Neutral Gas Distributions and Kinematics of Five Blue Compact Dwarf Galaxies

We present the results of high spatial resolution HI observations of five intrinsically compact dwarf galaxies which are currently experiencing a strong burst of star formation. The HI maps indicate that these systems have a complex and clumpy interstellar medium. Unlike typical dwarf irregular galaxies, these Blue Compact Dwarf (BCD) galaxies exhibit strong central concentrations in their neutral gas distributions which may provide a clue to the origin of their strong star-burst activity. Furthermore, while all of the systems do appear to be rotating, based on observed velocity gradients, the kinematics are complex. All systems have non-ordered kinematic structure at some level; some of the extended gas is not necessarily kinematically connected to the main system. The observed gas distributions and kinematics place constraints on evolutionary scenarios for BCDs. Evolutionary links between BCDs, dwarf irregulars, and dwarf ellipticals have been postulated to explain their high star formation rates and low luminosity, low metallicity nature. The BCDs appear to have higher central mass concentrations in both gas and stellar content than the dwarf irregulars, indicating that evolutionary scenarios connecting these two classes will require mass redistribution. In addition, the fact that BCDs are rotationally supported systems indicates that BCDs are unlikely to evolve into dwarf ellipticals without substantial loss of angular momentum. Thus, while such evolutionary scenarios may still be possible with the aid of mergers or tidal interactions, the isolated nature of BCDs suggests that the majority of BCDs will not fade to become objects similar to the present day dwarf ellipticals.Comment: 19 pages, 15 figures. To appear in A

Lopsidedness in dwarf irregular galaxies

We quantify the amplitude of the lopsidedness, the azimuthal angular asymmetry index, and the concentration of star forming regions, as represented by the distribution of the H$\alpha$ emission, in a sample of 78 late-type irregular galaxies. We bin the observed galaxies in two groups representing blue compact galaxies (BCDs) and low surface brightness dwarf galaxies (LSBs). The light distribution is analysed with a novel algorithm, which allows detection of details in the light distribution pattern. We find that while the asymmetry of the underlying continuum light, representing the older stellar generations, is relatively small, the H$\alpha$ emission is very asymmetric and is correlated in position angle with the continuum light. We test a model of random star formation over the extent of a galaxy by simulating HII regions in artificial dwarf galaxies. The implication is that random star formation over the full extent of a galaxy may be generated in LSB dwarf-irregular galaxies but not in BCD galaxies.Comment: 42 pages, LaTex. Accepted by: MNRAS, 13 Mar 200

The WHIQII Survey: Metallicities and Spectroscopic Properties of Luminous Compact Blue Galaxies

As part of the WIYN High Image Quality Indiana Irvine (WHIQII) survey, we present 123 spectra of emission-line galaxies, selected on intermediate redshift (.4<z<.8) galaxies with blue colors that appear physically compact. The sample includes 15 true Luminous Compact Blue Galaxies (LCBGs) and an additional 27 slightly less extreme emission-line systems. These galaxies represent a highly evolving class that may play an important role in the decline of star formation since z~1, but their exact nature and evolutionary pathways remain a mystery. Here, we use emission lines to determine metallicities and ionization parameters, constraining their intrinsic properties and state of star formation. Some LCBG metallicities are consistent with a "bursting dwarf" scenario, while a substantial fraction of others are not, further confirming that LCBGs are a highly heterogeneous population but are broadly consistent with the intermediate redshift field. In agreement with previous studies, we observe overall evolution in the luminosity-metallicity relation at intermediate redshift. Our sample, and particularly the LCBGs, occupy a region in the empirical R23-O32 plane that differs from luminous local galaxies and is more consistent with dwarf Irregulars at the present epoch, suggesting that cosmic "downsizing" is observable in even the most fundamental parameters that describe star formation. These properties for our sample are also generally consistent with lying between local galaxies and those at high redshift, as expected by this scenario. Surprisingly, our sample exhibits no detectable correlation between compactness and metallicity, strongly suggesting that at these epochs of rapid star formation, the morphology of compact star-forming galaxies is largely transient.Comment: ApJ accepted, 17 pages, 20 figures, 2 tables (complete tables in published version

Prognostic Markers in Pancreatic Cancer: the tumor and its environment

Incidence Pancreatic cancer is not one of the most common types of cancer; however it is most certainly one of the most devastating types, ranking fourth in the list of cancer related deaths with a 5-year survival of only 6%. In 2010 there were an estimated 43.140 new cases whereas 36.800 patients were expected to die from this disease in the United States. Worldwide, the expected numbers were 278.684 new cases and 266.669 deaths. In the Netherlands 2481 patients died of pancreatic cancer in 2010. Interestingly, whereas for most cancers, death rates have decreased over the years, those of pancreatic cancer have remained relatively stable. Pathogenesis In order to effectively diagnose, prevent and treat pancreatic cancer, a detailed understanding of the molecular biology of this disease is required. Like many other cancers, pancreatic cancer results from the accumulation of genetic alterations. It originates in the ductal epithelium and evolves from non-invasive precursor lesions of which pancreatic intraepithelial neoplasias (PanINs) are the best characterized. The progression from minimally dysplastic epithelium (PanIN grade 1) to more severe dysplasia (PanIN grades 2 and 3) and finally to invasive carcinoma is paralleled by the successive accumulation of genetic alterations of which some appear earlier than others (figure 1). A brief overview of the molecular mechanisms underlying the biology of pancreatic cancer is given in chapter 2

