415 research outputs found
Dilaton-Axion hair for slowly rotating Kerr black holes
Campbell et al. demonstrated the existence of axion ``hair'' for Kerr black
holes due to the non-trivial Lorentz Chern-Simons term and calculated it
explicitly for the case of slow rotation. Here we consider the dilaton coupling
to the axion field strength, consistent with low energy string theory and
calculate the dilaton ``hair'' arising from this specific axion source.Comment: 13 pages + 1 fi
Numerical test of the damping time of layer-by-layer growth on stochastic models
We perform Monte Carlo simulations on stochastic models such as the
Wolf-Villain (WV) model and the Family model in a modified version to measure
mean separation between islands in submonolayer regime and damping time
of layer-by-layer growth oscillations on one dimension. The
stochastic models are modified, allowing diffusion within interval upon
deposited. It is found numerically that the mean separation and the damping
time depend on the diffusion interval , leading to that the damping time is
related to the mean separation as for the WV model
and for the Family model. The numerical results are in
excellent agreement with recent theoretical predictions.Comment: 4 pages, source LaTeX file and 5 PS figure
Shifts in Soil Structure, Biological, and Functional Diversity Under Long-Term Carbon Deprivation
Soil organic matter is composed of a variety of carbon (C) forms. However, not all forms are equally accessible to soil microorganisms. Deprivation of C inputs will cause changes in the physical and microbial community structures of soils; yet the trajectories of such changes are not clear. We assessed microbial communities using phospholipid fatty acid profiling, metabarcoding, CO2 emissions, and functional gene microarrays in a decade-long C deprivation field experiment. We also assessed changes in a range of soil physicochemical properties, including using X-ray Computed Tomography imaging to assess differences in soil structure. Two sets of soils were deprived of C inputs by removing plant inputs for 10 years and 1 year, respectively. We found a reduction in diversity measures, after 10 years of C deprivation, which was unexpected based on previous research. Fungi appeared to be most impacted, likely due to competition for scarce resources after exhausting the available plant material. This suggestion was supported by evidence of bioindicator taxa in non-vegetated soils that may directly compete with or consume fungi. There was also a reduction in copies of most functional genes after 10 years of C deprivation, though gene copies increased for phytase and some genes involved in decomposing recalcitrant C and methanogenesis. Additionally, soils under C deprivation displayed expected reductions in pH, organic C, nitrogen, and biomass as well as reduced mean pore size, especially in larger pores. However, pore connectivity increased after 10 years of C deprivation contrary to expectations. Our results highlight concurrent collapse of soil structure and biodiversity following long-term C deprivation. Overall, this study shows the negative trajectory of continuous C deprivation and loss of organic matter on a wide range of soil quality indicators and microorganisms
Coarsening Dynamics of Crystalline Thin Films
The formation of pyramid-like structures in thin-film growth on substrates
with a quadratic symmetry, e.g., {001} surfaces, is shown to exhibit
anisotropic scaling as there exist two length scales with different time
dependences. Analytical and numerical results indicate that for most
realizations coarsening of mounds is described by an exponent n=0.2357.
However, depending on material parameters, n may lie between 0 (logarithmic
coarsening) and 1/3. In contrast, growth on substrates with triangular
symmetries ({111} surfaces) is dominated by a single length scale and an
exponent n=1/3.Comment: RevTeX, 4 pages, 3 figure
Cancer cells exploit an orphan RNA to drive metastatic progression.
Here we performed a systematic search to identify breast-cancer-specific small noncoding RNAs, which we have collectively termed orphan noncoding RNAs (oncRNAs). We subsequently discovered that one of these oncRNAs, which originates from the 3' end of TERC, acts as a regulator of gene expression and is a robust promoter of breast cancer metastasis. This oncRNA, which we have named T3p, exerts its prometastatic effects by acting as an inhibitor of RISC complex activity and increasing the expression of the prometastatic genes NUPR1 and PANX2. Furthermore, we have shown that oncRNAs are present in cancer-cell-derived extracellular vesicles, raising the possibility that these circulating oncRNAs may also have a role in non-cell autonomous disease pathogenesis. Additionally, these circulating oncRNAs present a novel avenue for cancer fingerprinting using liquid biopsies
Inappropriate p53 Activation During Development Induces Features of CHARGE Syndrome
CHARGE syndrome is a multiple anomaly disorder in which patients present with a variety of phenotypes, including ocular coloboma, heart defects, choanal atresia, retarded growth and development, genitourinary hypoplasia and ear abnormalities. Despite 70-90% of CHARGE syndrome cases resulting from mutations in the gene CHD7, which encodes an ATP-dependent chromatin remodeller, the pathways underlying the diverse phenotypes remain poorly understood. Surprisingly, our studies of a knock-in mutant mouse strain that expresses a stabilized and transcriptionally dead variant of the tumour-suppressor protein p53 (p53(25,26,53,54)), along with a wild-type allele of p53 (also known as Trp53), revealed late-gestational embryonic lethality associated with a host of phenotypes that are characteristic of CHARGE syndrome, including coloboma, inner and outer ear malformations, heart outflow tract defects and craniofacial defects. We found that the p53(25,26,53,54) mutant protein stabilized and hyperactivated wild-type p53, which then inappropriately induced its target genes and triggered cell-cycle arrest or apoptosis during development. Importantly, these phenotypes were only observed with a wild-type p53 allele, as p53(25,26,53,54)(/-) embryos were fully viable. Furthermore, we found that CHD7 can bind to the p53 promoter, thereby negatively regulating p53 expression, and that CHD7 loss in mouse neural crest cells or samples from patients with CHARGE syndrome results in p53 activation. Strikingly, we found that p53 heterozygosity partially rescued the phenotypes in Chd7-null mouse embryos, demonstrating that p53 contributes to the phenotypes that result from CHD7 loss. Thus, inappropriate p53 activation during development can promote CHARGE phenotypes, supporting the idea that p53 has a critical role in developmental syndromes and providing important insight into the mechanisms underlying CHARGE syndrome
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Climate warming leads to divergent succession of grassland microbial communities
Accurate climate projections require an understanding of the effects of warming on ecological communities and the underlying mechanisms that drive them . However, little is known about the effects of climate warming on the succession of microbial communities . Here we examined the temporal succession of soil microbes in a long-term climate change experiment at a tall-grass prairie ecosystem. Experimental warming was found to significantly alter the community structure of bacteria and fungi. By determining the time-decay relationships and the paired differences of microbial communities under warming and ambient conditions, experimental warming was shown to lead to increasingly divergent succession of the soil microbial communities, with possibly higher impacts on fungi than bacteria. Variation partition- and null model-based analyses indicate that stochastic processes played larger roles than deterministic ones in explaining microbial community taxonomic and phylogenetic compositions. However, in warmed soils, the relative importance of stochastic processes decreased over time, indicating a potential deterministic environmental filtering elicited by warming. Although successional trajectories of microbial communities are difficult to predict under future climate change scenarios, their composition and structure are projected to be less variable due to warming-driven selection. 1–3 4,
Elevated Carbon Dioxide Alters the Structure of Soil Microbial Communities
Pyrosequencing analysis of 16S rRNA genes was used to examine impacts of elevated CO2(eCO(2)) on soil microbial communities from 12 replicates each from ambient CO2(aCO(2)) and eCO(2) settings. The results suggest that the soil microbial community composition and structure significantly altered under conditions of eCO(2), which was closely associated with soil and plant properties
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