Effets de la pauvreté, la vulnérabilité biologique et la vulnérabilité psychosociale pendant la petite enfance pour les crises d'asthme à 7 ans dans la cohorte ÉLDEQ

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Long-distance structure of the X(3872)

We investigate heavy quark symmetries for heavy meson hadronic molecules, and explore the consequences of assuming the X(3872) and $Z_b(10610)$ as an isoscalar $D\bar D^*$ and an isovector $B\bar B^*$ hadronic molecules, respectively. The symmetry allows to predict new hadronic molecules, in particular we find an isoscalar $1^{++}$ $B\bar B^*$ bound state with a mass about 10580 MeV and the isovector charmonium partners of the $Z_b(10610)$ and the $Z_b(10650)$ states. Next, we study the $X(3872) \to D^0 \bar D^0\pi^0$ three body decay. This decay mode is more sensitive to the long-distance structure of the X(3872) resonance than its $J/\psi\pi\pi$ and $J/\psi3\pi$ decays, which are mainly controlled by the short distance part of the X(3872) molecular wave function. We discuss the $D^0 \bar D^0$ final state interactions, which in some situations become quite important. Indeed in these cases, a precise measurement of this partial decay width could provide precise information on the interaction strength between the $D^{(*)}\bar D^{(*)}$ charm mesons.Comment: Talk presented at the "XI International Conference on Hyperons, Charm and Beauty Hadrons (BEACH 2014)", Birmingham (U.K.), July 201

Renormalization of NN-Scattering with One Pion Exchange and Boundary Conditions

A non perturbative renormalization scheme for Nucleon-Nucleon interaction based on boundary conditions at short distances is presented and applied to the One Pion Exchange Potential. It is free of off-shell ambiguities and ultraviolet divergences, provides finite results at any step of the calculation and allows to remove the short distance cut-off in a suitable way. Low energy constants and their non-perturbative evolution can directly be obtained from experimental threshold parameters in a completely unique and model independent way when the long range explicit pion effects are eliminated. This allows to compute scattering phase shifts which are, by construction consistent with the effective range expansion to a given order in the C.M. momentum $p$. In the singlet $^1S_0$ and triplet $^3S_1- ^3D_1$ channels ultraviolet fixed points and limit cycles are obtained respectively for the threshold parameters. Data are described satisfactorily up to CM momenta of about $p \sim m_\pi$.Comment: 22 pages, 10 figures, revte

La Economía Política del Proceso Presupuestario: El caso peruano

Este estudio presenta el caso del Perú. El documento brinda una descripción de los actores principales involucrados en el proceso presupuestario y de sus interacciones. Describe los principales determinantes políticos y económicos del desempeño fiscal y considera el impacto de los arreglos políticos e institucionales que gobiernan el funcionamiento del proceso presupuestario en sus diferentes etapas.

Recursive Detection and Analysis of Nanoparticles in Scanning Electron Microscopy Images

In this study, we present a computational framework tailored for the precise detection and comprehensive analysis of nanoparticles within scanning electron microscopy (SEM) images. The primary objective of this framework revolves around the accurate localization of nanoparticle coordinates, accompanied by secondary objectives encompassing the extraction of pertinent morphological attributes including area, orientation, brightness, and length. Constructed leveraging the robust image processing capabilities of Python, particularly harnessing libraries such as OpenCV, SciPy, and Scikit-Image, the framework employs an amalgamation of techniques, including thresholding, dilating, and eroding, to enhance the fidelity of image processing outcomes. The ensuing nanoparticle data is seamlessly integrated into the RStudio environment to facilitate meticulous post-processing analysis. This encompasses a comprehensive evaluation of model accuracy, discernment of feature distribution patterns, and the identification of intricate particle arrangements. The finalized framework exhibits high nanoparticle identification within the primary sample image and boasts 97\% accuracy in detecting particles across five distinct test images drawn from a SEM nanoparticle dataset. Furthermore, the framework demonstrates the capability to discern nanoparticles of faint intensity, eluding manual labeling within the control group.Comment: 9 pages, 10 figure