The neurobiology of circadian rhythms

Purpose of review There is growing awareness of the importance of circadian rhythmicity in various research fields. Exciting developments are ongoing in the field of circadian neurobiology linked to sleep, food intake, and memory. With the current knowledge of critical ‘clock genes’ (genes found to be involved in the generation of circadian rhythms) and novel techniques for imaging cyclic events in brain and peripheral tissue, this field of research is rapidly expanding. We reviewed only some of the highlights of the past year, and placed these findings into a mutual circadian perspective. Recent findings Recent findings on the organization of the circadian clock systems are addressed, ranging from the retina to the suprachiasmatic nucleus and peripheral organs. Novel developments in sleep, food intake, and memory research linked to circadian aspects are discussed. Summary The neurobiology of circadian rhythms is pivotal to the orchestration of the temporal organization of an individual’s physiology and behavior. Endogenous circadian timing systems underlie coupling and uncoupling mechanisms of many neuronal and physiological processes, the latter possibly inducing health risks to the organism. The integration of sleep, food intake and memory in a circadian setting has clear potential as a systems neurobiology line of research.

A Search for Low Surface Brightness Structure Around Compact Narrow Emission Line Galaxies

As the most extreme members of the rapidly evolving faint blue galaxy population at intermediate redshift, the compact narrow emission line galaxies (CNELGs) are intrinsically luminous (-22 < M_B < -18) with narrow emission linewidths (30 < \sigma < 125 km/s). Their nature is heavily debated: they may be low-mass starbursting galaxies that will fade to present-day dwarf galaxies or bursts of star formation temporarily dominating the flux of more massive galaxies, possibly related to in situ bulge formation or the formation of cores of galaxies. We present deep, high-quality (~0.6 - 0.8 arcsec) images with CFHT of 27 CNELGs. One galaxy shows clear evidence for a tidal tail; the others are not unambiguously embedded in galactic disks. Approximately 55% of the CNELGS have sizes consistent with local dwarfs of small-to-intermediate sizes, while 45% have sizes consistent with large dwarfs or disks galaxies. At least 4 CNELGs cannot harbor substantial underlying disk material; they are low-luminosity galaxies at the present epoch (M_B > -18). Conversely, 15 are not blue enough to fade to low-luminosity dwarfs (M_B > -15.2). The majority of the CNELGs are consistent with progenitors of intermediate-luminosity dwarfs and low-luminosity spiral galaxies with small disks. CNELGs are a heterogeneous progenitor population with significant fractions (up to 44%) capable of fading into today's faint dwarfs (M_B > -15.2), while 15 to 85% may only experience an apparently extremely compact CNELG phase at intermediate redshift but remain more luminous galaxies at the present epoch.Comment: 16 pages, 14 figures, emulateapj, published in Ap

Possible Local Spiral Counterparts to Compact Blue Galaxies at Intermediate Redshift

We identify nearby disk galaxies with optical structural parameters similar to those of intermediate-redshift compact blue galaxies. By comparing HI and optical emission-line widths, we show that the optical widths substantially underestimate the true kinematic widths of the local galaxies. By analogy, optical emission-line widths may underrepresent the masses of intermediate-z compact objects. For the nearby galaxies, the compact blue morphology is the result of tidally-triggered central star formation: we argue that interactions and minor mergers may cause apparently compact morphology at higher redshift.Comment: 5 pages, uses emulateapj5 and psfig. To appear in ApJ

Discontinuities without discontinuity: The Weakly-enforced Slip Method

Tectonic faults are commonly modelled as Volterra or Somigliana dislocations in an elastic medium. Various solution methods exist for this problem. However, the methods used in practice are often limiting, motivated by reasons of computational efficiency rather than geophysical accuracy. A typical geophysical application involves inverse problems for which many different fault configurations need to be examined, each adding to the computational load. In practice, this precludes conventional finite-element methods, which suffer a large computational overhead on account of geometric changes. This paper presents a new non-conforming finite-element method based on weak imposition of the displacement discontinuity. The weak imposition of the discontinuity enables the application of approximation spaces that are independent of the dislocation geometry, thus enabling optimal reuse of computational components. Such reuse of computational components renders finite-element modeling a viable option for inverse problems in geophysical applications. A detailed analysis of the approximation properties of the new formulation is provided. The analysis is supported by numerical experiments in 2D and 3D.Comment: Submitted for publication in CMAM

Memorial Sloan-Kettering Cancer Center: Two Decades of Experience with Ductal Carcinoma In Situ of the Breast

Researchers at Memorial Sloan-Kettering Cancer Center have investigated many aspects of their experience with ductal carcinoma in situ of the breast over the past 20 years. This paper summarizes the most clinically relevant findings