MTPmle: A SAS Macro and Stata Programs for Marginalized Inference in Semi-Continuous Data

We develop a SAS macro and equivalent Stata programs that provide marginalized inference for semi-continuous data using a maximum likelihood approach. These software extensions are based on recently developed methods for marginalized two-part (MTP) models. Both the SAS and Stata extensions can fit simple MTP models for cross-sectional semi-continuous data. In addition, the SAS macro can fit random intercept models for longitudinal or clustered data, whereas the Stata programs can fit MTP models that account for subject level heteroscedasticity and for a complex survey design. Differences and similarities between the two software extensions are highlighted to provide a comparative picture of the available options for estimation, inclusion of random effects, convergence diagnosis, and graphical display. We provide detailed programming syntax, simulated and real data examples to facilitate the implementation of the MTP models for both SAS and Stata software users

Low Serum Hepcidin Is Associated With Reduced Shortâ Term Survival in Adults With Acute Liver Failure

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149282/1/hep30486_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149282/2/hep30486.pd

Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110729/1/epi12905.pd

Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/169284/1/hep31767_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/169284/2/hep31767-sup-0001-Supinfo.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/169284/3/hep31767.pd

Psychosocial Characteristics and Pain Burden of Patients With Suspected Sphincter of Oddi Dysfunction in the EPISOD Multicenter Trial

Patients with several painful functional gastrointestinal disorders (FGIDs) are reported to have a high prevalence of psychosocial disturbance. These aspects have not been studied extensively in patients with suspected Sphincter of Oddi dysfunction (SOD)

Challenges in planning and initiating a randomized clinical study of sphincter of Oddi dysfunction

Sphincter of Oddi dysfunction (SOD) is a controversial topic, especially in patients with no objective findings on laboratory or imaging studies (SOD type III). The value of ERCP manometry with sphincterotomy is unproven and carries significant risks

Effect of Endoscopic Sphincterotomy for Suspected Sphincter of Oddi Dysfunction on Pain-Related Disability Following Cholecystectomy: The EPISOD Randomized Clinical Trial

Abdominal pain after cholecystectomy is common and may be attributed to sphincter of Oddi dysfunction. Management often involves endoscopic retrograde cholangiopancreatography (ERCP) with manometry and sphincterotomy

Can patient and pain characteristics predict manometric sphincter of Oddi dysfunction in patients with clinically suspected sphincter of Oddi dysfunction?

Biliopancreatic-type postcholecystectomy pain, without significant abnormalities on imaging and laboratory test results, has been categorized as “suspected” sphincter of Oddi dysfunction (SOD) type III. Clinical predictors of “manometric” SOD are important to avoid unnecessary ERCP, but are unknown

SpHincterotomy for Acute Recurrent Pancreatitis Randomized Trial: Rationale, Methodology, and Potential Implications

Objectives: In patients with acute recurrent pancreatitis (ARP), pancreas divisum, and no other etiologic factors, endoscopic retrograde cholangiopancreatography (ERCP) with minor papilla endoscopic sphincterotomy (miES) is often performed to enlarge the minor papillary orifice, based on limited data. The aims of this study are to describe the rationale and methodology of a sham-controlled clinical trial designed to test the hypothesis that miES reduces the risk of acute pancreatitis. Methods: The SpHincterotomy for Acute Recurrent Pancreatitis (SHARP) trial is a multicenter, international, sham-controlled, randomized trial comparing endoscopic ultrasound + ERCP with miES vs. endoscopic ultrasound + sham for the management of ARP. A total of 234 consented patients having two or more discrete episodes of acute pancreatitis, pancreas divisum confirmed by magnetic resonance cholangiopancreatography, and no other clear etiology for acute pancreatitis will be randomized. Both cohorts will be followed for a minimum of 6 months and maximum of 48 months. Results: The trial is powered to detect a 33% risk reduction of acute pancreatitis frequency. Conclusions: The SHARP trial will determine whether ERCP with miES benefits patients with idiopathic ARP and pancreas divisum. Trial planning has informed the importance of blinded outcome assessors and long-term follow-up