Schuivende panelen

Schuivende panelen was de titel van een partijprogramma uit de jaren tachtig. Deze rede is echter geen politiek manifest. Hoewel een wetenschapper in staat moet zijn om politiek te bedrijven en de Allergologie als discipline sinds haar oprichting speelbal geweest is van politieke krachten gaat deze lezing vooral over verschuivingen en ontwikkelingen in het vakgebied. rede In verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar met als leeropdracht Allergologie aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam, op 20 april 200

Positive and negative AIT trials: What makes the difference?

Background: Allergen immunotherapy has proven to be efficacious in allergic rhinitis and asthma. However, results from randomised clinical trials may vary substantially. Clinical trials may unexpectedly fail. The purpose of this review is to discuss the possible factors that may contribute to a successful or unsuccessful study. Methods: Descriptive review exploring the possible causes of negative outcomes in allergen immunotherapy trials. Results: A series of factors may lead to negative results. Among of these are underpowering of the study, low allergen content in tested extracts, insufficient allergen exposure during monitoring and recruitment of inappropriate patients. In addition, the choice of the primary endpoint may be critical. Discussion: A clinical trial aims to evaluate the efficacy of an agent. However, studies with potential effective compounds may fail because of methodical issues. Sometimes, they are the cause of discrepancies between successful phase II and unsuccessful phase III trials. To understand more about failure of studies, investigators and editors should be encouraged to publish negative trials

Scattering amplitude of a single fracture under uniaxial stress

Remotely sensing the properties of fractures has applications ranging from exploration geophysics to hazard monitoring. Newly developed capabilities to measure the in-plane component of dense laser-based ultrasound wave fields allow us to test the applicability of a linear slip model to describe fracture properties. In particular, we estimate the diameter, and the normal and tangential compliance of a fracture from the measured scattering amplitudes of P and S waves in the laboratory. Finally, we show that the normal compliance decreases linearly with increasing uniaxial static stress in the plane of the fracture, but that our measurements of the SV scattered field do not show significant changes in the tangential complianc

Comparison of nasal responsiveness to histamine, methacholine and phentolamine in allergic rhinitis patients and controls

In a selected group of rhinitis patients with an IgE‐mediated allergy to house dust mites the nasal response to insufflation of histamine chloride, methacholine and phentolamine was demonstrated to be higher than in a control group. With the methods used histamine chloride was better at discriminating between healthy subjects and patients than methacholine or phentolamine. This discrimination was shown by assessing the severity of reflex‐mediated symptoms such as the number of sneezes and the amount of secretion, and not by differences in nasal airway resistance. Copyrigh

Making Retail Supply Chains Sustainable: Upgrading Opportunities for Developing Country Suppliers under Voluntary Quality Standards

This paper examines the sustainability claims of private quality standards, voluntary adopted by supermarket to improve the quality of products in respect of food safety, and environmental and social sustainability. The concept of ‘sustainability’ is defined as the opportunity for upgrading by developing country suppliers in the retail supply chains. The paper reports of an explorative analysis on the perceived effects of 36 quality standards in the retail on upgrading. Data was collected through a survey of a wide variety of relevant media: websites, scientific articles and reports, policy reports, and online newspaper articles. The overall conclusion is that the majority of the 36 standards are perceived to facilitate trading opportunities for developing country producers, but only for those suppliers who can meet the criteria of quality standards. The study found interesting differences between various categories of standards. Standards initiated by NGOs and partnerships are perceived to offer better upgrading opportunities to suppliers than do standards initiated by (inter-) governmental authorities, by individual firms, or by business associations. Standards with an explicit social and social/environmental focus have a more positive influence on process and product upgrading in developing countries compared to voluntary food safety standards. Product-specific standards offer better upgrading opportunities than do generic quality standards

Nasal allergy to avian antigens

This study describes the case of a patient who developed symptoms of rhinoconjunctivitis on exposure to budgerigars and parrots. An IgE‐mediated allergy to budgerigar, parrot and pigeon antigens was demonstrated using both in‐vivo challenge tests (skin and nasal provocation tests) and in‐vitro investigations (radio‐allergo‐sorbent test, histamine release test). The study shows that the development of nasal disease can be associated with allergy to avian antigens. Copyrigh

Experimental harvesting of fish populations drives genetically based shifts in body size and maturation

Size-selective harvesting in commercial fisheries can induce rapid changes in biological traits. While experimental and wild harvested populations often exhibit clear shifts in body size and maturation associated with fishing pressure, the relative contributions of genetic and environmental factors to these shifts remain uncertain and have been much debated. To date, observations of so-called fisheries-induced evolution (FIE) have been based solely on phenotypic measures, such as size data. Genetic data are hitherto lacking. Here, we quantify genetic versus environmental change in response to size-selective harvesting for small and large body size in guppies (Poecilia reticulata) across three generations of selection. We document for the first time significant changes at individual genetic loci, some of which have previously been associated with body size. In contrast, variation at neutral microsatellite markers was unaffected by selection, providing direct genetic evidence for rapid evolution induced by size-selective harvesting. These findings demonstrate FIE in an experimental system, with major implications for the sustainability of harvested populations, as well as impacts on size-structured communities and ecosystem processes. These findings highlight the need for scientists and managers to reconsider the capacity of harvested stocks to adapt to, and recover from, harvesting and predation. © 2013 The Ecological Society of America