4,302 research outputs found
Adult-onset Still's disease: Evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers
Background: Adult-onset Still's disease (AOSD) is rare inflammatory disease of unknown etiology that usually affects young adults. The more common clinical manifestations are spiking fevers, arthritis, evanescent rash, elevated liver enzymes, lymphadenopathy, hepatosplenomegaly, and serositis. The multi-visceral involvement of the disease and the different complications, such as macrophage activation syndrome, may strongly decrease the life expectancy of AOSD patients. Methods: This study aimed to identify the positive and negative features correlated with the outcome of patients. A retrospective analysis of AOSD patients prospectively admitted to three rheumatologic centers was performed to identify the clinical features present at the time of diagnosis and to predict the possible outcome. Furthermore, we investigated the as yet to be validated prognostic value of the systemic score previously proposed. Results: One hundred consecutive AOSD patients were enrolled. The mean systemic score showed that the majority of patients had a multi-organ involvement. Sixteen patients showed different complications, mainly the macrophage activation syndrome. A strong increase of inflammatory markers was observed. All patients received steroids at different dosages, 55 patients in association with immunosuppressive drugs and 32 in association with biologic agents. Sixteen patients died during the follow-up. Regression analysis showed that the higher values of the systemic score and the presence of AOSD-related complications, assessed at the time of diagnosis, were significantly correlated with patient mortality. A prognostic impact of the systemic score of 65 7.0 was reported. Conclusions: Our study showed that a higher systemic score and the presence of AOSD-related complications at the time of diagnosis were significantly associated with mortality. Of note, a cut-off at 7.0 of the systemic score showed a strong prognostic impact in identifying patients at risk of AOSD-related death
Liquid hot water pretreatment of Arundo Donax: a comparison between batch and a flow-through systems
Lignocellulosic biomass is a valuable alternative raw material to partially substitute oil as both energy
and chemical source. For example, polysaccharide constituents of lignocellulosic materials,
hemicellulose and cellulose, can be hydrolytically depolymerized using acid catalysts or enzymes,
while residual lignin can be used as a source of aromatic building blocks.
The kinetic severity of the hydrolysis process can be adjusted to maximize alternatively the yields in
fermentable sugars (bioethanol-way) or in chemicals such as furfural, hydroxymethylfurfural, levulinic
acid. It is well known that, before performing the main hydrolysis step, a pretreatment stage of the matrix is necessary to cleave the bonds between
hemicellulose, cellulose and lignin and to start breaking some of the polysaccharide chains. Liquid hot water (LHW) can be used for the pretreatment of biomass, without adding any acid to the system, thus avoiding the need of any subsequent neutralization step.
In order to move toward industrial scale plant for production of energy and bulk chemicals from
biomasses, continuous systems are desirable. An intermediate step toward the design of a continuous
layout is constituted by semi-continuous processes.
In this study, we have performed the LHW pretreatment of Arundo Donax (giant reed) in two different
systems: a microwave (MW)-assisted batch reactor, where high heating rate can be achieved leading
rapidly the system at the operative conditions of the pretreatment, and a fast heating flow-through
layout in which the flow rate of the process water stream can be tuned. The achieved
results highlight that in the microwave (MW)-assisted batch reactor good hemicelluloses solubilization,
little sugar degradation and insignificant lignin and cellulose fractionation can be obtained by
optimizing reaction temperature and time and that in the flow-through system high biomass conversion
as well as very limited formation of degradation products can be obtained by adjusting the flow rate of
the treatment water
Supernova 2012ec: Identification of the progenitor and early monitoring with PESSTO
We present the identification of the progenitor of the Type IIP SN 2012ec in
archival pre-explosion HST WFPC2 and ACS/WFC F814W images. The properties of
