1,050 research outputs found
Epithelial dysplasia of the stomach with gastric immunophenotype shows features of biological aggressiveness
Monitorização e validação de sistemas construtivos da arquitetura vernácula-reinterpretação da autossuficiência de uma casa de lavoura do Minho
Dissertação mestrado integrado em Arquitectura (área de especialização em Construção e Tecnologia)A arquitetura vernácula é reconhecida pela capacidade intrínseca de articular e resolver, com uma leitura inteligente
do contexto, os condicionalismos impostos pela permanência e sobrevivência do Homem em determinado local.
Entre as variantes reconhecidas nas diferentes regiões de Portugal e do mundo todas procuram criar condições
de permanência e desenvolvimento social, económico e cultural, mas porque estas construções foram desenvolvidas
em harmonia com os contextos em que se inserem, apresentam-se díspares, encontrando-se soluções similares apenas
entre locais onde os condicionalismos climáticos, ambientais geográficos ou culturais são idênticos.
Os novos desafios para a arquitetura ditam a procura de soluções mais integradas e conscientes quanto ao
consumo de recursos, para que se proporcione um futuro mais equilibrado e sustentável.
Neste sentido este trabalho propõe a validação e reinterpretação de alguns dos conhecimentos pragmáticos
de adaptação encontrados nesta arquitetura, desenvolvidos e aprimorados ao longo de gerações, em contextos de
escassez de recursos. O reconhecimento e a validação destas soluções pode diminuir conotações pejorativas que
relacionam o vernáculo com subdesenvolvimento das construções e dos modos de habitar, demonstrando o potencial
contemporâneo destas estratégias.
Esta investigação foca-se na Casa de Lavoura do Minho, caracterizada por uma forte ligação ao terreno de
cultivo e a capacidade de no passado ser autossuficiente na produção de alimento e abastecimento de energia e água.
São apresentados alguns exemplares deste tipo de construções e sistematizadas as características qualitativas já reconhecidas
por investigações anteriores. Algumas das soluções construtivas mais representativas foram posteriormente
verificadas in situ de forma a permitir conhecer o verdadeiro desempenho destas construções e assim avaliar quais
destas apresentam potencial para serem reinterpretadas no desenvolvimento de soluções mais integradas e sustentáveis
para o futuro.
As avaliações quantitativas demonstram que algumas das soluções e métodos construtivos reconhecidos na
arquitetura vernácula permitem desenvolver soluções que integram todas as dimensões da sustentabilidade, sendo
ainda um contributo valioso para o desenvolvimento de novos edifícios e intervenções de reabilitação.
Reconhecer a validade ou fragilidade das soluções permite que o projeto trabalhe as características da Casa de
Lavoura do Minho do ponto de vista do desenvolvimento e inovação, para uma utilização futura. Assim, o projeto assenta
nos conhecimentos vernaculares reconhecidos qualitativa e quantitativamente, permitindo a criação de uma rede de
ligações e relações que visem a complementaridade entre as partes e permitem que o projeto seja uma reinterpretação
da Casa de Lavora do Minho, mantendo a autossuficiência por via da evolução das soluções vernáculas e também da
inclusão de novos conhecimentos e tecnologias.The vernacular architecture is recognized by the intrinsic ability to articulate and solve, with an intelligent reading
of the context, the constraints imposed by the permanence and survival of man in a certain place.
Among the variants recognized in different regions of Portugal and the world, all of them seek to create conditions
of permanence to social, economic and cultural development, but because these buildings were developed in harmony
with the contexts in which they operate, they present themselves different from each other, with similar solutions solely
between places where climatic, geographical, cultural or environmental constraints are identical.
The new challenges for architecture dictate the demand for solutions more integrated and aware about the
consumption of resources, which provide a more balanced and sustainable future.
In this sense this paper proposes the validation and reinterpretation of some of the pragmatic knowledge
of adaptation found in these architecture, developed and refined over generations, in contexts of resource scarcity.
Recognition and validation of these solutions can decrease pejorative connotations that relate to underdevelopment the
vernacular buildings and modes of inhabiting, demonstrating the contemporary potential of these strategies.
This research focuses on Casa de Lavoura do Minho (Minho’s Farmhouse), characterized by a strong connection
to land cultivation and the ability to be self-sufficient in the past for the production of food and energy and water supply.
Some examples of this type of constructions are presented and systematic qualitative characteristics already recognized
by previous research. Some of the most representative building solutions were then evaluated in situ to allow to know
the true performance of these constructs and thus assess which of these have the potential to be reinterpreted in the
development of more integrated and sustainable solutions for the future.
