2,317 research outputs found
Double percolation effects and fractal behavior in magnetic/superconducting hybrids
Perpendicular magnetic anisotropy ferromagnetic/ superconducting (FM/SC)
bilayers with a labyrinth domain structure are used to study nucleation of
superconductivity on a fractal network, tunable through magnetic history. As
clusters of reversed domains appear in the FM layer, the SC film shows a
percolative behavior that depends on two independent processes: the arrangement
of initial reversed domains and the fractal geometry of expanding clusters. For
a full labyrinth structure, the behavior of the upper critical field is typical
of confined superconductivity on a fractal network.Comment: 15 pages, 5 figure
Controlled nucleation of topological defects in the stripe domain patterns of Lateral multilayers with Perpendicular Magnetic Anisotropy: competition between magnetostatic, exchange and misfit interactions
Magnetic lateral multilayers have been fabricated on weak perpendicular
magnetic anisotropy amorphous Nd-Co films in order to perform a systematic
study on the conditions for controlled nucleation of topological defects within
their magnetic stripe domain pattern. A lateral thickness modulation of period
is defined on the nanostructured samples that, in turn, induces a lateral
modulation of both magnetic stripe domain periods and average
in-plane magnetization component . Depending on lateral multilayer
period and in-plane applied field, thin and thick regions switch independently
during in-plane magnetization reversal and domain walls are created within the
in-plane magnetization configuration coupled to variable angle grain boundaries
and disclinations within the magnetic stripe domain patterns. This process is
mainly driven by the competition between rotatable anisotropy (that couples the
magnetic stripe pattern to in-plane magnetization) and in-plane shape
anisotropy induced by the periodic thickness modulation. However, as the
structural period becomes comparable to magnetic stripe period ,
the nucleation of topological defects at the interfaces between thin and thick
regions is hindered by a size effect and stripe domains in the different
thickness regions become strongly coupled.Comment: 10 pages, 7 figures, submitted to Physical Review
MANAGEMENT ACCOUNTING USES: EMPIRICAL EVIDENCE WITHIN INTERORGANIZATIONAL RELATIONSHIPS
Conversely to previous research focused in the study of only one use of management accounting systems (MAS) in interorganizational relationships, we develop a model to explore the interaction of both uses (decision control – decision management) offering empirical evidence through a survey in the relationship between a manufacturing firm and its outsourced firms. Through two MAS tools, designed and shared by the manufacturer, both parties inform about their use and their perception of the partner's use. The results show that the perceptions mediate the interaction between both uses, finding discrepancies between real use and perception. It is evidenced that the perception of the decision control of outsourced firms do not harm their decision management, strengthening the theory that both uses can be complementary and that a MAS can supervise partners without damage their use to improve their daily managememt.management accounting functions, interorganizational relationships.
The motion of a satellite of the moon
Analytical solution for motion of lunar orbital satellit
Clinical Value of Pharmacogenomic Testing in a Patient Receiving FOLFIRINOX for Pancreatic Adenocarcinoma
Pharmacogenomic testing may have clinical value in the treatment of patients with gastrointestinal malignancies such as colorectal and pancreatic cancer. These types of cancer are often treated with combination chemotherapy regimens. These regimens can lead to severe adverse effects in patients with diminished drug tolerability potentially due to certain genetic variants in the enzymes involved in the metabolism of the chemotherapies. Genetic variants resulting in decreased enzymatic activity of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) and dihydropyrimidine dehydrogenase (DPD) are known to increase irinotecan and 5-fluorouracil-related toxicity, respectively. We report a case of a patient with pancreatic adenocarcinoma who was found to be not only homozygous for the UGT1A1∗28 allele, but also heterozygous for a DPYD variant through pharmacogenomic testing. Potentially severe adverse effects were prevented in this patient’s case by implementing preemptive dose reductions. On the basis of the significant implications of chemotherapy-related toxicity in this and other similar cases, we report on the clinical value of integrating pharmacogenomic testing into clinical practice to allow for preemptive and/or point-of-care dose reductions in patients potentially at risk for increased toxicity. This is even more important in an era where combinatorial triplet chemotherapies are increasingly being used
