Desarrollo y Filantropía en el Uruguay Fundaciones: Comunitarias en Uruguay - Recursos locales para el desarrollo

El presente informe es el resultado de un proceso de investigación desarrollado en el marco del proyecto Fundaciones Comunitarias en Uruguay. Dicho estudio persigue el objetivo de analizar y delinear los perfiles de la filantropía local y profundizar sobre los desafíos que el concepto de fundaciones comunitarias plantea al contexto Uruguayo en la opinión de todos los involucrados en el desarrollo nacional

Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy

Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic. The pathogenesis of the disease is based on its ability to multiply and survive within phagocytic cells of the host, particularly macrophages and monocytes. The majority (90 %) of infected humans have a ?latent infection?, meaning they efficiently contain but do not spread the bacteria; they are infected but asymptomatic and not contagious. However the remaining 10 % have a lifetime risk of reactivating the infection and developing active tuberculosis (Sakamoto, 2012). The great destructive impact on public health, the co-infection with the human immunodeficiency virus (HIV) and the appearance of drug resistant strains of Mtb are demanding the development of new tools for prevention and treatment.During the last decade a greater understanding on the human immune response to Mtb infection as well as the contribution of factors linked to the pathogenesis of the disease has been achieved. Although the knowledge about the human immune response against Mtb as well as the contribution of factors linked to the pathogenesis of the disease have markedly increased in the last year, a deeper understanding of its immunopathogenesis will lead to the identification of new drugs and the development of effective vaccines.Fil: Zarelli, Valeria Eugenia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Giai, Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentin

La importancia de recuperarse del trabajo: una revisión del dónde, cómo y por qué

El objetivo del presente trabajo es realizar una revisión de la literatura científica de la recuperación del trabajo destacando, desde una perspectiva psicológica, su importancia para el bienestar psicosocial de las personas. La recuperación del trabajo es el proceso por el cual la persona disminuye sus niveles de estrés y renueva sus recursos y energías perdidas en la situación laboral. En esta revisión argumentamos que una adecuada recuperación diaria del estrés laboral es crucial para el mantenimiento del bienestar psicosocial de las personas. Iniciaremos, presentando la definición y las teorías psicológicas que pueden ayudar a explicar el proceso de recuperación. Seguidamente, expondremos las perspectivas desde las cuales se ha estudiado este constructo: escenarios, procesos y resultados. Por último, reflexionaremos sobre las implicaciones teóricas y prácticas de la recuperación del trabajo que nos animen, como psicólogos, al desarrollo de futuros estudios e intervenciones al respectoThe aim of this paper is to review the scientific literature highlighting the recovery work, from a psychological perspective, its importance for psychosocial well-being of people. Recovery from work refers to the process by which a person reduces their stress levels and renews its resources and energies lost during work situation. In this review we argue that an adequate daily recovery from work stress is crucial for the maintenance of well-being. We start establishing the recovery definition and theories that help us to understand the process of recovery. Subsequently, we discuss the perspectives from which recovery can be assessed: scenarios, processes and outcomes. Finally, we reflect on theoretical and practical implications of recovery from work in order to promote, as psychologists, the development of future research and interventions grounded on the psychological perspective

Construcción de la escala de autoeficacia en las experiencias de recuperación del trabajo

Quinzenes Jornades de Foment de la Investigació de la FCHS (Any 2009-2010

Development of a biosensor for copper detection in aqueous solutions using an Anemonia sulcata recombinant GFP

Fluorescent proteins from marine organisms represent potential candidates for biosensor development. In this paper, we described the isolation of a native green fluorescent protein from Anemonia sulcata and the cloning and purification of its equivalent as a recombinant protein in Escherichia coli. Furthermore, the spectroscopic behaviours of the native and recombinant GFPs were investigated as a function of Cu2+, Cd2+, Pb 2+ and Ni2+ concentration. Our results suggest the high selectivity of both proteins at copper than the other metals and, for the recombinant protein, a great sensitivity at a very low concentration (0.1-1 μM). Moreover, starting from these data, using the combination of molecular biology techniques and optical setup, we developed a device for the detection of Cu2+ in water solutions. The quenching effect detected with the device showed that the relative attenuation of the signal (0.46±0.02 AU) was slightly larger than the data measured by fluorescence spectra (0.65±0.03 AU). The good sensitivity in the span of two orders of the magnitude of Cu2+ concentration, the fact that the instrument is made up of low-cost and sturdy parts and the selective quenching of rAsGFP to copper ions make this setup suited as a low cost, on-the-field, copper ion-specific biosensor. © 2013 Springer Science+Business Media

A pharmacoeconomic analysis of the use of single MMC instillation in low risk NMIBC in Italy

BACKGROUND: Bladder cancer accounts for 5-10% of all cancers in Europe and up to 85% patients presents a noninvasive tumor, whose treatment of choice is the transurethral bladder resection (TURB) paired with adjuvant intravesical chemotherapy or immunotherapy. Despite several clinical trials showed that this treatment is safe and decreases recurrences by 17% to 44% this practice is limited for many reasons. The study objective is to analyze the economical advantages of the single immediate post operative Mitomycin C instillation in Non Muscle-invasive Bladder Cancer (NMIBC) low-risk patients.METHODS: A cost-benefit analysis was performed evaluating the economical gain that would raised from a scenario with a single immediate post operative mitomycin C instillation in each low-risk NMIBC patient who underwent to TURB. Net present value and cost-benefit ratio were calculated and sensitivity analyses were performed. Base case analysis was performed considering tumor recurrence rate reduction of 11.7% and a TURB costs of 2,167.0 €, while sensitivity analyses were performed using a recurrence rate reduction of 19.2% and 15.0% and a TURB cost of 2,472.93 €. The discount rate was 2%.RESULTS: The single immediate post operative instillation of mitomycin C resulted to be cost-beneficial with a cost-benefit ratio that goes from 0.48 to 0.79 when compared to TURB alone raising a Net Present Value that goes from 660,284.39 € to 2,650,530.79 €.CONCLUSION: This study demonstrates that even assuming conservative parameters for recurrence rates reduction, a single immediate post operative mitomycin C instillation in low risk NMIBC patients would lower not only the recurrence rate but also the caring cost for bladder cancer

