоящото проучване е да се установи степента на информираност относно очното здраве и профилактичната дейност на медицинските сестри, свързани с КЗС.Материали и методи: В периода 13-20.06.2016 г. е проучено мнението на 40 студенти първокурсници от специалности „Медицинска сестра` и „Акушерка`, обучаващи се в МУ-Варна, Филиал Велико Търново, и 30 медицински сестри от МОБАЛ „Д-р Стефан Черкезов` АД, гр. Велико Търново.Проведена бе анкета с 15 въпроса, от които 14 затворени и 1 отворен. Проучването бе анонимно.Резултатите сочат, че работата с компютър е съществена част от ежедневието на анкетираните. Разнообразните субективни симптоми, които се установиха, са резултат от неспазването на нормите за хигиена при работа с компютър. 49% от анкетираните не са информирани за нормите на хигиена, 39% ги познават и едва 20% - отчасти.Изводи: Необходимо е медицинските сестри да са запознати с „компютърния зрителен синдром`, за да могат да извършват ефективни дейности по превенция и профилактика на очните заболявания и обучение на пациенти в тази насока.New technologies have imposed the use of computers in all spheres of production, services and education on a daily basis. Computer vision syndrome is a complex of negative sensations and includes decreased blinking rate and tear production.Computer literacy is a necessary qualification in the nurse profession and the work before a computer screen is an everyday activity. It results in frequent complaints, such as watery eyes, burning eyes, sandy feeling in the eye, eye fatigue and headaches. A constant gaze shift from the keyboard to the screen or any printed material aggravates such symptoms. The purpose of the current survey is to evaluate the level of information about eye health and prophylactic activities of nurses related to CVS.Materials and Methods: The opinions of 40 firstyear students from the Nurse and Midwife programs of the Medical University of Varna at its Veliko Tarnovo Affiliate, and 30 nurses from the Regional Hospital Dr Stefan Cherkezov (MOBAL), Veliko Tarnovo, were surveyed in the period 13-20 June, 2016. They were asked 15 questions, 14 of which were closed-ended questions and one was open-ended. The survey was anonymous.The results show that the work done on a computer is an essential part of the surveyed people`s everyday routine. The different personal symptoms that were identified are the result of breaking the norms of hygiene in working on a computer. Of the surveyed, 49% are clueless about the hygienic norms; 39% are familiar with them and only 20% of the people are partially familiar.Conclusions: It is necessary for nurses to know about the computer vision syndrome so that they can work effectively towards prevention and prophylaxis of eye diseases and training patients in this direction

Phylogenetic analysis of the bacterial community in a crystallizer pond, Pomorie salterns, Bulgaria

The aim of this study was to investigate the bacterial community habituating P18, the biggest crystallizer pond in Pomorie salterns (34% salinity). The obtained results showed that the bacterial community differs from many previous reports of low bacterial diversity in hypersaline environments and demonstrates unusually high diversity of presented taxa, some unusual domination of diverse genera not reported before as dominant and identification of previously unknown 16S rRNA sequences. The retrieved 23 bacterial operational taxonomic units (OTUs) affiliated with 15 bacterial genera from four phyla – Firmicutes, 47.5%; Proteobacteria, 23.1%; Bacteroidetes, 22%; Deinococcus–Thermus, 2.4%; and one-candidate division SR1, 4.8%. Representatives of the phylum Firmicutes predominated in the bacterial community with almost half of the retrieved sequences. Almost all clones branched together with cultured halophiles or uncultured clones retrieved from saline niches. Despite of the high salt concentration, some of the closest phylogenetic neighbours were moderate halophiles. New sequences represented 42.3% of bacterial OTUs. Some of them formed separate branches with similarity less than 85%

Diversity and biosynthetic potential of culturable aerobic heterotrophic bacteria isolated from Magura Cave, Bulgaria

Biocapacity of bacteria inhabiting karstic caves to produce valuable biologically active compounds is still slightly investigated. A total of 46 culturable heterotrophic bacteria were isolated under aerobic conditions from the Gallery with pre-historical drawings in MaguraCave, Bulgaria. Phylogenetic analysis revealed that most of bacterial isolates affiliated with Proteobacteria (63%), followed by Actinobacteria (10.9%), Bacteroidetes (10.9%), and Firmicutes (6.5%). A strong domination of Gram-negative bacteria (total 81%) belonging to nine genera: Serratia, Pseudomonas, Enterobacter, Sphingobacterium, Stenotrophomonas, Commamonas, Acinetobacter, Obesumbacterium, and Myroides, was observed. Gram-positive isolates were represented by the genera Bacillus, Arthrobacter, and Micrococcus. One isolate showed a significant phylogenetic distance to the closest neighbor and could represent а novel species. Heterotrophic bacterial isolates from MaguraCave were investigated for hydrolytic enzymes production, antimicrobial and hemolytic activity. Predominance of producers of protease (87%), followed by xanthan lyase (64%), lipase (40%), β-glycosidase (40%), and phytase (21%) was observed. Over 75% of the isolates demonstrated antimicrobial and hemolytic activity. The results suggest that heterotrophic bacteria isolated from MaguraCave could be a valuable source of industrially relevant psychrotolerant enzymes and bioactive metabolites. This study is a first report on the taxonomic composition and biological activity of culturable bacteria inhabiting a cave in Bulgaria