Biochemical Evaluation of Withania Somnifera Root Powder on Adjuvant-Induced Arthritis in Rats

The present investigation was carried out to evaluate the biochemical effect of Withania somnifera Linn. Solanaceae, commonly known as ashwagandha on adjuvant induced arthritic rats. Results were compared to Indomethacin, a non steroidal anti-inflammatory drug. Arthritis was induced by an intra dermal injection of Complete Freund’s Adjuvant (0.1 ml) into the right hind paw of Wistar albino rats. Withania somnifera root powder (1000 mg/kg/day) and Indomethacin (3 mg/kg/day) were orally administered for 8 days (from 11th to 18th day) after adjuvant injection. After the experimental period, all the animals were sacrificed and serum, liver and spleen samples were collected for further biochemical analysis. A significant increase in the activities of gluconeogenic enzymes, tissue marker enzymes, blood glucose level, WBC, platelet count, erythrocyte sedimentation rate, and acute phase proteins (hyaluronic acid, fibrinogen and ceruloplasmin) was observed in adjuvant-induced arthritic rats, whereas the activities of glycolytic enzymes, body weight, levels of hemoglobin, RBC count, and packed cell volume were found to be decreased. These biochemical alterations observed in arthritic animals were ameliorated significantly after the administration of Withania somnifera root powder (1000 mg/kg/b.wt) and Indomethacin (3 mg/kg/b.wt). Our results suggest that Withania somnifera root powder is capable of rectifying the above biochemical changes in adjuvant arthritis and it may prove to be useful in treating rheumatoid arthritis

Genetic Variability in Indian Spinach (Basella alba L.)

Evaluation of eleven germplasm lines of the Indian spinach (basella) revealed maximum leaf weight/plant in IIHR-1 (160.5g), followed by IIHR-18 (111.6g) and IIHR-3 (98.3g). Results of genetic studies revealed that phenotypic coefficient of variation was higher than genotypic coefficient of variation for all the traits studied, indicating environmental influence on expression of these characters. Moderate heritability along with high genetic advance was recorded for leaf weight and total plant weight, indicating the presence of additive gene effects. Hence, selection can be employed for improvement of these characters in basella. Higher plant weight was found to be significantly and positively associated with branch number, leaf number, leaf weight and stem weight. Leaf number had the maximum direct positive effect on total plant weight, followed by leaf length. Indirect effects of other characters through these characters were also seen to be positive. Thus, for yield improvement in basella, emphasis may be laid on indirect selection through leaf characters like leaf number, leaf length and leaf weight

THE INFLUENCE OF HPC-L AND EUDRAGIT L30 D-55 ON DELAYED RELEASE OMEPRAZOLE MAGNESIUM MULTIPLE-UNIT PELLET SYSTEM

Objective: The objective of the study is to develop optimum, stable, delayed release pellets of omeprazole magnesium (20.6 mg dose). Omeprazole magnesium is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+ -ATPase at the secretory surface of the gastric parietal cell, which is orally administered drug, whereas omeprazole magnesium is degraded in stomach pH, so it is formulated as delayed release dosage form to absorb in intestinal pH.Methods: The formulation of delayed release pellets of omeprazole magnesium was developed by enteric film coating process varying the compositions of drug loading, barrier coating, and enteric coating using fluid bed processor. The prepared multiple pellets were filled into hard gelatin capsules as a single unit dosage forms.Results: The dissolution profile of formulation (F8) contains the efficient amount of hydroxypropyl cellulose-L and Eudragit L30 D55 leads to effective release of drug in 30 min. Fourier transform infrared and differential scanning colorimeter studies were conducted for the optimized formula to prove that the formula was not having incompatibility between the drug and excipients. The scanning electron microscopy studies were conducted to know the surface morphology of the pellets.Conclusion: It was concluded that optimized formulation (F8) shown good similarity with innovator. The results of the accelerated stability of final formulation revealed that storage conditions were excellent

A Personalized Fractional Produce Maker For Superfluous Double Multipliers

In this RBMPPG (modified component product) generator is recommended; it removes the additional ECW and thus provides a single step for RBPP collection. Due to this high portability and no additional load, redundant binary (RB) can be used to create high performance servo. The traditional RB extension requires one line extension to the selected RB product (RBPP), because the error correction voice (ECW) is made up of both Radiated Radix-4 root recording (MBE) and RB code. This occurs during one additional RBPP component of the MBE expansion component.  Therefore, the planned RBMPPG produces fewer production products compared to the standard RB MBE multiplier. The results show that the proposed RBMPPG-based design significantly improves the space and power consumption or voice length of each parliamentary in this extension is approximately thirty-three; this reduction over previous NB servo leads to a slight increase in delay (approximately 6%). The power of the product delay can be reduced to ninety-five percent using the selected Serb rib compared to the existing RB servo

Characterization, inheritance of male sterility and development of male sterile and maintainer lines in ridge gourd (Luffa acutangula (Roxb.) L.)

