Integrated stratigraphic reconstruction for the last 80 kyr in a deep sector of the Sardinia Channel (Western Mediterranean)

A quantitative analysis of planktonic foraminifera, coupled with petrophysical and paleomagnetic measurements and 14C AMS calibrations, was carried out on a deep core recovered in the Sardinia Channel (Western Mediterranean Sea), during the CIESM Sub2 survey, providing an integrated stratigraphic time-framework over the last 80 kyr. Significant changes in the quantitative distribution of planktonic foraminifera allowed the identification of several eco-bioevents useful to accurately mark the boundaries of the eco-biozones widely recognised in the Western Mediterranean records and used for large scale correlations. Namely, 10 eco-biozones were identified based on the relative abundance of selected climate sensitive planktonic foraminiferal species. Sixteen codified eco-bioevents were correlated with the Alboran Sea planktonic foraminiferal data and four climatic global events (Sapropel S1, Younger Dryas, Greenland Isotope Interstadial 1, Greenland Isotope Stadial 2, Heinrich event H1-H6) were recognized. The eco-bioevents together with the 14C AMS calibrations allowed us to define an accurate age model, spanning between 2 and 83 kyr. The reliability of the age model was confirmed by comparing the colour reflectance (550 nm%) data of the studied record with the astronomically tuned record from the Ionian sea (ODP-Site 964). A mean sedimentation rate of about 7 cm/kyr included three turbidite event beds that were chronologically constrained within the relative low stand and lowering sea level phases of the MIS 4 and 3. The deep-sea sedimentary record includes a distinct tephra occurring at the base of the core which dates 78 ka cal. BP. The paleomagnetic data provide a well-defined record of the characteristic remanent magnetization that may be used to reconstruct the geomagnetic paleosecular variation for the Mediterranean back to 83 kyr

Integrated stratigraphic reconstruction for the last 80 kyr in a deep sector of the Sardinia Channel (Western Mediterranean)

A quantitative analysis of planktonic foraminifera, coupled with petrophysical and paleomagnetic measurements and 14C AMS calibrations, was carried out on a deep core recovered in the Sardinia Channel (Western Mediterranean Sea), during the CIESM Sub2 survey, providing an integrated stratigraphic time-framework over the last 80 kyr. Significant changes in the quantitative distribution of planktonic foraminifera allowed the identification of several eco-bioevents useful to accurately mark the boundaries of the eco-biozones widely recognised in the Western Mediterranean records and used for large scale correlations. Namely, 10 eco-biozones were identified based on the relative abundance of selected climate sensitive planktonic foraminiferal species. Sixteen codified eco-bioevents were correlated with the Alboran Sea planktonic foraminiferal data and four climatic global events (Sapropel S1, Younger Dryas, Greenland Isotope Interstadial 1, Greenland Isotope Stadial 2, Heinrich event H1-H6) were recognized. The eco-bioevents together with the 14C AMS calibrations concurred to define an accurate age model, spanning between 2 and 83 kyr cal. BP. The reliability of the age model was confirmed by comparing the colour reflectance (550 nm%) data of the studied record with the astronomically tuned one of the Ionian sea (ODP-Site 964). A mean sedimentation rate of about 7 cm/kyr was evaluated including three turbidite event beds that were chronologically constrained within the relative low stand and lowering sea level phases of the MIS 4 and MIS 3. The deep sea sedimentary record includes a distinct tephra occurring at the base of the core which dates 79 ka. The paleomagnetic data provide a well-defined record of the characteristic remanent magnetization that may be used to reconstruct the geomagnetic paleosecular variation for the Mediterranean back to 83 kyr cal. BP

Sindrome fibromialgica : un caso clinico

La Sindrome Fibromialgica (SFM) \ue8 una malattia che colpisce i muscoli causando tensione muscolare e che si manifesta principalmente con le seguenti sensazioni: iperalgesia, rigidit\ue0, astenia e affaticamento. La diagnosi clinica non \ue8 sempre agevole poich\ue9 non esistono indagini di laboratorio che permettano l\u2019identificazione certa della malattia. Gli studi di neuro-imaging mostrano che la SFM sia legata ad una disfunzione cerebrale che non permette la corretta elaborazione del dolore, tuttavia non \ue8 chiaro se questa disfunzione ne sia causa o effetto. \uc8 indubbio per\uf2 che i fattori psicologici influiscano in maniera significativa sulla sintomatologia dolorosa. Il caso clinico proposto \ue8 riferito ad una paziente (A.) affetta da SFM inviata presso il Servizio di Psicoterapia del Dipartimento di Salute Mentale, Fondazione IRCSS Ca\u2019 Granda Ospedale Maggiore Policlinico di Milano. La paziente effettua una valutazione clinico-diagnostica al baseline (T0) che prevede la somministrazione della seguente batteria testale: Interviste Cliniche Semi-Strutturate per diagnosi secondo DSM-IV TR (SCID I e II), Hamilton Rating scale for Depression and Anxiety (HAM-D e HAM-A), Tema Relazionale Conflittuale Centrale (CCRT), Toronto Alexithymia Scale (TAS-20), Symptom Checklist (SCL-90-R) ed Inventory of Interpersonal Problems (IIP-127). Tale valutazione ha evidenziato un quadro psicopatologico caratterizzato da incapacit\ue0 di individuare e mentalizzare i propri stati emotivi e tendenza alla somatizzazione. In considerazione di quanto emerso e dei dati anamnestici della paziente, viene proposta una psicoterapia psicodinamica breve (STPP), della durata di 9 mesi, finalizzata al conseguimento di una maggiore consapevolezza di s\ue8 e delle proprie emozioni attraverso un focus centrato sul miglioramento delle relazioni interpersonali. Al termine del percorso psicoterapico la paziente esegue una valutazione follow-up (T1) con la medesima batteria testale utilizzata al T0. Le valutazioni al T1 non mostrano variazioni psicopatologiche clinicamente significative, tuttavia la paziente riferisce un vissuto soggettivo positivo, riportando la percezione di un miglioramento della sintomatologia algica cronica derivante da una maggior individuazione delle proprie sensazioni somatiche. Verranno illustrati brani delle sedute psicoterapeutiche per approfondire le principali tematiche cliniche

