Inverse correlation between testosterone and ventricle ejection fraction, hemodynamics and exercise capacity in heart failure patients with erectile dysfunction

BACKGROUND: Neurohormonal activation and abnormalities in growth hormone and testosterone concentrations have been reported in heart failure (HF). Erectile dysfunction(ED) is common in these patients and contributes to a low quality of life. No data are known regarding the correlation between testosterone and hemodynamics, exercise capacity and cardiac function in HF patients with ED, a marker of endothelial dysfunction. The aim of this study was to correlate testosterone levels with cardiac function, hemodynamic and exercise capacity in HF patients with ED. MATERIALS AND METHODS: Fifteen HF patients underwent a six-minute treadmill cardiopulmonary walking test (6'CWT) and, ten minutes later, a maximum cardiopulmonary exercise test. Also, testosterone and other hormones were determined at rest. RESULTS: Among hemodynamic variables only diastolic blood pressure on 6'CWT was correlated with testosterone levels(r =- 0.66, p = 0.007). The variables on exercise tests, VE/VCO2 slope and oxygen consumption did not show any correlation, except the distance at 6'CWT (r = 0.50, p = 0,047). Right and left ventricle ejection fraction showed inverse correlation with testosterone (r =- 0.55, p = 0.03 and r =- 0.69, p = 0.004 respectively). CONCLUSION: Testosterone levels correlated directly with distance at six-minute cardiopulmonary walk test and inversely with diastolic blood pressure, right and left ventricle ejection fraction in heart failure patients with erectile dysfunction. Further elucidation of mechanisms as regards testosterone action in these patients is warranted

Mass Production and Morphology of Marandu Brachiaria Under Different Nitrogen Rates in the Brazilian Savannah

Nitrogen is the nutrient that most contributes to increase forage productivity and quality. The objective was to evaluate Marandu brachiaria submitted to nitrogen doses in the Brazilian savannah through the total and green mass production, leaf:stem and brachiaria:weed ratio. Plots were established in a randomized block design, with four replications and four N doses 0, 50, 100 and 150 kg N/ha). After the uniformization cut, the data collect cycles occurred when the canopy reached 30 cm average height. Samples were taken until 15 cm from the ground in an area of 0.25 m2. Fractions were separated according botanical (brachiaria and weeds) and morphological (leaf, stem, dead material and inflorescence) components. The highest value of dry matter production and green mass production occurred at 96 and 72 kg N/ha dose (2,669 kg and 1,946 DM/ha). Above and below this value the mass production decreased . The highest relation green mass:dead material ratio was 4.00 at 150 kg N/ha dose. Marandu was able to control the weeds, and the best performance (4.67) was observed at 78 kg N/ha dose. Forage accumulation rate is the mass production/day and the highest accumulation rate occurred at 50 kg N/ha dose. Marandu had higher leaf:stem ratio with nitrogen dose 107 kg N/ha but above 50 kg/N the mass accumulation rate decrease which means that the fertilization cost is not favorable over up this dose, especially above dose 72 kg N/kg when there green mass production decrease

Electro-Thermal Behavior of Layer-Wound BSCCO Coils With and Without Insulation

In this work, the electro-thermal behavior of two layer-wound High Temperature Superconducting (HTS) coils, realized with and without electrical insulation, is compared. Both coils are wound from the same BSCCO tape, and have a very similar geometry, with the same number of turns and layers. A heat input is applied to both coils, by tuning the current supplied to resistive heaters realized through stainless steel tapes wound on the mandrel at the inner surface of both coils. The heaters are in contact with one full inner turn of the winding. The coils are cooled in a liquid nitrogen bath, and the heaters are supplied with a constant current. Then, the windings are charged until the tape critical current is exceeded, and the tests are repeated for different heat loads. The signals acquired through voltage taps, suitably soldered at the same locations in both windings, are compared at the same testing conditions. Finally, the electrical characteristic of the different layers of the coils is related to the temperature of the heater and of the various turns of the coil by means of a 1-D thermal model

Canopy Changes of Brachiaria Managed Under Continuous Stocking in the Dry-Water Transition