Valorization of citrus waste: use in catalysis for the oxidation of sulfides

The utilization and valorization of industrial waste is an effective strategy for environmental protection. Since the juice industry generates a huge amount of citrus waste, we studied the application of thermally treated orange peel in catalysis. On the other hand, Keggin heteropolyacids are excellent oxidant catalysts used as a replacement for conventional oxidants; however, their solubility in polar solvents and the low specific area limit their use as heterogeneous catalysts. The utilization of treated orange peel as heteropolyacid support for the selective oxidation of sulfides is presented here. Firstly, orange peel was thermally treated, and then it was incorporated with heteropolyacids (PMo) during the silica synthesis by the sol-gel method. Therefore, SiO2-PMo, SiO2-OP100-PMo, and SiO2-OP200-PMo were obtained, characterized by FTIR, SBET, XRD, and potentiometric titration, and were tested as heterogeneous catalysts in the selective oxidation of sulfide to sulfoxide in a greener process: H2O2 as oxidant and ethanol as solvent, at 25 °C.Centro de Investigación y Desarrollo en Ciencias Aplicada

Characterization of "Mais delle Fiorine" (Zea mays L.) and nutritional, morphometric and genetic comparison with other maize landraces of Lombardy region (Northern Italy)

AbstractThe loss of agrobiodiversity is a topic of global impact. On a local scale, Lombardy, in the Alpine macro-Region, has lost more than 78% of its plant agrobiodiversity. Only four maize (Zea mays L. subsp. mays) landraces of Lombardy are registered in the European Register of Conservation Varieties. However, there are other maize landraces in Lombardy such as "Mais delle Fiorine", which was characterized from an agronomic, morphometric, nutritional and genetic point of view in this research and then compared with the four other landraces already registered ("Spinato di Gandino", "Rostrato Rosso di Rovetta", "Scagliolo di Carenno" and "Nero Spinoso"). "Mais delle Fiorine" resulted richer in starch (81% ± 1.6) and zinc (35.8 ± 9.1 mg Kg−1) and lower in phosphorus (3256.7 ± 204.2 mg Kg−1). The kernels in the five landraces also differ in the mean shape that is obovate without beak. A genetic distinction between "Mais delle Fiorine" and the other varieties was observed, and in particular compared to "Nero Spinoso", while "Scagliolo di Carenno" and "Rostrato Rosso di Rovetta" showed great similarities. As regards agronomical trials, "Mais delle Fiorine" can grow from the Po Valley (90 m a.s.l.) to the mountain environments of the Seriana Valley (also over 900 m a.s.l.) without significant differences in grain yield. In addition, this landrace would seem able to tolerate environments where there is a greater probability of water stress

Síntesis, caracterización y evaluación de la actividad catalítica del ácido fosfomolíbdico encapsulado en un material compuesto de sílice y alúmina

Los heteropoliácidos (HPAs) son ácidos fuertes y potentes oxidantes, son muy solubles en solventes polares y poseen baja área específica. Debido a su baja solubilidad, se los suele soportar en distintas matrices para su uso como catalizadores heterogéneos y de esta manera ser recuperados y reutilizados

Síntesis y caracterización de materiales mixtos de sílice y alúmina como soporte de heteropoliácidos dopados con V y NB

La técnica sol-gel es muy utilizada en la síntesis de materiales mesoporosos, debido a que permite obtener de manera sencilla una gran variedad de compuestos de propiedades definidas, con características eco-compatibles. En nuestro grupo de investigación, desde hace varios años se utiliza esta técnica para la síntesis de diferentes materiales con aplicaciones tecnológicas. Entre los casos más estudiados se destacan los catalizadores en los cuales la fase activa son heteropoliacidos (HPAs) con estructura primaria tipo Keggin. Estos materiales son una excelente elección para una amplia variedad de reacciones ya que poseen propiedades red-ox, alta acidez, buena estabilidad térmica y química, y tienen un bajo costo. Este trabajo tiene como objetivo sintetizar y caracterizar catalizadores heterogéneos para ser aplicados en reacciones en fase líquida. Se realiza la inclusión en sílice y alúmina de ácido fosfomolíbdico, con estructura primaria tipo Keggin, dopado con V y Nb. Considerando que los radios iónicos: V (0,74 Ã…) y Nb (0,70 Ã…) son similares al de Mo (0,62 Ã…), su incorporación como dopante no supondría mayores modificaciones desde el punto de vista estérico. Se eligió sílice y alúmina porque ambas confieren estabilidad a la fase activa, provocando un buen comportamiento en las propiedades texturales y morfológicas, como se obtuvo en diversas reacciones de oxidación. Todos los materiales sintetizados fueron caracterizados mediante difracción de rayos X (DRX), espectroscopía infrarroja con transformada de Fourier (FT-IR), microscopía electrónica de barrido (SEM) y análisis químico semicuantitativo (EDS), titulación potenciométrica, y adsorción/desorción de N2 mediante el método BET. La capacidad catalítica de los catalizadores fue evaluada en la reacción de oxidación selectiva de difenil sulfuro, realizando el seguimiento de la reacción mediante cromatografía en capa delgada y cromatografía gaseosa.Universidad Nacional de La Plat