A Case of Osteonecrosis of the Jaw in a Patient with Crohn's Disease Treated with Infliximab

Background: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse drug reaction, occurring in patients undergoing treatments with antiresorptive or antiangiogenic agents, such as bisphosphonates, denosumab, or bevacizumab, for different oncologic and non-oncologic diseases. The aim of this study was to report a case of MRONJ in a patient taking infliximab, an anti-TNF-alpha antibody used to treat Crohn's disease, rheumatoid arthritis, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis. Case Report: A 49-year-old female patient affected by Crohn's disease, who had been undergoing 250 mg intravenous infliximab every six weeks for 12 years, with no history of antiresorptive or antiangiogenic agent administration, came to our attention for post-surgical MRONJ, associated with a wide cutaneous necrotic area of her anterior mandible. Following antibiotic cycles, the patient underwent surgical treatment with wide bone resection and debridement of necrotic tissues; after prolonged follow-up (16 months), the patient completely healed without signs of recurrence. Conclusions: Prevention of MRONJ by dental check-up before and during treatments with antiresorptive treatments (bisphosphonates or denosumab) is a well-established procedure. Although further studies are required to confirm the role of infliximab in MRONJ, based on the results of this study, we propose that patients who are going to be treated with infliximab should also undergo dental check-up before starting therapy, to possibly avoid MRONJ onset

Study on the differences of BMI between olms found in cave and the ones sampled in spring

The olm (Proteus anguinus) is a blind amphibian, depigmented and with an extremely reduced metabolism. These are adaptations to cave life that allow the animals to exploit this hostile (from a human perspective) habitat. Adaptations to cave life, should prevent successful exploitation of the external environment. However, although the Proteus is a cave animal, it has been reported by some authors in the spring environment, Our previous results showed that this presence, would seem not to be random, in but linked to very specific factors such as hydroperiod the absence of potential predators. In the light of these results, we have conducted a study with the aim of verifying whether the Proteus benefits from exploiting the trophic resources occurring in springs. Since June 2020 we have sampled 64 springs and 12 caves in the Monfalcone province, each olm found during the sampling was photographed, measured and weighed. A total of 73 different olms were analyzed and the Body Mass Index (BMI) was calculated for each individual. Olms found in springs had a significantly higher BMI than those found in caves. The BMI of springs’ olms was significantly related to amount of the trophic available, evidencing that they took advantages from exploiting the external environment. These results contribute to support the hypothesis of the non-random presence of the Proteus in the spring environment, the olm, in fact, seem to benefit from this type of habitat taking advantage of the greater number of resources present in it

Choreography Rehearsal ⋆

Abstract. We propose a methodology for statically predicting the possible interaction patterns of services within a given choreography. We focus on choreographies exploiting the event notification paradigm to manage service interactions. Control Flow Analysis techniques statically approximate which events can be delivered to match the choreography constraints and how the multicast groups can be optimised to handle event notification within the service choreography.

Predictive score using clinical and blood biomarkers in advanced non-small cell lung cancer (aNSCLC) patients treated with immunotherapy

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Nevirapine- Versus Lopinavir/Ritonavir-Based Initial Therapy for HIV-1 Infection among Women in Africa: A Randomized Trial

In a randomized control trial, Shahin Lockman and colleagues compare nevirapine-based therapy with lopinavir/ritonavir-based therapy for HIV-infected women without previous exposure to antiretroviral treatment

Risk of Severe Non AIDS Events Is Increased among Patients Unable to Increase their CD4+ T-Cell Counts >200+/μl Despite Effective HAART

Immunological non-response (INR) despite virological suppression is associated with AIDS-defining events/death (ADE). Little is known about its association with serious non-AIDS-defining events (nADE)