412 research outputs found
The Conformal Sector of F-theory GUTs
- Author
- A Sen
- AE Nelson
- AE Nelson
- Brian Wecht
- C Beasley
- C Beasley
- C-C Chiou
- Cumrun Vafa
- D Baumann
- F Benini
- F Marchesano
- GF Giudice
- GK Leontaris
- H Hayashi
- H Ooguri
- HP Nilles
- I Donkin
- J Marsano
- J Marsano
- JA Minahan
- JA Minahan
- JJ Heckman
- JJ Heckman
- JJ Heckman
- JJ Heckman
- JJ Heckman
- JJ Heckman
- JJ Heckman
- Jonathan J. Heckman
- JP Conlon
- KA Intriligator
- L Martucci
- LE Ibanez
- LE Ibáñez
- LE Ibáñez
- LJ Hall
- MB Einhorn
- MR Gaberdiel
- MR Gaberdiel
- N Arkani-Hamed
- O Aharony
- O DeWolfe
- O DeWolfe
- P Langacker
- PC Argyres
- R Auzzi
- R Blumenhagen
- S Dimopoulos
- S Dimopoulos
- S Raby
- SH Katz
- T Banks
- T Li
- T Weigand
- V Bouchard
- VA Novikov
- WJ Marciano
- Y-KE Cheung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/03/2012
- Field of study
D3-brane probes of exceptional Yukawa points in F-theory GUTs are natural
hidden sectors for particle phenomenology. We find that coupling the probe to
the MSSM yields a new class of N = 1 conformal fixed points with computable
infrared R-charges. Quite surprisingly, we find that the MSSM only weakly mixes
with the strongly coupled sector in the sense that the MSSM fields pick up
small exactly computable anomalous dimensions. Additionally, we find that
although the states of the probe sector transform as complete GUT multiplets,
their coupling to Standard Model fields leads to a calculable threshold
correction to the running of the visible sector gauge couplings which improves
precision unification. We also briefly consider scenarios in which SUSY is
broken in the hidden sector. This leads to a gauge mediated spectrum for the
gauginos and first two superpartner generations, with additional contributions
to the third generation superpartners and Higgs sector.Comment: v2: 51 pages, 2 figures, remark added, typos correcte
Adolescent endogenous sex hormones and breast density in early adulthood
- Author
- A McTiernan
- A Pettersson
- AW Root
- BL Sprague
- Brian L. Egleston
- C Klifa
- Catherine C. Klifa
- CG Woolcott
- CM Vachon
- Collaborative Group on Hormonal Factors in Breast Cancer
- D. Walt Chandler
- DH Bodicoat
- DJ Thompson
- DL Kleinberg
- E Obarzanek
- EJ Aiello
- Erin S. LeBlanc
- F Meyer
- FM Biro
- FM Biro
- FN Dewi
- Frank Z. Stanczyk
- G Guercio
- GA Colditz
- GA Greendale
- GA Greendale
- GA Greendale
- H Jernstrom
- H Johansson
- H-O Adami
- HR Nankin
- J Russo
- J Wei
- JA Shepherd
- JF Dorgan
- JF Dorgan
- JF Dorgan
- JF Dorgan
- JF Dorgan
- JF Dorgan
- JF Dorgan
- JH Chen
- JM Tanner
- JM Tanner
- Joanne F. Dorgan
- John A. Shepherd
- K Bay
- K Kerlikowske
- K Walker
- Kenneth Paris
- L Aksglaede
- L Hilakivi-Clarke
- L Ibanez
- Linda G. Snetselaar
- Linda Van Horn
- M Verheus
- M Yong
- MD Sternlicht
- MJ Borugian
- MJ Schoemaker
- ML Ahmed
- N Boyd
- NF Boyd
- NF Boyd
- Nola M. Hylton
- Norman L. Lasser
- P Ebeling
- PC Sizonenko
- R Vihko
- R Warren
- RC Littell
- RK Dearth
- RM Tamimi
- RM Tamimi
- SE Fenton
- Seungyoun Jung
- SM Cabrera
- T Key
- TJ Anderson
- TJ Key
- TR Milanese
- VA McCormack
- VA McCormack
- Victor J. Stevens
- W Rosner
- W Rosner
- Y Bremnes
