5,114 research outputs found
Bounding the graviton mass with binary pulsar observations
By comparing the observed orbital decay of the binary pulsars PSRB1913+16 and
PSRB1534+12 to that predicted by general relativity due to gravitational-wave
emission, we are able to bound the mass of the graviton to be less than
at 90% confidence. This is the first such
bound to be derived from dynamic gravitational fields. It is approximately two
orders of magnitude weaker than the static-field bound from solar system
observations, and will improve with further observations.Comment: 9 pages, 1 figure. Presented at Fourth Edoardo Amaldi Conference on
Gravitational Waves, Perth, 200
A Review of the External Validity of Clinical Trials with Beta-Blockers in Heart Failure
This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.Background: Beta-blockers (BBs) are the mainstay prognostic medication for all stages of chronic heart failure (CHF). There are many classes of BBs, each of which has varying levels of evidence to support its efficacy in CHF. However, most CHF patients have one or more comorbid conditions such as diabetes, renal impairment, and/or atrial fibrillation. Patient enrollment to randomized controlled trials (RCTs) often excludes those with certain comorbidities, particularly if the symptoms are severe. Consequently, the extent to which evidence drawn from RCTs is generalizable to CHF patients has not been well described. Clinical guidelines also underrepresent this point by providing generic advice for all patients. The aim of this review is to examine the evidence to support the use of BBs in CHF patients with common comorbid conditions.
Methods: We searched MEDLINE, PubMed, and the reference lists of reviews for RCTs, post hoc analyses, systematic reviews, and meta-analyses that report on use of BBs in CHF along with patient demographics and comorbidities.
Results: In total, 38 studies from 28 RCTs were identified, which provided data on six BBs against placebo or head to head with another BB agent in ischemic and nonischemic cardiomyopathies. Several studies explored BBs in older patients. Female patients and non-Caucasian race were underrepresented in trials. End points were cardiovascular hospitalization and mortality. Comorbid diabetes, renal impairment, or atrial fibrillation was detailed; however, no reference to disease spectrum or management goals as a focus could be seen in any of the studies. In this sense, enrollment may have limited more severe grades of these comorbidities.
Conclusions: RCTs provide authoritative information for a spectrum of CHF presentations that support guidelines. RCTs may provide inadequate information for more heterogeneous CHF patient cohorts. Greater Phase IV research may be needed to fill this gap and inform guidelines for a more global patient population
Use of shear sensitive coloured guest component to track powder mixing in adhesive binary mixtures
The mixing performance in binary powder blends with components exhibiting guest and host type interactions was assessed by tracking the colour change of the mixture. The operation parameters like mixing time and speed were studied in compositions containing lactose monohydrate as host and iron oxide nanoparticle as coloured guest components. The mixing characteristics were analysed through visual imaging and colorimetric estimations. Furthermore, surface analytical techniques like scanning electron microscope (SEM) for surface area coverage (SAC) determination and Finite Dilution Inverse Gas chromatography (FD-IGC) for surface energy heterogeneity characterisation were employed. The mixing sensitivity of the coloured tracer and the consequent colour transitions under different conditions helped in validating the mixing performance and operation conditions. The FD-IGC results showed a lowering of the energetic heterogeneity for better quality mixtures. Thus, a shear sensitive coloured nano-tracer can be utilised for a simple, quick and cost-effective estimation of the mixture quality and for the validation of mixing process
A numerical analysis of the influence of material properties on dry powder coating performance
Dry powder coating is a preferable surface modification technique over the traditional aqueous coating technique due to reduced energy waste and less environmental impact. Despite the benefits of dry powder coating, excessive amount of coating powder energy input is often applied to ensure sufficient coating is achieved. In this study, the Discrete Element Method (DEM) is utilised to assess the influence of material properties on dry coating efficiency in a blade-driven system. Granular Bond number is used to predict coating performance based on multiple simulations with varied material properties. This provides insight on the optimal range of material properties (size ratio, density ratio and surface energy) to achieve uniformly distributed coatings, thus providing precise control of the quantity of coating material required and minimising energy consumption
The plastic number and its generalized polynomial
The polynomial has a unique positive root known as plastic
number, which is denoted by and is approximately equal to .
