326 research outputs found
CATALYSIS ON COMBINATION OF IMIDAZOLE GROUPS OF Ni AND Co IONIC LIQUIDS
The coordination science of metallic nitrogen and sulfur mixes is a wellspring of incitement to many examination laborers, because of the way that it has special sound system compound, electrical, attractive materials, electronic, optoelectronics part and sensor in bioinorganic science. The utilization of blended giver ligands has expanded because of their reactant capability of their metal buildings in various natural transformation.(1) They are significant in homogeneous catalysis since they give adjustment and brief coordinative immersion to the metal community through chelation until a functioning site is required.(2) An enormous number of giver ligands with numerous contributor type stages (O,S,N,P,etc… .), charge and coordination number have been described(3,4) . The giver ligands of type N are especially fascinating. They are right now utilized as demonstrating dynamic destinations for metalloanzymes (5) furthermore, they have been applied for electrical transmitters and restorative chemistry(6).They show a hard contributor (N) and delicate giver (S) that can organize to a wide scope of metal particles .They can tie to a similar metal specifically coordination state giving an alternate bond strength and obligation for every contributor iota. There is too a current interest in the fuse of these N, S giver molecules (normally the ligands contain mix of imidazole gatherings or pyrazolyle or thiolato or thioether utilitarian groups)in macrocycles and in polydentate ligands to test the naturally applicable coordination's science, the supramolecular science ,or the electrical conduction or synergist response of various metals(7) Established researchers has demonstrated expanding revenue in heterogeneous annular - N-mixes and its symmetric buildings, for its capacity educating 2 spanning and interfacing during more acidic carbon iotas, imidazolium or benzimidazol rings for framing mixes containing spacer CH2CH2 or CH2CH2 CH2CH2(8). The logical has introduced different investigations about ionic fluids in green planning during ongoing year's .also, ionic fluids are drawing in extensive consideration as adaptable media and materials due to their impossible to miss physicochemical properties, warm soundness, and simple reusing (9) These days, natural salts, ionic salts and buildings have been utilized in the expulsion of sulfur mixes from diesel fuel for utilization of its particular physical and compound properties .Such as its warm soundness, and its dissolvability for an enormous number of inorganic and natural compound
CHEMICAL CONSTITUENTS FROM ETHANOL EXTRACT OF ABRUS PRECATORIUS BY USING GCMS TECHNIQUES
A large number of medicinal plants and their purified constituents have shown beneficial therapeutic potentials. In order to promote the use of medicinal plants as potential sources of antimicrobial compounds, it is important to thoroughly investigate their composition and activity and thus validate their use. The objectives of the present study are to analyze qualitative preliminary phytochemical screeningand antimicrobial properties of Abrus precatoriusL . The qualitative preliminary phytochemical performed in aqueous extracts and ethanolic extracts of Abrus precatoriusL were done and the bioactive compound was indentified with TLC , GC-MS and UV-VIS analysis. TLC of plant extract shows three bands for the presence of phenolic compound and Rf values were 0.4,0.45,and 0.48.The UV-VIS shows the spectra at278 and 457 nm confirms the organic chromophores and fifty compounds were identified in the ethanolic extracts by GC-MS.The major components present in the Abrusprecatoriuswere αCyclooctanedione ,Furanone , 2,4-Dihydroxy-2,5-dimethyl-3(2H)-furan-3-one , 2-Oxopentanedioic acid ,PropenylFormate ,and various other compounds were identified as low level. These phytochemical are responsible for various pharmacological actions
COMPARATIVE STUDY OF SODIUM BOROHYDRIDE CATALYSED REDUCTION REATIONS: SYNTHESIS AND CHARACTERIZATION OF BENZYL ALCOHOL AND ANTIBACTERIAL ACTIVITY
The project of this thesis is the comparative study of sodium borohydride catalyzed reactions and to synthesize benzyl alcohol via the reduction reaction of Benzaldehyde. Then it will be check for antibacterial property using Disc Diffusion Method. The scope of the work is highly effective in medical field because of its Antibacterial property. In my work I have compared the sodium borohydride catalyzed reaction by taking ethyl acetoacetate for one reaction and Benzaldehyde for another reaction with sodium borohydride. Spectral (FT-IR) Method was used to establish the bond shifting of carbonyl group into hydroxyl group. The main objectives of the thesis Comparison sodium borohydride catalyzed reaction, Synthesis of benzyl alcohol, Detection of the compound by TLC, Characterization by FT-IR, Evaluation of anti-bacterial property
Rajam Krishnan's Roja Ithalgal Novel