- ZJ Andersen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Comparative transcriptomics among floral organs of the basal eudicot Eschscholzia californica as reference for floral evolutionary developmental studies
- Author
- A Becker
- A Becker
- A Gibalova
- A Kanno
- A Lingel
- A Litt
- A Relogio
- A Sacan
- A Sessions
- AR Paolacci
- AS Chanderbali
- AS Rijpkema
- B Davies
- C Liu
- C Martin
- C Voelckel
- CL Anderson
- Claude W dePamphilis
- CM Ellis
- CW Tung
- Cynthia J Gibas
- DE Soltis
- DE Soltis
- DK Liscombe
- Donglan Tian
- DW Galbraith
- EA Schultz
- EM Friis
- EM Kramer
- F Huang
- F Li
- F Wellmer
- G Theissen
- GK Smyth
- H Li
- H Ma
- H Ma
- H Ma
- HC Lin
- HF Hsu
- HH Chou
- Hong Ma
- I Lee
- IS Baek
- J Kyozuka
- J Leebens-Mack
- J Nam
- J Peng
- J Putterill
- J Zhu
- James H Leebens-Mack
- JD Thompson
- JE Carlson
- JL Riechmann
- JP Wang
- JT Ascencio-Ibanez
- K Kaufmann
- L Cui
- Laura M Zahn
- LM Zahn
- LM Zahn
- LM Zahn
- M Goetz
- M Jakoby
- M Schmid
- MA Jaramillo
- MD Bennett
- MD Kane
- MG Heisler
- MJ Moore
- MJ Moore
- N Le Novere
- Naomi S Altman
- NS Altman
- P Das
- P Kerr Wall
- PK Endress
- PK Wall
- PK Wall
- PV Riccelli
- Qing Zhang
- QK Tan
- R Cui
- R Reinheimer
- Raad Gharaibeh
- S Drea
- S Kim
- S Lee
- S Ohmori
- S Orashakova
- S Wege
- SU Park
- T Yamaguchi
- TY Tzeng
- VA Bloomfield
- W Zhang
- WY Yang
- X Chen
- X Zhang
- Xuan Ma
- Y Wang
- YH Yang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Parkinson’s disease mouse models in translational research
- Author
- A Carlsson
- A Del Sol
- A Di Fonzo
- A Ghosh
- A Giovanni
- A Giovanni
- A Nishi
- A Ramirez
- A Tanaka
- A Wood-Kaczmar
- A Zimprich
- AB Manning-Bog
- AB Manning-Bog
- AB Singleton
- AE Lang
- AH Rajput
- AH Schapira
- AH Schapira
- AH Schapira
- AJ Lees
- AO Koob
- B Giovannone
- B Greten-Harrison
- B Winner
- B Winner
- B Winner
- BI Giasson
- BK Harvey
- BR Ritz
- C Auffray
- C Freichel
- C Hamani
- C Paisan-Ruiz
- C Paisan-Ruiz
- C Takazawa
- CA Gautier
- CC Stichel
- CH Good
- CH Hawkes
- CH Hawkes
- D Galter
- D Guehl
- D Haubenberger
- DD Song
- DE Cabin
- DF D’Costa
- DG Healy
- DM Gash
- DR Graham
- DY Hwang
- DY Hwang
- E Bezard
- E Bezard
- E Guatteo
- E Maries
- E Masliah
- E Rockenstein
- E Sidransky
- E Sotiriou
- E Tolosa
- EH Norris
- EK Richfield
- EK Tan
- EL Unger
- F Hirth
- F Marxreiter
- G Anderson
- G Martella
- G Srivastava
- G Steg
- G Vogel
- GA Churchill
- GC Davis
- GE Meredith
- GK Tofaris
- GM Halliday
- H Braak
- H Fujishiro
- H Putten van der
- H Schell
- H Yoshino
- HF Poon
- HL Melrose
- HM Gao
- I Gureviciene
- I Gureviciene
- I Irwin
- I Magen
- IS Pienaar
- IU Isaias
- J Bieschke
- J Bove
- J Burre
- J Jankovic
- J Menendez
- J Simon-Sanchez
- JA Rodriguez-Navarro
- JB Watson
- JJ Palacino
- JK Andersen
- JM Fearnley
- JM Itier
- JP Daher
- JW Langston
- JW Langston
- K Haugarvoll
- K Larsen
- K Ono
- K Prasad
- KR Chaudhuri
- L Aron
- L Chen
- L Chen
- L Maskri
- L Wang
- L Yavich
- L Yavich
- LJ Martin
- LM Martins
- LS Forno
- M Frasier
- M Hashimoto
- M Ikeda
- M Inden
- M Liu
- M Neumann
- M Nieto
- M Oksman
- M Periquet
- M Plaas
- M Sedelis
- M Thiruchelvam
- M Wakamatsu
- M Wakamatsu
- MA Nalls
- MC Chartier-Harlin
- ME Emborg
- MF Beal
- MF Chesselet
- MG Spillantini
- MH Polymeropoulos
- MI Ekstrand
