Single amino acid chelate complexes of the M (CO)(3)(+) core for correlating fluorescence and radioimaging studies (M=Tc-99m or Re)

Single amino acid chelates (SAACs) and SAAC-like bifunctional ligands can be exploited in the design of a variety of bioconjugates for facile metallation with the M(CO)3+ unit with M = 99mTc or Re. When the donor groups of the ligand are quinolone, thiazole or other similarly conjugated heterocycles, the rhenium complexes are fluorescent, affording complementary and isostructural fluorescent probes to the radioactive 99mTc analogues. The versatility of the approach has been demonstrated by the preparation of bioconjugates incorporating peptides, biotin, folic acid, thymidine and vitamin B12. In addition, the unusual photophysical properties observed for rhenium of the [bisthiazole-diamino butane-Re(CO)3+] derivative [BTBA-Re(CO)3]+ are discussed

Farm Seeker Needs Versus Farm Owner Offers: A Comparison and Analysis in the U.S. Midwest and Plains

Land access for new farmers and ranchers includes transfers from owners without family successors. We compare how farm seekers’ needs align with the offerings of farm owners whose farm assets may transfer out of family in the 12-state North Central Region as defined by the U.S. Department of Agriculture.[1] In Phase 1, managers of farm link services, which connect farm owners without a successor in their family to farm seekers, estimated the patterns demonstrated by their program’s seeker and owner participants through a question­naire. In Phase 2, managers of these and select other agricultural and rural programs circulated to their networks an online survey whose respondents included 178 farm seekers and 183 farm owners whose assets may transfer out of family. Findings denote similarities and barriers between the two groups. The biggest difference was that few owners offered an on-farm residence, which was a top need of seekers. In terms of similarities, the survey found no statistical differences in the groups’ respective locations on a rural-urban continuum, nor in land parcel sizes sought and offered. Half of farm link service providers concurred, observing a match between seeker and owner land needs. However, the other half of service providers reported wide differences, observing two patterns. First, incoming farmers preparing for commodity row crop, hay and fodder, and beef production are well-matched by owners with like type farms to offer, although new entrants often seek bigger parcels than owners offer. Second, seekers prepar­ing for specialty crop, dairy, and hog or poultry (outdoor and indoor) production far exceed the number of owners who offer the infrastructure and scale for these production systems, particularly for parcels under 40 acres.[2] Results suggest opportuni­ties for research and intervention to target barriers and areas of alignment between owner and seeker needs, especially for affordable on-farm housing for new farm operators