Literature is what portrays the human life in society. Notable among those literature is novels. Author Rajam Krishnan through his novel Roja Ithalgal not only highlights the problems faced by women in the society but also brings out the solutions for the problems and makes people aware of it. In this novel, the main character is a girl who falls in love in her youth. After that she is chased out of the house. That was her first problem and it becomes the main reason for her upcoming problems. Humans make mistakes. But you should give a chance to correct it. But this girl is not given a chance. Through this the author says that it is important to discipline people. In this novel, although many problems for women are caused by men, the author points out that there are some good men too. The author of this novel reveals the status of women in politics. In this article we can read that even though the country gained independence, women lacks freedom. The author says in this novel that when many problems occur to women, it is the majority of the women who help them to come out of the problems. Descriptive method is used in this article
LITERATURE GROWTH AND DEVELOPMENT OF “EARTHWORM”: A BIBLIOMETRIC ANALYSIS
An earthworm is a soil living organism and seems in soil. It helps to make the soil more nutritious and used as an organic fertilizer. So earthworms are called as best partner for the soil and the farmer. This research is concentrated on earthworm analysis. The records are collected from web of science database for the period of 2007 - 2016. Total number of publications collected for this study was 3939. Composting with worms is called as vermicomposting. It is a good way to dispose all organic wastes, such as vegetable and fruit peelings. By the vermicomposting, the wastes are converted into nutritious by earthworm. In every home, wastes are converted into this vermicomposting the home and the city are clean. And it maintains the country very clean and protects the surrounding clean. And it may use for the terrace garden and home garden plants. This compost is a green way for organic vegetables, fruits, flowers and soil. Most of the agricultural universities, give the awareness and training program of vermicomposting to the farmers. And now- a-days the farming based on vermicomposting has been developing
BIBLIOMETRIC ANALYSIS OF RESEARCH LITERATURE ON PIPER BETLE
Betel leaf plays an important role in ancient civilization. Chewing betel leaves with areca nut was pointed out in the pre-historic books. In 13th century, Marco Polo mentioned about the betel chewing among kings and nobles in India. Betel and areca nut plays an important role in Indian Culture, especially among Hindus. On that basis of idea the keyword of “Piper betle” or betel was collected from the Web of Science. This study is limited for the period 1997- 2016 with Bibexcel and Pajek tool. Scientists are so much interested to publish the research immediately in the journal article. English is the widely used communicable language. It is true in the betel research also. Added to that, this study focuses on publishing trend, authorship pattern, author’s productivity, h-index, co-authorship map, citation map
Information Seeking Behavior and User Pattern in Library by Faculties of Engineering Colleges in South Tamil Nadu- A Study
Engineers who are faculty members in engineering colleges now-a-days require not only adequate technological ability and problem solving skills, but also the necessary skills live active co-operation, effective communication and presentation, along with business ethics and inter-personal relationship. At present, engineering colleges have in common an additional responsibility properly provide excellent opportunities to every engineering student to properly utilize the technological knowledge.
The study was conducted with the help of a well structured, close-ended questionnaire. The respondents were selected on the basis of stratified random sampling method form the four southern districts of Tamil Nadu at the rate of 140 per district totaling 560 sampling respondents. All the respondents are faculty members from selected engineering colleges in these four districts.
The study concluded that university libraries have adopted all the new information and communication technologies (ICT) and electronic resources and they are efficiently used by the academic faculties. Most of the engineering colleges are provided with the advanced technologies in the departments so as to make effective teaching and research usage. The government has now, taken initiative to undergo several steps to improve the digital library infrastructure
Evaluation of effect of yoganidra on biochemical changes in polycystic ovarian syndrome women between the age of 18 - 35 years
PCOS (Polycystic Ovarian Syndrome), a complex syndrome with endocrine and metabolic disorder of chronic anovulation, polycystic ovaries and biochemical and clinical manifestations of hyperandrogenism. Hypothalamic - pituitary adrenal axis impairment, impaired insulin secretion and action, and ovarian dysfunction are the defects involved in pathophysiology of PCOS leads to a metabolic syndrome culminating in serious long-term consequences such as type 2 diabetes mellitus, endometrial hyperplasia and cardiovascular diseases.
OBJECTIVE:
An objective of the study is to evaluate the effect of YogaNidra on biochemical changes in Polycystic ovarian syndrome women between the age of 18-35 years.
METHODS:
This study was conducted on 40 adult women between the age of 18-35 years not under any medication and fulfilling the Rotterdam criteria and inclusion criteria of this study. The study design is experimental pre post, YogaNidra practiced for 40 minutes 6 days a week up to 90 days; parameters were recorded at the baseline and also at the end of the study.
