150 research outputs found
Tissue-specific regulatory network extractor (TS-REX): a database and software resource for the tissue and cell type-specific investigation of transcription factor-gene networks
The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. We developed TS-REX, a database/software system that supports the analysis of tissue and cell type-specific transcription factor-gene networks based on expressed sequence tag abundance of transcription factor-encoding genes in UniGene EST libraries. The use of expression levels of transcription factor-encoding genes according to hierarchical anatomical classifications covering different tissues and cell types makes it possible to filter out irrelevant binding site predictions and to identify candidates of potential functional importance for further experimental testing. TS-REX covers ESTs from H. sapiens and M. musculus, and allows the characterization of both presence and specificity of transcription factors in user-specified tissues or cell types. The software allows users to interactively visualize transcription factor-gene networks, as well as to export data for further processing. TS-REX was applied to predict regulators of Polycomb group genes in six human tumor tissues and in human embryonic stem cells
Co-production: towards a utopian approach
This article outlines how co-production might be understood as a utopian method, which both attends to and works against dominant inequalities. It suggests that it might be positioned āwithin, against, and beyondā current configurations of power in academia and society more broadly. It develops this argument by drawing on recent research funded through the UKās Connected Communities programme, led by the Arts and Humanities Research Council; and by attending to arguments from the field of Utopian Studies. It explores particular issues of power and control within the field of co-production, acknowledging that neoliberalism both constrains and co-opts such practice; and explores methodological and infrastructural issues such that its utopian potential might be realised
Streptomycin-loaded PLGA-alginate nanoparticles: preparation, characterization, and assessment
Molecular mass determination of saturated hydrocarbons: reactivity of Ī· 5-cyclopentadienylcobalt ion (CpCoĀ·+) and linear alkanes up to C-30
Synthesis of Amphiphilic Tadpole-Shaped Linear-Cyclic Diblock Copolymers via Ring-Opening Polymerization Directly Initiating from Cyclic Precursors and Their Application as Drug Nanocarriers
Characterization of Ī±,Ļ-dihydroxypolystyrene by gradient polymer elution chromatography and two-dimensional liquid chromatography
Study on atom transfer radical polymerization initiated by p-nitrophenyl initiator and synthesis of amino end-functionalized polymers thereof
Synthesis, Characterization and Biodegradability of Poly(Ethylene Glycol)-Bound Molecule Platinum Complexcontaining Ferrocenyl Moiety Using MALDI Time-of-Flight Mass Spectrometry
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