Pasture supplementation is an alternative to take advantage of the forage mass deferred in the rainy season and maintain or provide weight gain in periods of rain absence. The objective was to compare the structural characteristics, mass production, density and population dynamics of tillers of Urochloa brizantha cv. ‘Paiaguas’ and U. spp. cv. ‘Convert’ under fixed and continuous stocking with steers supplemented in the trough or on the ground in the water/dry transition period. The experiment was carried out at Jatai Federal University, from March to June, in a completely randomized design and a 2x2 factorial scheme, using six paddocks/treatment. The completely randomized design was adopted and variance analysis was performed with software SAS following the GLM procedure, were compared using repeated-measures. There was a significant interaction between Brachiaria and the method of supplementation for basal, aerial, and total tiller density. Convert had an average of 551 basal and 577 total tiller/m2. Paiaguas grass presented higher tiller density (1,03 vs. 582 tiller/m2) and higher tiller birth rate (12.92 vs. 9.14%) than Convert. No significant difference was observed between brachiarias. The average height of Paiaguas was 62.34 and 50.70 cm for Convert. The average height was 57.83 and on the ground it was 54.90 cm. Supplementation offer method changed Paiaguas canopy. The Convert showed higher leaf and dead mass production but lower weeds despite its smaller tillering

Canopy Changes of Brachiaria Managed Under Continuous Stocking in the Dry-Water Transition

Pasture supplementation is an alternative to take advantage of the forage mass deferred in the rainy season and maintain or provide weight gain in periods of rain absence. The objective was to compare the structural characteristics, mass production, density and population demography of tillers of Urochloa brizantha cv. Paiaguás and Urochloa spp. cv. Convert under fixed and continuous stocking with steers supplemented with pelleted concentrate supplied in the trough or on the ground in the water/dry transition period. The experiment was carried out in the Jatai Federal University, from March to June 2020, in a completely randomized design and a 2 x 2 factorial scheme, using six paddocks/treatment. SAS was used considering repeated measures (RM) at 5% to do variance analysis. There was a significant interaction between Brachiaria and the method of supplementation for basal tiller, aerial and total tiller density. Convert-grass had an average of 551 basal and 577 total tiller/m2. Paiaguas grass presented higher tiller density (1,028 vs. 582 tiller/m2) and higher tiller birth rate (12.92 vs. 9.14%) than Convert. No significant difference was observed between the brachiarias. The average height of Paiaguas-grass was 62.34 cm and 50.70 cm for Convert-grass. The average height was 57.83 cm and on the ground it was 54.90 cm. Supplementation offer method changed Paiaguas canopy. The Convert showed higher leaf and dead mass production but lower weeds despite its smaller tillering

Acute Aerobic Exercise Reduces 24-H Ambulatory Blood Pressure Levels in Long-Term-Treated Hypertensive Patients

BACKGROUND: Even with anti-hypertensive therapy, it is difficult to maintain optimal systemic blood pressure values in hypertensive patients. Exercise may reduce blood pressure in untreated hypertensive, but its effect when combined with long-term anti-hypertensive therapy remains unclear. Our purpose was to evaluate the acute effects of a single session of aerobic exercise on the blood pressure of long-term-treated hypertensive patients. METHODS: Fifty treated hypertensive patients (18/32 male/female; 46.5±8.2 years; Body mass index: 27.8±4.7 kg/m²) were monitored for 24 h with respect to ambulatory (A) blood pressure after an aerobic exercise session (post-exercise) and a control period (control) in random order. Aerobic exercise consisted of 40 minutes on a cycle-ergometer, with the mean exercise intensity at 60% of the patient's reserve heart rate. RESULTS: Post-exercise ambulatory blood pressure was reduced for 24 h systolic (126±8.6 vs. 123.1±8.7 mmHg, p=0.004) and diastolic blood pressure (81.9±8 vs. 79.8±8.5 mmHg, p=0.004), daytime diastolic blood pressure (85.5±8.5 vs. 83.9±8.8 mmHg, p=0.04), and nighttime S (116.8±9.9 vs. 112.5±9.2 mmHg, p<0.001) and diastolic blood pressure (73.5±8.8 vs. 70.1±8.4 mmHg, p<0.001). Post-exercise daytime systolic blood pressure also tended to be reduced (129.8±9.3 vs. 127.8±9.4 mmHg, p=0.06). These post-exercise decreases in ambulatory blood pressure increased the percentage of patients displaying normal 24h systolic blood pressure (58% vs. 76%, p=0.007), daytime systolic blood pressure (68% vs. 82%, p=0.02), and nighttime diastolic blood pressure (56% vs. 72%, p=0.02). Nighttime systolic blood pressure also tended to increase (58% vs. 80%, p=0.058). CONCLUSION: A single bout of aerobic exercise reduced 24h ambulatory blood pressure levels in long-term-treated hypertensive patients and increased the percentage of patients reaching normal ambulatory blood pressure values. These effects suggest that aerobic exercise may have a potential role in blood pressure management of long-term-treated hypertensive