Two male sterile mutants IIHRRG-12MS (long fruited) and IIHRRG-28MS (medium long fruited) were identified from the ridge gourd germplasm IIHR-12 and IIHR-28 respectively at ICAR-IIHR, Bengaluru. These two male-sterile (ms) sources were characterized by the production of rudimentary male flowers in the racemes in contrast to the bright yellow flowers with fertile pollen and healthy anthers in male fertile, monoecious plants. Using these ms lines the inheritance of male sterility was worked out, which is cytoplasmic genic male sterility (CGMS) type, with single dominant gene either in homozygous or heterozygous condition restoring male fertility in the presence of sterile cytoplasm. In order to develop F1 hybrids using male sterility, several male sterile and maintainer lines were developed in different genetic back grounds such as green/dark green fruit colour and short/medium long/long fruit length

SPACE VECTOR PWM SIGNAL GENERATION FOR ANY MULTILEVEL INVERTER BY USING REVERSE MAPPING TECHNIQUE

This paper proposes a generalized method for the generation of space vector pulse width modulation (SVPWM) signals for multilevel inverters. In the proposed method, the actual sector containing the tip of the reference space vector need not be identified. A method is presented to identify the center of a sub hexagon containing the reference space vector. Using the center of the sub hexagon, the reference space vector is mapped to the innermost sub hexagon, and the switching sequence corresponding to a two-level inverter is determined. A new technique is proposed in this paper, by which these two-level vectors are translated to the switching vectors of the multilevel inverter by adding the center of the sub hexagon to the two-level vectors. The proposed method can be extended to any n-level inverter, and a generalized algorithm is proposed. The scheme is explained for a five-level inverter, and experimental results are presented for a three-level inverter and seven level Inverter

Enhanced Dengue Outbreak Prediction in Tamilnadu using Meteorological and Entomological data

This paper focuses on studying the impact of climate data and vector larval indices on dengue outbreak. After a comparative study of the various LSTM models, Bidirectional Stacked LSTM network is selected to analyze the time series climate data and health data collected for the state of Tamil Nadu (India), for the period 2014 to 2020. Prediction accuracy of the model is significantly improved by including the mosquito larval index, an indication of VBD control measure.Comment: 6 Pages and submitted to ICAI'22 - The 24th International Conference on Artificial Intelligenc

MEASUREMENT OF USERS ACCEPTANCE OF SELECTED FINANCIAL TECHNOLOGY PRODUCTS AND SERVICES

Purpose: The goal of this study is to determine the degree to which users accept particular financial technology products and services by taking into account a variety of variables, including frequency of use, level of awareness, satisfaction, motivation for using fintech, satisfaction with that motivation, and behavioural intention to use fintech.   Theoretical Framework: There is relatively little literature now accessible to examine the degree of consumer acceptance of Financial Technology products and services. The field of financial technology still requires a lot of research and education, though.   Design/Methodology/Approach: A comprehensive evaluation of the literature served as the basis for the research design. Data gathering techniques include non-probability sampling (quota sampling). Users of particular Financial Technology products and services are queried using a standardised questionnaire to gather data. The 13 districts of Andhra Pradesh state were used as the source of the samples.   Findings: The data is analysed using techniques such as regression and Anova. The frequency of use, level of satisfaction, level of awareness, the intended use of the Fintech, the satisfaction with the intended use and the user's behavioural intention to use the Fintech all statistically significantly correlate with the user's level of acceptance in using the chosen Financial Technology products and services.   Research, Practical & Social implications:  This study determined the degree to which users accepted particular Financial Technology goods and services from diverse angles.   Originality/Value: This study aims to identify and quantify the effects of numerous variables on users' degree of acceptability of Fintech, including frequency of use, awareness and satisfaction levels, as well as the use of Fintech for specific purposes and behavioural intentions. Internet banking, NEFT, RTGS, IMPS, mobile banking, electronic wallets, stock trading applications, peer-to-peer lending applications, crowd funding, cash deposit machines, ATMs, and credit rating applications are the 12 Financial Technology products used in the study

A Hybrid Image Encoding Technique with DCT and Mosaic based Segmentation

Embedding the information in cover image is always an interesting research issue in the field of image steganography. In this paper, we are using a hybrid model with compression, data encoding and image mosiacing technique. Image (pixel values) can be compressed with efficient DCT technique, Data can be embedding in to cover image without losing the data integrity with LSB technique, because usage of significant bits of the image may damage the image and image can be parallel segmented without losing pixel integrity and combined at receiver end with improved noise free image mosaicking technique. Our experimental analysis gives more efficient results than traditional approaches

MANGO SEEDS: A POTENTIAL SOURCE FOR THE ISOLATION OF BIOACTIVE COMPOUNDS WITH ANTI-CANCER ACTIVITY

Objective: The mango (Mangifera indica L.), is a fruit with high levels of phytochemicals and the seeds have antioxidant, anti-inflammatory and anti-obesity effects. This study aims at the extraction of metabolites from mango seeds and evaluation of the antiproliferative properties on cancer cell lines.Methods: The antiproliferative effects of the ethanol extract of mango seeds were evaluated on the cancer cell line HeLa, CHO cell lines and also on normal human lymphocytes by MTT assay. The extract was purified by TLC and characterized by LC-MS methods.Results: The ethanol extract had significant cytotoxicity to HeLa cells and the bioactive fraction from the crude extract had antiproliferative effects with an IC50 value of<10µg/ml. Fluorescence microscopy, caspase and LDH activity assays were confirming the anticancer potential of fraction 6. This fraction had arrested the HeLa cells in G2/M phase and decrease in the percentage of cells in S phase. By LC-MS analysis, it was found to have an m/z value of 701.8 indicating it to be a novel one.Conclusions: Here mango seeds have shown promising potential as a novel source for the isolation of a bioactive compound with anticancer activity.Â