Equilibrium Properties of Temporally Asymmetric Hebbian Plasticity

A theory of temporally asymmetric Hebb (TAH) rules which depress or potentiate synapses depending upon whether the postsynaptic cell fires before or after the presynaptic one is presented. Using the Fokker-Planck formalism, we show that the equilibrium synaptic distribution induced by such rules is highly sensitive to the manner in which bounds on the allowed range of synaptic values are imposed. In a biologically plausible multiplicative model, we find that the synapses in asynchronous networks reach a distribution that is invariant to the firing rates of either the pre- or post-synaptic cells. When these cells are temporally correlated, the synaptic strength varies smoothly with the degree and phase of synchrony between the cells.Comment: 3 figures, minor corrections of equations and tex

Indinavir/Low-dose Ritonavir Containing HAART in HIV-1 Infected Children has Potent Antiretroviral Activity, but is Associated with Side Effects and Frequent Discontinuation of Treatment

We here present the study results of 21 HIV-1 infected children who were treated with indinavir plus low-dose ritonavir and two nucleoside reverse transcriptase inhibitors (NRTIs) for 48 weeks. Although this q12h HAART regimen had potent antiretroviral activity, it was frequently associated with side effects and discontinuation of therapy

Collimation and asymmetry of the hot blast wave from the recurrent nova V745 Scorpii

The recurrent symbiotic nova V745 Sco exploded on 2014 February 6 and was observed on February 22 and 23 by the Chandra X-ray Observatory Transmission Grating Spectrometers. By that time the supersoft source phase had already ended and Chandra spectra are consistent with emission from a hot, shock-heated circumstellar medium with temperatures exceeding 10^7K. X-ray line profiles are more sharply peaked than expected for a spherically-symmetric blast wave, with a full width at zero intensity of approximately 2400 km/s, a full width at half maximum of 1200 +/- 30 km/s and an average net blueshift of 165 +/- 10 km/s. The red wings of lines are increasingly absorbed toward longer wavelengths by material within the remnant. We conclude that the blast wave was sculpted by an aspherical circumstellar medium in which an equatorial density enhancement plays a role, as in earlier symbiotic nova explosions. Expansion of the dominant X-ray emitting material is aligned close to the plane of the sky and most consistent with an orbit seen close to face-on. Comparison of an analytical blast wave model with the X-ray spectra, Swift observations and near-infrared line widths indicates the explosion energy was approximately 10^43 erg, and confirms an ejected mass of approximately 10^-7 Msun. The total mass lost is an order of magnitude lower than the accreted mass required to have initiated the explosion, indicating the white dwarf is gaining mass and is a supernova Type 1a progenitor candidate.Comment: To appear in the Astrophysical Journa

Light transport in cold atoms: the fate of coherent backscattering in the weak localization regime

The recent observation of coherent backscattering (CBS) of light by atoms has emphasized the key role of the velocity spread and of the quantum internal structure of the atoms. Firstly, using highly resonant scatterers imposes very low temperatures of the disordered medium in order to keep the full contrast of the CBS interference. This criterion is usually achieved with standard laser cooling techniques. Secondly, a non trivial internal atomic structure leads to a dramatic decrease of the CBS contrast. Experiments with Rubidium atoms (with a non trivial internal structure) and with Strontium (with the simplest possible internal structure) show this behaviour and confirm theoretical calculations

Fast evolving pair-instability supernova models: evolution, explosion, light curves

With an increasing number of superluminous supernovae (SLSNe) discovered, the question of their origin remains open and causes heated debates in the supernova community. Currently, there are three proposed mechanisms for SLSNe: (1) pair-instability supernovae (PISNe), (2) magnetar-driven supernovae and (3) models in which the supernova ejecta interacts with a circumstellar material ejected before the explosion. Based on current observations of SLSNe, the PISN origin has been disfavoured for a number of reasons. Many PISN models provide overly broad light curves and too reddened spectra, because of massive ejecta and a high amount of nickel. In the current study, we re-examine PISN properties using progenitor models computed with the GENEC code. We calculate supernova explosions with FLASH and light-curve evolution with the radiation hydrodynamics code STELLA. We find that high-mass models (200 and 250 M⊙) at relatively high metallicity (Z = 0.001) do not retain hydrogen in the outer layers and produce relatively fast evolving PISNe Type I and might be suitable to explain some SLSNe. We also investigate uncertainties in light-curve modelling due to codes, opacities, the nickel-bubble effect and progenitor structure and composition

Ordering of droplets and light scattering in polymer dispersed liquid crystal films

We study the effects of droplet ordering in initial optical transmittance through polymer dispersed liquid crystal (PDLC) films prepared in the presence of an electrical field. The experimental data are interpreted by using a theoretical approach to light scattering in PDLC films that explicitly relates optical transmittance and the order parameters characterizing both the orientational structures inside bipolar droplets and orientational distribution of the droplets. The theory relies on the Rayleigh-Gans approximation and uses the Percus-Yevick approximation to take into account the effects due to droplet positional correlations.Comment: revtex4, 18 pages, 8 figure

Neuropsychiatric Adverse Effects of Synthetic Glucocorticoids:A Systematic Review and Meta-Analysis

