Global Value Chains during the Great Trade Collapse: A Bullwhip Effect?

This paper analyzes the performance of global value chains during the trade collapse. To do so, it exploits a unique transaction-level dataset on French firms containing information on cross-border monthly transactions matched with data on worldwide intra-firm linkages as defined by property rights (multinational business groups, hierarchies of firms). This newly assembled dataset allows us to distinguish firm-level transactions among two alternative organizational modes of global value chains: internalization of activities (intra-group trade/trade among related parties) or establishment of supply contracts (arm’s length trade/trade among unrelated parties). After an overall assessment of the role of global value chains during the trade collapse, we document that intra-group trade in intermediates was characterized by a faster drop followed by a faster recovery than arm’s length trade. Amplified fluctuations in terms of trade elasticities by value chains have been referred to as the "bullwhip effect" and have been attributed to the adjustment of inventories within supply chains. In this paper we first confirm the existence of such an effect due to trade in intermediates, and we underline the role that different organizational modes can play in driving this adjustment.trade collapse, multinational firms, global value chains, hierarchies of firms, vertical integration.

Direct dynamics of 2D cable-driven parallel robots including cables mass effect and its influence in the control performance

Cable-driven parallel robots are a type of parallel manipulators where rigid links are replaced by actuated cables. Although in many cases dynamic models that neglect the cables mass and elasticity are employed to simulate the robot behavior and test the control approach to be used, there are several situations in which their effect cannot be disregarded, especially when large span cables are used, and the cable mass density generates important cable sagging. This work proposes a dynamic model for planar cable-driven parallel robots with 3 degrees-of-freedom considering cables mass and elasticity. Furthermore, the effect of using control approaches based on massless inelastic cables dynamic models on robots with non-negligible cable mass and elasticity is finally assessed

Control strategy and performance of a small-size thermally integrated Carnot battery based on a Rankine cycle and combined with district heating

To encourage decarbonization and promote a widespread penetration of renewable energy sources in all energy sectors, the development of efficient energy storage systems is essential. Interesting grid-scale electricity storage technologies are the Carnot batteries, whose working principle is based on storing electricity in the form of thermal energy. The charging phase is performed through a heat pump cycle, and the discharging phase is conducted through a heat engine. Since both thermal and electric energy flows are involved, Carnot batteries can be adopted to provide more flexibility in heat and power energy systems. To this aim, efficient scheduling strategies are necessary to manage different energy flows. In this context, this work presents a detailed rule-based control strategy to schedule the synergetic work of a 10-kWe reversible heat pump/organic Rankine cycle Carnot battery integrated to a district heating substation and a photovoltaic power plant, to satisfy a local user's thermal and electric demand. The coupling of a Carnot battery with a district heating substation allows for shaving the thermal demand peaks through the thermal energy stored in the Carnot battery storage, allowing for a downsizing of the district heating substation, with a considerable reduction of the investment costs. Due to the multiplicity of the involved energy flows and the numerous modes of operation, a scheduling logic for the Carnot battery has been developed, to minimize the system operating costs, depending on the boundary conditions. To investigate the influence of the main system design parameters, a detailed and accurate model of the Carnot battery is adopted. Two variants of the reference system, with different heat pump cold source arrangements, are investigated. In the first case, the heat pump absorbs thermal energy from free waste heat. In the second case, the heat pump cold source is the return branch of the district heating substation. The simulation results show that, in the first case, the Carnot battery allows the downsizing of the district heating substation by 47 %, resulting in an annual gain of more than 5000 €. About 70 % of the economic benefit is due to the possibility of reducing the power size of the district heating substation, which can be from 300 to more than 500 kW. The payback period is estimated to be lower than 9 years, while in the second case, the Carnot battery is not able to provide a gain. Eventually, the influence of some parameters, such as the photovoltaic power plant surface, the storage volume, the electricity price profile and the reversible heat pump/organic Rankine cycle specific investment cost, on the techno-economic performance of the system, is investigated through a wide sensitivity analysis. According to the results, the photovoltaic panels surface does not significantly affect the economic gain, while the storage capacity strongly affects the system scheduling and the operating costs. Indeed, it is possible to identify that 13 m3 is the size of the storage volume that minimizes the payback period to 8.22 years, for the considered application. An increase in the electricity price without an increase in the thermal energy price leads to a decrease in economic gain because the benefit brought by the downsizing of district heating is less significant on the economic balance. The specific investment cost of the reversible heat pump/organic Rankine cycle does not influence the operating cost; thus, it does not change the Carnot battery management, nor the economic gain. The specific investment cost affects the payback period, which increases from 8.6 years for a specific cost of 2000 €/kWe to 15.7 years for a specific cost of 5000 €/kWe

Dynamic Control of a Novel Planar Cable-Driven Parallel Robot with a Large Wrench Feasible Workspace

