36 research outputs found

    Novel activities of safe-in-human broad-spectrum antiviral agents

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    Abstract According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.Peer reviewe

    Avoimen lähdekoodin hyödyntäminen väsymisanalyysissä

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    This article presents methods for combining fatigue data and unit loads to be applied for fatigue analysis within open-source FEM codes. Example results from literature are close to the results obtained with the present methods. Accordingly, open-source tools can be considered as a viable option for multi-axial fatigue analysis.Artikkelissa esitetään menetelmät väsymisdatan ja yksikkökuormien yhdistämisestä ja sen käytöstä avoimen lähdekoodin FEM-ohjelmistojen yhteydessä väsymisvaurion selvittämiseksi. Kirjallisuudesta löytyvän esimerkin ja ohjelmalla lasketut tulokset olivat lähellä toisiaan. Avoimen lähdekoodin tarjoamat ratkaisut ovat siis varteenotettavia moniaksiaalisen väsymisen analysoinnissa
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