In this note we study the zeroes of the generalized polynomial
for and prove that its unique positive
root tends to the golden ratio as . We also derive bounds on in terms of Fibonacci
numbers.Comment: Publisher's pdf versio
Bounding the mass of the graviton using gravitional-wave observations of inspiralling compact binaries
If gravitation is propagated by a massive field, then the velocity of
gravitational waves (gravitons) will depend upon their frequency and the
effective Newtonian potential will have a Yukawa form. In the case of
inspiralling compact binaries, gravitational waves emitted at low frequency
early in the inspiral will travel slightly slower than those emitted at high
frequency later, modifying the phase evolution of the observed inspiral
gravitational waveform, similar to that caused by post-Newtonian corrections to
quadrupole phasing. Matched filtering of the waveforms can bound such
frequency-dependent variations in propagation speed, and thereby bound the
graviton mass. The bound depends on the mass of the source and on noise
characteristics of the detector, but is independent of the distance to the
source, except for weak cosmological redshift effects. For observations of
stellar-mass compact inspiral using ground-based interferometers of the
LIGO/VIRGO type, the bound on the graviton Compton wavelength is of the order
of km, about double that from solar-system tests of Yukawa
modifications of Newtonian gravity. For observations of super-massive black
hole binary inspiral at cosmological distances using the proposed laser
interferometer space antenna (LISA), the bound can be as large as km. This is three orders of magnitude weaker than model-dependent
bounds from galactic cluster dynamics.Comment: 8 pages, RevTeX, submitted to Phys. Rev.
Formation and Structure of a Current Sheet in Pulsed-Power Driven Magnetic Reconnection Experiments
We describe magnetic reconnection experiments using a new, pulsed-power
driven experimental platform in which the inflows are super-sonic but
sub-Alfv\'enic.The intrinsically magnetised plasma flows are long lasting,
producing a well-defined reconnection layer that persists over many
hydrodynamic time scales.The layer is diagnosed using a suite of high
resolution laser based diagnostics which provide measurements of the electron
density, reconnecting magnetic field, inflow and outflow velocities and the
electron and ion temperatures.Using these measurements we observe a balance
between the power flow into and out of the layer, and we find that the heating
rates for the electrons and ions are significantly in excess of the classical
predictions. The formation of plasmoids is observed in laser interferometry and
optical self-emission, and the magnetic O-point structure of these plasmoids is
confirmed using magnetic probes.Comment: 14 pages, 12 figures. Accepted for publication in Physics of Plasma
Radial Squeezed States and Rydberg Wave Packets
We outline an analytical framework for the treatment of radial Rydberg wave
packets produced by short laser pulses in the absence of external electric and
magnetic fields. Wave packets of this type are localized in the radial
coordinates and have p-state angular distributions. We argue that they can be
described by a particular analytical class of squeezed states, called radial
squeezed states. For hydrogenic Rydberg atoms, we discuss the time evolution of
the corresponding hydrogenic radial squeezed states. They are found to undergo
decoherence and collapse, followed by fractional and full revivals. We also
present their uncertainty product and uncertainty ratio as functions of time.
Our results show that hydrogenic radial squeezed states provide a suitable
analytical description of hydrogenic Rydberg atoms excited by short-pulsed
laser fields.Comment: published in Physical Review
An Experimental Platform for Pulsed-Power Driven Magnetic Reconnection
We describe a versatile pulsed-power driven platform for magnetic
reconnection experiments, based on exploding wire arrays driven in parallel
[Suttle, L. G. et al. PRL, 116, 225001]. This platform produces inherently
magnetised plasma flows for the duration of the generator current pulse (250
ns), resulting in a long-lasting reconnection layer. The layer exists for long
enough to allow evolution of complex processes such as plasmoid formation and
movement to be diagnosed by a suite of high spatial and temporal resolution
laser-based diagnostics. We can access a wide range of magnetic reconnection
regimes by changing the wire material or moving the electrodes inside the wire
arrays. We present results with aluminium and carbon wires, in which the
parameters of the inflows and the layer which forms are significantly
different. By moving the electrodes inside the wire arrays, we change how
strongly the inflows are driven. This enables us to study both symmetric
reconnection in a range of different regimes, and asymmetric reconnection.Comment: 14 pages, 9 figures. Version revised to include referee's comments.
Submitted to Physics of Plasma
Why do dogs (Canis familiaris) select the empty container in an observational learning task?
Many argue that dogs show unique susceptibility to human communicative signals that make them suitable for being engaged in complex co-operation with humans. It has also been revealed that socially provided information is particularly effective in influencing the behaviour of dogs even when the human’s action demonstration conveys inefficient or mistaken solution of task. It is unclear, however, how the communicative nature of the demonstration context and the presence of the human demonstrator affect the dogs’ object-choice behaviour in observational learning situations. In order to unfold the effects of these factors, 76 adult pet dogs could observe a communicative or a non-communicative demonstration in which the human retrieved a tennis ball from under an opaque container while manipulating another distant and obviously empty (transparent) one. Subjects were then allowed to choose either in the presence of the demonstrator or after she left the room. Results showed a significant main effect of the demonstration context (presence or absence of the human’s communicative signals), and we also found some evidence for the response-modifying effect of the presence of the human demonstrator during the dogs’ choice. That is, dogs predominantly chose the baited container, but if the demonstration context was communicative and the human was present during the dogs’ choice, subjects’ tendency to select the baited container has been reduced. In agreement with the studies showing sensitivity to human’s communicative signals in dogs, these findings point to a special form of social influence in observational learning situations when it comes to learning about causally opaque and less efficient (compared to what comes natural to the dog) action demonstrations
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