CONTEXT: Synthetic glucocorticoids are widely used to treat patients with a broad range of diseases. While efficacious, glucocorticoids can be accompanied by neuropsychiatric adverse effects. OBJECTIVE: This systematic review and meta-analysis assesses and quantifies the proportion of different neuropsychiatric adverse effects in patients using synthetic glucocorticoids. METHODS: Six electronic databases were searched to identify potentially relevant studies. Randomized controlled trials, cohort studies, and cross-sectional studies assessing psychiatric side effects of glucocorticoids measured with validated questionnaires were eligible. Risk of bias was assessed with RoB 2, ROBINS-I, and AXIS appraisal tool. For proportions of neuropsychiatric outcomes, we pooled proportions, and when possible, differences in questionnaire scores between glucocorticoid users and nonusers were expressed as standardized mean differences (SMD). Data were pooled in a random-effects logistic regression model. RESULTS: We included 49 studies with heterogeneity in study populations, type, dose, and duration of glucocorticoids. For glucocorticoid users, meta-analysis showed a proportion of 22% for depression (95% CI, 14%-33%), 11% for mania (2%-46%), 8% for anxiety (2%-25%), 16% for delirium (6%-36%), and 52% for behavioral changes (42%-61%). Questionnaire scores for depression (SMD of 0.80 [95% CI 0.35-1.26]), and mania (0.78 [0.14-1.42]) were higher than in controls, indicating more depressive and manic symptoms following glucocorticoid use. CONCLUSION: The heterogeneity of glucocorticoid use is reflected in the available studies. Despite this heterogeneity, the proportion of neuropsychiatric adverse effects in glucocorticoid users is high. The most substantial associations with glucocorticoid use were found for depression and mania. Upon starting glucocorticoid treatment, awareness of possible psychiatric side effects is essential. More structured studies on incidence and potential pathways of neuropsychiatric side effects of prescribed glucocorticoids are clearly needed.</p

Neuropsychiatric Adverse Effects of Synthetic Glucocorticoids:A Systematic Review and Meta-Analysis

CONTEXT: Synthetic glucocorticoids are widely used to treat patients with a broad range of diseases. While efficacious, glucocorticoids can be accompanied by neuropsychiatric adverse effects. OBJECTIVE: This systematic review and meta-analysis assesses and quantifies the proportion of different neuropsychiatric adverse effects in patients using synthetic glucocorticoids. METHODS: Six electronic databases were searched to identify potentially relevant studies. Randomized controlled trials, cohort studies, and cross-sectional studies assessing psychiatric side effects of glucocorticoids measured with validated questionnaires were eligible. Risk of bias was assessed with RoB 2, ROBINS-I, and AXIS appraisal tool. For proportions of neuropsychiatric outcomes, we pooled proportions, and when possible, differences in questionnaire scores between glucocorticoid users and nonusers were expressed as standardized mean differences (SMD). Data were pooled in a random-effects logistic regression model. RESULTS: We included 49 studies with heterogeneity in study populations, type, dose, and duration of glucocorticoids. For glucocorticoid users, meta-analysis showed a proportion of 22% for depression (95% CI, 14%-33%), 11% for mania (2%-46%), 8% for anxiety (2%-25%), 16% for delirium (6%-36%), and 52% for behavioral changes (42%-61%). Questionnaire scores for depression (SMD of 0.80 [95% CI 0.35-1.26]), and mania (0.78 [0.14-1.42]) were higher than in controls, indicating more depressive and manic symptoms following glucocorticoid use. CONCLUSION: The heterogeneity of glucocorticoid use is reflected in the available studies. Despite this heterogeneity, the proportion of neuropsychiatric adverse effects in glucocorticoid users is high. The most substantial associations with glucocorticoid use were found for depression and mania. Upon starting glucocorticoid treatment, awareness of possible psychiatric side effects is essential. More structured studies on incidence and potential pathways of neuropsychiatric side effects of prescribed glucocorticoids are clearly needed.</p

Weak localization of light by cold atoms: the impact of quantum internal structure

Since the work of Anderson on localization, interference effects for the propagation of a wave in the presence of disorder have been extensively studied, as exemplified in coherent backscattering (CBS) of light. In the multiple scattering of light by a disordered sample of thermal atoms, interference effects are usually washed out by the fast atomic motion. This is no longer true for cold atoms where CBS has recently been observed. However, the internal structure of the atoms strongly influences the interference properties. In this paper, we consider light scattering by an atomic dipole transition with arbitrary degeneracy and study its impact on coherent backscattering. We show that the interference contrast is strongly reduced. Assuming a uniform statistical distribution over internal degrees of freedom, we compute analytically the single and double scattering contributions to the intensity in the weak localization regime. The so-called ladder and crossed diagrams are generalized to the case of atoms and permit to calculate enhancement factors and backscattering intensity profiles for polarized light and any closed atomic dipole transition.Comment: 22 pages Revtex, 9 figures, to appear in PR

"Optical conductance fluctuations: diagrammatic analysis in Landauer approach and non-universal effects"

The optical conductance of a multiple scattering medium is the total transmitted light of a diffuse incoming beam. This quantity, very analogous to the electronic conductance, exhibits universal conductance fluctuations. We perform a detailed diagrammatic analysis of these fluctuations. With a Kadanoff-Baym technique all the leading diagrams are systematically generated. A cancellation of the short distance divergencies occurs, that yields a well behaved theory. The analytical form of the fluctuations is calculated and applied to optical systems. Absorption and internal reflections reduce the fluctuations significantly.Comment: 25 pages Revtex 3.0, 18 seperate postscript figure