The Impact of International Financial Integration on Industry Growth

The empirical relationship between financial openness and growth is examined in this paper. In contrast to a large body of cross-country work investigating this link, I study the impact of financial integration on growth at the industry level. This paper provides evidence that financial openness has a positive effect on growth of industrial sectors, regardless of their characteristics. Moreover, industries that rely relatively more on external finance grow disproportionately faster in countries with more integrated financial systems. However, this industry-specific effect of financial openness decreases when I control for the development of the domestic financial system. Finally, the hypothesis that financial integration improved growth also by enhancing the functioning of the domestic financial system is tested. I find evidence of this indirect transmission channel of financial openness.Financial Integration, Financial Development, Growth

Rivaroxaban for the Treatment of Pulmonary Embolism

With the advent of new oral anticoagulants (NOACs) for the treatment of deep-vein thrombosis (DVT) and/or pulmonary embolism (PE), a new era of oral anticoagulation for patients with venous thromboembolism (VTE) has begun. Rivaroxaban is the first NOAC to receive regulatory approval for the acute and continued treatment of DVT and PE, and for the secondary prevention of VTE. Here, the clinical trials of rivaroxaban in patients with VTE are reviewed, and the clinical use of rivaroxaban for patients with PE is discussed. Even though rivaroxaban will facilitate the therapeutic management of PE, its use in specific clinical situations needs further study

Embolic strokes of undetermined source: prevalence and patient features in the ESUS Global Registry

Background: Recent evidence supports that most non-lacunar cryptogenic strokes are embolic. Accordingly, these strokes have been designated as embolic strokes of undetermined source (ESUS). Aims: We undertook an international survey to characterize the frequency and clinical features of ESUS patients across global regions. Methods: Consecutive patients hospitalized for ischemic stroke were retrospectively surveyed from 19 stroke research centers in 19 different countries to collect patients meeting criteria for ESUS. Results: Of 2144 patients with recent ischemic stroke, 351 (16%, 95% CI 15% to 18%) met ESUS criteria, similar across global regions (range 16% to 21%), and an additional 308 (14%) patients had incomplete evaluation required for ESUS diagnosis. The mean age of ESUS patients (62 years; SD = 15) was significantly lower than the 1793 non-ESUS ischemic stroke patients (68 years, p ≤ 0.001). Excluding patients with atrial fibrillation (n = 590, mean age = 75 years), the mean age of the remaining 1203 non-ESUS ischemic stroke patients was 64 years (p = 0.02 vs. ESUS patients). Among ESUS patients, hypertension, diabetes, and prior stroke were present in 64%, 25%, and 17%, respectively. Median NIHSS score was 4 (interquartile range 2–8). At discharge, 90% of ESUS patients received antiplatelet therapy and 7% received anticoagulation. Conclusions: This cross-sectional global sample of patients with recent ischemic stroke shows that one-sixth met criteria for ESUS, with additional ESUS patients likely among those with incomplete diagnostic investigation. ESUS patients were relatively young with mild strokes. Antiplatelet therapy was the standard antithrombotic therapy for secondary stroke prevention in all global regions

The rise of age homogamy in 19th century Western Europe

In many parts of Western Europe the age at first marriage and the level of celibacy declined in the second half of the 19th century. This weakening of the European marriage pattern (EMP) can be interpreted as a "classic" response to the increase of the standard of living, but a more far-reaching interpretation is that the erosion of the EMP was part of a cultural shift characterized by the rise of a new, less instrumental and more egalitarian view on marriage and partner selection. The latter vision implies the increase of the preference for a same age marriage. We test this explanation by using a combined Belgian-Dutch data set of marriage certificates (N = 766,412). Our findings corroborate the "cultural shift thesis."

Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections

BACKGROUND: Staphylococcus aureus (S. aureus) is a frequent cause of skin and soft tissue infections. A unique feature of S. aureus is the combined presence of coagulases that trigger fibrin formation and of the plasminogen activator staphylokinase (SAK). Whereas the importance of fibrin generation for S. aureus virulence has been established, the role of SAK remains unclear. We studied the role of plasminogen activation by SAK in a skin infection model in mice and evaluated the impact of alpha-2-antiplasmin (α(2)AP) deficiency on the spreading and proteolytic activity of S. aureus skin infections. The species-selectivity of SAK was overcome by adenoviral expression of human plasminogen. Bacterial spread and density was assessed non-invasively by imaging the bioluminescence of S. aureus Xen36. RESULTS: SAK-mediated plasmin activity increased the local invasiveness of S. aureus, leading to larger lesions with skin disruption as well as decreased bacterial clearance by the host. Even though fibrin and bacterial surfaces protected SAK-mediated plasmin activity from inhibition by α(2)AP, the deficiency of α(2)AP resulted in increased bacterial spreading. SAK-mediated plasmin also induced secondary activation of gelatinases, shown both in vitro and in lesions from the in vivo model. CONCLUSION: SAK contributes to the phenotype of S. aureus skin infections by enhancing bacterial spreading as a result of fibrinolytic and proteolytic activation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12866-014-0310-7) contains supplementary material, which is available to authorized users