the progenitor are further constrained by non-detections in pre-explosion WFPC2
F450W and F606W images. We report a series of early photometric and
spectroscopic observations of SN 2012ec. The r'-band light curve shows a
plateau with M(r')=-17.0. The early spectrum is similar to the Type IIP SN
1999em, with the expansion velocity measured at Halpha absorption minimum of
-11,700 km/s (at 1 day post-discovery). The photometric and spectroscopic
evolution of SN 2012ec shows it to be a Type IIP SN, discovered only a few days
post-explosion (<6d). We derive a luminosity for the progenitor, in comparison
with MARCS model SEDs, of log L/Lsun = 5.15+/-0.19, from which we infer an
initial mass range of 14-22Msun. This is the first SN with an identified
progenitor to be followed by the Public ESO Spectroscopic Survey of Transient
Objects (PESSTO).Comment: 6 pages, 3 figures, MNRAS accepte
Indacaterol/glycopyrronium/mometasone fixed dose combination for uncontrolled asthma
Introduction: Asthma symptoms can be relieved through a maintenance treatment combining long-acting β2-agonist and inhaled corticosteroids (LABA/ICS). However, for patients with inadequately controlled asthma, the LABA/ICS combination might not be sufficient, and clinical guidelines recommend the administration of inhaled long-acting muscarinic antagonists (LAMA) as an add-on therapy to better control asthma and improve lung function. For nearly two decades, the only LAMA to be approved on the market has been tiotropium. Areas covered: We reviewed recent clinical studies evaluating the safety and efficacy of LABA/LAMA/ICS fixed dose combinations by searching the PubMed database. Molecular mechanisms and clinical data support the use of a once-daily, single-inhaler fixed dose combination of the LABA/LAMA/ICS indacaterol/glycopyrronium/mometasone (IND/GLY/MF), the first therapy combining three agents in a fixed dose approved in Europe for the treatment of uncontrolled asthma. Expert opinion: IND/GLY/MF was superior to both IND/MF and salmeterol/fluticasone, a well-established LABA/ICS combination improving the lung function in uncontrolled asthma. Moreover, IND/GLY/MF, delivered through the Breezhaler inhaler in a single inhalation, is the first inhaled therapy prescribed alongside a digital companion, a sensor and the Propeller app, allowing for improved treatment adherence, reduced rescue inhaler usage and hospitalizations, increased patient satisfaction and asthma control
Reducing the impact of radioactivity on quantum circuits in a deep-underground facility
As quantum coherence times of superconducting circuits have increased from
nanoseconds to hundreds of microseconds, they are currently one of the leading
platforms for quantum information processing. However, coherence needs to
further improve by orders of magnitude to reduce the prohibitive hardware
overhead of current error correction schemes. Reaching this goal hinges on
reducing the density of broken Cooper pairs, so-called quasiparticles. Here, we
show that environmental radioactivity is a significant source of nonequilibrium
quasiparticles. Moreover, ionizing radiation introduces time-correlated
quasiparticle bursts in resonators on the same chip, further complicating
quantum error correction. Operating in a deep-underground lead-shielded
cryostat decreases the quasiparticle burst rate by a factor fifty and reduces
dissipation up to a factor four, showcasing the importance of radiation
abatement in future solid-state quantum hardware
The Active Corona of HD 35850 (F8 V)
We present Extreme Ultraviolet Explorer spectroscopy and photometry of the
nearby F8 V star HD 35850 (HR 1817). The EUVE spectra reveal 28 emission lines
from Fe IX and Fe XV to Fe XXIV. The Fe XXI 102, 129 A ratio yields an upper
limit for the coronal electron density, log n < 11.6 per cc. The EUVE SW
spectrum shows a small but clearly detectable continuum. The line-to-continuum
ratio indicates approximately solar Fe abundances, 0.8 < Z < 1.6. The resulting
emission-measure distribution is characterized by two temperature components at
log T of 6.8 and 7.4. The EUVE spectra have been compared with non-simultaneous
ASCA SIS spectra of HD 35850. The SIS spectrum shows the same temperature
distribution as the EUVE DEM analysis. However, the SIS spectral firs suggest
sub-solar abundances, 0.34 < Z < 0.81. Although some of the discrepancy may be
the result of incomplete X-ray line lists, we cannot explain the disagreement
between the EUVE line-to-continuum ratio and the ASCA-derived Fe abundance.