Quantitative evaluations demonstrate that some of the solutions and construction methods recognized in
vernacular architecture enable you to develop solutions that integrate all dimensions of sustainability, being still a
valuable contribution to the development of new buildings and rehabilitation interventions.
Recognize the validity or weakness of solutions enables the design to process features of Casa de Lavoura do
Minho (Minho’s Farmhouse) from the standpoint of development and innovation for future use. Thus, the project is
based on qualitative and quantitative vernacular knowledge recognized, allowing the creation of a network of connections
and relationships that seek complementarity between the parties and allowing the project to be a reinterpretation of the
Casa de Lavoura do Minho (Minho’s Farmhouse), maintaining self-sufficiency through the development of vernacular
solutions and also the inclusion of new knowledge and technologies
Elements of Bankruptcy Law and Business Rescue in Brazil
Culminating more than a decade of debates, the Brazilian government enacted the Nova Lei de Falências e Recuperação de Empresas, Law N° 11,101 (“Brazilian Bankruptcy Law” or “BBL”), which was published on 9 February 2005 and came into effect on 9 June 2005. It was the first major overhaul of Brazil’s corporate insolvency laws in sixty years. The BBL replaced the previous bankruptcy law, i.e. Decree-Law 7,661 (“Prior Bankruptcy Law”), which had been in force since 1945. The BBL represents a significant change in the principles and in the form of activity of the various players involved in bankruptcy and reorganisation processes in Brazil. Most ancient practices are now abandoned as society increasingly adapts itself to the new stimuli incorporated into the Brazilian legal system by the BBL, which has completed a decade in 2015
Empreendedorismo e desenvolvimento regional: o caso “DNA Cascais”
Comunicação apresentada no 14.º Workshop APDR – Empreendedorismo e Desenvolvimento RegionalOs conceitos de empreendedorismo e desenvolvimento regional são pouco
consensuais, em termos académicos. Pretendemos, por isso, através da revisão da literatura,
contribuir para a sua clarificação, escalpelizando, ainda, a sua interdependência. O objetivo
central deste artigo é a descrição e análise do caso “DNA Cascais”, que coloca na prática a
interligação entre o empreendedorismo e o desenvolvimento local, ao mesmo tempo que se
discutem as razões porque se pode considerar um exemplo de boas práticas no plano nacional
e até internacional. A DNA Cascais é uma agência de promoção e desenvolvimento do
empreendedorismo em geral, dirigida ao concelho de Cascais, que incide particularmente no
empreendedorismo jovem e no empreendedorismo social. No que respeita ao âmbito de
atuação, além de todos os serviços de apoio conducentes à criação de empresas, importa
realçar a educação para o empreendedorismo, incidindo sobre os jovens (a idade é crítica para
a aquisição/alteração de valores) e sobre os professores. A sigla DNA (Desenvolvimento de
Novas Atitudes) reflete o carácter multifacetado da sua intervenção remetendo não apenas
para os resultados (criação de empresas), mas muito particularmente para o processo
(formação, apoio e mitigação de riscos). A sua criação teve duas motivações: a primeira
relacionada com uma falha de mercado no apoio a empreendedores e, a segunda, com a
necessidade de dar resposta a níveis de desemprego elevados, especialmente entre os jovens.
O principal fator diferenciador do DNA é constituir uma resposta integrada à problemática do
empreendedorismo, denominado “ecossistema empreendedor”, premiado em termos
nacionais e europeus e que será devidamente detalhado. Os resultados dos diferentes
projetos revelam já um impacto significativo no desenvolvimento local não só pelo número de
actores locais envolvidos, mas também pelos resultados das empresas criadas, que permitem
antever já o retorno do investimento realizado e, ainda, pela visibilidade do projecto tanto a
nível nacional como internacional. Trata se, pois, de um caso ilustrativo da relação entre
empreendedorismo e desenvolvimento local, em que se aposta na concretização de ideias da
população local e na criação de uma atitude mais favorável ao empreendedorismo, atuando
sobre os valores da população mais jovem que, além dos resultados já alcançados,
presumimos terá repercussões significativas a médio/longo prazo.
Palavras chave: empreendedorismo, desenvolvimento local, ecossistema empreendedor,
criação de novas atitudesGenerally speaking, entrepreneurship and regional development are two concepts
that are oftenmisunderstood. In this sense, the purpose of the literature review is toprovide a better understanding of these two concepts which are deeply related and interdependent.