Cable-Driven Parallel Robots (CDPRs) are special manipulators where rigid links are replaced with cables. The use of cables offers several advantages over the conventional rigid manipulators, one of the most interesting being their ability to cover large workspaces since cables are easily winded. However, this workspace coverage has its limitations due to the maximum permissible cable tensions, i.e., tension limitations cause a decrease in the Wrench Feasible Workspace (WFW) of these robots. To solve this issue, a novel design based in the addition of passive carriages to the robot frame of three degrees-of-freedom (3DOF) fully-constrained CDPRs is used. The novelty of the design allows reducing the variation in the cable directions and forces increasing the robot WFW; nevertheless, it presents a low stiffness along the x direction. This paper presents the dynamic model of the novel proposal together with a new dynamic control technique, which rejects the vibrations caused by the stiffness loss while ensuring an accurate trajectory tracking. The simulation results show that the controlled system presents a larger WFW than the conventional scheme of the CDPR, maintaining a good performance in the trajectory tracking of the end-effector. The novel proposal presented here can be applied in multiple planar applications

Reactive Metals as Energy Storage and Carrier Media: Use of Aluminum for Power Generation in Fuel Cell-Based Power Plants

In recent years, the energy production sector has experienced a growing interest in new energy vectors enabling energy storage and, at the same time, intersectoral energy applications among users. Hydrogen is one of the most promising energy storage and carrier media featuring a very high gravimetric energy density, but a rather low volumetric energy density. To this regard, this study focuses on the use of aluminum as energy storage and carrier medium, offering high volumetric energy density (23.5 kWh L$^{-1}$), ease to transport and stock (e.g., as ingots), and is neither toxic nor dangerous when stored. In addition, mature production and recycling technologies exist for aluminum. Herein, the performance of power systems driven by aluminum powder in terms of electrical efficiency (η$_{(I)}$) and round‐trip efficiency (RTE) is analyzed. Along with the additional advantages relating to high volumetric energy density, and safety and management aspects, the aluminum‐based technology appears to outperform the power‐to‐power systems based on hydrogen and liquid fuels

Biomimetic graphene for enhanced interaction with the external membrane of astrocytes

© The Royal Society of Chemistry. Graphene and graphene substrates display huge potential as material interfaces for devices and biomedical tools targeting the modulation or recovery of brain functionality. However, to be considered reliable neural interfaces, graphene-derived substrates should properly interact with astrocytes, favoring their growth and avoiding adverse gliotic reactions. Indeed, astrocytes are the most abundant cells in the human brain and they have a crucial physiological role to maintain its homeostasis and modulate synaptic transmission. In this work, we describe a new strategy based on the chemical modification of graphene oxide (GO) with a synthetic phospholipid (PL) to improve interaction of GO with brain astroglial cells. The PL moieties were grafted on GO sheets through polymeric brushes obtained by atom-transfer radical-polymerization (ATRP) between acryloyl-modified PL and GO nanosheets modified with a bromide initiator. The adhesion of primary rat cortical astrocytes on GO-PL substrates increased by about three times with respect to that on glass substrates coated with standard adhesion agents (i.e. poly-d-lysine, PDL) as well as with respect to that on non-functionalized GO. Moreover, we show that astrocytes seeded on GO-PL did not display significant gliotic reactivity, indicating that the material interface did not cause a detrimental inflammatory reaction when interacting with astroglial cells. Our results indicate that the reported biomimetic approach could be applied to neural prosthesis to improve cell colonization and avoid glial scar formation in brain implants. Additionally, improved adhesion could be extremely relevant in devices targeting neural cell sensing/modulation of physiological activity

Experimental Performance of a Micro-ORC Energy System for Low Grade Heat Recovery

Abstract The state-of-the art of ORC energy systems is mainly dominated by large scale units in the MW range of power output, in the field of heat recovery at mid-high temperature levels (around 200-500°C), where multiple commercial realizations are available. Nevertheless, the cutting-edge niche of micro-ORC energy systems offers good solutions for low-temperature heat recovery. Many prototypes are currently under investigations, but a leading technology is not yet established. This work reports an experimental activity carried out for performance characterization of a prototypal micro-ORC energy system. In particular, the paper presents the test bench developed in the laboratories of the University of Bologna and the first obtained results in terms of thermodynamic performance and main components characteristics. The ORC system comprises a small reciprocating three-piston expander, run on R134a as operating fluid. Heat is provided to the ORC from an external source, via hot water at temperature below 100 °C, in order to simulate a low-enthalpy heat recovery process. The system rejects unused heat via a water cooled condenser. Thus, the investigated ORC is a plug and play system, requiring only to be connected to the hot and cold heat sources. The ORC system has been tested for prolonged operation at various thermal input conditions. In particular, the behavior of the key cycle parameters and performance indexes (e.g. max. and min. pressures, superheating temperature, expander isentropic efficiency, electric power output, etc.) are investigated as function of pump rotational speed (i.e. organic fluid mass flow rate), for three different set point values of the hot source (65 °C, 75 °C, 85 °C). The operating thermodynamic cycle has been completely characterized by means of a real-time measurement and acquisition tool, developed in LabVIEW environment. Performance variations of the system have been monitored: the electric power output ranges between 0.30 to 1.2 kW, with gross efficiency in the range 2.9-4.4 %, while the expander "electro-isentropic" efficiency results in the range of 35-42 %

