Caractéristiques cliniques et pronostic des états de mal convulsifs de 132 enfants (étude rétrospective sur 8 ans)

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

PROPHYLAXIE ANTICOAGULANTE LORS D'UN TRAITEMENT ANTI-INFLAMMATOIRE EN CHIRURGIE TRAUMATOLOGIE-ORTHOPEDIE (ETUDE CLINIQUE PROSPECTIVE AU C.H.U. DE REIMS)

REIMS-BU Santé (514542104) / SudocSudocFranceF

Boundary conditions treatment for super- critical flows with tabulated thermochemistry.

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Experimental investigation of Ethane and Propane injection under sub- and super-critical conditions

International audienceStudying a fluid flow under high-pressure conditions through reliable experiments is still nowadays a challenge.When the chamber pressure exceeds the critical pressure of working fluids the supercritical state of matter is reached and the distinction between gas and liquid becomes blurred. For such special conditions, experimental data are scarce and need to be consolidated. Indeed, the modification of the local refractive index induced by den- sity gradient needs to be analyzed with appropriate image-based technique.In the present study, the REFINE test bench (Real-gas Effect on Fluid Injection: a Numerical and Experimental study) has been designed at CORIA Lab to study the non-reactive injection of Ethane and Propane into Nitrogen under sub- and supercritical conditions. The ambient gas pressure can be raised up to 6 MPa and warmed up to 573 K to scan sub- and trans-critical injections. The chamber is equipped with two perpendicular optical axes allowing simultaneously different optical diagnostics. Experimental data are collected from shadowgraph and dif- fused backlight illumination techniques. Quantitative measurements of jet spre ding angle and breakup length arecompared to results coming from literature exhibiting multiple flows topologies

Autophagy and Mitophagy-Related Pathways at the Crossroads of Genetic Pathways Involved in Familial Sarcoidosis and Host-Pathogen Interactions Induced by Coronaviruses

Sarcoidosis is a multisystem disease characterized by the development and accumulation of granulomas, the hallmark of an inflammatory process induced by environmental and/or infectious and or genetic factors. This auto-inflammatory disease mainly affects the lungs, the gateway to environmental aggressions and viral infections. We have shown previously that genetic predisposition to sarcoidosis occurring in familial cases is related to a large spectrum of pathogenic variants with, however, a clustering around mTOR (mammalian Target Of Rapamycin)-related pathways and autophagy regulation. The context of the COVID-19 pandemic led us to evaluate whether such genetic defects may increase the risk of a severe course of SARS-CoV2 infection in patients with sarcoidosis. We extended a whole exome screening to 13 families predisposed to sarcoidosis and crossed the genes sharing mutations with the list of genes involved in the SARS-CoV2 host-pathogen protein-protein interactome. A similar analysis protocol was applied to a series of 100 healthy individuals. Using ENRICH.R, a comprehensive gene set enrichment web server, we identified the functional pathways represented in the set of genes carrying deleterious mutations and confirmed the overrepresentation of autophagy- and mitophagy-related functions in familial cases of sarcoidosis. The same protocol was applied to the set of genes common to sarcoidosis and the SARS-CoV2-host interactome and found a significant enrichment of genes related to mitochondrial factors involved in autophagy, mitophagy, and RIG-I-like (Retinoic Acid Inducible Gene 1) Receptor antiviral response signaling. From these results, we discuss the hypothesis according to which sarcoidosis is a model for studying genetic abnormalities associated with host response to viral infections as a consequence of defects in autophagy and mitophagy processes

Drivers of outcome in compensated alcohol-related cirrhosis: a prospective study

International audienc

Drivers of outcome in compensated alcohol-related cirrhosis: a prospective study

International audienc

PERSISTENT MODERATE ALCOHOL CONSUMPTION IMPACTS SURVIVAL IN PATIENTS WITH COMPENSATED ALCOHOL-RELATED CIRRHOSIS: ANALYSIS OF THE CIRRAL COHORT.

International audienc