This article aims at providing further clarification on these two concepts, focusing on a case study named as “DNACascais”. In terms of local development, “DNA Cascais” is considered to be a role model forlocal development in Portugal and also abroad, acting as a liaison between local developmentand entrepreneurship. “DNA Cascais” refers to a anagency aiming at the promotion and development of entrepreneurship, with a focus on youth and social entrepreneurshipdeveloped in the city of Cascais, Portugal. Apart from all supporting services related to the creation ofenterprises, it also contribute to provide a better understanding of entrepreneurship toboth young people and teachers, since these are more open to new ideas.
The acronym “DNA”(or NAD) which refers to “New AttitudesDevelopment”, pretends to be goal orientedthrough the creation of enterprise although it also follow up the whole process (orientation, support and risk management). Its creation came from, a lack of support to entrepreneurs andother business developers that wanted to start their own business. Also the high unemployment rates and the actual economic context led to a need of exploring new ways of developing ideas and business projects, and then create jobs. What makes DNA different is thefact that it approaches entrepreneurship as an interdependent network, known
as “entrepreneur ecosystem”, which has been rewarded as a case study both within the country andinternationally. The outcomes from the different projects reveal that asignificant impact has beennoticed in the local development, not only because of the actors involved on this project but also for the financial results of the enterprises already created, which enhances its imageand support the viability of this project. Briefly, this case will explore the relation betweenentrepreneurship and local development, based on preliminary ideas from the locals and thecreation of a better attitude in relation to entrepreneurship, focused on the youth, which willreflect on long term results
Importance of Entrepreneurship in the Organizational Performance of Higher Education Institutions
The traditional mission of higher education institutions (HEIs) are training, research, and the transfer
of knowledge to society. Nowadays, the third mission has been gaining importance, considering the
increasing relevance given to the creation of value by HEIs for society. Entrepreneurial activity is one
of the components with more impacts that value creation, but it is still seen as an activity parallel to the
main missions of HEIs, where training still takes on special importance. At the same time, the general ized movement of analysis of the organizational performance of HEIs, associated to its strategy but es sentially associated with national agencies for accreditations and the rankings, have been direct impacts
on its external image and the capacity to obtain students and financing. For the entrepreneurial activity
to move from an activity parallel to a prominent activity within HEIs, it must firstly have a strategic
framework, but also have measurement mechanisms, based on indicators, that allow to understand the
evolution of performance in this area.info:eu-repo/semantics/publishedVersio
IN VITRO AND IN VIVO REMOVAL OF ORAL ANTIDIABETIC AGENTS (METFORMIN) USING ACTIVATED CARBONS
Diabetes is the most worldwide common chronic disease,
according the International Diabetes Federation [1], more than
32 million citizens living in the European Union have
diabetes, representing nearly 10% of the population, to which
we should add equal number of people suffering from
impaired glucose tolerance. Diabetes prevalence is growing at
alarming rate worldwide, being of particular relevance the
type 2 diabetes. Nowadays 285 million people worldwide live
with diabetes and it is expected that this numbers will increase
by 20% until 2030 due to obesity and the ageing of the
population [1].
This growth leads to an increasing consumption of drugs such
as oral antidiabetics. Metformin is one of the active principles
most commonly used for this purpose being among the
pharmaceuticals with the highest production numbers
worldwide to treat type 2 diabetes because is cheap, has high
level of tolerance and when used in the prescribed dosage is
very secure with minimal side effects. However, in case of
overdose of metformin upon a ingestion of more than 10 times
the prescribed dosage, accidentally or on propose, lactic
acidosis and low blood pressure can occur. Overdoses with
metformin are relatively uncommon, but may have serious
consequences, if medical attention is not given on time, it may
lead to coma and ultimately death Because of its spread use
another problem must be taken into consideration, which
needs to be addressed, the occurrence of metformin residues in
sewage and surface waters due to improper discharge of the
non-used tablets to regular garbage [2]. This situation is
becoming a serious problem of environmental pollution and
public health.
This paper reports the use of activated carbon produced from
biomass for the removal of metformin in 2 different settings.
On one hand, from aqueous solutions and, in another hand,
from simulated biological fluids (gastric and intestinal)
conjugated with in vivo testing
Capital humano e desempenho das spin-offs académicas
Trabalho apresentado nas XXVII Jornadas Hispano-Lusas de Gestión Científica, 1 a 4 fevereiro de 2017, Alicante, EspanhaAs spin-offs académicas (ASO) são um fenómeno complexo, multidimensional, de elevado risco e cuja sobrevivência e desempenho são influenciados por fatores de natureza distinta.