- MI Ekstrand
- MJ Liu
- MJ Thiruchelvam
- MK Lee
- MR Cookson
- MS Goldberg
- MW Bishop
- N Pankratz
- N Pankratz
- N Takahashi
- N Wu
- Nico J. Diederich
- O Rascol
- P Ibanez
- P Liu
- P Wellstead
- PA Robinson
- Paul M. A. Antony
- PG Ravenstijn
- PJ Kahle
- PO Fernagut
- PO Fernagut
- R Betarbet
- R Cavalcanti-Kwiatkoski
- R Coelln Von
- R Coelln Von
- R Katzenschlager
- R Kruger
- R Nass
- R Savica
- R Setsuie
- R Sharon
- RH Kim
- RM Miller
- Rudi Balling
- S George
- S Gispert
- S Gispert
- S Greffard
- S Nuber
- S O’Gorman
- SM Fleming
- SM Fleming
- SM Fleming
- SM Goldman
- SN Witt
- T Gasser
- T Gasser
- T Gomez-Isla
- T Kitada
- T Kitada
- T Yasuda
- TA Yacoubian
- TB Ahn
- TC Frank-Cannon
- TH McNeill
- TM Dawson
- TN Taylor
- U Ungerstedt
- U Ungerstedt
- VA Morais
- W Li
- W Satake
- W Zhou
- WH Yu
- WR Markesbery
- X Li
- X Lin
- X Su
- X Su
- XH Lu
- XR Zhu
- Y Li
- Y Lim
- Y Matsuoka
- Y Tong
- YJ Li
- YM Kuo
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Animal models with high predictive power are a prerequisite for translational research. The closer the similarity of a model to Parkinson’s disease (PD), the higher is the predictive value for clinical trials. An ideal PD model should present behavioral signs and pathology that resemble the human disease. The increasing understanding of PD stratification and etiology, however, complicates the choice of adequate animal models for preclinical studies. An ultimate mouse model, relevant to address all PD-related questions, is yet to be developed. However, many of the existing models are useful in answering specific questions. An appropriate model should be chosen after considering both the context of the research and the model properties. This review addresses the validity, strengths, and limitations of current PD mouse models for translational research
Determination of regional lung air volume distribution at mid-tidal breathing from computed tomography: A retrospective study of normal variability and reproducibility
- Author
- AW Reske
- C Yilmaz
- Caroline Majoral
- CCW Hsia
- CJ Galban
- EA Hoffman
- G De Nunzio
- Georges Caillibotte
- ICRP (International Commission for Radiological Protection) Publication 66
- Ira Katz
- J Conway
- J Graf
- J Ibanez
- J Stocks
- J Wanger
- John Fleming
- Joy Conway
- JR McClelland
- JS Fleming
- JS Fleming
- JS Fleming
- JS Fleming
- KJ Friston
- KL Boedeker
- LA De Backer
- MF Biddiscombe
- Michael Bennett
- MJ Porter
- MS Brown
- N Patroniti
- P Ravikumar
- PA Gevenois
- PKP Burnell
- S Hu
- S Montesantos
- S Perring
- S Takeda
- Spyridon Montesantos
- TB Grydeland
- V Sauret
- VA Zavaletta
- WJ Kim
- Z Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
© 2014 Fleming et al.; licensee BioMed Central Ltd. Background: Determination of regional lung air volume has several clinical applications. This study investigates the use of mid-tidal breathing CT scans to provide regional lung volume data.Methods: Low resolution CT scans of the thorax were obtained during tidal breathing in 11 healthy control male subjects, each on two separate occasions. A 3D map of air volume was derived, and total lung volume calculated. The regional distribution of air volume from centre to periphery of the lung was analysed using