Designs of magnetic atom-trap lattices for quantum simulation experiments

We have designed and realized magnetic trapping geometries for ultracold atoms based on permanent magnetic films. Magnetic chip based experiments give a high level of control over trap barriers and geometric boundaries in a compact experimental setup. These structures can be used to study quantum spin physics in a wide range of energies and length scales. By introducing defects into a triangular lattice, kagome and hexagonal lattice structures can be created. Rectangular lattices and (quasi-)one-dimensional structures such as ladders and diamond chain trapping potentials have also been created. Quantum spin models can be studied in all these geometries with Rydberg atoms, which allow for controlled interactions over several micrometers. We also present some nonperiodic geometries where the length scales of the traps are varied over a wide range. These tapered structures offer another way to transport large numbers of atoms adiabatically into subwavelength traps and back.Comment: 9 pages, 10 figure

Stratigraphy and palaeoceanography of a topography-controlled contourite drift in the Pen Duick area, southern Gulf of Cádiz

The northern part of the Gulf of Cádiz has and still is receiving a lot of attention from the scientific community due to (amongst others) the recent IODP Expedition 339. In contrast, its southern part, or the Moroccan margin has received far less attention, although mud volcanoes, diapiric ridges and cold-water corals are present in this region. The El Arraiche mud volcano field is characterized by a compressive regime creating several ridges and assisting the migration of hydrocarbon fluids towards the seabed surface. This study presents seismic and multibeam evidence for the existence of a contourite drift at water depths between 550 and 650 meters along the southwestern flank of the Pen Duick Escarpment and Gemini Mud Volcano, within the El Arraiche Mud Volcano field. From the onset of the Quaternary, when the escarpment started to lift and the local mud volcanism initiated, contouritic deposition was initiated as well at the foot of both topographic obstacles. Initially, fairly low-velocity bottom currents gave rise to sheeted drift deposits, affected by the uplift of the escarpment or mud extrusion. From the Middle Pleistocene onwards, separated mounded drift deposits were formed due to intensified bottom currents. An Antarctic Intermediate Water origin is inferred as driving mechanism for the drift development, although glacial conditions are not yet well constrained. The influence of Mediterranean Outflow Water (MOW) cannot be substantiated here. Moreover, the changes recorded within this contourite drift differ from the MOW-dominated contourite depositional system in the northern Gulf of Cádiz, as drift deposits only occur as early as the base of the Quaternary (compared to the Early Pliocene for the north) and mounded drift deposits only occur from the Middle Pleistocene onwards (compared to the Early Pleistocene). Cold-water coral mounds have been observed within and on top of the sedimentary sequence at the foot of the Pen Duick Escarpment. This implies that environmental conditions in which cold-water corals thrive were not necessarily restricted to the top of the Pen Duick Escarpment

Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension

<b>Rationale:</b> MicroRNAs are small non-coding RNAs involved in the regulation of gene expression and have recently been implicated in the development of pulmonary arterial hypertension (PAH). Previous work established that miR-451 is up-regulated in rodent models of PAH.<p></p> <b>Objectives:</b> The role of miR-451 in the pulmonary circulation is unknown. We therefore sought to assess the involvement of miR-451 in the development of pulmonary arterial hypertension.<p></p> <b>Methods:</b> Silencing of miR-451 was performed in vivo using miR-451 knockout mice and an antimiR targeting mature miR-451 in rats. Coupled with exposure to hypoxia, indices of pulmonary arterial hypertension were assessed. The effect of modulating miR-451 on human pulmonary artery smooth muscle cell proliferation and migration was analysed.<p></p> <b>Measurements and Main Results:</b> We observed a reduction in systolic right ventricular pressure in hypoxic rats pre-treated with antimiR-451 compared to hypoxia alone (47.7 ± 1.36mmHg and 56.0 ± 2.03mmHg respectively, p<0.01). In miR-451 knockout mice following exposure to chronic hypoxia, no significant differences were observed compared to wild type hypoxic mice. In vitro analysis demonstrated that over-expression of miR-451 in human pulmonary artery smooth muscle cells promoted migration under serum-free conditions. No effect on cellular proliferation was observed.<p></p> <b>Conclusions:</b> Transient inhibition of miR-451 attenuated the development of pulmonary arterial hypertension in hypoxia exposed rats. Genetic deletion of miR-451 had no beneficial effect on indices of pulmonary arterial hypertension, potentially due to pathway redundancy compensating for the loss of miR-451.<p></p&gt

Klimaatscan Natura 2000 gebieden

Provincies hebben behoefte aan een beter inzicht in de mogelijke consequenties van klimaatverandering voor het bereiken van natuurdoelen die in het kader van Natura 2000 gesteld worden. Om zicht te krijgen op de mogelijke consequenties is een aanpak ontwikkeld en toegepast op twee geselecteerde case studie gebieden: de Oostelijke Vechtplassen en de Kampina en Oisterwijkse vennen. Is onderdeel van klimaateffectatla