Given its youth (t ~ 100 Myr), its rapid rotation (v sin i ~ 50 km/s), and its
high X-ray activity (Lx ~ 1.5E+30 ergs/s), HD 35850 may represent an activity
extremum for single, main-sequence F-type stars. The variability and EM
distribution can be reconstructed using the continuous flaring model of Guedel
provided that the flare distribution has a power-law index of 1.8. Similar
results obtained for other young solar analogs suggest that continuous flaring
is a viable coronal heating mechanism on rapidly rotating, late-type,
main-sequence stars.Comment: 32 pages incl. 14 figures and 3 tables. To appear in the 1999 April
10 issue of The Astrophysical Journa
Volatility Effects on the Escape Time in Financial Market Models
We shortly review the statistical properties of the escape times, or hitting
times, for stock price returns by using different models which describe the
stock market evolution. We compare the probability function (PF) of these
escape times with that obtained from real market data. Afterwards we analyze in
detail the effect both of noise and different initial conditions on the escape
time in a market model with stochastic volatility and a cubic nonlinearity. For
this model we compare the PF of the stock price returns, the PF of the
volatility and the return correlation with the same statistical characteristics
obtained from real market data.Comment: 12 pages, 9 figures, to appear in Int. J. of Bifurcation and Chaos,
200
Light curves of hydrogen-poor Superluminous Supernovae from the Palomar Transient Factory
We investigate the light-curve properties of a sample of 26 spectroscopically
confirmed hydrogen-poor superluminous supernovae (SLSNe-I) in the Palomar
Transient Factory (PTF) survey. These events are brighter than SNe Ib/c and SNe
Ic-BL, on average, by about 4 and 2~mag, respectively. The peak absolute
magnitudes of SLSNe-I in rest-frame band span ~mag, and these peaks are not powered by radioactive Ni,
unless strong asymmetries are at play. The rise timescales are longer for SLSNe
than for normal SNe Ib/c, by roughly 10 days, for events with similar decay
times. Thus, SLSNe-I can be considered as a separate population based on
photometric properties. After peak, SLSNe-I decay with a wide range of slopes,
with no obvious gap between rapidly declining and slowly declining events. The
latter events show more irregularities (bumps) in the light curves at all
times. At late times, the SLSN-I light curves slow down and cluster around the
Co radioactive decay rate. Powering the late-time light curves with
radioactive decay would require between 1 and 10 of Ni masses.
Alternatively, a simple magnetar model can reasonably fit the majority of
SLSNe-I light curves, with four exceptions, and can mimic the radioactive decay
of Co, up to days from explosion. The resulting spin values do
not correlate with the host-galaxy metallicities. Finally, the analysis of our
sample cannot strengthen the case for using SLSNe-I for cosmology.Comment: 120 pages, 48 figures, 78 tables. ApJ in pres
PESSTO monitoring of SN 2012hn: further heterogeneity among faint type I supernovae
We present optical and infrared monitoring data of SN 2012hn collected by the
Public ESO Spectroscopic Survey for Transient Objects (PESSTO). We show that SN
2012hn has a faint peak magnitude (MR ~ -15.7) and shows no hydrogen and no
clear evidence for helium in its spectral evolution. Instead, we detect
prominent Ca II lines at all epochs, which relates this transient to previously
described 'Ca-rich' or 'gap' transients. However, the photospheric spectra
(from -3 to +32 d with respect to peak) of SN 2012hn show a series of
absorption lines which are unique, and a red continuum that is likely intrinsic
rather than due to extinction. Lines of Ti II and Cr II are visible. This may
be a temperature effect, which could also explain the red photospheric colour.
A nebular spectrum at +150d shows prominent CaII, OI, CI and possibly MgI lines
which appear similar in strength to those displayed by core-collapse SNe. To
add to the puzzle, SN 2012hn is located at a projected distance of 6 kpc from
an E/S0 host and is not close to any obvious starforming region. Overall SN
2012hn resembles a group of faint H-poor SNe that have been discovered recently
and for which a convincing and consistent physical explanation is still
missing. They all appear to explode preferentially in remote locations offset
from a massive host galaxy with deep limits on any dwarf host galaxies,
favouring old progenitor systems. SN 2012hn adds heterogeneity to this sample
of objects. We discuss potential explosion channels including He-shell
detonations and double detonations of white dwarfs as well as peculiar
core-collapse SNe.Comment: 14 pages, 14 figures, accepted to MNRAS on 14/10/201
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