a radial transform and also using one dimensional profiles in three orthogonal directions.Results: The total air volumes for the right and left lungs were 1035 +/- 280 ml and 864 +/- 315 ml, respectively (mean and SD). The corresponding fractional air volume concentrations (FAVC) were 0.680 +/- 0.044 and 0.658 +/- 0.062. All differences between the right and left lung were highly significant (p < 0.0001). The coefficients of variation of repeated measurement of right and left lung air volumes and FAVC were 6.5% and 6.9% and 2.5% and 3.6%, respectively. FAVC correlated significantly with lung space volume (r = 0.78) (p < 0.005). FAVC increased from the centre towards the periphery of the lung. Central to peripheral ratios were significantly higher for the right (0.100 +/- 0.007 SD) than the left (0.089 +/- 0.013 SD) (p < 0.0001).Conclusion: A technique for measuring the distribution of air volume in the lung at mid-tidal breathing is described. Mean values and reproducibility are described for healthy male control subjects. Fractional air volume concentration is shown to increase with lung size.Air Liquid
Advances in structure elucidation of small molecules using mass spectrometry
- Author
- A Alexander
- A Broersen
- A Castro
- A Cuadros-Inostroza
- A Droit
- A Fredenhagen
- A Gordin
- A Kameyama
- A Kameyama
- A Kerber
- A Koulman
- A Luedemann
- A Makarov
- A Makarov
- A Makarov
- A Mitch
- A Nordstrom
- A Pelander
- A Ramos-Fernandez
- A Schmidt
- A Schreiber
- A Serb
- A Zhang
- A-EF Nassar
- AC Lee
- AD Hegeman
- AD Southam
- AG Marshall
- AG Marshall
- AG Pereira-Medrano
- AH Grange
- AH Grange
- AH Grange
- AH Payne
- AI Nepomuceno
- AJ Alexander
- AJ Richard
- AJ Williams
- AK Vrkic
- AL Heaton
- AL Piccinelli
- AL Rockwood
- AL Rockwood
- AL Rockwood
- AM Jennifer
- AN Lane
- AV Xianmei Cai
- AW Hill
- AWT Bristow
- B Christensen
- B Fan
- B Portet
- B Wen
- BD Nourse
- BL Ackermann
- BL Milman
- BO Keller
- BP Koch
- BS Mitrevski
- BY Renard
- C Birkemeyer
- C Brunnée
- C Hopley
- C Pan
- C Prakash
- C Seger
- C Tuniz
- C Vafiadi
- C Wittmann
- C Zhou
- CA Marchant
- CA Mueller
- CA Smith
- CE Wujcik
- CW Klampfl
- D Eric
- D Kuehl
- D Ryan
- D Schwudke
- D Sorensen
- D Strapoc
- DB Robb
- DB Robb
- DD Stranz
- DE Garcia
- DF Hochstrasser
- DJ Ashline
- DJ Weston
- DJ Weston
- DK Williams Jr
- DM Drexler
- DM Good
- DM Hawkins
- DM Horn
- DQ Liu
- DQ Liu
- DR Albaugh
- DS Cornett
- DS Wishart
- DS Wishart
- DS Wishart
- DW Hill
- DW Hill
- E Allard
- E Dudley
- E Gelpí
- E Gelpí
- E Gorlach
- E Hoffmann De
- E Pittenauer
- E Rijke de
- E Rosenberg
- E Skoczynska
- E Ventola
- E Werner
- EA Kapp
- EA Syrstad
- EC Tatsis
- ECM Chen
- EL Schymanski
- EL Schymanski
- EL Schymanski
- EM Thurman
- EM Thurman
- EM Thurman
- EP Go
- ER Wickremsinhe
- EW Deutsch
- EW Taylor
- F Cuyckens
- F Cuyckens
- F Kuhn
- F Matsuda
- F Matsuda
- F Milletti
- F Pont
- F Sacher
- F Steiner
- F Xu
- FF Hsu
- FF Hsu
- FF Hsu
- FW McLafferty
- FW McLafferty
- FW McLafferty
- FW McLafferty
- G Bouchoux
- G Bringmann
- G Chen
- G Hopfgartner
- G Miliauskas
- G Schlotterbeck
- G Yan
- GB Ge
- GE Hofmeister
- GJ Berkel Van
- GJ Dear
- GL Gauthier
- GL Glish
- GS Frysinger
- GS Gorman
- H Budzikiewicz
- H Chen
- H Chen
- H Choi