RESULT:
Results of this study showed that a significant reduction (P < 0.001) in FBS and PPBS and significant reduction (P < 0.0001) in HbA1C, GTT. There was a significant reduction (P <0.001) in cholesterol and triglyceride while a significant reduction (p < 0.001) seen among HDL, LDL, VLDL and on the anthropometric measurements significant reduction were seen in BMI(p < 0.001), Weight (p < 0.001) and WHR (p < 0.02).
SBP and DBP showed a significant reduction P < 0.0001) after YogaNidra reveals the parasympathetic domination over sympathetic nervous system.
CONCLUSION:
The present study demonstrated the efficacy of YogaNidra on biochemical profiles of PCOS women as an effective non pharmacological intervention in addressing the psychological and physiological concern of PCOS
ROLE OF EBSELEN, A SELENOORGANO COMPOUND IN CISPLATIN INDUCED NEPHROTOXICITY IN WISTAR RATS
Objective: Nephrotoxicity is encountered worldwide, irrespective of several factors, but drug induced nephrotoxicity is a complication that is attributed to the high dose and even low dose of drugs. Cisplatin, a platinum complex used in the chemotherapy of several solid tumors was found to have a chief dose limiting side effect namely nephrotoxicity, which occurred due to lipid peroxidation and formation of reactive oxygen species. Ebselen, a eleno organo compound, a glutathione peroxidase mimic with anti-oxidant activity was used in our study to evaluate its nephro protective potential.
Methods: Male wistar rats, 6-8 wks old, weighing 180-200 grams were used for the study, which was carried out for a period of 7 wks. Animals were divided into five groups; each group consisting of 6 animals. Group I served as control. Group IV & V received the test drug Ebselen in doses of 10 mg/kg & 20 mg/kg respectively. Group III received Amifostine at 50 mg/kg. The drugs were administered once a week intraperitoneally for 5 wks. Nephrotoxicity was induced at a dose of 5 mg/kg single dose for groups II to V in the 6th wk and the drugs in group III, IV & V continued for 5 days post induction. In the 7th wk blood samples were collected for biochemical analysis and kidney tissues for histopathological study.
Results: The serum urea, creatinine levels were significantly increased in Cisplatin group compared to other groups. The estimation of antioxidant levels (catalase, superoxide dismutase and glutathione peroxidise) was significantly decreased in cisplatin group and increased in other groups. The estimation of Malondialdehyde an indicator of lipid peroxidation was significantly increased in group II and decreased in drug treated group. Histopathology results of animals treated with Cisplatin showed inflammatory changes such as tubular degeneration, edema, and necrosis, infiltration of cells in tubular interstitum, mild intertubular hemorrhage and atrophy of glomeruli which was severe in group II. Some changes were also observed in Group III, IV and V animals but with less severity.
Conclusion: The result of our study effectively proves the antioxidant potential of Ebselen in ameliorating Cisplatin induced nephrotoxicity
Cloning, Expression, Sequence Analysis and Homology Modeling of the Prolyl Endoprotease from Eurygaster integriceps Puton
Eurygaster integriceps Puton, commonly known as sunn pest, is a major pest of wheat in Northern Africa, the Middle East and Eastern Europe. This insect injects a prolyl endoprotease into the wheat, destroying the gluten. The purpose of this study was to clone the full length cDNA of the sunn pest prolyl endoprotease (spPEP) for expression in E. coli and to compare the amino acid sequence of the enzyme to other known PEPs in both phylogeny and potential tertiary structure. Sequence analysis shows that the 5ꞌ UTR contains several putative transcription factor binding sites for transcription factors known to be expressed in Drosophila that might be useful targets for inhibition of the enzyme. The spPEP was first identified as a prolyl endoprotease by Darkoh et al., 2010. The enzyme is a unique serine protease of the S9A family by way of its substrate recognition of the gluten proteins, which are greater than 30 kD in size. At 51% maximum identity to known PEPs, homology modeling using SWISS-MODEL, the porcine brain PEP (PDB: 2XWD) was selected in the database of known PEP structures, resulting in a predicted tertiary structure 99% identical to the porcine brain PEP structure. A Km for the recombinant spPEP was determined to be 210 ± 53 µM for the zGly-Pro-pNA substrate in 0.025 M ethanolamine, pH 8.5, containing 0.1 M NaCl at 37 °C with a turnover rate of 172 ± 47 µM Gly-Pro-pNA/s/µM of enzyme
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