Numerical study of jets produced by conical wire arrays on the Magpie pulsed power generator

The aim of this work is to model the jets produced by conical wire arrays on the MAGPIE generator, and to design and test new setups to strengthen the link between laboratory and astrophysical jets. We performed the modelling with direct three-dimensional magneto-hydro-dynamic numerical simulations using the code GORGON. We applied our code to the typical MAGPIE setup and we successfully reproduced the experiments. We found that a minimum resolution of approximately 100 is required to retrieve the unstable character of the jet. We investigated the effect of changing the number of wires and found that arrays with less wires produce more unstable jets, and that this effect has magnetic origin. Finally, we studied the behaviour of the conical array together with a conical shield on top of it to reduce the presence of unwanted low density plasma flows. The resulting jet is shorter and less dense.Comment: Accepted for publication in Astrophysics & Space Science. HEDLA 2010 conference procedings. Final pubblication will be available on Springe

Acute aerobic exercise reduces 24-h ambulatory blood pressure levels in long-term-treated hypertensive patients

BACKGROUND: Even with anti-hypertensive therapy, it is difficult to maintain optimal systemic blood pressure values in hypertensive patients. Exercise may reduce blood pressure in untreated hypertensive, but its effect when combined with long-term anti-hypertensive therapy remains unclear. Our purpose was to evaluate the acute effects of a single session of aerobic exercise on the blood pressure of long-term-treated hypertensive patients. METHODS: Fifty treated hypertensive patients (18/32 male/female; 46.5±8.2 years; Body mass index: 27.8±4.7 kg/m²) were monitored for 24 h with respect to ambulatory (A) blood pressure after an aerobic exercise session (post-exercise) and a control period (control) in random order. Aerobic exercise consisted of 40 minutes on a cycle-ergometer, with the mean exercise intensity at 60% of the patient's reserve heart rate. RESULTS: Post-exercise ambulatory blood pressure was reduced for 24 h systolic (126±8.6 vs. 123.1±8.7 mmHg, p=0.004) and diastolic blood pressure (81.9±8 vs. 79.8±8.5 mmHg, p=0.004), daytime diastolic blood pressure (85.5±8.5 vs. 83.9±8.8 mmHg, p=0.04), and nighttime S (116.8±9.9 vs. 112.5±9.2 mmHg,

Long-Term Oral Administration of Theaphenon-E Improves Cardiomyocyte Mechanics and Calcium Dynamics by Affecting Phospholamban Phosphorylation and ATP Production

Background/Aims: Dietary polyphenols from green tea have been shown to possess cardio-protective activities in different experimental models of heart diseases and age-related ventricular dysfunction. The present study was aimed at evaluating whether long term in vivo administration of green tea extracts (GTE), can exert positive effects on the normal heart, with focus on the underlying mechanisms. Methods: The study population consisted of 20 male adult Wistar rats. Ten animals were given 40 mL/day tap water solution of GTE (concentration 0.3%) for 4 weeks (GTE group). The same volume of water was administered to the 10 remaining control rats (CTRL). Then, in vivo and ex vivo measurements of cardiac function were performed in the same animal, at the organ (hemodynamics) and cellular (cardiomyocyte mechanical properties and intracellular calcium dynamics) levels. On cardiomyocytes and myocardial tissue samples collected from the same in vivo studied animals, we evaluated: (1) the intracellular content of ATP, (2) the endogenous mitochondrial respiration, (3) the expression levels of the Sarcoplasmic Reticulum Ca2+-dependent ATPase 2a (SERCA2), the Phospholamban (PLB) and the phosphorylated form of PLB, the L-type Ca2+ channel, the Na+-Ca2+ exchanger, and the ryanodine receptor 2. Results: GTE cardiomyocytes exhibited a hyperdynamic contractility compared with CTRL (the rate of shortening and re-lengthening, the fraction of shortening, the amplitude of calcium transient, and the rate of cytosolic calcium removal were significantly increased). A faster isovolumic relaxation was also observed at the organ level. Consistent with functional data, we measured a significant increase in the intracellular ATP content supported by enhanced endogenous mitochondrial respiration in GTE cardiomyocytes, as well as higher values of the ratios phosphorylated-PLB/PLB and SERCA2/PLB. Conclusions: Long-term in vivo administration of GTE improves cell mechanical properties and intracellular calcium dynamics in normal cardiomyocytes, by increasing energy availability and removing the inhibitory effect of PLB on SERCA2