Optical coherence tomography angiography of foveal hypoplasia

AIMS: To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. METHODS: In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. RESULTS: Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with poor vision demonstrated high grades of foveal hypoplasia. The superficial retinal capillary plexus was intact in the foveal area in all cases, with no demonstrable foveal avascular zone. The deep retinal capillary plexus was absent to variable degrees in most cases, but was most persistent in those cases with reduced vision. CONCLUSIONS: The superficial retinal capillary plexus is present in cases with foveal hypoplasia, while the deep retinal capillary plexus is absent to varying degrees. Our findings support the hypothesis that an intact foveal avascular zone of the deep capillary plexus allows for outer retinal photoreceptor specialisation to occur unimpeded, resulting in preserved visual acuity, while this process may be inhibited by an absent deep capillary foveal avascular zone with resultant poor vision

Doping the Kane-Mele-Hubbard model: A Slave-Boson Approach

We study the Kane-Mele-Hubbard model both at half-filling and away from half-filling using a slave-boson mean-field approach at zero temperature. We obtain a phase diagram at half-filling and discuss its connection to recent results from quantum Monte Carlo, slave-rotor, and $Z_2$ mean-field studies. In particular, we find a small window in parameter space where a spin liquid phase with gapped spin and charge excitations reside. Upon doping, we show the spin liquid state becomes a superconducting state by explicitly calculating the singlet pairing order parameters. Interestingly, we find an "optimal" doping for such superconductivity. Our work reveals some of the phenomenology associated with doping an interacting system with strong spin-orbit coupling.Comment: 11 pages and 9 figure

New multi-proxy record shows potential impacts of precipitation on the rise and ebb of Bronze Age and imperial Persian societies in southeastern Iran

The Achaemenids and Sasanian ‘Persian’ Empires were significant political, economic, and social forces in the Late Bronze Age and Late Antiquity Eurasia, respectively, which have left marks on the heritage of the Mediterranean and Middle Eastern world. While attention is often focused on military and political conditions when discussing the prosperity and decline of these imperial powers, their realms, which crossed a variety of environmental settings, were highly dependent on the predictability of rainfall that drove agriculture and effective provisioning. Here, we present a multi-proxy sedimentological, geochemical, and palynological record from a 2.5-m long peat deposit near the excavation site in Konar Sandal near Jiroft in southeastern Iran, covering 4000-850 cal yr BP. Around 3950 cal yr BP a wet period prevailed based on elemental ratios, stable C isotope, pollen, and diagnostic lipids. Between 3900 and 3300 cal yr BP, wet/semi-wet conditions developed with the appearance of Cerealia-type pollen. Dry and windy conditions followed (ca. 3300-2900 cal yr BP), which coincided with the Siberian anticyclones and climatic shifts developing in the Eastern Mediterranean region. Consequently, the Bronze Age settlements around Jiroft, dependent on agriculture, underwent a steady decline. A prolonged wet period followed (ca. 2900-2300 cal yr BP) with the abundance of Sparganium-type pollen and the aquatic lipid proxy (Paq). This change coincided with intensive agricultural practices and the flourishing of the powerful Median and Achaemenid empires. The shift to high Ti/Al ratios coeval with the lowest δ13COM values suggests an increase in aeolian activity and dry conditions ca. 2100-1650 cal yr BP. The Jiroft valley again experienced wet conditions between 1550 and 1300 cal yr BP, which overlapped with the economic prosperity of the middle to late Sasanian empire. The paleoenvironmental reconstruction indicates that wet periods and intensive agriculture coincide with the Persian empires' zenith, political influence, and economic affluence. Therefore, contextualized and detailed paleoenvironmental records are desirable to explore the interplay of political and climatic factors in the development and fragmentation of the ancient settlements and imperial powers in Eurasian history.1. Introduction 2. Geographical setting 3. Materials and methods 3.1. Sampling, magnetic susceptibility, and grain size analysis 3.2. Radiocarbon analyses 3.3. Elemental and mineralogical analyses 3.4. C/N and stable isotope analyses 3.4.1. Lipid extraction 3.5. Pollen analysis 4. Results 4.1. Age-depth model and chronology 4.2. Units 4.2.1. Unit 1 (U 1; 250-189 cm; ca. 4000-3550 cal yr BP) 4.2.2. Unit 2 (U 2; 189-164 cm; ca. 3550-3300 cal yr BP) 4.2.3. Unit 3 (U 3; 164-134 cm; ca. 3300-2900 cal yr BP) 4.2.4. Unit 4 (U 4; 134-106 cm; ca. 2900-2300 cal yr BP) 4.2.5. Unit 5 (U 5; 106-61 cm; ca. 2300-1550 cal yr BP) 4.2.6. Unit 6 (U 6; 61-10 cm; ca. 1550-850 cal yr BP) 5. Discussion 5.1. Paleoclimate preceding the decline of the Jiroft civilization 5.2. The Late Bronze Age decline in Jiroft 5.3. Rise and fall of the Persian Empire 5.3.1. The pre-Islamic period and recent times 6. Conclusion

