Sertraline and Phenytoin Drug Interaction in a Geriatric Patient

This report presents the case of a 78-year-old man residing in a nursing home who presented with a 2-month history of increasing lethargy and confusion. These symptoms coincided with the initiation of sertraline in the patient. Among other medications, he was also taking phenytoin. The medical team concluded that the cause of the patient’s lethargy and confusion was a drug interaction between sertraline and phenytoin. Phenytoin was held, while the sertraline was slowly tapered to discontinuation. The patient’s symptoms resolved soon thereafter. Future research is needed to better guide clinicians in appropriate selection, dosing, and monitoring of selective serotonin reuptake inhibitors with concomitant phenytoin use.Key words: phenytoin, sertraline, SSRIs, drug interactio

Equivariant differential characters and symplectic reduction

We describe equivariant differential characters (classifying equivariant circle bundles with connections), their prequantization, and reduction

Testing Convolutional Neural Networks for finding strong gravitational lenses in KiDS

Convolutional Neural Networks (ConvNets) are one of the most promising methods for identifying strong gravitational lens candidates in survey data. We present two ConvNet lens-finders which we have trained with a dataset composed of real galaxies from the Kilo Degree Survey (KiDS) and simulated lensed sources. One ConvNet is trained with single \textit{r}-band galaxy images, hence basing the classification mostly on the morphology. While the other ConvNet is trained on \textit{g-r-i} composite images, relying mostly on colours and morphology. We have tested the ConvNet lens-finders on a sample of 21789 Luminous Red Galaxies (LRGs) selected from KiDS and we have analyzed and compared the results with our previous ConvNet lens-finder on the same sample. The new lens-finders achieve a higher accuracy and completeness in identifying gravitational lens candidates, especially the single-band ConvNet. Our analysis indicates that this is mainly due to improved simulations of the lensed sources. In particular, the single-band ConvNet can select a sample of lens candidates with $\sim40\%$ purity, retrieving 3 out of 4 of the confirmed gravitational lenses in the LRG sample. With this particular setup and limited human intervention, it will be possible to retrieve, in future surveys such as Euclid, a sample of lenses exceeding in size the total number of currently known gravitational lenses.Comment: 16 pages, 10 figures. Accepted for publication in MNRA

Reusable Agena study. Volume 2: Technical

The application of the existing Agena vehicle as a reusable upper stage for the space shuttle is discussed. The primary objective of the study is to define those changes to the Agena required for it to function in the reusable mode in the 100 percent capture of the NASA-DOD mission model. This 100 percent capture is achieved without use of kick motors or stages by simply increasing the Agena propellant load by using optional strap-on-tanks. The required shuttle support equipment, launch and flight operations techniques, development program, and cost package are also defined

M-theory and Characteristic Classes

In this note we show that the Chern-Simons and the one-loop terms in the M-theory action can be written in terms of new characters involving the M-theory four-form and the string classes. This sheds a new light on the topological structure behind M-theory and suggests the construction of a theory of `higher' characteristic classes.Comment: 8 pages. Error in gravitational term fixed; minor corrections; reference and acknowledgement adde

Polymers pushing Polymers: Polymer Mixtures in Thermodynamic Equilibrium with a Pore

We investigate polymer partitioning from polymer mixtures into nanometer size cavities by formulating an equation of state for a binary polymer mixture assuming that only one (smaller) of the two polymer components can penetrate the cavity. Deriving the partitioning equilibrium equations and solving them numerically allows us to introduce the concept of "polymers-pushing-polymers" for the action of non-penetrating polymers on the partitioning of the penetrating polymers. Polymer partitioning into a pore even within a very simple model of a binary polymer mixture is shown to depend in a complicated way on the composition of the polymer mixture and/or the pore-penetration penalty. This can lead to enhanced as well as diminished partitioning, due to two separate energy scales that we analyse in detail.Comment: 10 pages, 6 figure

Charge Lattices and Consistency of 6D Supergravity

We extend the known consistency conditions on the low-energy theory of six-dimensional N = 1 supergravity. We review some facts about the theory of two-form gauge fields and conclude that the charge lattice Gamma for such a theory has to be self-dual. The Green-Schwarz anomaly cancellation conditions in the supergravity theory determine a sublattice of Gamma. The condition that this sublattice can be extended to a self-dual lattice Gamma leads to a strong constraint on theories that otherwise appear to be self-consistent.Comment: 15 pages. v2: minor changes; references, additional example added; v3: minor corrections and clarifications added, JHEP versio

Non-Gaussian velocity distributions in excited granular matter in the absence of clustering

The velocity distribution of spheres rolling on a slightly tilted rectangular two dimensional surface is obtained by high speed imaging. The particles are excited by periodic forcing of one of the side walls. Our data suggests that strongly non-Gaussian velocity distributions can occur in dilute granular materials even in the absence of significant density correlations or clustering. When the surface on which the particles roll is tilted further to introduce stronger gravitation, the collision frequency with the driving wall increases and the velocity component distributions approach Gaussian distributions of different widths.Comment: 4 pages, 5 figures. Additional information at http://physics.clarku.edu/~akudrolli/nls.htm

Extremely red galaxies in the Phoenix Deep Survey

The Phoenix Deep Survey (PDS) is a multiwavelength survey based on deep 1.4 GHz radio observations used to identify a large sample of star forming galaxies to z=1. Here we present an exploration of the evolutionary constraints on the star-forming population imposed by the 1.4 GHz source counts, followed by an analysis of the average properties of extremely red galaxies in the PDS, by using the "stacking" technique.Comment: 4 pages, 3 figures, "Multiwavelength Cosmology" Mykonos, June 2003, conference proceeding

Dust Reddening in SDSS Quasars

We explore the form of extragalactic reddening toward quasars using a sample of 9566 quasars with redshifts 0<z<2.2, and accurate optical colors from the Sloan Digital Sky Survey (SDSS). We confirm that dust reddening is the primary explanation for the red ``tail'' of the color distribution of SDSS quasars. Our fitting to 5-band photometry normalized by the modal quasar color as a function of redshift shows that this ``tail'' is well described by SMC-like reddening but not by LMC-like, Galactic, or Gaskell et al. (2004) reddening. Extension to longer wavelengths using a subset of 1886 SDSS-2MASS matches confirms these results at high significance. We carry out Monte-Carlo simulations that match the observed distribution of quasar spectral energy distributions using a Lorentzian dust reddening distribution; 2% of quasars selected by the main SDSS targeting algorithm (i.e., which are not extincted out of the sample) have E_{B-V} > 0.1; less than 1% have E_{B-V} > 0.2, where the extinction is relative to quasars with modal colors. Reddening is uncorrelated with the presence of intervening narrow-line absorption systems, but reddened quasars are much more likely to show narrow absorption at the redshift of the quasar than are unreddened quasars. Thus the reddening towards quasars is dominated by SMC-like dust at the quasar redshift.Comment: 29 pages including 8 figures. AJ, September 2004 issu