The impact of the Little ice age on coccolithophores in the central Mediterranea Sea

The Little ice age (LIA) is the last episode of a series of Holocene climatic anomalies. There is still little knowledge on the response of the marine environment to the pronounced cooling of the LIA and to the transition towards the 20th century global warming. Here we present decadal-scale coccolithophore data from four short cores recovered from the central Mediterranean Sea (northern Sicily Channel and Tyrrhenian Sea), which on the basis of ²¹⁰Pb activity span the last 200-350 years. The lowermost part of the record of one of the cores from the Sicily Channel, Station 407, which extends down to 1650 AD, is characterized by drastic changes in productivity. Specifically, below 1850 AD, the decrease in abundance of F. profunda and the increase of placoliths, suggest increased productivity. The chronology of this change is related to the main phase of the Little Ice Age, which might have impacted the hydrography of the southern coast of Sicily and promoted vertical mixing in the water column. The comparison with climatic forcings points out the importance of stronger and prolonged northerly winds, together with decreased solar irradiance

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

Antihistaminic activity of the alkaloids isolated from Caribbean Agelas sponges.

Four Caribbean Age/as sponges (A. clathrodes, A. conifera. A dispar. A. longisstma) have been investigated for the alkaloid composition Along with a series of known bromopyrrole alkaloids, two related novel compounds of this class, dispacamides C (7) and D (8), were found and their structures determined with spectroscopic methods All the isolated Agelas. bromopyrrole alkaloids have been evaluated for the antihistaminic activity on the guinea pig ileum

The cobas P 630 instrument: A dedicated pre-analytic solution to optimize COBAS(®) AmpliPrep/COBAS(®) TaqMan(®) system workflow and turn-around-time.

The cobas p 630, a fully automated pre-analytical instrument for primary tube handling recently introduced to complete the Cobas(®) TaqMan systems portfolio, was evaluated in conjunction with: the COBAS(®) AmpliPrep/COBAS(®) TaqMan HBV Test, v2.0, COBAS(®) AmpliPrep/COBAS(®) TaqMan HCV Test, v1.0 and COBAS(®) AmpliPrep/COBAS(®) TaqMan HIV Test, v2.0. The instrument performance in transferring samples from primary to secondary tubes, its impact in improving COBAS(®) AmpliPrep/COBAS(®) TaqMan workflow and hands-on reduction and the risk of possible cross-contamination were assessed. Samples from 42 HBsAg positive, 42 HCV and 42 HIV antibody (Ab) positive patients as well as 21 healthy blood donors were processed with or without automated primary tubes. HIV, HCV and HBsAg positive samples showed a correlation index of 0.999, 0.987 and of 0.994, respectively. To assess for cross-contamination, high titer HBV DNA positive samples, HCV RNA and HIV RNA positive samples were distributed in the cobas p 630 in alternate tube positions, adjacent to negative control samples within the same rack. None of the healthy donor samples showed any reactivity. Based on these results, the cobas p 630 can improve workflow and sample tracing in laboratories performing molecular tests, and reduce turnaround time, errors, and risks

Comparison of anti–hepatitis D virus (HDV) ETI-AB-DELTAK-2 assay and the novel LIAISON® XL MUREX anti-HDV assay in the diagnosis of HDV infection

Hepatitis B/D virus infection leads to severe liver disease. HDV infection is not routinely investigated since the diagnosis is based on enzyme immunoassays (EIAs), which are not available in all laboratories. This study investigates the performance of new automated assay for anti HDV Ab detection: LIAISON® XL Murex anti-HDV. HBsAg-positive samples were evaluated for HDV serology using the ETI-AB-DELTAK-2 and the new LIAISON® XL Murex with a concordance of 97.5% and 2.42% discordant results. The discordant specimens reacted negatively with EIA and positively with the new test. Dilutions of HDV-purified antibodies and HDV-positive samples were tested with both assays, showing a lower detection limit for the new assay. In conclusion, LIAISON® XL Murex showed a good concordance with the reference method and allowed a more rapid HDV detection. This new diagnostic tool may be useful for a more efficient approach to the HDV diagnosis and evaluation of HDV epidemiology