123 research outputs found
Using corrugation stitch in submammary fold at the reconstructive breast surgery
The aim of the research was to develop a new technique for suturing the surgical incision in submammary area after subpectoral reconstructive breast surgery with good cosmetic result. Clinical observation group included 10 patients. It was found that the new technique of suturing the surgical incision, in comparison with the method offered by M.B. Calobrace et al. (2014), allows to decrease the duration of suturing from 6 min 10 Β± 0.06 sec down to 5 min 29 Β± 0.04 sec (Ρ < 0.01), to reduce number of stitches from 24 down to 15, to shorten postoperative stitch from 4.24 Β± 0.06 cm down to 3.71 Β± 0.07 cm (Ρ < 0.01), and to shorten cicatrix length in 1 year after the operation from 4.78 Β± 0.19 cm down to 4.25 Β± 0.22 cm (Ρ < 0.05). Therefore, the developed technique of suturing the surgical wound provides the location of postoperative cicatrix in the area of submammary fold which makes it less noticeable. Moreover, it allows to shorten the length of postoperative cicatrix, decrease the duration of the surgery and to secure adequate stability of implant fixation
EXPERIENCE TREATMENT OF CHILDREN WITH POST-BURN SCAR CONTRACTURE OF THE NECK
Cicatricial deformations of the neck occur in 4-30.5 % of children suffered from burn trauma, and are the most severe consequences. Early reconstructive surgery in this pathology provides free growth and development of the skull and upper body and promote psychological and social recovery of the child. The treatment of such patients presents great difficulties, and in each case requires an individual approach. The article presents the experience of treatment of two children with severe scar contracture of the neck, complicated by the lack of reserves in undamaged tissues of the neck and the surrounding areas. We used a combination of several methods of skin grafting, including axial flow and the prefabrication of flaps, divided in time into stages. In one case in a child with total neck contracture, we performed pre-surgical (3.5 weeks before the main stage surgical intervention) preparation of the two flaps - scapular and epaulet flaps. In the other case, 4-year old girl with subtotal flexion contracture, a month before the main surgery we prepared scapular flap and increased its area expander dermotension, with endoscopic implantation of endoexpander. In this paper, we describe in detail the technology of operative treatment of these two patients. In both cases, there were no postoperative complications. The use of modern medical technologies based on conventional techniques in surgical correction of severe flexion scar contractures of the neck of the presented patients decided both functional and aesthetic problems
Dynamic tests of multi-detector radiometric system on central blood circulation phantom
Phantoms of organs and biological systems are widely used for verification of radioisotope protocols. The construction and operation of the heart and circulation phantom is described. The present model was designed for experimental testing of multi-detector radiometric system, prototype of which was designed in Ural Federal University as an extension and alternative to Anger camera and single-photon-emission tomography radionuclide diagnostics. The model represents vital dynamic properties of the single-chamber pulsing heart and circulation, featuring adjustable heart rate, blood volume, ejection fraction and flowrate. The trial experiments were performed with 99m Tc-pertechnetate to obtain time-activity curves and the ejection fraction was thus measured basing on first-pass radio angiography technique. Β© Published under licence by IOP Publishing Ltd
ORTHOTOPIC INTESTINOPLASTY OF URINARY BLADDER - A COMPLEX APPROACH
We analyzed the results of treatment of 57 patients who had. cystectomy with forming of orthotopic cystoplastte urinary bladder. Cystoplastis was performed by the original method. The approach to the choice of method, for creating orthotopic bladder was complex. Take into account the length of ileum resection, the technique of formation and the shape of the bladder, pre-calculated volume of orthotopic urinary bladder technique was used to create antireflux ureteral-intestinal anastomosis. Such an approach to reduce the risk of postoperative complications and to maintain the high, quality of life for patients
COMPLiCATiONS AFTER CYSTECTOMY AND THEiR TREATMENT
