Is demagnetization an efficient optimization method?

Demagnetization, commonly employed to study ferromagnets, has been proposed as the basis for an optimization tool, a method to find the ground state of a disordered system. Here we present a detailed comparison between the ground state and the demagnetized state in the random field Ising model, combing exact results in $d=1$ and numerical solutions in $d=3$. We show that there are important differences between the two states that persist in the thermodynamic limit and thus conclude that AC demagnetization is not an efficient optimization method.Comment: 2 pages, 1 figur

Autoerotic accidental death by Self-inflicted asphyxia by Body-wrapping in a plastic curtain

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Prevalence of comorbidities according to predominant phenotype and severity of chronic obstructive pulmonary disease

BACKGROUND: In addition to lung involvement, several other diseases and syndromes coexist in patients with chronic obstructive pulmonary disease (COPD). Our purpose was to investigate the prevalence of idiopathic arterial hypertension (IAH), ischemic heart disease, heart failure, peripheral vascular disease (PVD), diabetes, osteoporosis, and anxious depressive syndrome in a clinical setting of COPD outpatients whose phenotypes (predominant airway disease and predominant emphysema) and severity (mild and severe diseases) were determined by clinical and functional parameters. METHODS: A total of 412 outpatients with COPD were assigned either a predominant airway disease or a predominant emphysema phenotype of mild or severe degree according to predictive models based on pulmonary functions (forced expiratory volume in 1 second/vital capacity; total lung capacity %; functional residual capacity %; and diffusing capacity of lung for carbon monoxide %) and sputum characteristics. Comorbidities were assessed by objective medical records. RESULTS: Eighty-four percent of patients suffered from at least one comorbidity and 75% from at least one cardiovascular comorbidity, with IAH and PVD being the most prevalent ones (62% and 28%, respectively). IAH prevailed significantly in predominant airway disease, osteoporosis prevailed significantly in predominant emphysema, and ischemic heart disease and PVD prevailed in mild COPD. All cardiovascular comorbidities prevailed significantly in predominant airway phenotype of COPD and mild COPD severity. CONCLUSION: Specific comorbidities prevail in different phenotypes of COPD; this fact may be relevant to identify patients at risk for specific, phenotype-related comorbidities. The highest prevalence of comorbidities in patients with mild disease indicates that these patients should be investigated for coexisting diseases or syndromes even in the less severe, pauci-symptomatic stages of COPD. The simple method employed to phenotype and score COPD allows these results to be translated easily into daily clinical practice

Mean Curvature Flow on Ricci Solitons

We study monotonic quantities in the context of combined geometric flows. In particular, focusing on Ricci solitons as the ambient space, we consider solutions of the heat type equation integrated over embedded submanifolds evolving by mean curvature flow and we study their monotonicity properties. This is part of an ongoing project with Magni and Mantegazzawhich will treat the case of non-solitonic backgrounds \cite{a_14}.Comment: 19 page

Preliminary definitions for the sonographic features of synovitis in children

Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process. A Likert scale of 1-5 with 1 indicating complete disagreement and 5 complete agreement was used. A minimum of 80% of the experts scoring 4 or 5 was required for final approval. The definitions were then validated on 120 standardized US images of the wrist, MCP and tibiotalar joints displaying various degrees of synovitis at various ages. Results B-Mode and Doppler should be used for assessing synovitis in children. A US definition of the various components (i.e. synovial hypertrophy, effusion and Doppler signal within the synovium) was developed. The definition was validated on still images with a median of 89% (range 80-100) of participants scoring it as 4 or 5 on a Likert scale. Conclusions US definitions of synovitis and its elementary components covering the entire pediatric age range were successfully developed through a Delphi process and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of synovitis in clinical practice and research

Robust global state feedback stabilization of cement mills

peer reviewedPlugging is well known to be a major cause of instability in industrial cement mills. A simple nonlinear model able to simulate the plugging phenomenon is presented. It is shown how a nonlinear robust controller can be designed in order to fully prevent the mill from pluggin

Fuel performance simulations of ESNII prototypes: Results on the MYRRHA case study

Nominal and transient conditions of the ESNII prototypes were investigated in the INSPYRE Project using the European fuel performance codes GERMINAL, MACROS and TRANSURANUS. This Deliverable presents the results of the simulations of the MYRRHA case study: MYRRHA nominal irradiation conditions and the occurrence of a beam power jump (over‐power) transient at the beginning and end of life of the fuel pin in reactor. Besides the application of the reference (“pre‐INSPYRE”) code versions, the activity involves the evaluation of the impact of the improved models of MOX fuel properties developed in INSPYRE and implemented in the three fuel performance codes. These modelling advances concern the thermal properties (thermal conductivity, melting temperature), mechanical properties (thermal expansion, Young’s modulus) and the mechanistic treatment of fission gas behaviour and release from MOX fuels. The results yielded by the pre‐INSPYRE and post‐INSPYRE versions of the codes involved are presented and assessed in terms of evolution in time, as well as axial and radial profiles of significant quantities, both integral and local. Then, the code results are compared with the design limits set for the MYRRHA fuel pins, in particular the maximal fuel temperature admitted, which prevents fuel melting, and the maximal allowed cladding plasticity that ensures the cladding integrity. The outcome is a complete compliance of the pin behaviour with the design limits, respecting adequate margins even in the case of the hottest fuel pin and in the case of beam power jump transients

Triple-Phase Multidetector Computed Tomography in Distinguishing Canine Hepatic Lesions

The liver has a unique vascular supply, and triple-phase contrast-enhanced computed tomography examinations are being performed in order to characterize liver lesions. This study aimed to look for any associations between the attenuation values of liver lesions and their histological classification. The inclusion criteria for this retrospective study were focal or multifocal liver lesions and histological diagnosis. All of the dogs underwent pre-contrast and triple-phase postcontrast computed tomography (CT) examinations with identical timings of the postcontrast series. Thirtyone dogs were included in the study, and various benign and malignant pathologies were identified. The results did not identify any significant differences between the benign and malignant liver lesions, nor between the individual histological diagnoses. Inflammatory lesions were significantly different compared to the normal liver parenchyma, and significant hypoattenuation was found in the portal and delayed venous phases. Hemangiosarcomas were significantly hypoattenuating to the normal liver parenchyma in the pre-contrast and arterial phases, and also to all of the benign lesions in the arterial phase. The other pathologies showed variable attenuation patterns in the different postcontrast phases, and differentiation was not possible. On the basis of this study, triple-phase contrast-enhanced computed tomography cannot differentiate between benign and malignant liver lesions, and biopsy and further histological analysis are necessar

New insights into the biodegradation of thiodiglycol, the hydrolysis product of Yperite (sulfur mustard gas)

Aims: To isolate thiodiglycol (TDG)-degrading bacteria, the mustard gas hydrolysis product, and to characterize the metabolites formed and the enzymes involved in the degradation. Methods and Results: Two strains, identified as Achromobacter xylosoxydans G5 and Paracoccus denitrificans E4, isolated from a petroleum-contaminated soil, utilized TDG as sole carbon and sulfur source. During the degradation of TDG by strain E4 [(2-hydroxyethyl)thio] acetic acid (HETA), thiodiglycolic acid (TDGA) and bis-(2-hydroxyethyl)disulfide (BHEDS) were identified by gas chromatography\u2013mass spectrometry analysis, while HETA and TDGA were identified for strain G5. Two-dimensional isoelectric focussing-gel electrophoresis (2-D IEF/SDS\u2013PAGE) maps of protein extracts of P. denitrificans E4 grown on TDG showed a spot identified as a methanol dehydrogenase. Increased expression of a putative iscS gene, involved in sulfur assimilation, was observed in TDG-grown cells of A. xylosoxydans G5. Conclusions: TDG degradation by P. denitrificans E4 occurred through two pathways: one involved cleavage of the C\u2013S bond of HETA, yielding BHEDS and the other, oxidation of the alcoholic groups of TDG, yielding TDGA. The cleavage of the C\u2013S bond of TDGA gave mercaptoacetic acid, further oxidized to acetate and sulfate. Significance and Impact of the Study: Increased knowledge of TDG-degrading bacteria and the possibility of using them in a tailored-two-stage mustard gas destruction process