Comparison of ophthalmic training in 6 English-speaking countries

OBJECTIVE: To compare key characteristics of ophthalmology training programs in 6 different English-speaking countries: Australia, New Zealand, Canada, Ireland, the United Kingdom, and the United States. PARTICIPANTS: Seven ophthalmologists with personal knowledge of all 6 systems contributed. METHODS: The main features examined were career pathway, duration of training, surgical training, governing bodies, and examination structure. Data were collected from the literature, online resources, and personal experience. RESULTS: Several differences were highlighted, including length of training (ranging from 4 to 9 years after medical school), number of surgical procedures such as cataracts (ranging from minimum 86 to approximately 600), and structure of fellowship training. CONCLUSIONS: As trainees increasingly seek international experience to enhance their knowledge and skills, the similarities and differences between training programs in different countries have become more relevant. Some of these differences may reflect differing needs of different patient populations and different healthcare delivery systems across the globe. However, these differences should also prompt educators to more carefully scrutinize their own training system and search for potential improvements

Short range Coulomb correlations render massive Dirac fermions massless

Tight binding electrons on a honeycomb lattice are described by an effective Dirac theory at low energies. Lowering symmetry by an alternate ionic potential ($\Delta$) generates a single-particle gap in the spectrum. We employ the dynamical mean field theory (DMFT) technique, to study the effect of on-site electron correlation ($U$) on massive Dirac fermions. For a fixed mass parameter $\Delta$, we find that beyond a critical value $U_{c1}(\Delta)$ massive Dirac fermions become massless. Further increasing $U$ beyond $U_{c2}(\Delta)$, there will be another phase transition to the Mott insulating state. Therefore the competition between the single-particle gap parameter, $\Delta$, and the Hubbard $U$ restores the semi-metallic nature of the parent Hamiltonian. The width of the intermediate semi-metallic regime shrinks by increasing the ionic potential. However, at small values of $\Delta$, there is a wide interval of $U$ values for which the system remains semi-metal.Comment: 4 pages, 5 figure

The Intersection of GERD, Aspiration, and Lung Transplantation

Lung transplantation is a radical but life-saving treatment option for patients with end-stage lung diseases, such as idiopathic pulmonary fibrosis (IPF) and scleroderma. In light of the proposed association and controversy linking gastroesophageal reflux disease (GERD) to IPF and lung transplant outcome, the American Gastroenterological Association convened during the DDW in Washington in May 2015 a multidisciplinary group of experts in the field of GERD and lung transplantation to make considerations about the care of these patients based on available data and subsequent expert panel discussion at this symposium. The following topics were discussed: (1) pathophysiology of GERD-induced pulmonary symptoms, (2) GERD evaluation before and after lung transplantation, (3) outcome of lung transplantation for IPF and scleroderma, and (4) role of laparoscopic fundoplication before or after lung transplantation

Deep Multi-modality Soft-decoding of Very Low Bit-rate Face Videos

We propose a novel deep multi-modality neural network for restoring very low bit rate videos of talking heads. Such video contents are very common in social media, teleconferencing, distance education, tele-medicine, etc., and often need to be transmitted with limited bandwidth. The proposed CNN method exploits the correlations among three modalities, video, audio and emotion state of the speaker, to remove the video compression artifacts caused by spatial down sampling and quantization. The deep learning approach turns out to be ideally suited for the video restoration task, as the complex non-linear cross-modality correlations are very difficult to model analytically and explicitly. The new method is a video post processor that can significantly boost the perceptual quality of aggressively compressed talking head videos, while being fully compatible with all existing video compression standards.Comment: Accepted by Proceedings of the 28th ACM International Conference on Multimedia(ACM MM),202