923 research outputs found

    Standard Chartered Bank: Women on Corporate Boards in India 2010

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    This first Standard Chartered Bank: Women on Corporate Boards in India 2010 report looks at the representation of women on the boards of India's leading companies on the Bombay Stock Exchange (BSE-100) . It ranks the companies in terms of the gender diversity of their boards, with those with the highest percentage of women on their boards appearing at the top. The report also examines the general topic of gender diversity on the boards of the BSE-100 by presenting the findings of interviews with 18 female directors of BSE-100 companies

    On Validating Closed-Loop Behaviour from Noisy Frequency-Response Measurements

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    It is shown how noisy closed-loop frequency-response measurements can be used to obtain pointwise in frequency bounds on the possible difference between the actual closed-loop system and the closed-loop comprising a nominal model of the plant and the stabilising controller. To this end, Vinnicombe's gap metric framework for robustness analysis plays a central role. Indeed, an optimisation problem and corresponding algorithm are proposed for estimating the chordal distance between the frequency responses of the nominal plant model and a plant that is consistent with the closed-loop data and a priori information, when projected onto the Riemann sphere

    City Love

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    Simon Vinnicombe, ā€˜City Loveā€™, (UK: Bloomsbury Publishing, 2013), ISBN 9781472528810

    Enzyme sequestration by the substrate: An analysis in the deterministic and stochastic domains.

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    This paper is concerned with the potential multistability of protein concentrations in the cell. That is, situations where one, or a family of, proteins may sit at one of two or more different steady state concentrations in otherwise identical cells, and in spite of them being in the same environment. For models of multisite protein phosphorylation for example, in the presence of excess substrate, it has been shown that the achievable number of stable steady states can increase linearly with the number of phosphosites available. In this paper, we analyse the consequences of adding enzyme docking to these and similar models, with the resultant sequestration of phosphatase and kinase by the fully unphosphorylated and by the fully phosphorylated substrates respectively. In the large molecule numbers limit, where deterministic analysis is applicable, we prove that there are always values for these rates of sequestration which, when exceeded, limit the extent of multistability. For the models considered here, these numbers are much smaller than the affinity of the enzymes to the substrate when it is in a modifiable state. As substrate enzyme-sequestration is increased, we further prove that the number of steady states will inevitably be reduced to one. For smaller molecule numbers a stochastic analysis is more appropriate, where multistability in the large molecule numbers limit can manifest itself as multimodality of the probability distribution; the system spending periods of time in the vicinity of one mode before jumping to another. Here, we find that substrate enzyme sequestration can induce bimodality even in systems where only a single steady state can exist at large numbers. To facilitate this analysis, we develop a weakly chained diagonally dominant M-matrix formulation of the Chemical Master Equation, allowing greater insights in the way particular mechanisms, like enzyme sequestration, can shape probability distributions and therefore exhibit different behaviour across different regimes
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