One step closer to influenza vaccine inclusiveness

Flu virus infection is a common cause of acute respiratory illness, with the major incidence in pediatric age, high morbidity, and mortality. The flu vaccine is recommended for all people aged ≥6 months, unless specific contraindications are present. Younger and older age, pregnancy, chronic diseases like asthma, and immunodeficiency are risk factors for severe complications following flu infection. Thus, these categories represent the target for flu vaccine strategies in most countries. Inactivated influenza vaccine (IIV), recombinant influenza vaccine (RIV) or live‐attenuated influenza virus (LAIV) are currently available, with specific precautions and contraindications. We aim to resume the current indications for vaccines in the vulnerable populations to support flu vaccination inclusiveness, in anticipation of a “universal vaccine” strategy

Cytokine release syndrome after CAR infusion in pediatric patients with refractory/relapsed B-ALL: is there a role for diclofenac?

BACKGROUND: Cytokine release syndrome (CRS) is a major complication after chimeric-antigen receptor T-cell treatment, characterized by an uncontrolled systemic inflammatory reaction. We investigated the potential role of diclofenac in the management of CRS in five pediatric patients treated for relapsed/refractory B-lineage acute lymphoblastic leukemia. METHODS: In case of persistent fever with fever-free intervals shorter than 3 hours, diclofenac continuous infusion was initiated, at the starting dose of 0.5 mg/Kg/day, the lowest effective pediatric dose in our experience, possibly escalated up to 1 mg/Kg/day, as per institutional guidelines. RESULTS: CRS occurred at a median of 20 hours (range 8–27) after tisagenlecleucel infusion. Diclofenac was started at a median of 20 hours (range 13–33) after fever onset. A mean of 3.07 febrile peaks without diclofenac and 0.95 with diclofenac were reported (p = 0.02). Clinical benefit was achieved by hampering the progression of tachypnea and tachycardia. Despite fever control, CRS progressed in four of the five patients, and hypotension requiring vasopressors and fluid retention, as well as hypoxia, occurred. Vasopressors were followed by 1–2 doses of tocilizumab (one in patient 2 and two in patients 3, 4, and 5), plus steroids in patients 4 and 5. CONCLUSION: Based on a limited number of patients, diclofenac leads to better fever control, which translates into symptom relief and improvement of tachycardia, but could not prevent the progression of CRS

Therapeutic sequences in patients with grade 1−2 neuroendocrine tumors (NET): an observational multicenter study from the ELIOS group

Purpose: Many different treatments are suggested by guidelines to treat grade 1−2 (G1−G2) neuroendocrine tumors (NET). However, a precise therapeutic algorithm has not yet been established. This study aims at identifying and comparing the main therapeutic sequences in G1−G2 NET. Methods: A retrospective observational Italian multicenter study was designed to collect data on therapeutic sequences in NET. Median progression-free survival (PFS) was compared between therapeutic sequences, as well as the number and grade of side effects and the rate of dose reduction/treatment discontinuation. Results: Among 1182 patients with neuroendocrine neoplasia included in the ELIOS database, 131 G1–G2 gastroenteropancreatic, lung and unknown primary NET, unresectable or persistent/relapsing after surgery, treated with ≥2 systemic treatments, were included. Four main therapeutic sequences were identified in 99 patients: (A) somatostatin analogs (SSA) standard dose to SSA high dose (n = 36), (B) SSA to everolimus (n = 31), (C) SSA to chemotherapy (n = 17), (D) SSA to peptide receptor radionuclide therapy (PRRT) (n = 15). Median PFS of the second-line treatment was not reached in sequence A, 33 months in sequence B, 20 months in sequence C, 30 months in sequence D (p = 0.16). Both total number and severity of side effects were significantly higher in sequences B and C than A and D (p = 0.04), as well as the rate of dose reduction/discontinuation (p = 0.03). Conclusions: SSA followed by SSA high dose, everolimus, chemotherapy or PRRT represent the main therapeutic sequences in G1−G2 NET. Median PFS was not significantly different between sequences. However, the sequences with SSA high dose or PRRT seem to be better tolerated than sequences with everolimus or chemotherapy