Articulating, reclaiming and celebrating the professionalism of teacher educators in England

This paper examines the cumulative effects on teacher educators of a series of ideological and policy changes in the English teacher education landscape since the early 80s. We argue that these rapid changes have marginalized the role of the university in teacher learning and resulted in narrower, more instrumental forms of teacher education. Within this landscape we see a distinct need to re-state (and reinstate) the importance of higher education-based teacher educators, and to reclaim and celebrate their practices and the nature of the professionalism involved. We invite the reader to rethink teacher educator professionalism as what is enacted by teacher educators, as engaged in their professional activities. A view of enacted professionalism gives central stage to and trusts the professional judgement of teacher educators to do what they deem is good, appropriate, or best – understood in a broad sense – to support the professional learning of newcomers in the profession

Global survey of the frequency of atrial fibrillation-associated stroke: embolic stroke of undetermined source global registry

Background and Purpose—Atrial fibrillation (AF) is increasingly recognized as the single most important cause of disabling ischemic stroke in the elderly. We undertook an international survey to characterize the frequency of AF-associated stroke, methods of AF detection, and patient features. Methods—Consecutive patients hospitalized for ischemic stroke in 2013 to 2014 were surveyed from 19 stroke research centers in 19 different countries. Data were analyzed by global regions and World Bank income levels. Results—Of 2144 patients with ischemic stroke, 590 (28%; 95% confidence interval, 25.6–29.5) had AF-associated stroke, with highest frequencies in North America (35%) and Europe (33%) and lowest in Latin America (17%). Most had a history of AF before stroke (15%) or newly detected AF on electrocardiography (10%); only 2% of patients with ischemic stroke had unsuspected AF detected by poststroke cardiac rhythm monitoring. The mean age and 30-day mortality rate of patients with AF-associated stroke (75 years; SD, 11.5 years; 10%; 95% confidence interval, 7.6–12.6, respectively) were substantially higher than those of patients without AF (64 years; SD, 15.58 years; 4%; 95% confidence interval, 3.3–5.4; P<0.001 for both comparisons). There was a strong positive correlation between the mean age and the frequency of AF (r=0.76; P=0.0002). Conclusions—This cross-sectional global sample of patients with recent ischemic stroke shows a substantial frequency of AF-associated stroke throughout the world in proportion to the mean age of the stroke population. Most AF is identified by history or electrocardiography; the yield of conventional short-duration cardiac rhythm monitoring is relatively low. Patients with AF-associated stroke were typically elderly (>75 years old) and more often women

Maine Campus September 26 1957

In traction applications, electrical drivetrain components are subjected to unpredictable load and temperature variations depending on the driving cycle and ambient conditions. As performance and power density requirements are getting increasingly stringent, the power electronic devices and electromagnetic actuators are stressed heavily due to temperature cycling effects and face the risk of overheating, compromising lifetime and reliability. To protect the drivetrain from thermally induced failure, a model-based thermal management strategy is proposed in this paper. Critical component temperatures are calculated online with a combined loss and thermal model and are limited progressively by applying constraints to loss-influencing operating variables. Starting from the requested torque, the dq-current setpoint calculation is formulated as a constraint optimization problem in order to protect all drivetrain components while maximizing overall efficiency over the entire torque speed operating range, including field weakening at elevated speed. Unlike conventional approaches, which are often adhoc or based on de-rating, the proposed strategy allows the drivetrain to operate safely at maximum performance limits, without unnecessarily degrading performance.status: publishe

Arnout Hauben & Johanna Spaey, To War. A Journey Along the Front of World War I

Infotainment is supposed to disseminate historical knowledge to a broader audience, and I am fully aware that this unavoidably implies the loss of some nuance in favour of the genre’s entertaining aspect. The problem with Arnout Hauben and Johanna Spaey’s Ten Oorlog. Een reis langs het front van WO I is that its informative aspect is not subject to nuance but rather flawed by inaccuracies. A few preliminary remarks. Reading the title raises some suspicions: the subtitle, A Journey Along the F..

Research capacity building in and on teacher education: developing practice and learning

Research is widely acknowledged as a key element of professional learning for intending and serving teachers, as well as for their teacher educators. And yet, despite this centrality, research in teacher education is often subjected to critique and contestation. Internationally, the quality of such research has been questioned, and there are on-going issues about when, how and why teacher educators and teachers (can) engage in research. Initiatives to build research capacity in teacher education thus remain of crucial importance. Here we focus on this issue, aiming to analyse how to strengthen the field of teacher education locally and internationally. We first set out a conceptual framework for considering capacity building, and then analyse three international examples of practice in teacher education research: the Norwegian Doctoral School (NAFOL); the use of self-study research in Belgium (Flanders); and the Teacher Education Research Network (TERN), a social practices initiative in England. The contextualised analysis of these local capacity-building initiatives exemplifies what factors influence their enactments and outcomes and, in so doing, also inform a more ‘glocal’ understanding of how to build research capacity in and on teacher education. From this follows our overall question: what can be learned from these cases about how to build research capacity in and on teacher education