A Letter of Christine Van Raalte to Her Brother, Ben

A letter of Christine Van Raalte to her brother, Ben, reporting on the family\u27s new life in Amelia. She is very positive about her experiences there but is a bit homesick for her family and friends in Holland.https://digitalcommons.hope.edu/vrp_1860s/1498/thumbnail.jp

Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice

AIMS: More than two billion people worldwide are deficient in key micronutrients. Single micronutrients have been used at high doses to prevent and treat dietary insufficiencies. Yet the impact of combinations of micronutrients in small doses aiming to improve lipid disorders and the corresponding metabolic pathways remains incompletely understood. Thus, we investigated whether a combination of micronutrients would reduce fat accumulation and atherosclerosis in mice. METHODS AND RESULTS: Lipoprotein receptor-null mice fed with an original combination of micronutrients incorporated into the daily chow showed reduced weight gain, body fat, plasma triglycerides, and increased oxygen consumption. These effects were achieved through enhanced lipid utilization and reduced lipid accumulation in metabolic organs and were mediated, in part, by the nuclear receptor PPARα. Moreover, the micronutrients partially prevented atherogenesis when administered early in life to apolipoprotein E-null mice. When the micronutrient treatment was started before conception, the anti-atherosclerotic effect was stronger in the progeny. This finding correlated with decreased post-prandial triglyceridaemia and vascular inflammation, two major atherogenic factors. CONCLUSION: Our data indicate beneficial effects of a combination of micronutritients on body weight gain, hypertriglyceridaemia, liver steatosis, and atherosclerosis in mice, and thus our findings suggest a novel cost-effective combinatorial micronutrient-based strategy worthy of being tested in humans

A Letter of Christine Van Raalte to Her Brothers, Ben and Dirk

A letter of Christine Van Raalte to her brothers, Ben and Dirk, thanking them profusely for writing her. She reports on life in Amelia, making some very interesting comments. Some of these Dutchmen are peculiar people - you cannot imagine how terribly ignorant and stupid some of them are.https://digitalcommons.hope.edu/vrp_1860s/1505/thumbnail.jp

How Many Concussions Would It Take for Athletes to Choose to Discontinue Participation in Their Primary Sport?

The process by which athletes decide to continue or discontinue sport participation after concussion has not been explicated. Intercollegiate and club sport athletes (N = 394) completed an online survey that included assessments of demographic factors, the total number of concussions (and anterior cruciate ligament (ACL) tears) that would prompt sport retirement, concussion history, and athletic identity. On average, participants reported that they would retire from their primary sport after sustaining 3 to 4 concussions (and approximately 2 ACL tears). The total number of concussions reported was negatively correlated with the number of additional concussions it would take to precipitate sport retirement. Athletic identity was positively associated with the number of concussions that participants with a history of one or more concussions reported would prompt them to retire from their primary sport. The results provide information of potential utility to professionals implementing concussion education programs and working with athletes at risk of experiencing concussion

Correspondence and Concordance of Retrospective and Concurrent Responses to Physiotherapists and Sport Psychology Questionnaire Items

Orthopedic and sport-related injuries are a major public health concern and a common reason for referral to physical therapy. The use of psychological techniques by physical therapists has been assessed in research studies primarily with retrospective self-report questionnaires that have not been validated against concurrent assessments of the same behaviors. The primary purpose of this study was to examine the extent to which the results obtained from physical therapists’ retrospective self-reports of their use of psychological techniques reflect their use of the techniques assessed concurrently. Physical therapists (N = 14) completed the Physiotherapists and Sport Psychology Questionnaire (PSPQ) at the beginning of this study and a checklist based on the PSPQ at the end of the sessions with patients (N = 306). Patients also completed the checklist at the end of the sessions. Across 12 psychological techniques, the physical therapists’ retrospective (PSPQ) responses showed relatively weak correspondence (mean r = 0.31) and poor concordance with their concurrent (checklist) responses. Compared to the physical therapists’ checklist responses, the patients’ checklist responses showed weaker correspondence (mean r = 0.03) and better concordance with the physical therapists’ PSPQ responses. The findings suggest that retrospective self-reports may not accurately reflect the use of psychological techniques by physical therapists and, consequently, that physical therapists should consider documenting their use of psychological techniques as close to their implementation as possible. Suggestions for improved assessment are provided

Development and Preliminary Validation of a Sport-Specific Self-Report Measure of Identity Foreclosure

A sport-specific, self-report measure of identity foreclosure was developed through a systematic process that included item pool generation, expert review, administration of items to a development sample of intercollegiate student athletes (N = 326), item evaluation, and administration of scales to validation samples of intercollegiate student athletes (N = 322, N = 54, and N = 64, respectively). The process yielded two four-item scales reflecting commitment to the occupational identity of athlete and one 4-item scale reflecting active exploration of roles other than that of athlete that (a) are internally consistent and temporally stable, (b) demonstrate preliminary factorial and convergent validity, and (c) can be used to create indices of identity foreclosure tailored to the sport context. The resulting Sport-Specific Measure of Identity Foreclosure has potential utility as an assessment tool for research and practice with athletes

An N-ethyl-n-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess

Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, maybe due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion is stimulated by CRH, and we report a mouse model for Cushing's syndrome due to an N-ethyl-N-nitrosourea (ENU) induced Crh mutation at -120 bp of the promoter region, which significantly increased luciferase reporter activity and was thus a gain-of-function mutation. Crh -120/+ mice, when compared with wild-type littermates, had obesity, muscle wasting, thin skin, hair loss, and elevated plasma and urinary concentrations of corticosterone. In addition, Crh-120/+ mice had hyperglycemia, hyperfructosaminemia, hyperinsulinemia, hypercholesterolemia, hypertriglyceridemia, and hyperleptinemia but normal adiponectin. Crh -120/+ mice also had low bone mineral density, hypercalcemia, hypercalciuria, and decreased concentrations of plasma PTH and osteocalcin. Bone histomorphometry revealed Crh-120/+ mice to have significant reductions in mineralizing surface area, mineral apposition, bone formation rates, osteoblast number, and the percentage of corticoendosteal bone covered by osteoblasts, which was accompanied by an increase in adipocytes in the bone marrow. Thus, a mouse model for Cushing's syndrome has been established, and this will help in further elucidating the pathophysiological effects of glucocorticoid excess and in evaluating treatments for corticosteroid-induced osteoporosis. Copyrigh