Workers as objects: The nature of working objectification and the role of perceived alienation

The aim of the present study is to advance the research on working objectification by analyzing its nature and the mechanism underlying this process. In particular, we hypothesized that working objectification involved an automatic association of the worker with an object and a full denial of humanness related to both agency and experience. Further, we expected that perceived alienation could explain the relationship between critical working conditions and objectifying perceptions. Results showed that, compared to an artisan, a factory worker was automatically associated with the objectrelated words rather than with person-related words. Furthermore, the factory worker was perceived as having less agency and experience than the artisan. Finally, the perception of the factory work as fragmented, repetitive, and other-directed was related to a view of work as being more alienating, which, in turn, led to the increased objectification of the worker. Theoretical and practical implications are discussed

Intergroup biologization and outgroup prejudice in the time of COVID-19

Through two studies (N = 602) conducted in Italy between February and March 2020, we examined the impact of the COVID-19 emergency on biologization\u2014a form of dehumanization that involves the perception of others as contagious entities\u2014and outgroup prejudice. Overall, results showed that higher emergency perception was associated with greater biologization toward the groups most affected by the virus, namely the Chinese outgroup and the Italian ingroup. In turn, biologization toward the outgroup increased prejudice against that group. We also found that when the pandemic hit Italy, the greater emergency perception was associated with increased emotional closeness with Chinese people, resulting in reduced biologization and prejudice toward them. However, these results held true only for Italian respondents who reported higher levels of ingroup biologization. Taken together, our findings contribute to the knowledge gaps of biologization and prejudice by also providing relevant insights into the ongoing health emergency

Objectified conformity: Working self-objectification increases conforming behavior

The present work explores whether self-objectification triggered by doing peculiar work activities would increase people\u2019s conforming behavior. We conducted an experimental study in which participants (N = 140) were asked to perform a high objectifying activity (vs. low objectifying activity vs. baseline condition) simulating a real computer job. Afterwards, their levels of self-objectification and conforming behavior were assessed. Results revealed that participants who performed the high objectifying activity self-objectified (i.e., perceived themselves as lacking human mental states) more than the other conditions and, in turn, conformed more to the judgments of unknown similar others. Crucially, increased self-objectification mediated the effects of the high objectifying activity on enhancing conforming behavior. Theoretical and applied implications of these findings are discusse

Improved efficacy response attributed to diagnostic selection – Interim results of the phase 1 experience from ALKA-372-001

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Validation of an Engineered Cell Model for In Vitro and In Vivo HIF-1 alpha Evaluation by Different Imaging Modalities

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[18F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma

The high glycolytic activity of multiple myeloma (MM) cells is the rationale for use of Positron Emission Tomography (PET) with 18F-fluorodeoxyglucose ([18F]FDG) to detect both bone marrow (BM) and extramedullary disease. However, new tracers are actively searched because [18F]FDG-PET has some limitations and there is a portion of MM patients who are negative. Glutamine (Gln) addiction has been recently described as a typical metabolic feature of MM cells. Yet, the possible exploitation of Gln as a PET tracer in MM has never been assessed so far and is investigated in this study in preclinical models. Firstly, we have synthesized enantiopure (2S,4R)-4-fluoroglutamine (4-FGln) and validated it as a Gln transport analogue in human MM cell lines, comparing its uptake with that of 3H-labelled Gln. We then radiosynthesized [18F]4-FGln, tested its uptake in two different in vivo murine MM models, and checked the effect of Bortezomib, a proteasome inhibitor currently used in the treatment of MM. Both [18F]4-FGln and [18F]FDG clearly identified the spleen as site of MM cell colonization in C57BL/6 mice, challenged with syngeneic Vk12598 cells and assessed by PET. NOD.SCID mice, subcutaneously injected with human MM JJN3 cells, showed high values of both [18F]4-FGln and [18F]FDG uptake. Bortezomib significantly reduced the uptake of both radiopharmaceuticals in comparison with vehicle at post treatment PET. However, a reduction of glutaminolytic, but not of glycolytic, tumor volume was evident in mice showing the highest response to Bortezomib. Our data indicate that [18F](2S,4R)-4-FGln is a new PET tracer in preclinical MM models, yielding a rationale to design studies in MM patients

Methods of identifying and recruiting older people at risk of social isolation and loneliness: A mixed methods review

BackgroundLoneliness and social isolation are major determinants of mental wellbeing, especially among older adults. The effectiveness of interventions to address loneliness and social isolation among older adults has been questioned due to the lack of transparency in identifying and recruiting populations at risk. This paper aims to systematically review methods used to identify and recruit older people at risk of loneliness and social isolation into research studies that seek to address loneliness and social isolation.MethodsIn total, 751 studies were identified from a structured search of eleven electronic databases combined with hand searching of reference bibliography from identified studies for grey literature. Studies conducted between January 1995 and December 2017 were eligible provided they recruited community living individuals aged 50 and above at risk of social isolation or loneliness into an intervention study.ResultA total of 22 studies were deemed eligible for inclusion. Findings from these studies showed that the most common strategy for inviting people to participate in intervention studies were public-facing methods including mass media and local newspaper advertisements. The majority of participants identified this way were self-referred, and in many cases self-identified as lonely. In most cases, there was no standardised tool for defining loneliness or social isolation. However, studies that recruited via referral by recognised agencies reported higher rates of eligibility and enrolment. Referrals from primary care were only used in a few studies. Studies that included agency referral either alone or in combination with multiple forms of recruitment showed more promising recruitment rates than those that relied on only public facing methods. Further research is needed to establish the cost-effectiveness of multiple forms of referral.ConclusionFindings from this study demonstrate the need for transparency in writing up the methods used to approach, assess and enrol older adults at risk of becoming socially isolated. None of the intervention studies included in this review justified their recruitment strategies. The ability of researchers to share best practice relies greatly on the transparency of research