- H Gallart-Ayala
- H Hayen
- H Hayen
- H Hong
- H Horai
- H Kaspar
- H Lu
- H Neuweger
- H Oberacher
- H Oberacher
- H Rodriguez
- H Song
- H Zhang
- H Zhang
- H Zhang
- H Zhang
- HA Clark
- HF Sturt
- HJ Cooper
- HJ Sterling
- HK Lim
- HK Lim
- I Ferrer
- I Francois
- I Marchi
- I Molnár-Perl
- IA Kaltashov
- ID Wilson
- IG Zenkevich
- IM Lazar
- J Dalluge
- J Delaney
- J Diana
- J Downing
- J Draper
- J Han
- J Hummel
- J Hummel
- J Meija
- J Schiller
- J Schmidt
- J Segura
- J Somuramasami
- J Souady
- J Zhang
- J Zhang
- J-L Faulon
- JA Falkner
- JA Falkner
- JB Fenn
- JC Bradley
- JC Dickens
- JC Fjeldsted
- JC Hannis
- JC Schwartz
- JCL Erve
- JD Williams
- JE Biller
- JE Elias
- JEP Syka
- JG Stroh
- JH Futrell
- JH Gross
- JH Zhu
- JH Zhu
- JI Haleem
- JK Baker
- JK Wolken
- JL Holmes
- JL Little
- JL Wolfender
- JM Halket
- JM Kirk
- JM Phalp
- JR Wickens
- JS Brodbelt
- JS Forrester
- JS Sinninghe Damsté
- JS Splitter
- JSB Vlieger de
- JT Watson
- K Akiyama
- K Biemann
- K Dettmer
- K Dreisewerd
- K Guo
- K Heberger
- K Hobby
- K Horvath
- K Kandasamy
- K Katerina
- K Laniewski
- K Levsen
- K Levsen
- K Miyamoto
- K Qian
- K Schug
- K Varmuza
- K Yang
- KG Lloyd
- KP Bateman
- KR Jonscher
- KW Cheng
- KX Wan
- L Calcagnile
- L Dinan
- L Feldberg
- L Karsten
- L Leclercq
- L Li
- L Li
- L Mondello
- L Ramaley
- L Sleno
- L Sleno
- L Yang
- L Zhang
- LA McDonnell
- LC Short
- LM Fell
- M Adahchour
- M Badertscher
- M Bedair
- M Bogusz
- M Brown
- M Eggink
- M Emmerling
- M Fernandes-Whaley
- M Gergov
- M Gfrerer
- M Gu
- M Hamacher
- M Heinonen
- M Holcapek
- M Ibanez
- M Jalali-Heravi
- M Karas
- M Karelson
- M Kellmann
- M Kiffe
- M Krauss
- M Krummen
- M Lehane
- M Mann
- M Okamoto
- M Palit
- M Pavlic
- M Pulfer
- M Scheurell
- M Scholz
- M Trunzer
- M Wind
- M Wind
- M Yao
- M Zhu
- MA Eash
- ME Elyashberg
- ME Hansen
- MG Zampolli
- ML Bandu
- MM Savitski
- MM Siegel
- MM Yao
- MP Balogh
- MP Balogh
- MP Balogh
- MP Washburn
- MR Anari
- MR Anari
- MS Bereman
- MS Molchanova
- MT Olson
- MT Rodgers
- MT Sheldon
- N Hertkorn
- N Huang
- N Jaitly
- N Ohashi
- N Reig
- NB Cech
- NE Manicke
- O Corcoran
- O David Sparkman
- O Fiehn
- O Fiehn
- O Pelkonen
- OM Saad
- OV Krokhin
- P Ausloos
- P Calza
- P Dwivedi
- P Fontana
- P Giavalisco
- P Kiousi
- P Lampen
- P Marriott
- P McCormack
- P Mendes
- P Murray-Rust
- P Schmitt-Kopplin
- P Zhu
- PA Sutton
- PB Lukka
- PC Carvalho
- PE Adams
- PE Sauer
- PGA Pedrioli
- Q Li
- Q Li
- Q Xiong
- R Almeida
- R Baigorri
- R Harkewicz
- R Hellborg
- R Kaliszan
- R Knochenmuss
- R Kostiainen
- R Li
- R Mylonas
- R Nakabayashi
- R Ramanathan
- R Samudrala
- R Schiewek
- R Wu
- R Zenobi
- RA Scheltema
- RA Shellie
- RA Zubarev
- RA Zubarev
- RB Cody
- RD Loss
- RF Staack
- RG Cooks
- RG Cooks
- RG Dromey
- RH Perry
- RJ Beynon
- RJ Mortishire-Smith
- RJ Mortishire-Smith
- RK Snider
- RM Smith
- RM Smith
- RP Lattimer
- RS Plumb
- RS Plumb
- RT Kelly
- S Bocker
- S Bocker
- S Borth
- S Bourcier
- S Buckingham
- S Christophoridou
- S Dresen
- S Dua
- S Ekins
- S Jarussophon
- S Kim
- S Kothari
- S Ma
- S Nojima
- S Ojanpera
- S Rogers
- S Sang
- S Su
- S Trimpin
- S Urayama
- S Wolf
- SA McLuckey
- SC Bell
- SC Habicht
- SE Ong
- SE Scheppele
- SE Stein
- SE Stein
- SE Stein
