Galaxy Formation by Galactic Magnetic Fields

Galaxies exhibit a sequence of various morphological types, i.e., the Hubble sequence, and they are basically composed of spheroidal components (elliptical galaxies and bulges in spiral galaxies) and disks. It is known that spheroidal components are found only in relatively massive galaxies with M=10^{10-12} M_sun, and all stellar populations in them are very old, but there is no clear explanation for these facts. Here we present a speculative scenario for the origin of the Hubble sequence, in which magnetic fields ubiquitously seen in galaxies have played a crucial role. We first start from a strange observational fact that magnetic field strengths observed in spiral galaxies sharply concentrate at a few microgauss, for a wide range of galaxy luminosity and types. We then argue that this fact and the observed correlation between star formation activity and magnetic field strength in spiral galaxies suggest that spheroidal galaxies have formed by starbursts induced by strong magnetic fields. Then we show that this idea naturally leads to the formation of spheroidal systems only in massive and high-redshift objects in hierarchically clustering universe, giving a simple explanation for various observations.Comment: 7 pages including 2 figures. Accepted by ApJ Letter

Faraday Rotation Measure Synthesis

We extend the rotation measure work of Burn (1966) to the cases of limited sampling of lambda squared space and non-constant emission spectra. We introduce the rotation measure transfer function (RMTF), which is an excellent predictor of n-pi ambiguity problems with the lambda squared coverage. Rotation measure synthesis can be implemented very efficiently on modern computers. Because the analysis is easily applied to wide fields, one can conduct very fast RM surveys of weak spatially extended sources. Difficult situations, for example multiple sources along the line of sight, are easily detected and transparently handled. Under certain conditions, it is even possible to recover the emission as a function of Faraday depth within a single cloud of ionized gas. Rotation measure synthesis has already been successful in discovering widespread, weak, polarized emission associated with the Perseus cluster (De Bruyn and Brentjens, 2005). In simple, high signal to noise situations it is as good as traditional linear fits to polarization angle versus lambda squared plots. However, when the situation is more complex or very weak polarized emission at high rotation measures is expected, it is the only viable option.Comment: 17 pages, 14 figures, accepted by A&A, added references, corrected typo

Distances to the high galactic latitude molecular clouds G192-67 and MBM 23-24

We report on distance determinations for two high Galactic latitude cloud complexes, G192-67 and MBM 23-24. No distance determination exists in the literature for either cloud. Thirty-four early type stars were observed towards the two clouds, more than half of which have parallaxes measured by the Hipparcos satellite. For the remaining stars we have made spectroscopic distance estimates. The data consist of high resolution echelle spectra centered on the Na I D lines, and were obtained over six nights at the Coude Feed telescope at Kitt Peak National Observatory. Interstellar absorption lines were detected towards some of the stars, enabling estimates of the distances to the clouds of 109 +/- 14 pc for G192-67, and of 139 +/- 33 pc for MBM 23-24. We discuss the relationship of these clouds to other ISM features such as the Local Hot Bubble and the local cavity in neutral hydrogen.Comment: 15 pages, 6 embedded figures, to be published in the ApJ Vol. 516, No.

Neuronal migration defects in the Loa dynein mutant mouse

<p>Abstract</p> <p>Background</p> <p>Cytoplasmic dynein and its regulatory proteins have been implicated in neuronal and non-neuronal cell migration. A genetic model for analyzing the role of cytoplasmic dynein specifically in these processes has, however, been lacking. The Loa (Legs at odd angles) mouse with a mutation in the dynein heavy chain has been the focus of an increasing number of studies for its role in neuron degeneration. Despite the location of this mutation in the tail domain of the dynein heavy chain, we previously found a striking effect on coordination between the two dynein motor domains, resulting in a defect in dynein run length <it>in vitro </it>and <it>in vivo</it>.</p> <p>Results</p> <p>We have now tested for effects of the Loa mutation on neuronal migration in the developing neocortex. Loa homozygotes showed clear defects in neocortical lamination and neuronal migration resulting from a reduction in the rate of radial migration of bipolar neurons.</p> <p>Conclusions</p> <p>These results present a new genetic model for understanding the dynein pathway and its functions during neuronal migration. They also provide the first evidence for a link between dynein processivity and somal movement, which is essential for proper development of the brain.</p

