Approaching the Kosterlitz-Thouless transition for the classical XY model with tensor networks

We apply variational tensor-network methods for simulating the Kosterlitz-Thouless phase transition in the classical two-dimensional XY model. In particular, using uniform matrix product states (MPS) with non-Abelian O(2) symmetry, we compute the universal drop in the spin stiffness at the critical point. In the critical low-temperature regime, we focus on the MPS entanglement spectrum to characterize the Luttinger-liquid phase. In the high-temperature phase, we confirm the exponential divergence of the correlation length and estimate the critical temperature with high precision. Our MPS approach can be used to study generic two-dimensional phase transitions with continuous symmetries

Drug Discov Today

RNA interference (RNAi) describes the post-transcriptional silencing of gene expression that occurs in response to the introduction of double-stranded RNA into cells. Application of RNAi in experimental systems has provided a great leap forward in the elucidation of gene function. To facilitate large-scale functional genomics studies using RNAi, several high throughput approaches have been developed based on microarray or microwell assays. Recent establishment of large libraries of RNAi reagents combined with a variety of detection assays further opens the door for genome-wide screens of gene function in mammalian cells. The review provides a comprehensive overview on current RNA interference-based high throughput genomic technologies. The cell array- and microwell plate-based loss-of-function cell assays are presented

Making connections: Using skill theory to recognize how students build and rebuild understanding

In this companion to Marc Schwartz and Kurt Fischer's article, Patricia King and JoNes VanHecke describe how student affairs educators can help students become sophisticated thinkers.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50666/1/155_ftp.pd

The Connes-Lott program on the sphere

We describe the classical Schwinger model as a study of the projective modules over the algebra of complex-valued functions on the sphere. On these modules, classified by $\pi_2(S^2)$, we construct hermitian connections with values in the universal differential envelope which leads us to the Schwinger model on the sphere. The Connes-Lott program is then applied using the Hilbert space of complexified inhomogeneous forms with its Atiyah-Kaehler structure. It splits in two minimal left ideals of the Clifford algebra preserved by the Dirac-Kaehler operator D=i(d-delta). The induced representation of the universal differential envelope, in order to recover its differential structure, is divided by the unwanted differential ideal and the obtained quotient is the usual complexified de Rham exterior algebra over the sphere with Clifford action on the "spinors" of the Hilbert space. The subsequent steps of the Connes-Lott program allow to define a matter action, and the field action is obtained using the Dixmier trace which reduces to the integral of the curvature squared.Comment: 34 pages, Latex, submitted for publicatio

Liberal arts student learning outcomes: An integrated approach

Researchers completing a study of liberal arts education sought to identify learning outcomes associated with both wisdom and citizenship. They have synthesized these themes into seven outcomes that facilitate effective student learning and development.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57388/1/222_ftp.pd

Connes-Lott model building on the two-sphere

In this work we examine generalized Connes-Lott models on the two-sphere. The Hilbert space of the continuum spectral triple is taken as the space of sections of a twisted spinor bundle, allowing for nontrivial topological structure (magnetic monopoles). The finitely generated projective module over the full algebra is also taken as topologically non-trivial, which is possible over $S^2$. We also construct a real spectral triple enlarging this Hilbert space to include "particle" and "anti-particle" fields.Comment: 57 pages, LATE

Subclinical coronary atherosclerosis identified by coronary computed tomographic angiography in asymptomatic morbidly obese patients

Obesity is a common public health problem and obese individuals in particular have a disproportionate incidence of acute coronary events. This study was undertaken to identify coronary artery lesions as well as associated clinical features, risk factors and demographics in patients with a body mass index (BMI) >40 kg/m2 without known coronary artery disease (CAD). Morbidly obese subjects were prospectively recruited to undergo coronary computed tomographic angiography (CCTA) using a dual-source computed tomography (CT) system. CAD was defined as the presence of any atherosclerotic lesion in any one coronary artery segment. The presence, location, and severity of atherosclerosis were related to patient characteristics. Forty-one patients (28 women, mean age, 50.4±10.0 years, mean BMI, 43.8±4.8 kg/m2) served as the study population. Of these, 25 patients (61%) had at least one coronary stenosis. All but 2 patients within the CAD cohort had coronary artery calcium (CAC) scores >0, and most plaques identified (75.4%) were non-calcified. There was a predilection of calcified and non-calcified atherosclerosis involving the left anterior descending (LAD) coronary artery compared with other coronary segments. Univariate predictors of CAD included older age, dyslipidemia, and diabetes. In this preliminary study of young morbidly obese patients, CCTA detected a high prevalence of calcified and non-calcified CAD, although the later predominated

Screening of human gene promoter activities using transfected-cell arrays

Promoters are the best characterized transcriptional regulatory sequences in complex genomes because of their predictable location immediately upstream of transcription start sites. Despite a substantial body of literature describing transcriptional promoters, the identification of true start sites for all human transcripts is far from complete. The same is true of the key structural and functional elements responsible for promoter action in different cell types. In order to identify elements responsible for promoter activity, we applied transfected-cell array technology to functionally evaluate promoters for genes involved in inflammatory bowel disease. Seventy-four promoters were examined by reverse transfection of a promoter-fluorescent reporter constructs into a human embryonic kidney cell line (HEK293T). Sixteen (21.6%) promoters were found to be active in HEK293 T cells. Correlations between promoter activity and endogenous transcript level were calculated, and 75% of active promoters were found to be associated with transcriptional activity of their gene counterparts. These results provide experimental evidence of promoter activity, which may aid in understanding the regulation of gene expression. Moreover, this is the first large-scale functional study of regulatory sequences to use a high-throughput transfected-cell array technique