Entre a fase de investigação e a entrada no mercado têm que enfrentar uma grande diversidade de desafios e de riscos entre os quais um dos mais importantes é assegurar os recursos adequados para o seu desenvolvimento.
Este artigo analisa a influência do capital humano das equipas de fundadores no desempenho das ASO, constructo multidimensional que integra nove fatores relacionados com a qualificação, formação, experiência e dimensão das equipas.
Através de uma combinação de dados recolhidos por questionário em 42 spin-offs portuguesas criadas entre os anos de 2005 e 2008, foram testadas oito hipóteses.
Os resultados permitiram encontrar suporte empírico para a correlação positiva entre o capital humano das equipas de fundadores e o desempenho das ASO nos anos iniciais após a sua criação.Academic spin-offs (ASO) are a complex and multidimensional phenomenon with high risk and whose survival and performance are influenced by different factors. Between research and market entry the ASO have to face a wide range of challenges and risks, and the most important is to ensure the resources for its development.
This paper analyzes the influence of human capital of founding teams in the performance of ASO, a multidimensional construct which integrates eight factors related to the qualifications, training, experience and size of the teams.
Through a combination of data collected by questionnaire in 42 Portuguese Spin-offs, created between the years 2005 and 2008, eight hypotheses were tested.
The results have shown empirical support to the positive correlation between the human capital of the founding team and the performance of ASO in the early years after its creation.N/
Spin-offs académicas em portugal: influência dos recursos tecnológicos no desempenho
Trabalho apresentado nas XXVI Jornadas Luso-Espanholas de Gestão Cientifica, 3 a 6 fevereiro de 2016, Idanha-a-Nova, PortugalAs spin-offs académicas (ASO) são um importante mecanismo de transferência de conhecimento. Contudo, a sua taxa de sobrevivência/desempenho é baixa ainda que comparativamente com outras tipologias de novas empresas possa ser mais alta. Apesar da sua relevância na transferência de conhecimento, são ainda relativamente escassos os estudos sobre este fenómeno que necessita de ser melhor compreendido.
Este artigo analisa a influência dos recursos tecnológicos no desempenho das ASO, constructo multidimensional aqui representado pelas patentes registadas, investimento em I&D e relacionamento com a instituição de origem.
Metodologicamente foram definidas hipóteses, testadas através de uma combinação de dados recolhidos por questionário através de entrevista presencial e por dados secundários obtidos numa ampla diversidade de fontes para 42 ASO Portuguesas criadas entre os anos de 2005 e 2008.
Os resultados permitiram encontrar suporte empírico para a correlação positiva entre os recursos tecnológicos (patentes, investimento em I&D, relacionamento com a instituição de origem) e o desempenho das ASO.The academic spin-offs (ASO) are a relevant tool of knowledge transfer. Even though ASO’s survival/performance rate is recognised to be low, it is higher than the average survival/performance rate of other types of start-ups. However, there are scarce studies about this instrument that needs to be better understood.
This paper deals with the influence of technological resources on ASO’s performance, a multidimensional construct represented in this study by registered patents, R&D investment and the relationship with the parent institution.
The hypothesis have been tested by the combination of data collected through a questionnaire administered through a personal interview and secondary data obtained from various sources on 42 Portuguese ASO formed between 2005 and 2008. The results allowed to find empirical support for the correlation between technological resources
(patents, R&D investment and relationship with the parent institution) and the ASO’s performance
A genetic algorithm approach for the single machine scheduling problem with linear earliness and quadratic tardiness penalties
In this paper, we consider the single machine scheduling problem with linear earliness and quadratic tardiness costs, and no machine idle time. We propose a genetic approach based on a random key alphabet. Several genetic algorithms based on this approach are presented. These versions differ on the generation of the initial population, as well as on the use of local search. The proposed procedures are compared with the best existing heuristic, as well as with optimal solutions for the smaller instance sizes. The computational results show that the performance of the proposed genetic approach is improved by the addition of a local search procedure, as well as by the insertion of simple heuristic solutions in the initial population. Indeed, the genetic versions that include either or both of these features not only provide significantly better results, but are also much faster. The genetic versions that use local search are clearly superior to the best existing heuristic, and the improvement in performance increases with both the size and difficulty of the instances. These procedures are also quite close to the optimum, and provided an optimal solution for most of the test instances.scheduling, single machine, linear earliness, quadratic tardiness, genetic algorithms
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