103 research outputs found
New Symmetries in Crystals and Handed Structures
For over a century, the structure of materials has been described by a
combination of rotations, rotation-inversions and translational symmetries. By
recognizing the reversal of static structural rotations between clockwise and
counterclockwise directions as a distinct symmetry operation, here we show that
there are many more structural symmetries than are currently recognized in
right- or left-handed handed helices, spirals, and in antidistorted structures
composed equally of rotations of both handedness. For example, though a helix
or spiral cannot possess conventional mirror or inversion symmetries, they can
possess them in combination with the rotation reversal symmetry. Similarly, we
show that many antidistorted perovskites possess twice the number of symmetry
elements as conventionally identified. These new symmetries predict new forms
for "roto" properties that relate to static rotations, such as rotoelectricity,
piezorotation, and rotomagnetism. They also enable symmetry-based search for
new phenomena, such as multiferroicity involving a coupling of spins, electric
polarization and static rotations. This work is relevant to structure-property
relationships in all material structures with static rotations such as
minerals, polymers, proteins, and engineered structures.Comment: 15 Pages, 4 figures, 3 Tables; Fig. 2b has error
Massive Gravity: Exorcising the Ghost
We consider Higgs massive gravity [1,2] and investigate whether a nonlinear
ghost in this theory can be avoided. We show that although the theory
considered in [10,11] is ghost free in the decoupling limit, the ghost
nevertheless reappears in the fourth order away from the decoupling limit. We
also demonstrate that there is no direct relation between the value of the
Vainshtein scale and the existence of nonlinear ghost. We discuss how massive
gravity should be modified to avoid the appearance of the ghost.Comment: 16 page
Lessons from the decoupling limit of Horava gravity
We consider the so-called "healthy" extension of Horava gravity in the limit
where the Stuckelberg field decouples from the graviton. We verify the alleged
strong coupling problem in this limit, under the assumption that no large
dimensionless parameters are put in by hand. This follows from the fact that
the dispersion relation for the Stuckelberg field does not have the desired z =
3 anisotropic scaling in the UV. To get the desired scaling and avoid strong
coupling one has to introduce a low scale of Lorentz violation and retain some
coupling between the graviton and the Stuckelberg field. We also make use of
the foliation preserving symmetry to show how the Stuckelberg field couples to
some violation of energy conservation. We source the Stuckelberg field using a
point particle with a slowly varying mass and show that two such particles feel
a constant attractive force. In this particular example, we see no Vainshtein
effect, and violations of the Equivalence Principle. The latter is probably
generic to other types of source and could potentially be used to place lower
bounds on the scale of Lorentz violation.Comment: 18 pages, 1 figure. Version to appear in JHEP. Conclusions with
respect to strong coupling modified - our strong coupling analysis does not
apply to a low scale of Lorentz violation. Expanded Equivalence Principle
violation discussion, noting it presents a challenge to low scale Lorentz
violation, exactly the scenario designed to cure strong coupling. Other minor
corrections and references adde
Dark Matter from Minimal Flavor Violation
We consider theories of flavored dark matter, in which the dark matter
particle is part of a multiplet transforming nontrivially under the flavor
group of the Standard Model in a manner consistent with the principle of
Minimal Flavor Violation (MFV). MFV automatically leads to the stability of the
lightest state for a large number of flavor multiplets. If neutral, this
particle is an excellent dark matter candidate. Furthermore, MFV implies
specific patterns of mass splittings among the flavors of dark matter and
governs the structure of the couplings between dark matter and ordinary
particles, leading to a rich and predictive cosmology and phenomenology. We
present an illustrative phenomenological study of an effective theory of a
flavor SU(3)_Q triplet, gauge singlet scalar.Comment: 10 pages, 2 figures; v2: references added, minor changes to collider
analysis, conclusions unchange
CKM matrix and CP violation in B-mesons
Planned as a review of CPV in B-mesons which covered recent B-factories
results these lectures appeared to be a bit wider. It is not natural to be
limited by direct CPV and that in mixing in B-mesons and not to speak about the
analogous phenomena in K-mesons since it is very useful and interesting to
study what is common and what is different in these systems and why. CKM matrix
elements are extracted from K and B mixings and decays and the deviation from
unitarity of CKM matrix may become a place in which New Physics will show up.