We analyzed the results of treatment of 110 patients who had. cystectomy with, different types of urinary diversion. In the early postoperative period next complications occurred: prolonged intestinal paresis, dynamic ileus, thrombosis of the external iliac artery failure of intestinal anastomosis and the uretero-reservoir anastomosis, lymphocele formation, exacerbation of chronic pyelonephritis. In the late postoperative major complications were: urinary incontinence, stricture of the uretero-reservoir anastomosis, bladder stone formation. Conducted. operational and conservative methods of treatment allowed the arrest caused complications
Recyclizations of 2-aminobenzylimines and thioaroylhydrazones of N-substituted N-hydroxy-3-oxobutanamides
A universal scheme is proposed for the molecular design of heterocyclic recyclizations by replacing the exocyclic hydroxyl groups in exo-trig- ring-chain tautomeric molecules with substituted amines or hydrazines. The practical applicability of this approach is demonstrated by the condensations of 5-hydroxy-5-methyl-3-isoxazolidinones with thioaroyl-hydrazines and 2-aminomethylaniline. The condensation products were studied by modern 1H, 13C and 15N NMR spectroscopic methods using three solvents: CDCl3, DMSO[D6] and CD3CN. The solvent was found to have a strong effect to the relative amounts of the tautomers
A portable radiometric system for nuclear medicine
It's shown suggested methods for diagnosing pathological processes in biological objects using a developed portable radiometric system with four gamma-ray detectors. Designed portable radiometric system was used to make 2D imaging of anatomical structures. The system can value pharmacokinetics in several points of wide area of interest at the patient body. In this study specially designed phantoms were used. Phantom models of the liver and blood circulation system were made to assay radiometric system. The construction concept and possible applications of the system in the practice of radionuclide diagnostic studies in vivo are presented. Β© 2018 Elsevier Lt
TephraKam: geochemical database of glass compositions in tephra and welded tuffs from the Kamchatka volcanic arc (northwestern Pacific)
Tephra layers produced by volcanic eruptions are widely used for correlation and dating of various deposits and landforms, for synchronization of disparate paleoenvironmental archives, and for reconstruction of magma origin. Here we present our original database TephraKam, which includes chemical compositions of volcanic glass in tephra and welded tuffs from the Kamchatka volcanic arc. The database contains 7049 major element analyses obtained by electron microprobe and 738 trace element analyses obtained by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) on 487 samples collected in proximity of their volcanic sources in all volcanic zones in Kamchatka. The samples characterize about 300 explosive eruptions, which occurred in Kamchatka from the Pliocene until historic times. Precise or estimated ages for all samples are based on published 39Ar/40Ar dates of rocks and 14C dates of host sediments, statistical age modelling and geologic relationships with dated units. All data in TephraKam is supported by information about source volcanoes and analytical details. Using the data, we present an overview of geochemical variations of Kamchatka volcanic glasses and discuss application of this data for precise identification of tephra layers, their source volcanoes, temporal and spatial geochemical variations of pyroclastic rocks in Kamchatka
ΠΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΠΌΠΈΡΠΎΠ³Π΅Π½Π°ΠΊΡΠΈΠ²ΠΈΡΡΠ΅ΠΌΡΠ΅ ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΊΠΈΠ½Π°Π·Ρ ΠΊΠ°ΠΊ Π½ΠΎΠ²ΠΎΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΠΎΡΡΠ° ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ
This review presents current classification, functions of main groups of mitogen-activated protein kinases (MAPK) and summarizes data on the ways of their activation and functioning, giving particular emphasis to p38 MAPK. The authors consider the influence on these signaling cascades as a promising direction for activation of connective tissue growth. This article summarizes international practices on the activation and blocking of intracellular cascades and also the authorsβ own experience in this field. In particular, the article shows that p38 MAP-kinase stimulation while JNK inactivation causes accelerated formation of connective tissue in the area of postoperative surgical scar. The authors prove the opportunity to manage connective tissue growth influencing MAPK cascades β prolonged blockade of p38 ΠΠΠ Π reduces scar width and collagen fiber density in the area of postoperative scars and decreases intensity of adhesions in the abdominal cavity in abdominal trauma.Therefore, considering the importance and flexibility of MAP-kinase mechanisms of cell growth regulation and differentiation, studying the use of these mechanisms in biological processes (such as inflammation, apoptosis, regeneration) and the development the methods of management of these processes show promise. Using stimulators and inhibitors of MAP-kinase mechanisms is a promising new direction in treatment of the diseases with pathogeny related to the disorder of cellular differentiation, proliferation, excessive cytokine production and regulation of connective tissue growth.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½Π°Ρ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ, ΡΡΠ½ΠΊΡΠΈΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
Π³ΡΡΠΏΠΏ ΠΌΠΈΡΠΎΠ³Π΅Π½Π°ΠΊΡΠΈΠ²ΠΈΡΡΠ΅ΠΌΡΡ
ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΊΠΈΠ½Π°Π· (ΠΠΠ Π). ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΠΏΡΡΡΡ
ΠΈΡ
Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠ½ΠΎΠ²Π½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Ρ Ρ38 ΠΠΠ Π. Π ΠΎΠ±Π·ΠΎΡΠ΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° Π΄Π°Π½Π½ΡΠ΅ ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΠ΅ ΠΊΠ°ΡΠΊΠ°Π΄Ρ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ΠΎ ΠΊΠ°ΠΊ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΡΠΎΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ. Π ΡΡΠΎΠΌ Π°ΡΠΏΠ΅ΠΊΡΠ΅ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½ ΠΌΠΈΡΠΎΠ²ΠΎΠΉ ΠΎΠΏΡΡ ΠΏΠΎ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΈ Π±Π»ΠΎΠΊΠ°Π΄Π΅ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΊΠ°ΡΠΊΠ°Π΄ΠΎΠ². ΠΠ±ΠΎΠ±ΡΠ΅Π½ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΎΠΏΡΡ ΡΠ°Π±ΠΎΡΡ Π² Π΄Π°Π½Π½ΠΎΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ. Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ Ρ38 ΠΠΠ Π ΠΏΡΠΈ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ JNK ΠΊΠ°ΡΠΊΠ°Π΄Π° Π²Π΅Π΄Π΅Ρ ΠΊ ΡΡΠΊΠΎΡΠ΅Π½Π½ΠΎΠΌΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π² Π·ΠΎΠ½Π΅ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ±ΡΠ°, Π΄ΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΠΎΡΡΠΎΠΌ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΡΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Π½Π° ΠΠΠ -ΠΊΠΈΠ½Π°Π·Π½ΡΠ΅ ΠΊΠ°ΡΠΊΠ°Π΄Ρ. ΠΡΠΎΠ»ΠΎΠ½Π³ΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ Π±Π»ΠΎΠΊΠ°Π΄Π° Ρ38 ΠΠΠ Π ΡΠ½ΠΈΠΆΠ°Π΅Ρ ΡΠΈΡΠΈΠ½Ρ ΠΊΠΎΠΆΠ½ΠΎΠ³ΠΎ ΡΡΠ±ΡΠ° ΠΈ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½ΠΎΠ²ΡΡ
Π²ΠΎΠ»ΠΎΠΊΠΎΠ½ Π² Π·ΠΎΠ½Π΅ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΡΠ±ΡΠ°, ΡΠ½ΠΈΠΆΠ°Π΅Ρ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΏΠ°ΠΉΠΊΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² Π±ΡΡΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΠΏΡΠΈ ΡΡΠ°Π²ΠΌΠ΅ Π±ΡΡΡΠΈΠ½Ρ.Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΡΠΈΡΡΠ²Π°Ρ Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ ΠΈ ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΠΠ -ΠΊΠΈΠ½Π°Π·Π½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ° ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ, ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ°ΡΡΠΈΡ Π΄Π°Π½Π½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π² ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»Ρ- Π½ΡΡ
Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
, ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅, Π°ΠΏΠΎΠΏΡΠΎΠ·, ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π½Π° ΡΡΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ². ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΈΠΌΡΠ»ΡΡΠΎΡΠΎΠ² ΠΈ Π±Π»ΠΎΠΊΠ°ΡΠΎΡΠΎΠ² ΠΠΠ -ΠΊΠΈΠ½Π°Π·Π½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΊΠ°ΠΊ Π½ΠΎΠ²ΠΎΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΌΠ½ΠΎΠ³ΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π· ΠΊΠΎΡΠΎΡΡΡ
ΡΠ²ΡΠ·Π°Π½ Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ, ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ, ΠΈΠ·Π±ΡΡΠΎΡΠ½ΠΎΠΉ Π²ΡΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ², ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠΎΡΡΠΎΠΌ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ.
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