Systematic analysis of the impact of mixing locality on Mixing-DAC linearity for multicarrier GSM

In an RF transmitter, the function of the mixer and the DAC can be combined in a single block: the Mixing-DAC. For the generation of multicarrier GSM signals in a basestation, high dynamic linearity is required, i.e. SFDR>85dBc, at high output signal frequency, i.e. ƒout ˜ 4GHz. This represents a challenge which cannot be addressed efficiently by current available hardware or state-of-the-art published solutions. Mixing locality indicates if the mixing operation is executed locally in each DAC unit cell or globally on the combined DAC output signal. The mixing locality is identified as one of the most important aspects of the Mixing-DAC architecture with respect to linearity. Simulations of a current steering Mixing-DAC show that local mixing with a local output cascode can result in the highest linearity, i.e. IMD3<-88dBc at ƒout=4GHz

A 14b 200MS/s DAC with SFDR>78dBc, IM3

A 14-bit 200MS/s current-steering DAC with a novel digital calibration technique called dynamic-mismatch mapping (DMM) is presented. Compared to traditional static-mismatch mapping and dynamic element matching, DMM reduces the nonlinearities caused by both amplitude and timing errors, without noise penalty. This 0.14µm CMOS DAC achieves a state-of-the-art performance of SFDR>78dBc, IM

Peroxisomal ABC transporters: functions and mechanism

Peroxisomes are arguably the most biochemically versatile of all eukaryotic organelles. Their metabolic functions vary between different organisms, between different tissue types of the same organism, and even between different developmental stages or in response to changed environmental conditions. New functions for peroxisomes are still being discovered and their importance is underscored by the severe phenotypes that can arise as a result of peroxisome dysfunction. The β-oxidation pathway is central to peroxisomal metabolism, but the substrates processed are very diverse, reflecting the diversity of peroxisomes across species. Substrates for β-oxidation enter peroxisomes via ATP Binding Cassette (ABC) transporters of the ABCD subfamily and are activated by specific acyl CoA synthetases for further metabolism. Humans have three peroxisomal ABCD family members, which are half transporters that homodimerise and have distinct but partially overlapping substrate specificity; S. cerevisiae has two half transporters that heterodimerise and plants have a single peroxisomal ABC transporter that is a fused heterodimer and which appears to be the single entry point into peroxisomes for a very wide variety of β-oxidation substrates. Our studies suggest that the Arabidopsis peroxisomal ABC transporter AtABCD1 (COMATOSE/PXA1/PED3) accepts acyl CoA substrates, cleaves them before or during transport followed by reactivation by peroxisomal synthetases. We propose that this is a general mechanism to provide specificity to this class of transporters and by which amphipathic compounds are moved across peroxisome membranes

Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks

Susceptibility to scrapie, a transmissible spongiform encephalopathy in sheep, is modulated by the genetic make-up of the sheep. Scrapie control policies, based on selecting animals of resistant genotype for breeding, have recently been adopted by the Netherlands and other European countries. Here we assess the effectiveness of a breeding programme based on selecting rams of resistant genotype to obtain outbreak control in classical scrapie-affected sheep flocks under field conditions. In six commercially-run flocks following this breeding strategy, we used genotyping to monitor the genotype distribution, and tonsil biopsies and post-mortem analyses to monitor the occurrence of scrapie infection. The farmers were not informed about the monitoring results until the end of the study period of six years. We used a mathematical model of scrapie transmission to analyze the monitoring data and found that where the breeding scheme was consistently applied, outbreak control was obtained after at most four years. Our results also show that classical scrapie control can be obtained before the frequency of non-resistant animals is reduced to zero in the flock. This suggests that control at the national scale can be obtained without a loss of genetic polymorphisms from any of the sheep breeds