So we discuss this simple and elegant piece of Standard Model as well.Comment: 51 pages, 10 figures, to be published in the Proceedings of the XXXI
ITEP Winter School, Moscow, Russia, 18-26 February 200
Second-look PET-CT following an initial incomplete PET-CT response to (chemo)radiotherapy for head and neck squamous cell carcinoma
OBJECTIVES:
The limited positive predictive value of an incomplete response on PET-CT following (chemo)radiotherapy for head and neck squamous cell carcinoma (HNSCC) means that the optimal management strategy remains uncertain. The aim of the study is to assess the utility of a 'second-look' interval PET-CT.
METHODS:
Patients with HNSCC who were treated with (chemo)radiotherapy between 2008 and 2017 and underwent (i) baseline and (ii) response assessment PET-CT and (iii) second-look PET-CT following incomplete (positive or equivocal scan) response were included. Endpoints were conversion rate to complete response (CR) and test characteristics of the second-look PET-CT.
RESULTS:
Five hundred sixty-two patients with HNSCC underwent response assessment PET-CT at a median of 17Â weeks post-radiotherapy. Following an incomplete response on PET-CT, 40 patients underwent a second-look PET-CT at a median of 13Â weeks (range 6-25) from the first response PET-CT. Thirty-four out of 40 (85%) patients had oropharyngeal carcinoma. Twenty-four out of 40 (60%) second-look PET-CT scans converted to a complete locoregional response. The primary tumour conversion rate was 15/27 (56%) and the lymph node conversion rate was 14/19 (74%). The sensitivity, specificity, positive predictive value and negative predictive value (NPV) of the second-look PET-CT were 75%, 75%, 25% and 96% for the primary tumour and 100%, 92%, 40% and 100% for lymph nodes. There were no cases of progression following conversion to CR in the primary site or lymph nodes.
CONCLUSIONS:
The majority of patients who undergo a second-look PET-CT convert to a CR. The NPV of a second-look PET-CT is high, suggesting the potential to avoid surgical intervention.
KEY POINTS:
âą PET-CT is a useful tool for response assessment following (chemo)radiotherapy for head and neck squamous cell carcinoma. âą An incomplete response on PET-CT has a limited positive predictive value and optimal management is uncertain.
âą These data show that with a 'second-look' interval PET-CT, the majority of patients convert to a complete metabolic response. When there is doubt about clinical and radiological response, a 'second-look' PET-CT can be used to spare patients unnecessary surgical intervention
Degenerate higher order scalar-tensor theories beyond Horndeski up to cubic order
We present all scalar-tensor Lagrangians that are cubic in second derivatives of a scalar field, and that are degenerate, hence avoiding Ostrogradsky instabilities. Thanks to the existence of constraints, they propagate no more than three degrees of freedom, despite having higher order equations of motion. We also determine the viable combinations of previously identified quadratic degenerate Lagrangians and the newly established cubic ones. Finally, we study whether the new theories are connected to known scalar-tensor theories such as Horndeski and beyond Horndeski, through conformal or disformal transformations
f(R) theories
Over the past decade, f(R) theories have been extensively studied as one of
the simplest modifications to General Relativity. In this article we review
various applications of f(R) theories to cosmology and gravity - such as
inflation, dark energy, local gravity constraints, cosmological perturbations,
and spherically symmetric solutions in weak and strong gravitational
backgrounds. We present a number of ways to distinguish those theories from
General Relativity observationally and experimentally. We also discuss the
extension to other modified gravity theories such as Brans-Dicke theory and
Gauss-Bonnet gravity, and address models that can satisfy both cosmological and
local gravity constraints.Comment: 156 pages, 14 figures, Invited review article in Living Reviews in
Relativity, Published version, Comments are welcom
Bi-galileon theory II: phenomenology
We continue to introduce bi-galileon theory, the generalisation of the single galileon model introduced by Nicolis et al. The theory contains two coupled scalar fields and is described by a Lagrangian that is invariant under Galilean shifts in those fields. This paper is the second of two, and focuses on the phenomenology of the theory. We are particularly interesting in models that admit solutions that are asymptotically self accelerating or asymptotically self tuning. In contrast to the single galileon theories, we find examples of self accelerating models that are simultaneously free from ghosts, tachyons and tadpoles, able to pass solar system constraints through Vainshtein screening, and do not suffer from problems with superluminality, Cerenkov emission or strong coupling. We also find self tuning models and discuss how Weinberg's no go theorem is evaded by breaking Poincar\'e invariance in the scalar sector. Whereas the galileon description is valid all the way down to solar system scales for the self-accelerating models, unfortunately the same cannot be said for self tuning models owing to the scalars backreacting strongly on to the geometry
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