Antibacterial Activity of Functionalized 1-(2',4'-Dihydroxy-5'- Substituted Phenyl)-3-Thienyl-Propane-1,3-Diones Bearing Potential O,O,S-Pharmacophores

Abstract A series of highly functionalized 1-(2',4'-dihydroxy-5'-substituted phenyl)-3-thienylpropane-1,3-diones 3a-g have been produced upon Baker-Venkataraman rearrangement of 4-hydroxy-5-substituted-2-thienoyloxyacetophenones 2a-g using dimethylsulphoxide in NaOH. All the synthesized motifs 3a-g were confirmed by the spectroscopic analyses and evaluated for antibacterial efficacy against different pathogens