Postural evaluation and balance analysis in nordic skiing beginners

Se trata de un estudio de diseño transversal con evaluación del control postural antes-después de un curso de iniciación al esquí nórdico (5 jornadas, 6h/día), a un grupo experimental de 25 sujetos, participantes de la formación, y un grupo control de 8 sujetos. Se pretende evaluar el efecto de un entrenamiento inicial de esquí nórdico sobre el control postural en jóvenes deportistas. La estabilidad corporal se evaluó por medio de un test estabilométrico, calculando el área de desviación del centro de presiones por medio de una plataforma de fuerzas con sensores electrónicos. No se aprecian diferencias significativas en el grado de mejora del equilibrio entre el grupo experimental y el grupo control. Nuevos estudios con una mayor exigencia en la formación en esquí nórdico y un mayor número de sujetos en el grupo control son requeridosCross-sectional study with evaluation of postural control before and after a course of initiation to Nordic skiing (5 days, 6 hours per day). The sample consisted of an experimental group of 25 subjects participated in the training and a control group of 8 subjects. It is intended to evaluate the effect of initial training of Nordic skiing on postural control in young athletes. The physical stability was evaluated by a stabilometric test, calculating the deviation of the area of the center of pressures by the use of a force platform with electronic sensors. No significant differences were observed in the degree of improvement of the balance between the experimental group and the control group. New studies with a greater emphasis on training in Nordic skiing and a greater number of subjects in the control group are require

Hospitalizations related to respiratory viral infections during the 2017/18 season in the Valencia Region of Spain

Objectives To describe the impact and severity of hospitalizations related to respiratory viral infections using data from weeks 2017-37 to 2018-19 in the Valencia Region of Spain. Methods All consenting admitted patients were included in the study if they were non-institutionalized, residents in any of the participating hospitals' catchment areas, not discharged from a previous hospital admission within 30 days, had an influenza-like illness (ILI, only for patients ≥5 years old) and were hospitalized within 7 days of the onset of symptoms. Demographic and clinical information was collected by interviewing and/or from clinical records. Swabs were tested by real-time reverse transcription polymerase chain reaction (RT-PCR) for influenza, respiratory syncytial virus (RSV), metapneumovirus, parainfluenza, rhinovirus/enterovirus, adenovirus, coronavirus and bocavirus. Hospitalization incidence rates were calculated by virus and age. Severity was explored through Intensive Care Unit (ICU) admission, death in hospital, mechanical ventilation, extracorporeal membrane oxygenation and the length of hospitalization. Results The hospitalization incidence rates related to respiratory viral infections were 1062.89, 31.38, 36.12 and 434.64 per 100,000 in patients <5, 5 to <18, 18 to <65 and ≥65 years old (y.o.), respectively. The incidence rates were especially high in children <1 y.o. and in adults ≥85 y.o.: 3311.94 and 1044.77 per 100,000, respectively. The highest rates were detected for influenza, rhinovirus/enterovirus and RSV: 63.11, 40.20 and 25.81 per 100,000, respectively. Among infected patients, 2% were admitted to the ICU, 4% needed mechanical ventilation and 4% died in hospital. No differences in severity were detected among viruses. The median length of hospitalization among infected patients was 5 days (Interquartile Range, IQR: 3-8 days). Conclusions Respiratory viral infections affected mainly young children and elderly people. Influenza, rhinovirus/enterovirus and RSV were the most commonly detected infections. No differences in severity were detected between the assessed viruses.Medicin