- SE Stein
- SF Anabel
- SG Roussis
- SG Villas-Bôas
- SJ Bos
- SJ Gaskell
- SJ Rochfort
- SJ Valentine
- SS Ebada
- SS Rubakhin
- SY Ow
- T Alon
- T Alon
- T Beier
- T Chen
- T Kind
- T Kind
- T Kind
- T Kind
- T Kind
- T Lynch
- T Reemtsma
- T Shinkawa
- TA Lydic
- TA Ternes
- TA Ternes
- TG Payne
- TJ Kauppila
- TM Kertesz
- TM Kertesz
- TM Schaub
- TR Covey
- TR Northen
- TR Sana
- TRI Cataldi
- V Exarchou
- V Kovácik
- V Sanz-Nebot
- V Vukics
- V Zaikin
- VA Petyuk
- VI Babushok
- VV Mihaleva
- W Timm
- W Windig
- W Zhong
- W Zou
- WC Byrdwell
- WC Byrdwell
- WC Yang
- WF Smyth
- WMA Niessen
- WTB Anthony
- X Feng
- X Han
- X Liang
- X-J Li
- XY Zhu
- Y Cai
- Y Chen
- Y Chen
- Y Duan
- Y Konishi
- Y Lin
- Y Liu
- Y Park
- Y Sawada
- Y Shinbo
- Y Wang
- Y Wang
- YA Jeilani
- YK Wang
- YR Luo
- Z Tozuka
- Z Yeping
- ZP Yao
- Publication venue
- Springer Vienna
- Publication date
- 01/01/2010
- Field of study
The structural elucidation of small molecules using mass spectrometry plays an important role in modern life sciences and bioanalytical approaches. This review covers different soft and hard ionization techniques and figures of merit for modern mass spectrometers, such as mass resolving power, mass accuracy, isotopic abundance accuracy, accurate mass multiple-stage MS(n) capability, as well as hybrid mass spectrometric and orthogonal chromatographic approaches. The latter part discusses mass spectral data handling strategies, which includes background and noise subtraction, adduct formation and detection, charge state determination, accurate mass measurements, elemental composition determinations, and complex data-dependent setups with ion maps and ion trees. The importance of mass spectral library search algorithms for tandem mass spectra and multiple-stage MS(n) mass spectra as well as mass spectral tree libraries that combine multiple-stage mass spectra are outlined. The successive chapter discusses mass spectral fragmentation pathways, biotransformation reactions and drug metabolism studies, the mass spectral simulation and generation of in silico mass spectra, expert systems for mass spectral interpretation, and the use of computational chemistry to explain gas-phase phenomena. A single chapter discusses data handling for hyphenated approaches including mass spectral deconvolution for clean mass spectra, cheminformatics approaches and structure retention relationships, and retention index predictions for gas and liquid chromatography. The last section reviews the current state of electronic data sharing of mass spectra and discusses the importance of software development for the advancement of structure elucidation of small molecules
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
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- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang K
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- Zhang M
- Zhang M
- Zhang Q
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- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
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- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
- Author
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- Abbott B
- Abbott DC