Study of CuI thin films properties for application as anode buffer layer in organic solar cells
After chemico-physical characterization of CuI thin films, the structures indium tin oxide (ITO) /CuI are systematically studied. We show that the morphology of the 3 nm thick CuI film depends on its deposition rate. To obtain smooth homogeneous CuI film, it is necessary to depose it at 0.005 nm/s. After optimization of the deposition conditions of CuI, it is shown that it behaves like a template for the organic layer. For instance, when the organic film is copper-phthalocyanine, the molecules which are usually perpendicular to the plane of the substrate lie parallel to it when deposited onto CuI. In a same way, when the electron donor is a prophyrin derivative, CuI allows to double the power conversion efficiency of the cells based on the heterojunction porphyrin/C-60. When CuI is used as anode buffer layer, it increases systematically the short circuit current, the open circuit voltage, thus the efficiency of the organic solar cell. These effects are related, not only to the improvement of the band matching between the ITO and the electron donor, but also to the templating effect of the CuI. Moreover, we show that the beneficial effect of CuI. is effective, not only with ITO, but also with fluorine doped tin oxide
Recurrent hypercortisolism after removal of an ACTH secretor pituitary adenoma associated with an adrenal macronodule
A 29 years old patient was sent to our Outpatient Clinic of Endocrinology presenting clinic of hypercortisolism. Laboratorial study: High urinary free cortisol (UFC); serum cortisol - 25 microg/dl (8 am) (5-25) and 20 microg/dL (11pm); ACTH - 20 pg/mL (9-52) (8 am) and 14 pg/mL (11 pm); serum cortisol after dexamethasone suppression test: 14,9 mg/dL; CRH test: elevation of ACTH; Pituitary MRI: microadenoma; abdominal CT: nodule on the left adrenal. During inferior petrosal sinus sampling with CRH stimulation, ACTH reached 368 pg/mL on the right and 136 pg/mL on the left side. The patient was submitted to transsphenoidal surgery. After surgery, hypertension and physical stigmata improved. In 2006, a relapse of Cushing syndrome was suspected due to worsening of hypertension and increase of weight. A slight increase of UFC, undetectable ACTH and serum cortisol after dexamethasone suppression test equal to 16 microg/dL were found. On abdominal CT, the adrenal nodule kept the same characteristics. In December 2006, the patient was submitted to left adrenalectomy. After surgery, blood pressure normalized, UFC and serum cortisol were reduced, needing substitutive therapy. Progressive tapering of hydrocortisone doses lead to discontinuation in March 2007. He is clinically well, without any treatment. This is an unusual case, in which after surgical cure of Cushing disease, secretory autonomy of a coexisting adrenal nodule occurred. This clinical case is relevant, pointing out the complexity of hypercortisolism cases and the need of long follow-up
Vortex ratchet reversal at fractional matching fields in kagom\'e-like array with symmetric pinning centers
Arrays of Ni nanodots embedded in Nb superconducting films have been
fabricated by sputtering and electron beam lithography techniques. The arrays
are periodic triangular lattices of circular Ni dots arranged in a
kagom\'e-like pattern with broken reflection symmetry. Relevant behaviors are
found in the vortex lattice dynamics : i) At values lower than the first
integer matching field, several fractional matching fields are present when the
vortex lattice moves parallel or perpendicular to the reflection symmetry axis
of the array showing a clear anisotropic character in the magnetoresistance
curves, ii) injecting an ac current perpendicular to the reflection symmetry
axis of the array yields an unidirectional motion of the vortex lattice
(ratchet effect) as a result of the interaction between the whole vortex
lattice and the asymmetric lattice of dots, iii) increasing the input current
amplitudes the ratchet effect changes polarity independently of matching field
values. These experimental results can be explained taking into account the
vortex lattice density.Comment: 9 pages, 4 figures, 1 tabl
Directional vortex motion guided by artificially induced mesoscopic potentials
Rectangular pinning arrays of Ni dots define a potential landscape for vortex
motion in Nb films. Magnetotransport experiments in which two in-plane
orthogonal electrical currents are injected simultaneously allow selecting the
direction and magnitude of the Lorentz force on the vortex-lattice, thus
providing the angular dependence of the vortex motion. The background
dissipation depends on angle at low magnetic fields, which is progressively
smeared out with increasing field. The periodic potential locks in the vortex
motion along channeling directions. Because of this, vortex-lattice direction
of motion is up to 85o away from the applied Lorentz force direction.Comment: PDF file includes figure
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