Runner’s Profile and Propensity to Sports Injury

Se evalúa las relaciones entre el perfil sociodemográfico, la accidentabilidad y la propensión al accidente de los participantes en tres eventos deportivos: Zurich Marató de Barcelona, Cros de Muntanya Can Caralleu, y Marató Borredà-Xtrail. Una adaptación del cuestionario de propensión al accidente deportivo (PAD-22) de Latorre y Pantoja (2013) fue administrado a un total de 237 corredores. Los principales resultados muestran que: los corredores tienden a ser mayoritariamente varones, de entre 30 y 46 años, asalariados, con estudios postobligatorios, con experiencia previa en eventos de larga distancia, entrenan una media de 4 veces y un total de 7 horas a la semana; y los corredores de la maratón por asfalto tienen una sobreestimación de la Competencia Percibida y grados de Competitividad mayores a los corredores por montañaThis study evaluates relations between sociodemographic profile, accident rate and accident’s propensity of three sport events participants: Zurich Marató de Barcelona, Cros de Muntanya Can Caralleu & Marató Borredà-Xtrail. The used method was an adaptation of the sports accident prone scale (PAD-22) from Latorre y Pantoja (2013), to 237 runners. The main results show that: runners tend to be mostly men, aged of 30-46 years, are salaried, have post-compulsory studies, have some experience in long distance events, train a mean of 4 times and more than 7 hours per week; and marathon asphalt runners have a overestimation of Perceived Competence and elevated degrees of Competitiveness, more than trail runnersEste trabajo forma parte del Proyecto de Investigación, con código 2014 PINEF 00006 y ha sido realizado con el apoyo del programa de becas predoctorales del Instituto Nacional de Educación Física de Cataluña (PINEFC-2015). Agradecemos el apoyo dado por el INEFC en la realización de este estudio, puesto que, sin su cobijo, no se hubiera podido llevar a cabo con las mismas condicione

New Measurement of the Cosmic-Ray Positron Fraction from 5 to 15 GeV

We present a new measurement of the cosmic-ray positron fraction at energies between 5 and 15 GeV with the balloon-borne HEAT-pbar instrument in the spring of 2000. The data presented here are compatible with our previous measurements, obtained with a different instrument. The combined data from the three HEAT flights indicate a small positron flux of non-standard origin above 5 GeV. We compare the new measurement with earlier data obtained with the HEAT-e+- instrument, during the opposite epoch of the solar cycle, and conclude that our measurements do not support predictions of charge sign dependent solar modulation of the positron abundance at 5 GeV.Comment: accepted for publication in PR

N-terminal acetylation promotes synaptonemal complex assembly in C. elegans

N-terminal acetylation of the first two amino acids on proteins is a prevalent cotranslational modification. Despite its abundance, the biological processes associated with this modification are not well understood. Here, we mapped the pattern of protein N-terminal acetylation in Caenorhabditis elegans, uncovering a conserved set of rules for this protein modification and identifying substrates for the N-terminal acetyltransferase B (NatB) complex. We observed an enrichment for global protein N-terminal acetylation and also specifically for NatB substrates in the nucleus, supporting the importance of this modification for regulating biological functions within this cellular compartment. Peptide profiling analysis provides evidence of cross-talk between N-terminal acetylation and internal modifications in a NAT substrate-specific manner. In vivo studies indicate that N-terminal acetylation is critical for meiosis, as it regulates the assembly of the synaptonemal complex (SC), a proteinaceous structure ubiquitously present during meiosis from yeast to humans. Specifically, N-terminal acetylation of NatB substrate SYP-1, an SC structural component, is critical for SC assembly. These findings provide novel insights into the biological functions of N-terminal acetylation and its essential role during meiosis

Fusion of 8He with 206Pb around Coulomb barrier energies

The experimental study of the fusion of light neutron-rich nucleus 8He with 206Pb is reported in this work. A fusion stack of 206Pb targets has been used for this study. The most prominent evaporation residue (210Po), which has half-life of 138 days and decays by alpha emission, is populated in the reaction. Radiochemical analysis technique is used to extract the yield of this evaporation residue.Ministerio de Ciencia e Innovavión FPA2007-63074European Union 21269

Initial therapy, regimen change, and persistence in a spanish cohort of newly treated type 2 diabetes patients: A retrospective, observational study using real-world data

The World Health Organization considers the non-adherence to medication a significant issue with global impact, especially in chronic conditions such as type 2 diabetes. We aim to study antidiabetic treatment initiation, add-on, treatment switching, and medication persistence. We conducted an observational study on 4247 individuals initiating antidiabetic treatment between 2013 and 2014 in the EpiChron Cohort (Spain). We used Cox regression models to estimate the likelihood of non-persistence after a one-year follow-up, expressed as hazard ratios (HRs). Metformin was the most frequently used first-line antidiabetic (80% of cases); combination treatment was the second most common treatment in adults aged 40–79 years, while dipeptidyl peptidase-4 inhibitors were the second most common in individuals in their 80s and over, and in patients with renal disease. Individuals initiated on metformin were less likely to present addition and switching events compared with any other antidiabetic. Almost 70% of individuals initiated on monotherapy were persistent. Subjects aged 40 and over (HR 0.53–0.63), living in rural (HR 0.79) or more deprived areas (HR 0.77–0.82), or receiving polypharmacy (HR 0.84), were less likely to show discontinuation. Our findings could help identify the population at risk of discontinuation, and offer them closer monitoring for proper integrated management to improve prognosis and health outcomes