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- Abhayasinghe DK
- Abidi SH
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- Zhang G
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- Zhemchugov A
- Zheng Z
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- Zieminska D
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √=13TeV
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- Zemaityte G
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- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
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- Zhu C
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- Zhu H
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- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb−1 of s√=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38−0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
Muon reconstruction and identification efficiency in ATLAS using the full Run 2 pp collision data set at \sqrt{s}=13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Agullo PM
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahnen JV
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
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- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
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- Alves FLL
- Alviggi MG
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov AV
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- Laudrain A
- Laurier A
- Lavorgna M
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- Yigitbasi E
- Yildiz HD
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- Zaffaroni E
- Zahreddine J
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- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zeissner SV
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhu C
- Zhu CG
- Zhu H
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
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- Zivkovic L
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- Zorbas TG
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2021
- Field of study
This article documents the muon reconstruction and identification efficiency obtained by the ATLAS experiment for 139 \hbox {fb}^{-1} of pp collision data at \sqrt{s}=13 TeV collected between 2015 and 2018 during Run 2 of the LHC. The increased instantaneous luminosity delivered by the LHC over this period required a reoptimisation of the criteria for the identification of prompt muons. Improved and newly developed algorithms were deployed to preserve high muon identification efficiency with a low misidentification rate and good momentum resolution. The availability of large samples of Z\rightarrow \mu \mu and J/\psi \rightarrow \mu \mu decays, and the minimisation of systematic uncertainties, allows the efficiencies of criteria for muon identification, primary vertex association, and isolation to be measured with an accuracy at the per-mille level in the bulk of the phase space, and up to the percent level in complex kinematic configurations. Excellent performance is achieved over a range of transverse momenta from 3 GeV to several hundred GeV, and across the full muon detector acceptance of |\eta |<2.7
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