"Back to the land and all its beauty" : managing cultural resources, natural resources, and wilderness on North Manitou Island, Sleeping Bear Dunes National Lakeshore, Michigan

Indiana University-Purdue University Indianapolis (IUPUI)This thesis focuses on the history of human impact on North Manitou Island, Michigan, the management of natural and cultural resources on the island by Sleeping Bear Dunes National Lakeshore, and the often conflicting beliefs and attitudes about wilderness and cultural resources that influenced (and continue to influence) management of the island by Sleeping Bear’s administrators

A System Dynamics Evaluation Model: Implementation of Health Information Exchange for Public Health Reporting

The objective of this study is to evaluate complex dynamics involved in implementing electronic health information exchange for public health reporting at a state health department, and to identify policy implications to inform similar implementations. Qualitative data were collected over eight months from seven experts at NYS DOH who implemented web services and protocols for querying, receipt, and validation of electronic data supplied by regional health information organizations. Extensive project documentation also was collected. During group meetings experts described the implementation process and created reference modes and causal diagrams that the evaluation team used to build a preliminary model. System dynamics modeling techniques were applied iteratively to build causal loop diagrams representing the implementation. Validation of the diagrams was done iteratively by individual experts followed by group review online, and through confirmatory review of documents a! nd artifacts. Three casual loop diagrams captured well-recognized system dynamics: Sliding Goals, Project Rework, and Maturity of Resources. The findings were associated with specific policies that address funding, leadership, ensuring expertise, planning for rework, communication, and timeline management. This evaluation illustrates the value of a qualitative approach to system dynamics modeling. As a tool for strategic thought about complicated and intense processes, qualitative models can be produced with fewer resources than a full simulation, yet still provide insights that are timely and relevant. System dynamics techniques clarified endogenous and exogenous factors at play in a highly complex technology implementation, which may inform other states engaged in implementing HIE supported by federal HITECH legislatio

Desperately seeking fixedness: practitioners accounts of 'becoming doctoral researchers

We draw upon the concept of liminality to explore the experiences of practitioners enrolled on a UK Doctor of Business Administration (DBA) programme. We analyse twenty practitioners’ reflective journals to detail how the DBA liminal space was negotiated. More specifically, we describe how practitioners deal with their struggles of identity incoherence or ‘monsters of doubt’ which are amplified in the DBA context owing to the complex nature of the separation phase of liminality. We identify three broad methods deployed in this endeavour: ‘scaffolding’; ‘putting the past to work’ and ‘bracketing’- which evidence practitioners ‘desperately seeking fixedness’. We make three contributions – first, we provide empirical insights into the experiences of the increasingly significant, but still under researched, DBA student. Second, we develop our understandings of monsters of doubt through illustrating how these are negotiated for learning to progress. Finally, we contribute to wider discussions of ‘becoming’ to demonstrate the simultaneous and paradoxical importance of movement and fixedness in order to learn and become

Non-equilibrium Gross-Pitaevskii dynamics of boson lattice models

Motivated by recent experiments on trapped ultra-cold bosonic atoms in an optical lattice potential, we consider the non-equilibrium dynamic properties of such bosonic systems for a number of experimentally relevant situations. When the number of bosons per lattice site is large, there is a wide parameter regime where the effective boson interactions are strong, but the ground state remains a superfluid (and not a Mott insulator): we describe the conditions under which the dynamics in this regime can be described by a discrete Gross-Pitaevskii equation. We describe the evolution of the phase coherence after the system is initially prepared in a Mott insulating state, and then allowed to evolve after a sudden change in parameters places it in a regime with a superfluid ground state. We also consider initial conditions with a "pi phase" imprint on a superfluid ground state (i.e. the initial phases of neighboring wells differ by pi), and discuss the subsequent appearance of density wave order and "Schrodinger cat" states.Comment: 16 pages, 11 figures; (v2) added reference

Quantum corrections to the dynamics of interacting bosons: beyond the truncated Wigner approximation

We develop a consistent perturbation theory in quantum fluctuations around the classical evolution of a system of interacting bosons. The zero order approximation gives the classical Gross-Pitaevskii equations. In the next order we recover the truncated Wigner approximation, where the evolution is still classical but the initial conditions are distributed according to the Wigner transform of the initial density matrix. Further corrections can be characterized as quantum scattering events, which appear in the form of a nonlinear response of the observable to an infinitesimal displacement of the field along its classical evolution. At the end of the paper we give a few numerical examples to test the formalism.Comment: published versio

Vav1/2/3-null mice define an essential role for vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells

The Vav family of Rho guanine nucleotide exchange factors is thought to orchestrate signaling events downstream of lymphocyte antigen receptors. Elucidation of Vav function has been obscured thus far by the expression of three highly related family members. We generated mice lacking all Vav family proteins and show that Vav-null mice produce no functional T or B cells and completely fail to mount both T-dependent and T-independent humoral responses. Whereas T cell development is blocked at an early stage in the thymus, immature B lineage cells accumulate in the periphery but arrest at a late “transitional” stage. Mechanistically, we show that the Vav family is crucial for both TCR and B cell receptor (BCR)–induced Ca(2+) signaling and, surprisingly, is only required for mitogen-activated protein kinase (MAPK) activation in developing and mature T cells but not in B cells. Thus, the abundance of immature B cells generated in Vav-null mice may be due to intact Ras/MAPK signaling in this lineage. Although the expression of Vav1 alone is sufficient for normal lymphocyte development, our data also reveal lineage-specific roles for Vav2 and Vav3, with the first demonstration that Vav3 plays a critical compensatory function in T cells. Together, we define an essential role for the entire Vav protein family in lymphocyte development and activation and establish the limits of functional redundancy both within this family and between Vav and other Rho–guanine nucleotide exchange factors

