Issues Pertaining to Rebuilt Vehicle Titles

In Kentucky, salvage titles are issued when a vehicle has been wrecked, destroyed, or damaged and the cost of repairs exceeds 75 percent of the vehicle’s fair market value. Once a vehicle is repaired to roadworthy condition it is issued a rebuilt title. Kentucky issued 110,000 rebuilt and salvage titles in 2018. Over the 2014 to 2018 period, the number of rebuilt and salvage titles issued climbed 31 percent. The economic impact of rebuilt and salvage titles in Kentucky is considerable — approximately $331 million in 2018, based on data for the taxable values or sales prices of vehicles. To document titling practices for rebuilt and salvage vehicles adopted by other agencies, the Kentucky Transportation Center (KTC) distributed a survey to all American states and Canadian provinces and territories. From it, researchers learned that Ohio has a very robust inspection program for rebuilt and salvage vehicles. The survey and interviews with Ohio personnel revealed that other states have persistent concerns about Kentucky’s rebuilt and salvage titles. In particular, some states do not accept Kentucky’s red titles (rebuilt and salvage vehicles that were transferred into Kentucky). Ohio inspectors have identified multiple stolen vehicles that had been titled as rebuilt or salvage in the Commonwealth. To improve the rebuilt and salvage vehicle titling process, state administrators in the Division of Motor Vehicle Licensing could consider implementing a program similar to Ohio’s in terms of technology, workflow and the inspection cost assessed to individuals or businesses wishing to obtain a rebuilt or salvage title

Linking Bad Credentials to Safety Issues

This study assesses (1) the effectiveness of the Kentucky Automated Truck Screening (KATS) system, (2) the relationship between credential and vehicle safety violations, (3) the relationship between credential and driver safety violations, and (4) the relationship between credential violations and crashes. The KATS system, which is installed at weigh stations throughout the Commonwealth of Kentucky, is highly effective at detecting KYU, IFTA, and UCR violations with sensitivities of 80.54, 87.56, and 88.28 percent, respectively. However, the system is less effective at detecting IRP violations (sensitivity = 20.83 percent). There is a statistically significant relationship between credentialing and vehicle safety violations, and the same is true for credentialing violations and driver safety violations. Carriers with at least one KYU, IFTA, UCR, or IRP violation were 111.16 percent more likely to receive a citation for a vehicle safety violation than motor carriers without credentialing violations. Compared to carriers without credentialing violations, carriers with at least one credentialing violation were 112.50 percent more likely to receive a citation related to driver safety. In terms of the relationship between Kentucky-based credentialing violations and nationwide crashes (major crashes only), carriers with at least one credentialing violation were 35.43 percent more likely to be involved in a serious crash than carriers without credentialing violations

Modelling Changes To Survey Response Items Over Time In A Britain Financial Literacy Education Study

This study develops a general method for modeling changes in response to items relating to students perceptions of personal finance and financial products. The new method is illustrated to analyze data from a sample of 1,250 students aged 16-18 who participated in a financial capability education study in the UK. We demonstrate how a quantitative indicator of the changes in students' responses can be applied in various educational research projects, particularly as a measure of program effectiveness. Predictions are based on prior survey responses, which are taken as relevant historical information for a cohort of students. We find significant changes in the responses of students towards reported career choice following the Financial Literacy Education course at national colleges in the UK

Developing a Baseline for Customer Satisfaction in the Kentucky Transportation Cabinet\u27s Department of Vehicle Regulation

Among the Kentucky Transportation Cabinet’s (KYTC) business units, the Department of Vehicle Regulation (DVR) has the most interactions with members of the public and other government agencies. Given its high profile and public visibility, it is critical for the department to provide high-quality customer service. Lacking data on customer perceptions of DVR’s level of service, the department commissioned researchers at the Kentucky Transportation Center (KTC) to conduct a baseline and rebaseline customer satisfaction surveys. Along with administering surveys to external customers, KTC’s research team also polled DVR staff to gauge employee morale and identify areas which could be improved. Approximately 90% of departmental staff believe that DVR provides a high level of customer service, and most viewed the department’s divisions favorably. Staff, however, noted the importance of fostering an open, equitable, and collaborative workspace as well as the importance of having up-to-date technological tools to perform daily job functions. With respect to the baseline and rebaseline external customer surveys, this study measured a slight decline in overall customer satisfaction. In the baseline survey, 81% of respondents were very or somewhat satisfied with the service they received; in the rebaseline survey 77% said the same. Regression modeling found a strong negative relationship between number of call escalations (i.e., call transfers) and customer satisfaction; call duration had a smaller but negative impact on customer satisfaction. Survey respondents expressed a growing preference for using electronic means (email, website) to interact with DVR. Moving forward, it will be critical for DVR to dedicate resources to improving its website and streamlining other modes of electronic communication, reducing the number of call escalations, and shortening average call durations – particularly hold times

ytopt: Autotuning Scientific Applications for Energy Efficiency at Large Scales

As we enter the exascale computing era, efficiently utilizing power and optimizing the performance of scientific applications under power and energy constraints has become critical and challenging. We propose a low-overhead autotuning framework to autotune performance and energy for various hybrid MPI/OpenMP scientific applications at large scales and to explore the tradeoffs between application runtime and power/energy for energy efficient application execution, then use this framework to autotune four ECP proxy applications -- XSBench, AMG, SWFFT, and SW4lite. Our approach uses Bayesian optimization with a Random Forest surrogate model to effectively search parameter spaces with up to 6 million different configurations on two large-scale production systems, Theta at Argonne National Laboratory and Summit at Oak Ridge National Laboratory. The experimental results show that our autotuning framework at large scales has low overhead and achieves good scalability. Using the proposed autotuning framework to identify the best configurations, we achieve up to 91.59% performance improvement, up to 21.2% energy savings, and up to 37.84% EDP improvement on up to 4,096 nodes

