Review of: Science Advice to the President (William T. Golden, ed. AAAS Press 2d Ed. 1993).

Review of: Science Advice to the President (William T. Golden, ed. AAAS Press 2d Ed. 1993). Acknowledgments, index of names, introductions, notes, tables. ISBN 0-87168-509-4 [340 pp. $29.95 paper. American Association for the Advancement of Science, 1333 H St. NW, Washington DC 20701.

The development of endo-selective epoxide-opening cascades in water

This tutorial review traces the development of endo-regioselective epoxide-opening reactions in water. Templated, water-promoted epoxide-opening cyclization reactions can offer rapid access to subunits of the ladder polyethers, a fascinating and complex family of natural products. This review may be of interest to those curious about the ladder polyethers and their hypothesized biogenesis, about organic reactions in water, and about the development and application of cascade reactions in organic synthesis

Adjustable Prone Trolley Design for People Suffering from Spinal Cord Injuries in Nepal

For people suffering from spinal cord injuries, it is important to stay active. However, with spinal cord injuries, the use of a wheelchair isn’t feasible. These patients require a prone trolley. A prone trolley is a horizontal pad with four wheels that a patient can maneuver and control while lying in a prone position. Our partner, International Nepal Fellowship (INF), deals directly with patients who suffer from spinal cord injuries on a daily basis. INF, a Christian, medical organization, manages a hospital in Pokhara, Nepal which specializes in treating patients with spinal cord injuries. The Nepal Prone Trolley Team’s goal is to provide our partner with a sustainable prone trolley design and create the required manufacturing documentation to enable them to produce the prone trolleys in country at their Green Pastures hospital. The team began our work by researching what a prone trolley is, how it functions and what is currently available. During the research, the team discovered that there weren’t many examples of a manually powered prone trolley or critical dimensions for ergonomics for manually powered trolleys. This drove the team to develop testing methods and preliminary designs specifically for INF. Various basic designs were considered, but, through communication with INF, a single design was chosen. Computer modeling of this design was used to decrease the overall weight of the trolley and simplify the frame. With most of the design finalized, the team is ready to begin prototyping next semester.https://mosaic.messiah.edu/engr2021/1012/thumbnail.jp

Designing a Locally Manufacturable Wheelchair for Nepal

People with disabilities in developing countries often lack the basic equipment needed to assist them in their daily lives. International Nepal Fellowship (INF) is a Christian medical organization located in Nepal that provides medical care and assistance to people with disabilities and other conditions. Currently, INF imports expensive wheelchairs that undergo a prolonged border process before being received. INF has reached out to the Collaboratory to design a wheelchair that can withstand the challenges of Nepal’s terrain and can be manufactured from local materials. The Nepal Wheelchair team has set out to design a wheelchair that can fulfill their needs. In previous work, the team researched wheelchair designs and took a trip to Nepal. From this trip, more information was gained, an initial prototype was constructed, and locally available materials and parts from Nepal were brought back. This year, as a result of knowledge gained through constructing the second prototype, many design changes were tested and implemented. The team researched standards and created testing procedures to ensure the changes to the rear wheel mount, caster wheel mount, footrest, and seat design would uphold the strength and durability of the wheelchair. These design changes have enhanced patient safety and experience in the wheelchair while still keeping the design easily manufacturable. The team also researched options for adding push rims and through using a roller bender were able to construct them. Moving forward, the team will continue to finalize manufacturing documentation and take a second trip to Nepal this May. Funding for this work provided by The Collaboratory for Strategic Partnerships and Applied Research.https://mosaic.messiah.edu/engr2022/1012/thumbnail.jp

Adjustable Prone Trolley Design for People Suffering from Spinal Cords Injuries in Nepal

For people who suffer from spinal cord injuries in Nepal, rehabilitation and care are often difficult to receive, especially for those for whom fewer resources are available. Thankfully, International Nepal Fellowship (INF), a non-profit serving Nepal for nearly 70 years, aids patients with spinal cord injuries at Green Pastures Hospital and Rehabilitation Centre in Pokhara, Nepal. A crucial part of any rehabilitation is adequate exercise to improve circulation and prevent sores and muscular atrophy. Yet, due to the nature of the injury, using a traditional wheelchair is not an option to fulfill this need for those with spinal cord injuries. Therefore, Green Pastures uses prone trolleys so that these patients can exercise. A prone trolley is a horizontal cushioned board where the patient lies flat on their stomach and is able to move themselves using the wheels attached to the cushioned board. Despite the importance of the prone trolley, the trolleys at Green Pastures Hospital have a few critical issues. The major issue is that the prone trolleys are internationally imported, which not only means that delivery can take months, but also that the trolleys are also difficult to repair when damaged. Both these factors severely hamper Green Pastures Hospital’s ability to provide spinal cord injured patients with the care they need. The Nepal Prone Trolley team, a part of Messiah University Collaboratory, seeks to develop and design a fundamentally better prone trolley for INF. The goal of our project is to design a prone trolley that can be fabricated by the INF staff with locally sourced materials. The advantage of this new design is that it will be easier to obtain and can easily be repaired when needed. After creating a design that satisfies our goal and fulfills the criteria of a functional prone trolley as defined by INF, we were able to fabricate a prototype of the prone trolley using resources and techniques available in Pokhara. Moving forward, we will conduct testing and redesign the trolley so that our finalized prone trolley design will be able to transform how Green Pastures Hospital aids their spinal cord injury patients. Funding for this work provided by The Collaboratory for Strategic Partnerships and Applied Research.https://mosaic.messiah.edu/engr2022/1011/thumbnail.jp

