The influence of age on tooth supported fixed prosthetic restoration longevity. A systematic review

OBJECTIVE: The purpose of this study was to investigate the possible influence of age on the longevity of tooth supported fixed prosthetic restorations, using a systematic review process. DATA SOURCES: To identify relevant papers an electronic search was made using various databases (MEDLINE via Pubmed, EMBASE, The Cochrane Register of RCTs, the database of abstracts of Reviews of Effects-DARE), augmented by hand searching of key prosthodontic journals (International Journal of Prosthodontics, Journal of Prosthetic Dentistry and Journal of Prosthodontics) and reference cross-check. STUDY SELECTION: Assessment and selection of studies identified were conducted in a two phase procedure, by two independent reviewers utilizing specific inclusion and exclusion criteria. The minimum mean follow-up time was set at 5 years. RESULTS: The initial database search yielded 513 relevant titles. After the subsequent filtering process, 22 articles were selected for full-text analysis, finally resulting in 11 studies that met the inclusion criteria. All studies were classified as category C according to the strength of evidence. Meta-analysis was not possible due to the non-uniformity of the data available. The final studies were presented with conflicting results. The majority of the final studies did not report a statistically significant effect of age on fixed prostheses survival, whilst only one study reported poorer prognosis for elderly patients, and two studies reported poorer prognosis for middle-aged patients. CONCLUSIONS: The results of this systematic review showed that increased age of patients should not be considered as a risk factor for the survival of fixed prostheses. Although the majority of studies did not show any effect of age on the survival of fixed prostheses, there was some evidence that middle-aged patients may present with higher failure rates

Nematic-Isotropic Transition with Quenched Disorder

Nematic elastomers do not show the discontinuous, first-order, phase transition that the Landau-De Gennes mean field theory predicts for a quadrupolar ordering in 3D. We attribute this behavior to the presence of network crosslinks, which act as sources of quenched orientational disorder. We show that the addition of weak random anisotropy results in a singular renormalization of the Landau-De Gennes expression, adding an energy term proportional to the inverse quartic power of order parameter Q. This reduces the first-order discontinuity in Q. For sufficiently high disorder strength the jump disappears altogether and the phase transition becomes continuous, in some ways resembling the supercritical transitions in external field.Comment: 12 pages, 4 figures, to be published on PR

Can one hear the shape of the Universe?

It is shown that the recent observations of NASA's explorer mission "Wilkinson Microwave Anisotropy Probe" (WMAP) hint that our Universe may possess a non-trivial topology. As an example we discuss the Picard space which is stretched out into an infinitely long horn but with finite volume.Comment: 4 page

Quenched disorder and spin-glass correlations in XY nematics

We present a theoretical study of the equilibrium ordering in a 3D XY nematic system with quenched random disorder. Within this model, treated with the replica trick and Gaussian variational method, the correlation length is obtained as a function of the local nematic order parameter and the effective disorder strength. These results clarify what happens in the limiting cases of diminishing order parameter and disorder strength, that is near a phase transition of a pure system. In particular, it is found that quenched disorder is irrelevant as the order parameter tends to zero and hence does not change the character of the continuous XY nematic to isotropic phase transition. We discuss how these results compare with experiments and simulationsComment: 19 pages, 6 figures, corrected typo

Mechanism of lignin inhibition of enzymatic biomass deconstruction

Background The conversion of plant biomass to ethanol via enzymatic cellulose hydrolysis offers a potentially sustainable route to biofuel production. However, the inhibition of enzymatic activity in pretreated biomass by lignin severely limits the efficiency of this process. Results By performing atomic-detail molecular dynamics simulation of a biomass model containing cellulose, lignin, and cellulases (TrCel7A), we elucidate detailed lignin inhibition mechanisms. We find that lignin binds preferentially both to the elements of cellulose to which the cellulases also preferentially bind (the hydrophobic faces) and also to the specific residues on the cellulose-binding module of the cellulase that are critical for cellulose binding of TrCel7A (Y466, Y492, and Y493). Conclusions Lignin thus binds exactly where for industrial purposes it is least desired, providing a simple explanation of why hydrolysis yields increase with lignin removal

Levels of interaction: a user-guided experience in large-scale virtual environments

This paper investigates a range of challenges faced in the design of a serious game, teaching history to a player immersed in an 'open' virtual environment. In the context of this paper, such an environment is described as an exploratory, expansive virtual world within which a user may interact in a non-linear, situated fashion with both the environment and virtual characters. The main contribution of this paper consists in the introduction of the levels of interaction (LoI), a novel framework designed to assist in the creation of interactions between the player and characters. The LoI approach also addresses the necessity for balancing computational efficiency with the need to provide believable and interactive virtual characters, by allowing varying degrees of animation, display and, ultimately, interaction detail. This paper demonstrates the challenges faced when implementing such a technique, as well as the potential benefits it brings

Self-powered, flexible and room temperature operated solution processed hybrid metal halide p-type sensing element for efficient hydrogen detection

Hydrogen (H2) is a well-known reduction gas and for safety reasons is very important to be detected. The most common systems employed along its detection are metal oxide-based elements. However, the latter demand complex and expensive manufacturing techniques, while they also need high temperatures or UV light to operate effectively. In this work, we first report a solution processed hybrid mixed halide spin coated perovskite films that have been successfully applied as portable, flexible, self-powered, fast and sensitive hydrogen sensing elements, operating at room temperature. The minimum concentrations of H2 gas that could be detected was down to 10 ppm. This work provides a new pathway on gases interaction with perovskite materials, launches new questions that must be addressed regarding the sensing mechanisms involved due to the utilization of halide perovskite sensing elements while also demonstrates the potential that these materials have on beyond solar cell applications

Factors affecting the chemical efficacy of 2% sodium hypochlorite against oral steady-state dual-species biofilms:Exposure time and volume application

Aim To study the influence of time and volume of 2% sodium hypochlorite (NaOCl) on biofilm removal and to investigate the changes induced on the biofilm architecture. Steady-state, dual-species biofilms of standardized thickness and a realistic contact surface area between biofilms and NaOCl were used. Methodology Streptococcus oralis J22 and Actinomyces naeslundii T14V-J1 biofilms were grown on saliva-coated hydroxyapatite discs within sample holders in the Constant Depth Film Fermenter (CDFF) for 96 h. Two per cent NaOCl was statically applied for three different time intervals (60, 120 and 300 s) and in two different volumes (20 and 40 mu L) over the biofilm samples. The diffusion-driven effects of time and volume on biofilm disruption and dissolution were assessed with Optical Coherence Tomography (OCT). Structural changes of the biofilms treated with 2% NaOCl were studied with Confocal Laser Scanning Microscopy (CLSM) and Low Load Compression Testing (LLCT). A two-way analysis of variance (2-way anova) was performed, enabling the effect of each independent variable as well as their interaction on the outcome measures. Results Optical coherence tomography revealed that by increasing the exposure time and volume of 2% NaOCl, both biofilm disruption and dissolution significantly increased. Analysis of the interaction between the two independent variables revealed that by increasing the volume of 2% NaOCl, significant biofilm dissolution could be achieved in less time. Examination of the architecture of the remaining biofilms corroborated the EPS-lytic action of 2% NaOCl, especially when greater volumes were applied. The viscoelastic analysis of the 2% NaOCl-treated biofilms revealed that the preceding application of higher volumes could impact their subsequent removal. Conclusions Time and volume of 2% NaOCl application should be taken into account for maximizing the anti-biofilm efficiency of the irrigant and devising targeted disinfecting regimes against remaining biofilms