Coherent acoustic vibration of metal nanoshells

Using time-resolved pump-probe spectroscopy we have performed the first investigation of the vibrational modes of gold nanoshells. The fundamental isotropic mode launched by a femtosecond pump pulse manifests itself in a pronounced time-domain modulation of the differential transmission probed at the frequency of nanoshell surface plasmon resonance. The modulation amplitude is significantly stronger and the period is longer than in a gold nanoparticle of the same overall size, in agreement with theoretical calculations. This distinct acoustical signature of nanoshells provides a new and efficient method for identifying these versatile nanostructures and for studying their mechanical and structural properties.Comment: 5 pages, 3 figure

TRIDENT: an infrared camera optimized for the detection of methanated substellar companions around nearby stars

A near-infrared (0.85-2.5 microns) camera in use at the Canada-France-Hawaii Telescope and at the 1.6m telescope of the Observatoire du Mont-Megantic is described. The camera is based on a Hawaii-1 1024x1024 HgCdTe array detector. Its main feature is to acquire three simultaneous images at three wavelengths (simultaneous differential imaging) across the methane absorption bandhead at 1.6 micron, enabling an accurate subtraction of the stellar point spread function (PSF) and the detection of faint close methanated companions. The instrument has no coronagraph and features a fast (1 MHz) data acquisition system without reset anomaly, yielding high observing efficiencies on bright stars. The performance of the instrument is described, and it is illustrated by CFHT images of the nearby star Ups And. TRIDENT can detect (3 sigma) a methanated companion with DeltaH=10 at 0.5 arcsec from the star in one hour of observing time. Non-common path aberrations between the three optical paths are the limiting factors preventing further PSF attenuation. Reference star subtraction and instrument rotation improve the detection limit by one order of magnitude.Comment: 8 pages, 6 figures, to appear in SPIE 486

A Magnetized Local Supercluster and the Origin of the Highest Energy Cosmic Rays

A sufficiently magnetized Local Supercluster can explain the spectrum and angular distribution of ultra-high energy cosmic rays. We show that the spectrum of extragalactic cosmic rays with energies below $\sim 10^{20}$ eV may be due to the diffusive propagation in the Local Supercluster with fields of $\sim 10^{-8} - 10^{-7}$ Gauss. Above $\sim 10^{20}$ eV, cosmic rays propagate in an almost rectilinear way which is evidenced by the change in shape of the spectrum at the highest energies. The fit to the spectrum requires that at least one source be located relatively nearby at $\sim 10-15$ Mpc away from the Milky Way. We discuss the origin of magnetic fields in the Local Supercluster and the observable predictions of this model.Comment: 11 pages, 2 figures, submitted to PR

Acid-Labile Traceless Click Linker for Protein Transduction

Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of reversible pH-sensitive bonds. The azidomethyl-methylmaleic anhydride (AzMMMan) linker was found compatible with different click chemistries, demonstrated in bioreversible protein modification with dyes, polyethylene glycol, or a transduction carrier. Linkages were stable at physiological pH but reversible at the mild acidic pH of endosomes or lysosomes. We show that pH-reversible attachment of a defined endosome-destabilizing three-arm oligo(ethane amino)amide carrier generates an effective shuttle for protein delivery. The cargo protein nlsEGFP, when coupled via the traceless AzMMMan linker, experiences efficient cellular uptake and endosomal escape into the cytosol, followed by import into the nucleus. In contrast, irreversible linkage to the same shuttle hampers nuclear delivery of nlsEGFP which after uptake remains trapped in the cytosol. Successful intracellular delivery of bioactive ß-galactosidase as a model enzyme was also demonstrated using the pH-controlled shuttle system