Designing a Locally Manufacturable Wheelchair for Nepal

Persons with disabilities in developing countries often lack the basic equipment needed to assist them in their daily lives. International Nepal Fellowship (INF) is a Christian medical organization located in Nepal that provides medical care and assistance to people with disabilities and other conditions. Currently, INF imports expensive wheelchairs that undergo a prolonged border process before being received. INF has reached out to the Collaboratory to design a wheelchair that can withstand the challenges of Nepal’s terrain and can be manufactured from local materials. The Nepal Wheelchair team accepted this challenge and set out to design a wheelchair that can fulfill their needs. The team began by researching wheelchair models for inspiration and eventually settled on two preliminary designs. In January 2020, the team traveled to Pokhara, Nepal to gain feedback from the staff at INF and select a final design based on their comments. During this trip, the team acquired and brought back locally available materials and parts available in Nepal in order to construct a prototype. This year, prototyping has been completed for the following elements: the central frame, wheel lock, footrest, wheel mounting assemblies and armrest fixtures. As a result of knowledge gained during prototyping, some design changes to the wheelchair have been made. Moving forward, the team will test the overall prototype for durability and prepare a manufacturing manual for INF.https://mosaic.messiah.edu/engr2021/1010/thumbnail.jp

Scavenging by threatened turtles regulates freshwater ecosystem health during fish kills

Humans are increasing the frequency of fish kills by degrading freshwater ecosystems. Simultaneously, scavengers like freshwater turtles are declining globally, including in the Australian Murray–Darling Basin. Reduced scavenging may cause water quality problems impacting both ecosystems and humans. We used field and mesocosm experiments to test whether scavenging by turtles regulates water quality during simulated fish kills. In the field, we found that turtles were important scavengers of fish carrion. In mesocosms, turtles rapidly consumed carrion, and water quality in mesocosms with turtles returned to pre-fish kill levels faster than in turtle-free controls. Our experiments have important ecological implications, as they suggest that turtles are critical scavengers that regulate water quality in freshwater ecosystems. Recovery of turtle populations may be necessary to avoid the worsening of ecosystem health, particularly after fish kills, which would have devastating consequences for many freshwater species

A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: Synthesis and structure-activity relationships

a b s t r a c t A series of 3-(phenoxy-phenyl-methyl)-pyrrolidine analogues were discovered to be potent and balanced norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors. Several of these compounds were identified to have suitable in vitro pharmacokinetic properties for an orally dosed and CNS-targeted drug. Compound 39b, in particular, was identified as a potent NET and SERT reuptake inhibitor (NSRI) with minimal off-target activity and demonstrated robust efficacy in the spinal nerve ligation model of pain behavior

Clinical characteristics and outcomes of Richter transformation: experience of 204 patients from a single center

The natural history, prognostication and optimal treatment of Richter transformation developed from chronic lymphocytic leukemia (CLL) are not well defined. We report the clinical characteristics and outcomes of a large series of biopsy-confirmed Richter transformation (diffuse large B-cell lymphoma or high grade B-cell lymphoma, n=204) cases diagnosed from 1993 to 2018. After a median follow up of 67.0 months, the median overall survival (OS) was 12.0 months. Patients who received no prior treatment for CLL had significantly better OS (median 46.3 vs. 7.8 months;

Quantitative Proteomics Reveals Myosin and Actin as Promising Saliva Biomarkers for Distinguishing Pre-Malignant and Malignant Oral Lesions

Oral cancer survival rates increase significantly when it is detected and treated early. Unfortunately, clinicians now lack tests which easily and reliably distinguish pre-malignant oral lesions from those already transitioned to malignancy. A test for proteins, ones found in non-invasively-collected whole saliva and whose abundances distinguish these lesion types, would meet this critical need.To discover such proteins, in a first-of-its-kind study we used advanced mass spectrometry-based quantitative proteomics analysis of the pooled soluble fraction of whole saliva from four subjects with pre-malignant lesions and four with malignant lesions. We prioritized candidate biomarkers via bioinformatics and validated selected proteins by western blotting. Bioinformatic analysis of differentially abundant proteins and initial western blotting revealed increased abundance of myosin and actin in patients with malignant lesions. We validated those results by additional western blotting of individual whole saliva samples from twelve other subjects with pre-malignant oral lesions and twelve with malignant oral lesions. Sensitivity/specificity values for distinguishing between different lesion types were 100%/75% (p = 0.002) for actin, and 67%/83% (p<0.00001) for myosin in soluble saliva. Exfoliated epithelial cells from subjects' saliva also showed increased myosin and actin abundance in those with malignant lesions, linking our observations in soluble saliva to abundance differences between pre-malignant and malignant cells.Salivary actin and myosin abundances distinguish oral lesion types with sensitivity and specificity rivaling other non-invasive oral cancer tests. Our findings provide a promising starting point for the development of non-invasive and inexpensive salivary tests to reliably detect oral cancer early