timed flat infusion tfi 5 fluorouracil with irinotecan and oxaliplatin in pancreatic adenocarcinomas a single institution experience with fir fox regimen

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Nonlinear Polariton Fluids in a Flatband Reveal Discrete Gap Solitons

Phase frustration in periodic lattices is responsible for the formation of dispersionless flat bands. The absence of any kinetic energy scale makes flat band physics critically sensitive to perturbations and interactions. We report here on the experimental investigation of the nonlinear dynamics of cavity polaritons in the gapped flat band of a one-dimensional Lieb lattice. We observe the formation of gap solitons with quantized size and very abrupt edges, signature of the frozen propagation of switching fronts. This type of gap solitons belongs to the class of truncated Bloch waves, and had only been observed in closed systems up to now. Here the driven-dissipative character of the system gives rise to a complex multistability of the nonlinear domains generated in the flat band. These results open up interesting perspective regarding more complex 2D lattices and the generation of correlated photon phases.Comment: 6 pages, 4 figures + supplemental material (6 pages, 6 figures

Preferência de Bemisia tabaci, biótipo B (Hemiptera: aleyrodidae) a genótipos de soja.

O objetivo do trabalho foi avaliar a preferência de B. tabaci a 18 genótipos de soja com chance de escolha, em condições de casa de vegetação. Os genótipos avaliados foram: BRI 04-01668, BRI 04-01685, BRI 04-02770, BRI 04-02855, BRI 04-02935, BRI 04-02983, BRS 7860RR, BRS Barreira, BRS Gisele RR, BRS Juliana, BRS Valiosa RR, BRSGO 7960, BRSGO 8060, CD219, CD 215, Emgopa 302RR, IAC 17 e IAC 19. Os materiais com menores infestações de ovos e ninfas foram: BRI 04-01668, BRI 04-01685, BRI 04-02770 e IAC 17 (padrão de resistência) e os mais infestados foram BRS Juliana RR e Emgopa 302RR Os genótipos BRS 7860RR e BRSGO 8060 apresentaram o mesmo perfil de não preferência que IAC19 (padrão de resistência)

Mancha areolada de Thanatephorus da seringueira na Amazônia: identificação filogenética e variação genética em populações do patógeno.

A mancha areolada de Thanatephorus é uma das doenças mais importantes da seringueira (Hevea brasiliensis) na Amazônia. Apesar disso, questão importante sobre o real posicionamento filogenético deste patógeno ainda não foi respondida. Neste estudo, nós analisamos os padrões de variação genética em seqüências da região ITS-5.8S do rDNA de uma população de T. cucumeris (fase assexuada = Rhizoctonia solani AG 2-2) associado à mancha areolada da seringueira amostrada em Belém (Pará), Manaus (Amazonas) e Xapuri/Rio Branco (Acre) na Amazônia, e comparando-a filogeneticamente com membros do complexo AG 2 descritos mundialmente. Este estudo representa um passo importante para revelar a etiologia da fase assexuada de T.cucumeris da seringueira

Mutational and copy number asset of primary sporadic neuroendocrine tumors of the small intestine

Small intestine neuroendocrine tumors (SI-NETs) represent the most common histotype among small intestine neoplasms, and metastatic disease is usually present at diagnosis. A retrospective series of 52 sporadic primary surgically resected SI-NETs, which were metastatic at diagnosis, was analyzed by high-coverage target sequencing (HCTS) for the mutational status of 57 genes and copy number status of 40 genes selected from recently published genome sequencing data. Seven genes were found to be recurrently mutated: CDKN1B (9.6%), APC and CDKN2C (each 7.7%), BRAF, KRAS, PIK3CA, and TP53 (each 3.8%). Copy number analysis showed frequent allelic loss of 4 genes located on chromosome 18 (BCL2, CDH19, DCC, and SMAD4) in 23/52 (44.2%) and losses on chromosomes 11 (38%) and 16 (15%). Other recurrent copy number variations were gains for genes located on chromosomes 4 (31%), 5 (27%), 14 (36%), and 20 (20%). Univariate survival analysis showed that SRC gene copy number gains were associated with a poorer prognosis (p = 0.047). Recurrent copy number variations are important events in SI-NET and SRC may represent a novel prognostic biomarker for this tumor type

