Rainfall rate retrieval in presence of path attenuation using C-band polarimetric weather radars

Weather radar systems are very suitable tools for the monitoring of extreme rainfall events providing measurements with high spatial and temporal resolution over a wide geographical area. Nevertheless, radar rainfall retrieval at C-band is prone to several error sources, such as rain path attenuation which affects the accuracy of inversion algorithms. In this paper, the so-called rain profiling techniques (namely the surface reference method FV and the polarimetric method ZPHI) are applied to correct rain path attenuation and a new neural network algorithm is proposed to estimate the rain rate from the corrected measurements of reflectivity and differential reflectivity. A stochastic model, based on disdrometer measurements, is used to generate realistic range profiles of raindrop size distribution parameters while a T-matrix solution technique is adopted to compute the corresponding polarimetric variables. A sensitivity analysis is performed in order to evaluate the expected errors of these methods. It has been found that the ZPHI method is more reliable than FV, being less sensitive to calibration errors. Moreover, the proposed neural network algorithm has shown more accurate rain rate estimates than the corresponding parametric algorithm, especially in presence of calibration errors

RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells

The balance between antiapoptotic and proapoptotic proteins of the Bcl-2 family is critical in determining the fate of T cells in response to death stimuli. Proapoptotic genes, such as bax, are generally regulated by the p53 family of transcription factors, whereas NF-kappaB subunits can activate the transcription of antiapoptotic Bcl-2 members. Here, we show that CD28 activation protects memory T cells from irradiation-induced apoptosis by both upregulating bcl-xL and inhibiting bax gene expression. We found that p73, but not p53, binds to and trans-activates the bax gene promoter in irradiated T cells. The activation of RelA/NF-kappaB subunit in CD28 costimulated T cells and its binding onto the bax gene promoter results in suppression of bax transcription and decrease in both p73 and RNA polymerase II recruitment in vivo. RelA recruitment on the bax gene promoter is also accompanied by the lost of p300 binding and the parallel appearance of histone deacetylase-1-containing complexes. These findings identify RelA/NF-kappaB as a critical regulator of T-cell survival by affecting the balance of Bcl-2 family members

fatal bullous pyoderma gangrenosum in a patient with klinefelter s syndrome

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Satellite radiometric remote sensing of rainfall fields: multi-sensor retrieval techniques at geostationary scale

International audienceThe Microwave Infrared Combined Rainfall Algorithm (MICRA) consists in a statistical integration method using the satellite microwave-based rain-rate estimates, assumed to be accurate enough, to calibrate spaceborne infrared measurements on limited sub-regions and time windows. Rainfall retrieval is pursued at the space-time scale of typical geostationary observations, that is at a spatial resolution of few kilometers and a repetition period of few tens of minutes. The actual implementation is explained, although the basic concepts of MICRA are very general and the method is easy to be extended for considering innovative statistical techniques or measurements from additional space-borne platforms. In order to demonstrate the potentiality of MICRA, case studies over central Italy are also discussed. Finally, preliminary results of MICRA validation by ground based remote and in situ measurements are shown and a comparison with a Neural Network (NN) based technique is briefly illustrated

On the calibration of DC resistance ratio bridges

Current comparator bridges are employed for the realization of the resistance scale from the quantum Hall effect in several National Metrology Institutes and calibration centers. Quantum resistance standards under development, based on novel materials and tabletop dry cryostats, make the more achievable DC current comparator bridges (DCCs) a viable alternative to the more accurate but more expensive cryogenic current comparator bridges (CCCs). A DCC ratios' calibration against a reference CCC is a straightforward way to improve the DCC's performances and the resistance scale overall accuracy.The paper reports the calibration results of two DCCs on the ratios employed in a 1 omega to 10 k omega resistance scale traceable to a 12.906 k omega quantized Hall resistance, showing a good reproducibility and stability of the DCC readings over the measurement period and supporting the possibility of a DCC errors' correction and of a realization of the primary resistance scale at the 10-8 level

HEMODIALYSIS-RELATED LYMPHOMONONUCLEAR RELEASE OF INTERLEUKIN 12 IN PATIENTS WITH END-STAGE RENAL DISEASE.

