277 research outputs found
Proposal for SPS beam time for the baby MIND and TASD neutrino detector prototypes
The design, construction and testing of neutrino detector prototypes at CERN
are ongoing activities. This document reports on the design of solid state baby
MIND and TASD detector prototypes and outlines requirements for a test beam at
CERN to test these, tentatively planned on the H8 beamline in the North Area,
which is equipped with a large aperture magnet. The current proposal is
submitted to be considered in light of the recently approved projects related
to neutrino activities with the SPS in the North Area in the medium term
2015-2020
Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue
The multifunctional nature of human flavoproteins is critically linked to their ability to populate multiple conformational states. Ligand binding, post-translational modifications and disease-associated mutations can reshape this functional landscape, although the structure-function relationships of these effects are not well understood. Herein, we characterized the structural and functional consequences of two mutations (the cancer-associated P187S and the phosphomimetic S82D) on different ligation states which are relevant to flavin binding, intracellular stability and catalysis of the disease-associated NQO1 flavoprotein. We found that these mutations affected the stability locally and their effects propagated differently through the protein structure depending both on the nature of the mutation and the ligand bound, showing directional preference from the mutated site and leading to specific phenotypic manifestations in different functional traits (FAD binding, catalysis and inhibition, intracellular stability and pharmacological response to ligands). Our study thus supports that pleitropic effects of disease-causing mutations and phosphorylation events on human flavoproteins may be caused by long-range structural propagation of stability effects to different functional sites that depend on the ligation-state and site-specific perturbations. Our approach can be of general application to investigate these pleiotropic effects at the flavoproteome scale in the absence of high-resolution structural models. © 202
Clinical value of cytological features of buccal cells in patients with Alzheimer's disease
The article presents the features of the buccal cells in patients with Alzheimer's disease. In the biomaterial of people with this pathology were identified buccal cells with cytogenetic disorders (an increase in the number of cells with micronucleus). The clinical value of the micronucleus test for patients with Alzheimer's disease was estimated.В статье представлены особенности буккальной цитограммы у пациентов с болезнью Альцгеймера. В биоматериале людей с данной патологией выявлены клетки буккального эпителия с цитогенетическими нарушениями (повышение количества клеток с микроядрами). Проведена оценка клинической ценности микроядерного теста буккального эпителия для пациентов с болезнью Альцгеймера
Synchronization of the Distributed Readout Frontend Electronics of the Baby MIND Detector
Baby MIND is a new downstream muon range detector for the WGASCI experiment. This article discusses the distributed readout system and its timing requirements. The paper presents the design of the synchronization subsystem and the results of its test
Baby MIND: A magnetised spectrometer for the WAGASCI experiment
The WAGASCI experiment being built at the J-PARC neutrino beam line will
measure the difference in cross sections from neutrinos interacting with a
water and scintillator targets, in order to constrain neutrino cross sections,
essential for the T2K neutrino oscillation measurements. A prototype Magnetised
Iron Neutrino Detector (MIND), called Baby MIND, is being constructed at CERN
to act as a magnetic spectrometer behind the main WAGASCI target to be able to
measure the charge and momentum of the outgoing muon from neutrino charged
current interactions.Comment: Poster presented at NuPhys2016 (London, 12-14 December 2016). Title +
4 pages, LaTeX, 6 figure
Baby MIND Experiment Construction Status
Baby MIND is a magnetized iron neutrino detector, with novel design features,
and is planned to serve as a downstream magnetized muon spectrometer for the
WAGASCI experiment on the T2K neutrino beam line in Japan. One of the main
goals of this experiment is to reduce systematic uncertainties relevant to
CP-violation searches, by measuring the neutrino contamination in the
anti-neutrino beam mode of T2K. Baby MIND is currently being constructed at
CERN, and is planned to be operational in Japan in October 2017.Comment: Poster presented at NuPhys2016 (London, 12-14 December 2016). 4
pages, LaTeX, 7 figure
Baby MIND: A magnetized segmented neutrino detector for the WAGASCI experiment
T2K (Tokai-to-Kamioka) is a long-baseline neutrino experiment in Japan
designed to study various parameters of neutrino oscillations. A near detector
complex (ND280) is located 280~m downstream of the production target and
measures neutrino beam parameters before any oscillations occur. ND280's
measurements are used to predict the number and spectra of neutrinos in the
Super-Kamiokande detector at the distance of 295~km. The difference in the
target material between the far (water) and near (scintillator, hydrocarbon)
detectors leads to the main non-cancelling systematic uncertainty for the
oscillation analysis. In order to reduce this uncertainty a new
WAter-Grid-And-SCintillator detector (WAGASCI) has been developed. A magnetized
iron neutrino detector (Baby MIND) will be used to measure momentum and charge
identification of the outgoing muons from charged current interactions. The
Baby MIND modules are composed of magnetized iron plates and long plastic
scintillator bars read out at the both ends with wavelength shifting fibers and
silicon photomultipliers. The front-end electronics board has been developed to
perform the readout and digitization of the signals from the scintillator bars.
Detector elements were tested with cosmic rays and in the PS beam at CERN. The
obtained results are presented in this paper.Comment: In new version: modified both plots of Fig.1 and added one sentence
in the introduction part explaining Baby MIND role in WAGASCI experiment,
added information for the affiliation
The clinical case of acute promyelocytic leukemia in a patient with high cytogenetic risk
The article presents an overview of the clinical case of acute promyelocytic leukemia in a patient with high cytogenetic risk. Key methods for laboratory diagnosis of this disease are indicated.В статье представлен обзор клинического случая острого промиелоцитарного лейкоза у пациента с высоким цитогенетическим риском. Указаны основные методы лабораторной диагностики данного заболевани
Hygienic assessment of the food of teenagers in the conditions of major and average populations
The article presents the results of a survey on the relationship between the health status of adolescents and nutritional opportunities in urban and family conditions.В статье представлены результаты анкетирования, посвященного изучению взаимосвязи между состоянием здоровья подростков и особенностям питания в городских и сельских семьях
The LBNO long-baseline oscillation sensitivities with two conventional neutrino beams at different baselines
The proposed Long Baseline Neutrino Observatory (LBNO) initially consists of
kton liquid double phase TPC complemented by a magnetised iron
calorimeter, to be installed at the Pyh\"asalmi mine, at a distance of 2300 km
from CERN. The conventional neutrino beam is produced by 400 GeV protons
accelerated at the SPS accelerator delivering 700 kW of power. The long
baseline provides a unique opportunity to study neutrino flavour oscillations
over their 1st and 2nd oscillation maxima exploring the behaviour, and
distinguishing effects arising from and matter. In this paper we
show how this comprehensive physics case can be further enhanced and
complemented if a neutrino beam produced at the Protvino IHEP accelerator
complex, at a distance of 1160 km, and with modest power of 450 kW is aimed
towards the same far detectors. We show that the coupling of two independent
sub-MW conventional neutrino and antineutrino beams at different baselines from
CERN and Protvino will allow to measure CP violation in the leptonic sector at
a confidence level of at least for 50\% of the true values of
with a 20 kton detector. With a far detector of 70 kton, the
combination allows a sensitivity for 75\% of the true values of
after 10 years of running. Running two independent neutrino
beams, each at a power below 1 MW, is more within today's state of the art than
the long-term operation of a new single high-energy multi-MW facility, which
has several technical challenges and will likely require a learning curve.Comment: 21 pages, 12 figure
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