Energy Spectra, Altitude Profiles and Charge Ratios of Atmospheric Muons

We present a new measurement of air shower muons made during atmospheric ascent of the High Energy Antimatter Telescope balloon experiment. The muon charge ratio mu+ / mu- is presented as a function of atmospheric depth in the momentum interval 0.3-0.9 GeV/c. The differential mu- momentum spectra are presented between 0.3 and about 50 GeV/c at atmospheric depths between 13 and 960 g/cm^2. We compare our measurements with other recent data and with Monte Carlo calculations of the same type as those used in predicting atmospheric neutrino fluxes. We find that our measured mu- fluxes are smaller than the predictions by as much as 70% at shallow atmospheric depths, by about 20% at the depth of shower maximum, and are in good agreement with the predictions at greater depths. We explore the consequences of this on the question of atmospheric neutrino production.Comment: 11 pages, 8 figures, to appear in Phys. Rev. D (2000

The Longitudinal Distribution of Solar Energetic Particles

Using observations from the High Energy Telescopes (HETs) on STEREO A and B and similar observations from SoHO, near-Earth, we have identified ~250 individual solar energetic particle events that include >14 MeV protons since the beginning of the STEREO mission [1]. Between the end of December 2009, when the STEREO A and B spacecraft were, respectively, ahead and behind Earth by ~ 65° in ecliptic longitude, and the end of December 2013, 43 different events were clearly detected at all three locations. The observed intensities of such an event are usually assumed to be Gaussian distributed as a function of the longitudes of the Parker Spiral footpoints at the Sun for each observer. This neglects the fact that the interplanetary magnetic field may have large deviations from Parker Spirals, e.g. due to coronal mass ejections from prior events. Nonetheless, we have fit Gaussians to the peak intensities observed simultaneously at three spacecraft for all 43 events. The Gaussian peak intensity is poorly correlated with the corresponding CME speed and the FWHM is uncorrelated with the CME speed. Surprisingly, however, there appear to be distinctly non-random variations of the FWHM values from event to event

An Extreme Solar Event of 20 January 2005: Properties of the Flare and the Origin of Energetic Particles

The extreme solar and SEP event of 20 January 2005 is analyzed from two perspectives. Firstly, we study features of the main phase of the flare, when the strongest emissions from microwaves up to 200 MeV gamma-rays were observed. Secondly, we relate our results to a long-standing controversy on the origin of SEPs arriving at Earth, i.e., acceleration in flares, or shocks ahead of CMEs. All emissions from microwaves up to 2.22 MeV line gamma-rays during the main flare phase originated within a compact structure located just above sunspot umbrae. A huge radio burst with a frequency maximum at 30 GHz was observed, indicating the presence of a large number of energetic electrons in strong magnetic fields. Thus, protons and electrons responsible for flare emissions during its main phase were accelerated within the magnetic field of the active region. The leading, impulsive parts of the GLE, and highest-energy gamma-rays identified with pi^0-decay emission, are similar and correspond in time. The origin of the pi^0-decay gamma-rays is argued to be the same as that of lower energy emissions. We estimate the sky-plane speed of the CME to be 2000-2600 km/s, i.e., high, but of the same order as preceding non-GLE-related CMEs from the same active region. Hence, the flare itself rather than the CME appears to determine the extreme nature of this event. We conclude that the acceleration, at least, to sub-relativistic energies, of electrons and protons, responsible for both the flare emissions and the leading spike of SEP/GLE by 07 UT, are likely to have occurred simultaneously within the flare region. We do not rule out a probable contribution from particles accelerated in the CME-driven shock for the leading GLE spike, which seemed to dominate later on.Comment: 34 pages, 14 Postscript figures. Solar Physics, accepted. A typo corrected. The original publication is available at http://www.springerlink.co