Abstract: Interleukin-12 (IL-12) is a cytokine produced by peripheral blood mononuclear cells (PBMC) that causes interferon-gamma (IFN-gamma) production and enhancement of cell-mediated cytotoxicity. To clarify the role of hemodialysis biocompatibility on IL-12 production and uremic immunodeficiency, we have studied the IL-12 and IFN-gamma release by PBMC harvested from 12 patients dialyzed with cuprophan membrane (CU), eight patients dialyzed with polymethylmethacrylate membrane (PMMA), and eight nondialyzed uremic patients (UR). Ten healthy subjects constituted the control group (CON). PBMC were cultured for 48 h with and without nonspecific mitogen stimulation. In unstimulated conditions, CU showed an IL-12 PBMC production higher than CON, UR, and PMMA (46.67 +/- 30.13 versus 2.56 +/- 1.38, 6.16 +/- 7.09, and 4.62 +/- 4.76 pg/ml, respectively; P < 0.01). IL-12 production was correlated with C3a concentration measured at the outlet of hemodialyzer after 15 min of dialysis (r = 0.69, P < 0.01). IL-12 release in CU remained unchanged under mitogen stimulation (44.34 +/- 23.86 pg/ml) and was lower than in CON, UR, and PMMA (66.0 +/- 12.41, 68.37 +/- 25.78, and 67.75 +/- 22.61 pg/ml, respectively; P < 0.05). IFN-gamma production was similar, in unstimulated conditions, in all groups. Under stimulation, IFN-gamma release was lower in CU (13.42 +/- 12.04 IU/ml) than in CON, UR, and PMMA (51.84 +/- 30.74, 32.16 +/- 13.86, and 32.16 +/- 13.86 IU/ml, respectively; P < 0.01). These results demonstrate that hemodialysis with CU induces monocyte activation with an enhanced release of IL-12. On the contrary, stimulated PBMC production of both IL-12 and IFN-gamma is lower in these patients than in CON, UR, and PMMA. The altered release of these cytokines could play a role in cell-mediated immunodeficiency of the uremic patients dialyzed with CU

Metrological assessment of DC current comparator resistance bridges

Direct-current comparator bridges (DCC) are the working horses of primary resistance metrology in the intermediate resistance range. Having a ratio accuracy reaching 10^-7 or better, they allow the realization of resistance scales and the calibration of artifact standard resistors for customers. In this paper we compare the performances of three commercial DCC bridges, by performing measurements on resistors in decadal ratios (1 Ω to 10 kΩ) of very high stability in a thermostated environment. The results show that the three bridges give mutually compatible results within the manufacturer’s specifications, therefore mutually validating the bridges; nevertheless, the readings time series show quite different statistical behavior, with internal correlations, making an evaluation of the Type A measurement uncertainty not trivial

Interactive management control via analytic hierarchy process (AHP). An empirical study in a public university hospital.

Management control in public university hospitals is a challenging task because of continuous changes due to external pressures (e.g. economic pressures, stakeholder focuses and scientific progress) and internal complexities (top management turnover, shared leadership, technological evolution, and researcher oriented mission). Interactive budgeting contributed to improving vertical and horizontal communication between hospital and stakeholders and between different organizational levels. This paper describes an application of Analytic Hierarchy Process (AHP) to enhance interactive budgeting in one of the biggest public university hospital in Italy. AHP improved budget allocation facilitating elicitation and formalization of units’ needs. Furthermore, AHP facilitated vertical communication among manager and stakeholders, as it allowed multilevel hierarchical representation of hospital needs, and horizontal communication among staff of the same hospital, as it allowed units’ need prioritization and standardization, with a scientific multi-criteria approach, without using complex mathematics. Finally, AHP allowed traceability of a complex decision making processes (as budget allocation), this aspect being of paramount importance in public sectors, where managers are called to respond to many different stakeholders about their choices

Extracutaneous involvement of pyoderma gangrenosum

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New insights into the pathogenesis of bullous pemphigoid: 2019 update

There are several lines of evidence indicating that the physiopathological bases of bullous pemphigoid (BP), the most common subepidermal autoimmune bullous disease, are hallmarked by the production of autoantibodies directed against the hemidesmosomal anchoring proteins BP180 and BP230. In contrast to the robustness of the latter assumption, the multifaceted complexity of upstream and downstream mechanisms implied in the pathogenesis of BP remains an area of intense speculation. So far, an imbalance between T regulatory cells and autoreactive T helper (Th) cells has been regarded as the main pathogenic factor triggering the autoimmune response in BP patients. However, the contributory role of signaling pathways fostering the B cell stimulation, such as Toll-like receptor activation, as well as that of ancillary inflammatory mechanisms responsible for blister formation, such as Th17 axis stimulation and the activation of the coagulation cascade, are still a matter of debate. In the same way, the pathomechanisms implied in the loss of dermal-epidermal adhesion secondary to autoantibodies binding are not fully understood. Herein, we review in detail the current concepts and controversies on the complex pathogenesis of BP, shedding light on the most recent theories emerging from the literature