Extrusion-based additive manufacturing technologies: State of the art and future perspectives

Extrusion-based additive manufacturing (AM) has recently become widespread for the layer-by-layer fabrication of three-dimensional prototypes and components even with highly complex shapes. This technology involves extrusion through a nozzle by means of a plunger-, filament- or screw-based mechanism; where necessary, this is preceded by heating of the feedstock material to reduce its viscosity sufficiently to facilitate extrusion. Extrusion-based AM offers greater design freedom, larger building volumes and more cost-efficient production than liquid- and powder-based AM processes. Although this technology was originally developed for polymeric filament materials, it is now increasingly applied to a wide variety of material classes, including metallic, edible and construction materials. This is in part thanks to the recent development of AM-specific feedstock materials (AM materials), in which materials that are not intrinsically suited to extrusion, for example because of high melting points or brittleness, are combined with other, usually polymeric materials that can be more readily extruded. This paper comprehensively and systematically reviews the state of the art in the field of extrusion-based AM, including the techniques applied and the individual challenges and developments in each materials class for which the technology is being developed. The paper includes material- and process-centred suitability analysis of extrusion-based AM, and a comparison of this technology with liquid- and powder-based AM processes. Prospective applications of this technology are also briefly discussed

Investigation of variability in apparent values of materials properties in thermo-mechanical uniaxial tensile tests on sheet metals

Thermo-mechanical uniaxial tensile testing is commonly carried out to characterise the mechanical properties of materials under conditions which mimic advanced industrial forming processes, such as hot stamping of steels and aluminium alloys, and to generate microstructures for metallographic investigation. However, in this type of testing, heat loss to the specimen grips can lead to nonuniform temperature distributions along the gauge length, resulting in challenges in determining absolute values of materials properties at the nominal temperature of interest. The present study investigates the effect of these nonuniform temperature distributions on the variability in the thermo-mechanical properties as measured in the tests, and in the microstructures of the tested specimens. For this purpose, uniaxial tensile tests on the boron steel 22MnB5 and aluminium alloy AA6082 were performed under hot stamping conditions using a Gleeble 3800 thermal-mechanical physical simulation system, in which the specimens were heated using resistance heating and the strain fields were measured using digital image correlation (DIC). The nonuniformity of the temperature distributions along the gauge length was quantified. Both the strains and the strain rates along the gauge length were then computed and the effects of factors such as pre-forming gauge length, post-forming gauge length and specimen design on the spatial distribution of strains and strain rates were investigated. The effects of these factors on the values of thermo-mechanical properties determined from the tests, such as the ductility and the ultimate tensile strength (UTS), were also analysed and quantified. This study reveals the variability in the apparent values of materials properties as determined by thermo-mechanical testing resulting from nonuniform temperature distributions, and provides experimental data for the development of new standards for thermo-mechanical tests in future

Hot sheet metal forming strategies for high-strength aluminum alloys: a review-fundamentals and applications

In the past decade, aluminum alloys have become important structural materials in the automotive industry, thanks to their low density, high strength, high fracture toughness, and good fatigue performance. However, an important limitation of aluminum alloys is their poor formability at room temperature; as a result, numerous studies have been conducted with the aim of developing forming techniques to overcome this and facilitate the forming of more complex-shaped components. Following an overview on the metallurgical background of aluminum alloys, this article reviews recent developments in forming processes for aluminum alloys. The focus is on process variants at room temperature and at higher temperatures and on a new hot forming technique promising considerable improvements in formability. This review summarizes the influence of different process parameters on microstructures and mechanical properties. Particular emphasis is given to process design and to the underlying microstructural phenomena governing the strengthening mechanisms

A national survey of services for the prevention and management of falls in the UK

Background: The National Health Service (NHS) was tasked in 2001 with developing service provision to prevent falls in older people. We carried out a national survey to provide a description of health and social care funded UK fallers services, and to benchmark progress against current practice guidelines. Methods: Cascade approach to sampling, followed by telephone survey with senior member of the fall service. Characteristics of the service were assessed using an internationally agreed taxonomy. Reported service provision was compared against benchmarks set by the National Institute for Health and Clinical Excellence (NICE). Results: We identified 303 clinics across the UK. 231 (76%) were willing to participate. The majority of services were based in acute or community hospitals, with only a few in primary care or emergency departments. Access to services was, in the majority of cases, by health professional referral. Most services undertook a multi-factorial assessment. The content and quality of these assessments varied substantially. Services varied extensively in the way that interventions were delivered, and particular concern is raised about interventions for vision, home hazard modification, medication review and bone health. Conclusion: The most common type of service provision was a multi-factorial assessment and intervention. There were a wide range of service models, but for a substantial number of services, delivery appears to fall below recommended NICE guidance

Investigation of the effect of initial states of medium-Mn steel on deformation behaviour under hot stamping conditions