Chandra High-Resolution X-Ray Spectrum of Supernova Remnant 1E0102.2-7219

Chandra High Energy Transmission Grating Spectrometer observations of the supernova remnant 1E0102.2-7219 in the Small Magellanic Cloud reveal a spectrum dominated by X-ray emission lines from hydrogen-like and helium-like ions of oxygen, neon, magnesium and silicon, with little iron. The dispersed spectrum shows a series of monochromatic images of the source in the light of individual spectral lines. Detailed examination of these dispersed images reveals Doppler shifts within the supernova remnant, indicating bulk matter velocities on the order of 1000 km/s. These bulk velocities suggest an expanding ring-like structure with additional substructure, inclined to the line of sight. A two-dimensional spatial/velocity map of the SNR shows a striking spatial separation of redshifted and blueshifted regions, and indicates a need for further investigation before an adequate 3D model can be found. The radii of the ring-like images of the dispersed spectrum vary with ionization stage, supporting an interpretation of progressive ionization due to passage of the reverse shock through the ejecta. Plasma diagnostics with individual emission lines of oxygen are consistent with an ionizing plasma in the low density limit, and provide temperature and ionization constraints on the plasma. Assuming a pure metal plasma, the mass of oxygen is estimated at ~6 solar masses, consistent with a massive progenitor.Comment: 47 pages, 14 figures, accepted for publication in Ap

Developing cardiac and skeletal muscle share fast-skeletal myosin heavy chain and cardiac troponin-I expression

Skeletal muscle derived stem cells (MDSCs) transplanted into injured myocardium can differentiate into fast skeletal muscle specific myosin heavy chain (sk-fMHC) and cardiac specific troponin-I (cTn-I) positive cells sustaining recipient myocardial function. We have recently found that MDSCs differentiate into a cardiomyocyte phenotype within a three-dimensional gel bioreactor. It is generally accepted that terminally differentiated myocardium or skeletal muscle only express cTn-I or sk-fMHC, respectively. Studies have shown the presence of non-cardiac muscle proteins in the developing myocardium or cardiac proteins in pathological skeletal muscle. In the current study, we tested the hypothesis that normal developing myocardium and skeletal muscle transiently share both sk-fMHC and cTn-I proteins. Immunohistochemistry, western blot, and RT-PCR analyses were carried out in embryonic day 13 (ED13) and 20 (ED20), neonatal day 0 (ND0) and 4 (ND4), postnatal day 10 (PND10), and 8 week-old adult female Lewis rat ventricular myocardium and gastrocnemius muscle. Confocal laser microscopy revealed that sk-fMHC was expressed as a typical striated muscle pattern within ED13 ventricular myocardium, and the striated sk-fMHC expression was lost by ND4 and became negative in adult myocardium. cTn-I was not expressed as a typical striated muscle pattern throughout the myocardium until PND10. Western blot and RT-PCR analyses revealed that gene and protein expression patterns of cardiac and skeletal muscle transcription factors and sk-fMHC within ventricular myocardium and skeletal muscle were similar at ED20, and the expression patterns became cardiac or skeletal muscle specific during postnatal development. These findings provide new insight into cardiac muscle development and highlight previously unknown common developmental features of cardiac and skeletal muscle. © 2012 Clause et al

The Interplanetary Network Supplement to the Fermi GBM Catalog - An AO-2 and AO-3 Guest Investigator Project

In the first two years of operation of the Fermi GBM, the 9-spacecraft Interplanetary Network (IPN) detected 158 GBM bursts with one or two distant spacecraft, and triangulated them to annuli or error boxes. Combining the IPN and GBM localizations leads to error boxes which are up to 4 orders of magnitude smaller than those of the GBM alone. These localizations comprise the IPN supplement to the GBM catalog, and they support a wide range of scientific investigations

A Model for Solving the Optimal Water Allocation Problem in River Basins with Network Flow Programming When Introducing Non-Linearities

[EN] The allocation of water resources between different users is a traditional problem in many river basins. The objective is to obtain the optimal resource distribution and the associated circulating flows through the system. Network flow programming is a common technique for solving this problem. This optimisation procedure has been used many times for developing applications for concrete water systems, as well as for developing complete decision support systems. As long as many aspects of a river basin are not purely linear, the study of non-linearities will also be of great importance in water resources systems optimisation. This paper presents a generalised model for solving the optimal allocation of water resources in schemes where the objectives are minimising the demand deficits, complying with the required flows in the river and storing water in reservoirs. Evaporation from reservoirs and returns from demands are considered, and an iterative methodology is followed to solve these two non-network constraints. The model was applied to the Duero River basin (Spain). Three different network flow algorithms (Out-of-Kilter, RELAX-IVand NETFLO) were used to solve the allocation problem. Certain convergence issues were detected during the iterative process. There is a need to relate the data from the studied systems with the convergence criterion to be able to find the convergence criterion which yields the best results possible without requiring a long calculation time.We thank the Spanish Ministry of Economy and Competitivity (Comision Interministerial de Ciencia y Tecnologia, CICYT) for funding the projects INTEGRAME (contract CGL2009-11798) and SCARCE (program Consolider-Ingenio 2010, project CSD2009-00065). 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