6,770 research outputs found
Low solar absorptance and emittance surfaces utilizing vacuum deposited techniques Final report, 1 Jun. 1967 - 25 Mar. 1968
Optical properties and stability of vacuum deposited silver and dielectric film coating
NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease.
Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood. Inflammasomes are broadly expressed in haematopoietic and non-haematopoietic cells and can trigger numerous downstream responses including production of IL-1β, IL-18, eicosanoids and pyroptotic cell death. Here we show a mouse model with endogenous NLRC4 inflammasome activation in Lysozyme2 + cells (monocytes, macrophages and neutrophils) in vivo exhibits a severe systemic inflammatory disease, reminiscent of human patients that carry mutant auto-active NLRC4 alleles. Interestingly, specific NLRC4 activation in Mrp8 + cells (primarily neutrophil lineage) is sufficient to cause severe inflammatory disease. Disease is ameliorated on an Asc -/- background, and can be suppressed by injections of anti-IL-1 receptor antibody. Our results provide insight into the mechanisms by which NLRC4 inflammasome activation mediates auto-inflammatory disease in vivo
How Reforming The Tort Of Negligent Hiring Can Enhance The Economic Activity Of A State, Be Good For Business And Protect The Victims Of Certain Crimes
This article will focus on reforming the tort of negligent hiring to limit the liability of employers while also ensuring the compensation of certain victims when the employer fails to meet the requirements of the reformed tort. While the tort is currently recognized by most states, the states that have recognized the tort have different standards for liability and little clarity is provided to employers on how to avoid liability. By creating certainty in the marketplace through a reformed negligent hiring tort, states can encourage business activity from civic-minded businesses while holding businesses, which fail to exhibit good civic behavior, strictly liable for the actions of its employees in certain situations
Professional Development School Support of the Elementary GLOBE Curriculum A Facilitated Adaptation of Inquiry Science
This qualitative study focused on identifying barriers and remedies to those barriers found when teaching elementary school science. The Elementary GLOBE Program (2006) was the curriculum selected when doing the 18 month study. The researcher asked what made Elementary GLOBE (EG) easy and/or difficult to use. The researcher also wished to ascertain what impact did the adoption of EG have on the delivery of science instruction in the K-4 grade classrooms participating in this study. Two professional developments schools (PDS), located in a Mid Atlantic state were the sites for the study. Both schools are in an urban setting and affiliated with a nearby land grant university.;The main purpose of this study was to investigate how elementary teachers integrate inquiry-based science in their classrooms. This was accomplished by providing an inservice workshop on an elementary science curriculum (EG) to six teachers. Then teachers were observed instructing with the newly learned curriculum. During the course of the study, teachers kept journals about their experiences teaching science. Later, they gave interviews about their classroom and school environments while teaching science.;To ascertain trustworthiness, a member check in the form of a questionnaire was given to the participating teachers to determine the reliability of the findings at the conclusion of the study. Seven out of seven teachers agreed that EG changed the way their students experienced science. Five out of seven participants felt EG increased their confidence to teach science. Time management was identified as the major barrier to teaching science with six out seven teachers agreeing with this finding. Although accommodation was identified as a barrier, four out of seven agreed to this finding even though there was a high prevalence of diversity in the studied schools and EG was not presented in the any language other than English. Five of the seven participants preferred teaching science with EG over the approved textbook used by the schools. There is a dearth of primary level earth system science materials, so the findings from this study provide evidence for an engaging curriculum promoting science and literacy
How Army Officers Attending the Command and General Staff Officers Course Decide Whether or Not to Pursue a Master’s Degree: Factors that Impact Their Decision and Unexpected Themes that Emerged
This qualitative case study explored how Army officers attending the Command and General Staff Officers Course (CGSOC) decided whether or not to attend graduate school. CGSC students were interviewed and their own narratives described how they made their decisions
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