57 research outputs found
Primary PCI in STEMI: The Role of Thrombo-aspiration
Acutemyocardial infarction is a potentially life-threatening disease that remains achallenge for the Interventional Cardiologist. Manual thrombectomy is easilyapplicable and several studies have confirmed its favorable effect onmyocardial perfusion especially when it is combined with intracoronary adjunctivepharmacotherapy. During the last years, several catheters with differentcharacteristics have been introduced in clinical practice. Newer randomizedtrials will further clarify the role and the indications of manual thrombectomyin patients with STEMI submitted to pPCI
Reproducibility of intravascular ultrasound radiofrequency data analysis: Implications for the design of longitudinal studies
Objectives: The purpose of this study was to assess in vivo the reproducibility of tissue characterization using spectral analysis of intravascular ultrasound (IVUS) radiofrequency data (IVUS-VH). Background: Despite the need for reproducibility data to design longitudinal studies, such information remains unexplored. Methods and results: IVUS-VH (Volcano Corp., Rancho Cordova, USA) was performed in patients referred for elective percutaneous intervention and in whom a non-intervened vessel was judged suitable for a safe IVUS interrogation. The IVUS catheters used were commercially available catheters (20 MHz, Volcano Corp., Rancho Cordova, USA). Following IVUS-VH acquisition, and after the disengagement and re-engagement of the guiding catheter, an additional acquisition was performed using a new IVUS catheter. Fifteen patients with 16 non-significant lesions were assessed by 2 independent observers. The relative inter-catheter differences regarding geometrical measurements were negligible for both observers. The inter-catheter relative difference in plaque cross-sectional area (CSA) was 3.2% for observer 1 and 0.5% for observer 2. The limits of agreement for (observer 1 measurements) lumen, vessel, plaque and plaque burden measurements were 0.82, -1.10 mm 2;0.80, -0.66 mm2;1.08, -0.66 mm2; and 5.83, -3.89%; respectively. Limits of agreement for calcium, fibrous, fibrolipidic and necrotic core CSA measurements were 0.22, -0.25 mm2;1.02, -0.71 mm2;0.61, -0.65 mm2; and 0.43, -0.38 mm2 respectively. Regarding the inter-observer agreement, the limits of agreement for lumen, vessel, plaque and plaque burden measurements were 2.61, -2.09 mm2;2.20-3.03 mm2;1.70, -3.04 mm2; and 9.16, -16.41%; respectively, and for calcium, fibrous, fibrolipidic and necrotic core measurements of 0.08, -0.09 mm2;0.89, -1.28 mm2;0.74, -1.06 mm2; and 0.16, -0.20 mm2; respectively. Conclusions: The present study demonstrates that the geometrical and compositional output of IVUS-VH is acceptably reproducible
1950年代の日中貿易と日中関係― 日中貿易促進団体の活動を中心に ―
博士(学術)神戸大
Significance of characterization of non-culprit lesions: An underscored clinical problem
Sudden death or acute coronary syndromes are frequently the first
manifestation of plaque rupture at non-culprit lesions. Thus,
identification of high-risk non-culprit plaques may have significant
impact on the prognosis of patients with coronary artery disease. At
present a widely accepted diagnostic method to prospectively identify
such ‘high-risk’ plaques is not available. Improved identification of
high-risk plaques by novel imaging coronary modalities currently
available is a goal of great importance since it will result in major
decreases in coronary artery disease morbidity and mortality. Potential
new treatments with systemic, regional, and local approaches have been
proposed. In this review article we focus on common and different
morphologic characteristics between culprit and non-culprit lesions, the
natural history of non-culprit lesions, and potential methods to
identify the high-risk lesions for future adverse cardiovascular events.
(C) 2007 Elsevier Ireland Ltd. All rights reserved
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