Medium-Mn (MMn) steels have received much research attention recently because their low austenitisation temperature enables low-temperature hot stamping (LTHS). However, the effect of the initial state of the material on the hot stamping performance is still unknown. In this study, the effect of different initial states on the deformation behaviour of a typical MMn steel during uniaxial tensile testing under LTHS conditions (deformation at 500–600 °C under strain rates of 0.01–1 s−1) are investigated using a Gleeble 3800 materials simulator; the final mechanical properties after austenitising and quenching are also examined. The microstructure of each material state before and after the LTHS heating cycle is characterised using scanning electron microscopy (SEM) and electron backscatter diffraction (EBSD). Of the three states investigated the hot rolled and annealed (HRA) state shows the best hot deformation performance represented by larger strain hardening exponent and higher total elongation, followed by the cold-rolled (CR) state, with the cold-rolled and annealed (CRA) state exhibiting the worst performance. The final mechanical properties, however, are very similar among the three states. In addition, the yield point phenomenon is found during hot deformation in both the CR and CRA states, and absent in the HRA state. The hot deformation behaviour has been discussed in terms of differences in microstructural properties, namely the grain size and its degree of heterogeneity

Housebound patients' experiences of a falls service provided by a team of community physiotherapists

Background/ aims: To explore the experiences of patients of a falls service provided by a community physiotherapy team to elderly, housebound people who have fallen. Methods: Six housebound, elderly patients who had been referred to the service were interviewed in their own homes. The interviews were transcribed and a thematic analysis framework was used to analyse the data. Codes were identified and developed into key themes which addressed the overall research question. Results: The analysis revealed that the participants presented with multiple risk factors including recurrent falls and comorbidities and were at high risk of falls. Exercise was understood to increase their mobility and the majority expressed a fear of falling. They appeared to have a limited understanding of the referral process, the cause of their falls and the interventions that may reduce their risk of falling. Conclusions: A multidisciplinary falls team, established and recognised as a central point of referral for the care of people who have fallen could enhance the care of elderly, housebound people who have fallen. The team with their specialist knowledge and understanding of the multifactorial nature of falls and appropriate interventions could co-ordinate and monitor the assessments and interventions needed with the relevant professionals and services

Effect of Angiogenesis Inhibitor Bevacizumab on Survival in Patients with Cancer: A Meta-Analysis of the Published Literature

Bevacizumab is a recombinant humanized monoclonal antibody against vascular endothelial growth factor which has been used in conjunction with other anti-cancer agents in the treatment of patients with many cancers. It remains controversial whether bevacizumab can prolong survival in cancer patients. This meta-analysis was therefore performed to evaluate effect of bevacizumab on survival in cancer patients. PubMed, EMBASE, and Web of Science databases were searched for English-language studies of randomized controlled trials comparing bevacizumab with control therapy published through February 8, 2012. Progression-free survival, overall survival, and one-year survival rate were analyzed using random- or fixed-effects model. Thirty one assessable randomized controlled trials were identified. A significant improvement in progression-free survival in cancer patients was attributable to bevacizumab compared with control therapy (hazard ratio, 0.72; 95% confidence interval, 0.68 to 0.76; p<0.001). Overall survival was also significantly longer in patients were treated with bevacizumab (hazard ratio, 0.87; 95% confidence interval, 0.83 to 0.91; p<0.001). The significant benefit in one-year survival rate was further seen in cancer patients receiving bevacizumab (odds ratio, 1.30; 95% confidence interval, 1.20 to 1.41; p<0.001). Current evidences showed that bevacizumab prolong progression-free survival and overall survival, and increase one-year survival rate in cancer patients as compared with control therapy

Non-pharmacological management of osteoporosis: a consensus of the Belgian Bone Club

This consensus article reviews the various aspects of the non-pharmacological management of osteoporosis, including the effects of nutriments, physical exercise, lifestyle, fall prevention, and hip protectors. Vertebroplasty is also briefly reviewed. Non-pharmacological management of osteoporosis is a broad concept. It must be viewed as an essential part of the prevention of fractures from childhood through adulthood and the old age. The topic also includes surgical procedures for the treatment of peripheral and vertebral fractures and the post-fracture rehabilitation. The present document is the result of a consensus, based on a systematic review and a critical appraisal of the literature. Diets deficient in calcium, proteins or vitamin D impair skeletal integrity. The effect of other nutriments is less clear, although an excessive consumption of sodium, caffeine, or fibres exerts negative effects on calcium balance. The deleterious effects of tobacco, excessive alcohol consumption and a low BMI are well accepted. Physical activity is of primary importance to reach optimal peak bone mass but, if numerous studies have shown the beneficial effects of various types of exercise on bone mass, fracture data as an endpoint are scanty. Fall prevention strategies are especially efficient in the community setting, but less evidence is available about their effectiveness in preventing fall-related injuries and fractures. The efficacy of hip protectors remains controversial. This is also true for vertebroplasty and kyphoplasty. Several randomized controlled studies had reported a short-term advantage of vertebroplasty over medical treatment for pain relief, but these findings have been questioned by recent sham-controlled randomized clinical studies