Linking Bad Credentials to Safety Issues

SPR 20-583This study assesses (1) the effectiveness of the Kentucky Automated Truck Screening (KATS) system, (2) the relationship between credential and vehicle safety violations, (3) the relationship between credential and driver safety violations, and (4) the relationship between credential violations and crashes. The KATS system, which is installed at weigh stations throughout the Commonwealth of Kentucky, is highly effective at detecting KYU, IFTA, and UCR violations with sensitivities of 80.54, 87.56, and 88.28 percent, respectively. However, the system is less effective at detecting IRP violations (sensitivity = 20.83 percent). There is a statistically significant relationship between credentialing and vehicle safety violations, and the same is true for credentialing violations and driver safety violations. Carriers with at least one KYU, IFTA, UCR, or IRP violation were 111.16 percent more likely to receive a citation for a vehicle safety violation than motor carriers without credentialing violations. Compared to carriers without credentialing violations, carriers with at least one credentialing violation were 112.50 percent more likely to receive a citation related to driver safety. In terms of the relationship between Kentucky-based credentialing violations and nationwide crashes (major crashes only), carriers with at least one credentialing violation were 35.43 percent more likely to be involved in a serious crash than carriers without credentialing violations

Objective response by mRECIST as a predictor and potential surrogate end point of overall survival in advanced HCC

Background & Aims: The Modified Response Evaluation Criteria in Solid Tumors (mRECIST) was developed to overcome the limitations of standard RECIST criteria in response assessment of hepatocellular carcinoma (HCC). We aimed to investigate whether objective response by mRECIST accurately predicted overall survival (OS) in patients with advanced HCC treated with systemic targeted therapies and also to preliminarily assess this endpoint as a potential surrogate of OS.Methods: Individual patient data from the BRISK-PS randomized phase III trial comparing brivanib vs. placebo (the first to prospectively incorporate mRECIST) were used to analyze objective response as a predictor of OS in a time-dependent covariate analysis. Patients with available imaging scans during follow-up were included (n = 334; 85% of those randomized). Moreover, a correlation of the survival probability in deciles vs. the observed objective response was performed to evaluate its suitability as a surrogate end-point.Results: Objective response was observed in 11.5% and 1.9% of patients treated with brivanib and placebo respectively, and was associated with a better survival (median OS 15.0 vs. 9.4 months, p < 0.001). In addition, objective response had an independent prognostic value (HR = 0.48; 95% confidence interval [CI], 0.26-0.91, p = 0.025) along with known prognostic factors. Finally, objective response showed promising results as a surrogate of OS in this trial (R = -0.92; 95% CI, -1 to -0.73, p < 0.001). It was an early indicator of the treatment effect (median time to objective response was 1.4 months).Conclusions: Objective response by mRECIST in advanced HCC predicts OS and thus can be considered as a candidate surrogate end-point. Further studies are needed to support this finding.Lay summary: There is a need to identify surrogate end-points for overall survival in advanced hepatocellular carcinoma. We studied patients from the phase III BRISK trial, comparing brivanib treatment with placebo after sorafenib progression. We demonstrate that objective response is an independent predictor of survival and qualifies as a potential surrogate end-point for overall survival in this patient population.Clinical trial number: NCT00825955

Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 1: Glucocorticoid-Associated Osteonecrosis.

BACKGROUND: Glucocorticoid usage, a leading cause of osteonecrosis of the femoral head (ONFH), and its prevalence was reported in 25%-50% of non-traumatic ONFH patients. Nevertheless, there have been no unified criteria to classify glucocorticoid-associated ONFH (GA-ONFH). In 2015, the Association Research Circulation Osseous addressed the issue of developing a classification scheme. METHODS: In June 2017, a task force was set up to conduct a Delphi survey concerning ONFH. The task force invited 28 experts in osteonecrosis/bone circulation from 8 countries. Each round of the Delphi survey consists of questionnaires, analysis of replies, and feedback reports to the panel. After 3 rounds of the survey, the panel reached a consensus on the classification criteria. The response rates were 100% (Round 1), 96% (Round 2), and 100% (Round 3), respectively. RESULTS: The consensus on the classification criteria of GA-ONFH included the following: (1) patients should have a history of glucocorticoid use >2 g of prednisolone or its equivalent within a 3-month period; (2) osteonecrosis should be diagnosed within 2 years after glucocorticoid usage, and (3) patients should not have other risk factor(s) besides glucocorticoids. CONCLUSION: Association Research Circulation Osseous established classification criteria to standardize clinical studies concerning GA-ONFH

Tim3 binding to galectin-9 stimulates antimicrobial immunity

The interaction between Tim3 on Th1 cells and galectin-9 on Mycobacterium tuberculosis–infected macrophages restricts the bacterial growth by stimulating caspase-1–dependent IL-1β secretion

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts