Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line

Background. Chemotherapy, radiotherapy, and surgery are routine treatments of breast cancer. However, these methods could only improve the living survival. Nowadays the combined therapy including herbals such as crocin is to study for improving breast cancer treatment. The purpose of this study was to evaluate the effects of crocin, paclitaxel, and radiation on MCF-7 cell. Methods. To evaluate the effect of crocin, paclitaxel, and radiation on survival rate of MCF-7 cells MTT assay was done. To investigate the apoptotic effect of experimental groups PI-flow cytometry was used and expression of apoptotic proteins (caspase-7, caspase-9, PARP, and p53) was studied by western blot. Results. This study revealed that the combined therapy of 0.01μmol/mL paclitaxel and 2.5 mg/mL crocin after 48 h could cause IC50 for MCF-7 cell line. This study showed that the combined therapy of 2 Gy gamma radiation with crocin could rise apoptosis in MCF-7 cell line from 21 (related to using 2 Gy gamma radiation alone) to 46.6. Conclusion. Crocin and paclitaxel and crocin and gamma radiation had synergistic effect on MCF-7 cell line to get more significant apoptosis. © 2015 Faeze Vali et al

An innovative framework for real-time monitoring of pollutant point sources in river networks

Simultaneous identification of the location and release history of pollutant sources in river networks is an ill-posed and complicated problem, particularly in the case of multiple sources with time-varying release patterns. This study presents an innovative method for solving this problem using minimum observational data. To do so, a procedure is proposed in which, the number and the suspected reaches to the existence of pollutant sources are determined. This is done by defining two different types of monitoring stations with an adaptive arrangement in addition to real-time data collection and reliable flow and transport mathematical models. In the next step, the sources’ location and their release history are identified by solving the inverse source problem employing a geostatistical approach. Different scenarios are discussed for different conditions of number, release history and location of pollutant sources in the river network. Results indicated the capability of the proposed method in identifying the characteristics of the sources in complicated cases. Hence, it can be effectively used for the comprehensive monitoring of river networks for different purposes

Sedimentary Iron Cycling and the Origin and Preservation of Magnetization in Platform Carbonate Muds, Andros Island, Bahamas

Carbonate muds deposited on continental shelves are abundant and well-preserved throughout the geologic record because shelf strata are difficult to subduct and peritidal carbonate units often form thick, rheologically strong units that resist penetrative deformation. Much of what we know about pre-Mesozoic ocean chemistry, carbon cycling, and global change is derived from isotope and trace element geochemistry of platform carbonates. Paleomagnetic data from the same sediments would be invaluable, placing records of paleolatitude, paleogeography, and perturbations to the geomagnetic field in the context and relative chronology of chemostratigraphy. To investigate the depositional and early diagenetic processes that contribute to magneitzation in carbonates, we surveyed over 500 core and surface samples of peritidal, often microbially bound carbonate muds spanning the last not, vert, similar 1000 yr and deposited on top of Pleistocene aeolianites in the Triple Goose Creek region of northwest Andros Island, Bahamas. Sedimentological, geochemical, magnetic and ferromagnetic resonance properties divide the sediment columns into three biogeochemical zones. In the upper sediments, the dominant magnetic mineral is magnetite, produced by magnetotactic bacteria and dissimiliatory microbial iron metabolism. At lower depths, above or near mean tide level, microbial iron reduction dissolves most of the magnetic particles in the sediment. In some cores, magnetic iron sulfides precipitate in a bottom zone of sulfate reduction, likely coupled to the oxidation of decaying mangrove roots. The remanent magnetization preserved in all oriented samples appears indistinguishable from the modern local geomagnetic field, which reflects the post-depositional origin of magnetic particles in the lower zone of the parasequence. While we cannot comment on the effects of late-stage diagenesis or metamorphism on remanence in carbonates, we postulate that early-cemented, thin-laminated parasequence tops in ancient peritidal carbonates are mostly likely to preserve syn-depositional paleomagnetic directions and magnetofossil stratigraphies

NORM Technique based PAPR Reduction in MC-CDMA Systems

Multicarrier code division multiple access (MC-CDMA) is one of the promising technologies for future-generation wireless networks. It offers high data rates, protection against frequency-selective fading and efficient utilization of the spectrum. The peak to average power ratio (PAPR) is very high in MCCDMA systems. The partial transmit sequence technique (PTS) and the selective mapping technique (SLM) reduce the PAPR with more computational complexity. In this study, the NORM technique was used for PAPR reduction in MC-CDMA systems. The performance of NORM was analyzed with PTS and SLM in terms of cumulative complementary distribution, power saving gain, amplifier efficiency, computational complexity and bit error rate. Simulation results showed that NORM has better PAPR reduction with less computational complexity

Structural study of the coordination behavior of a tetradentate NO3-donor amino alcohol ligand toward a CdII:HgII mixture

In this work, the reaction of 2,2′,2″-nitrilotriethanol (NTE) with a 1:1 mixture of CdI2 and HgI2 is investigated. The complex [Cd(NTE)2][Hg2(μ-I)2I4] was synthesized and identified by elemental analysis, FT-IR, 1H NMR spectroscopy and single-crystal X-ray diffraction. The structure of the [HNTE]Cl salt is also presented. In the crystal structure of the complex, the cadmium atom has a CdN2O6 environment in a slightly distorted cube geometry. This geometry is one of the rare cube geometries with a minimum distortion among the Cambridge Structural Database structures for cadmium complexes. The anionic moiety has a binuclear structure with the mercury atoms being in tetrahedral environments. In the network of the complex, in addition to O−H · · · I hydrogen bonds, there are I · · · I interactions which lead to ten-membered rings.Publisher PDFPeer reviewe

Gigantism in unique biogenic magnetite at the Paleocene-Eocene Thermal Maximum

We report the discovery of exceptionally large biogenic magnetite crystals in clay-rich sediments spanning the Paleocene-Eocene Thermal Maximum (PETM) in a borehole at Ancora, New Jersey. Aside from previously-described abundant bacterial magnetofossils, electron microscopy reveals novel spearhead-like and spindle-like magnetite up to 4 μm long and hexaoctahedral prisms up to 1.4 μm long. Similar to magnetite produced by magnetotactic bacteria, these single-crystal particles exhibit chemical composition, lattice perfection, and oxygen isotopes consistent with an aquatic origin. Electron holography indicates single-domain magnetization despite their large crystal size. We suggest that the development of a thick suboxic zone with high iron bioavailability – a product of dramatic changes in weathering and sedimentation patterns driven by severe global warming – drove diversification of magnetite-forming organisms, likely including eukaryotes

An active power control approach for wake-induced load alleviation in a fully developed wind farm boundary layer

This paper studies a closed-loop wind farm control framework for active power control (APC) with a simultaneous reduction of wake-induced structural loads within a fully developed wind farm flow interacting with the atmospheric boundary layer. The main focus is on a classical feedback control, which features a simple control architecture and a practical measurement system that are realizable for real-time control of large wind farms. We demonstrate that the wake-induced structural loading of the downstream turbines can be alleviated, while the wind farm power production follows a reference signal. A closed-loop APC is designed first to improve the power-tracking performance against wake-induced power losses of the downwind turbines. Then, the nonunique solution of APC for the wind farm is exploited for aggregated structural load alleviation. The axial induction factors of the individual wind turbines are considered control inputs to limit the power production of the wind farm or to switch to greedy control when the demand exceeds the power available in the wind. Furthermore, the APC solution domain is enlarged by an adjustment of the power set-points according to the locally available power at the waked wind turbines. Therefore, the controllability of the wind turbines is improved for rejecting the intensified load fluctuations inside the wake. A large-eddy simulation model is employed for resolving the turbulent flow, the wake structures, and its interaction with the atmospheric boundary layer. The applicability and key features of the controller are discussed with a wind farm example consisting of 3×4 turbines with different wake interactions for each row. The performance of the proposed APC is evaluated using the accuracy of the wind farm power tracking and the wake-induced damage equivalent fatigue loads of the towers of the individual wind turbines.</p

The survival rate of hepatocellular carcinoma in asian countries: A systematic review and meta-analysis

Hepatocellular carcinoma or Liver cancer (LC) is the sixth most common cancer and the fourth cause of death worldwide in 2018. There has not been a comprehensive study on the survival rate of patients with LC in Asia yet. Therefore, the present study was conducted to evaluate the survival rate of patients with LC in Asian countries. The methodology of the present study is based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. The researchers searched five international databases including Medline/PubMed, Scopus, Embase, Web of Knowledge and ProQuest until July 1, 2018. We also searched Google Scholar for detecting grey literature. The Newcastle-Ottawa Quality Assessment Form was used to evaluate the quality of selected papers. A total of 1425 titles were retrieved. 63 studies met the inclusion criteria. Based on the random-effect model one-year, three-year and five-year survival rate of LC were 34.8 (95 CI; 30.3-39.3), 19 (95 CI; 18.2-21.8) and 18.1 (95 CI;16.1-20.1) respectively. According to the results of our study, the LC survival rate in Asian countries is relatively lower than in Europe and North America. © 2020, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved