The influence of the moisture content of microcrystalline cellulose on the coating process in a fluidized bed

Overweight and obesity is a health threat of increasing concern and understanding the neurobiology behind obesity is instrumental to the development of effective treatment regimes. Serotonergic neurotransmission is critically involved in eating behaviour; cerebral level of serotonin (5-HT) in animal models is inversely related to food intake and body weight and some effective anti-obesity agents involve blockade of the serotonin transporter (SERT). We investigated in 60 healthy volunteers body mass index (BMI) and regional cerebral SERT binding as measured with [(11)C]DASB PET. In a linear regression model with adjustment for relevant covariates, we found that cortical and subcortical SERT binding was negatively correlated to BMI (-0.003 to -0.012 BP(ND) unit per kg/m(2)). Tobacco smoking and alcohol consumption did not affect cerebral SERT binding. Several effective anti-obesity drugs encompass blockade of the SERT; yet, our study is the first to demonstrate an abnormally decreased cerebral SERT binding in obese individuals. Whether the SERT has a direct role in the regulation of appetite and eating behaviour or whether the finding is due to a compensatory downregulation of SERT secondary to other dysfunction(s) in the serotonergic transmitter system, such as low baseline serotonin levels, remains to be established

A tale of two worlds:assessing the vulnerability of enclave shielding runtimes

status: publishe

Social implications of new mediated spaces: The need for a rethought design approach

Departing from the traditional understanding of the social implications of urban design and the underlying notion of ‘place’, the chapter first questions its current relevance vis-à-vis the mediated city. It examines whether ICT has given rise to the establishment of new notions of space and place, identifying new design challenges for cities and rethought approaches to the production of space. In view of the latter, the chapter subsequently questions the manner with which digital media may facilitate inclusive design of public spaces. In order to address this objective, the chapter illustrates some interesting empirical data emanating from literature and research projects based in the UK, Poland and Malta. The case studies in the literature illustrate how ICTs are being used as tools within participatory processes for the inclusive design of urban public and recreational spaces and in order to gauge citizen/user expectations towards urban space. The chapter finally attempts to redefine public participation through ICT and to frame the above discussion within the potentially newly redefined role of urban designers involved in such processes. The underlying question to be addressed in this chapter, therefore, has to deal with the manner with which urban professionals may effectively achieve inclusive participatory design, particularly in light of new phenomena brought about by the mediated city and with the potential of this newly obtained and enriched data

FAPα and αSMA mark different subsets of fibroblasts in normal kidney and conventional renal cell carcinoma

Several studies suggested a correlation between cancer associated fibroblasts (CAF) and cancer progression, but data on conventional renal cell carcinoma (cRCC) is still lacking. We aimed to analyse the impact of αSMA positive myo-CAF and FAPα expressing i-CAF on postoperative relapse of cRCC. We applied immunohistochemistry on tissue-multiarray (TMA) containing 736 consecutively operated cRCC without metastasis at the time of diagnosis. We analysed the correlation between the amount and pattern of αSMA and FAPα expressing CAFs and tumour cells and postoperative tumour relapse. Stromal fibroblasts of each cRCC displayed αSMA immunreaction but only 142 of the 736 tumours showed positive FAPα staining. There was no correlation between the amount of αSMA and or FAPα positive CAFs and tumour progression. However, tumours with large tourtous vessels with strong αSMA positive immunreaction have more then two times higher risk of postoperative tumour relapse (RR=2.198, p = 0.005). Patients with cRCC (57) showing cytoplasmic αSMA staining of tumour cells had a nearly two times higher risk for postoperative progression (RR=1.776, p = 0.014).There is no significant correlation between the density of αSMA or FAPα positive CAFs and postoperative relapse of cRCCs, therefore CAFs in cRCC are not suitable targets for therapy. Further limitation of anti-CAF therapy of cRCC that stromal cells of normal kidney are positive with αSMA antibody

Motor preparation, motor execution, attention, and executive functions in attention deficit/hyperactivity disorder (ADHD)

Attention and executive functions were investigated in medicated and unmedicated children with ADHD combined type using a novel selective reaching task. This task involved responding as rapidly as possible to a target while at times having to ignore a distractor. Results indicated that unmedicated children with ADHD showed slow and inaccurate responding. Slow responding reflected problems at the stage of movement preparation but not movement execution. An attentional impairment, rather than a motor planning problem per se, appeared to underlie the slow movement preparation. Inaccurate responding reflected problems with response inhibition and selective attention, impulsivity, set- shifting, and difficulties in maintaining vigilance. Although medicated children with ADHD did not show slow movement preparation, they did show some response inaccuracy, resulting especially from impulsive responding. These findings suggest that ADHD is characterized by slow motor preparation ( but not motor execution), and deficits in selective attention, vigilance, and executive functions. Preliminary results suggest that stimulant medication may resolve some of these motor, attentional and executive function deficits