Unidirectional Neuronal Cell growth and Differentiation on Aligned Polyhydroxyalkanoate Blend Microfibres with Varying Diameters

Polyhydroxyalkanoates (PHAs) are a family of prokaryotic-derived biodegradable and biocompatible natural polymers known to exhibit neuroregenerative properties. In this work, poly(3-hydroxybutyrate), P(3HB) and poly(3-hydroxyoctanoate), P(3HO), have been combined to form blend fibres for directional guidance of neuronal cell growth and differentiation. A 25:75 P(3HO)/P(3HB) blend (PHA blend) was used for the manufacturing of electrospun fibres as resorbable scaffolds to be used as internal guidance lumen structures in nerve conduits. The biocompatibility of these fibres was studied using neuronal and Schwann cells. Highly aligned and uniform fibres with varying diameters were fabricated by controlling electrospinning parameters. The resulting fibre diameters were 2.4 ± 0.3 µm, 3.7 ± 0.3 µm and 13.5 ± 2.3 µm for small, medium and large diameter fibres respectively. The cell response to these electrospun fibres was investigated with respect to growth and differentiation. Cell migration observed on the electrospun fibres showed topographical guidance in accordance with the direction of the fibres. The correlation between fibre diameter and neuronal growth under two conditions; individually and in co-culture with Schwann cells was evaluated. Results obtained from both assays revealed that all PHA blend fibre groups were able to support growth and guide aligned distribution of neuronal cells and there was a direct correlation between the fibre diameter and neuronal growth and differentiation. This work has led to the development of a family of unique biodegradable and highly biocompatible 3D substrates capable of guiding and facilitating the growth, proliferation and differentiation of neuronal cells as internal structures within nerve conduits

Intermediate-scale theory for electrons coupled to frustrated local-moments

A classic route for destroying long-lived electronic quasiparticles in a weakly interacting Fermi liquid is to couple them to other low-energy degrees of freedom that effectively act as a bath. We consider here the problem of electrons scattering off the spin fluctuations of a geometrically frustrated antiferromagnet, whose non-linear Landau-Lifshitz dynamics, which remains non-trivial at all temperatures, we model in detail. At intermediate temperatures and in the absence of any magnetic ordering, the fluctuating local-moments lead to a non-trivial angular anisotropy of the scattering-rate along the Fermi surface, which disappears with increasing temperature, elucidating the role of "hot-spots". Over a remarkably broad window of intermediate and high temperatures, the electronic properties can be described by employing a local approximation for the dynamical spin-response. This we contrast with the more familiar setup of electrons scattering off classical phonons, whose high-temperature limit differs fundamentally on account of their unbounded Hilbert space. We place our results in the context of layered magnetic delafossite compounds.Comment: 4.5 pages, 3 figures. Supplementary material: 6 pages, 4 figure

Silica passivated conjugated polymer nanoparticles for biological imaging applications

Colorectal and prostate cancers are major causes of cancer-related death, with early detection key to increased survival. However, as symptoms occur during advanced stages and current diagnostic methods have limitations, there is a need for new fluorescent probes that remain bright, are biocompatible and can be targeted. Conjugated polymer nanoparticles have shown great promise in biological imaging due to their unique optical properties. We have synthesised small, bright, photo-stable CN-PPV, nanoparticles encapsulated with poloxamer polymer and a thin silica shell. By incubating the CN-PPV silica shelled cross-linked (SSCL) nanoparticles in mammalian (HeLa) cells; we were able to show that cellular uptake occurred. Uptake was also shown by incubating the nanoparticles in RWPE-1, WPE1-NB26 and WPE1- NA22 prostate cancer cell lines. Finally, HEK cells were used to show the particles had limited cytotoxicity