Asymmetric Fluid Criticality I: Scaling with Pressure Mixing

The thermodynamic behavior of a fluid near a vapor-liquid and, hence, asymmetric critical point is discussed within a general ``complete'' scaling theory incorporating pressure mixing in the nonlinear scaling fields as well as corrections to scaling. This theory allows for a Yang-Yang anomaly in which \mu_{\sigma}^{\prime\prime}(T), the second temperature derivative of the chemical potential along the phase boundary, diverges like the specific heat when T\to T_{\scriptsize c}; it also generates a leading singular term, |t|^{2\beta}, in the coexistence curve diameter, where t\equiv (T-T_{\scriptsize c}) /T_{\scriptsize c}. The behavior of various special loci, such as the critical isochore, the critical isotherm, the k-inflection loci, on which \chi^{(k)}\equiv \chi(\rho,T)/\rho^{k} (with \chi = \rho^{2} k_{\scriptsize B}TK_{T}) and C_{V}^{(k)}\equiv C_{V}(\rho,T)/\rho^{k} are maximal at fixed T, is carefully elucidated. These results are useful for analyzing simulations and experiments, since particular, nonuniversal values of k specify loci that approach the critical density most rapidly and reflect the pressure-mixing coefficient. Concrete illustrations are presented for the hard-core square-well fluid and for the restricted primitive model electrolyte. For comparison, a discussion of the classical (or Landau) theory is presented briefly and various interesting loci are determined explicitly and illustrated quantitatively for a van der Waals fluid.Comment: 21 pages in two-column format including 8 figure

preliminary results of principe predictors of resistance to immunotherapy with nivolumab niv study in advanced pretreated non small cell lung cancer apnsclc investigating the role of an immune genomic signature igs including jak2 jak3 pias4 ptpn2 stat3 ifnar2 alterations

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Impact of Mutation Density and Heterogeneity on Papillary Thyroid Cancer Clinical Features and Remission Probability

BACKGROUND: The need to integrate the classification of cancer with information on the genetic pattern has emerged in recent years for several tumors. METHODS: The genomic background of a large series of 208 papillary thyroid cancers (PTC) followed at a single center was analyzed by a custom MassARRAY genotyping platform, which allows the simultaneous detection of 19 common genetic alterations, including point mutations and fusions. RESULTS: Of the PTCs investigated, 71% were found to have pathognomonic genetic findings, with BRAFV600E and TERT promoter mutations being the most frequent monoallelic alterations (42% and 23.5%, respectively), followed by RET/PTC fusions. In 19.2% of cases, two or more point mutations were found, and the co-occurrence of a fusion with one or more point mutation(s) was also observed. Coexisting BRAFV600E and TERT promoter mutations were detected in a subgroup of aggressive PTCs (12%). A correlation between several aggressive features and mutation density was found, regardless of the type of association (i.e., only point mutations, or point mutations and fusions). Importantly, Kaplan-Meier curves demonstrated that mutation density significantly correlated with a higher risk of persistent disease. In most cases, the evaluation of the allelic frequencies normalized for the cancer cell content indicated the presence of the monoallelic mutation in virtually all tumor cells. A minority of cases was found to harbor low allelic frequencies, consistent with the presence of the mutations in a small subset of cancer cells, thus indicating tumor heterogeneity. Consistently, the presence of coexisting genetic alterations with different allelic frequencies in some tumors suggests that PTC can be formed by clones/subclones with different mutational profiles. CONCLUSIONS: A large mono-institutional series of PTCs was fully genotyped by means of a cost- and time-effective customized panel, revealing a strong impact of mutation density and genetic heterogeneity on the clinical features and on disease outcomes, indicating that an accurate risk stratification of thyroid cancer cannot rely on the analysis of a single genetic event. Finally, the heterogeneity found in some tumors warrants attention, since the occurrence of this phenomenon is likely to affect response to targeted therapies